Review
Medicine, General & Internal
Maria Noviani, Vasuki Ranjani Chellamuthu, Salvatore Albani, Andrea Hsiu Ling Low
Summary: Systemic sclerosis (SSc) is a complex multi-systemic disease with high mortality. Timing of appropriate treatments targeted at the underlying disease process is critical for improved outcomes. Molecular stratification can guide personalized therapies and potentially lead to better patient outcomes by integrating molecular characteristics and clinical phenotypes.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Chenxi Liu, Guang Song, Songxin Yan, Yangzhige He, Chaojun Hu, Yong Hou, Xiaoting Wen, Liubing Li, Fengchun Zhang, Heng Zhu, Yongzhe Li
Summary: A novel autoantibody, anti-SNRPA, has been identified and validated as a potential biomarker for diagnosing systemic sclerosis, using a protein array-based approach.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Paul C. Evans, Sean M. Davidson, Johann Wojta, Magnus Baeck, Sveva Bollini, Mairi Brittan, Alberico L. Catapano, Bill Chaudhry, Matthijs Cluitmans, Massimiliano Gnecchi, Tomasz J. Guzik, Imo Hoefer, Rosalinda Madonna, Joao P. Monteiro, Henning Morawietz, Elena Osto, Teresa Padro, Judith C. Sluimer, Carlo Gabriele Tocchetti, Kim Van der Heiden, Gemma Vilahur, Johannes Waltenberger, Christian Weber
Summary: This article reviews the highlights of cardiovascular basic science published in 2021 and early 2022. It covers topics including non-coding RNAs, single-cell 'omics, extracellular vesicles, cardiovascular sensing of mechanical force, atherosclerosis, cardiac arrhythmia, inducible pluripotent stem cell technology, and the association between COVID-19 and the cardiovascular system.
CARDIOVASCULAR RESEARCH
(2022)
Review
Health Care Sciences & Services
Francesco Bonomi, Silvia Peretti, Gemma Lepri, Vincenzo Venerito, Edda Russo, Cosimo Bruni, Florenzo Iannone, Sabina Tangaro, Amedeo Amedei, Serena Guiducci, Marco Matucci Cerinic, Silvia Bellando Randone
Summary: Machine learning shows promising applications in systemic sclerosis, including early diagnosis, classification, and treatment prediction, offering new possibilities for precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Giorgia Leodori, Chiara Pellicano, Valerio Basile, Amalia Colalillo, Luca Navarini, Antonietta Gigante, Francesca Gulli, Mariapaola Marino, Umberto Basile, Edoardo Rosato
Summary: This study aimed to evaluate the longitudinal association between basal serum adiponectin and skin thickness in systemic sclerosis (SSc) patients. The results showed a correlation between decreased serum adiponectin levels and increased skin thickness.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Theodoros Karampitsakos, Brenda M. Juan-Guardela, Argyris Tzouvelekis, Jose D. Herazo-Maya
Summary: Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and lethal chronic lung disease. Precision medicine approaches have not been effectively implemented in IPF clinical practice, despite the existence of numerous diagnostic, prognostic, and theragnostic biomarker candidates.
Review
Medicine, General & Internal
Thilo von Groote, Melanie Meersch-Dini
Summary: Sepsis and septic shock are major public health concerns, but current treatment strategies often lack precision. Biomarkers provide opportunities to improve patient care and clinical research, by predicting and evaluating these conditions. They can potentially pave the way for precision medicine in sepsis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Dawn L. Demeo
Summary: Considering sex and gender differences is crucial in achieving precision pulmonary medicine, especially in developing reliable COPD biomarkers. Attention to these differences may lead to progress in biomarker development and clinical innovation to improve lung health for both men and women.
Review
Biochemistry & Molecular Biology
Maria Alexandra Angelescu, Octavian Andronic, Simona Olimpia Dima, Irinel Popescu, Irit Meivar-Levy, Sarah Ferber, Daniela Lixandru
Summary: Diabetes mellitus is a complex disease that requires early diagnosis and treatment to prevent complications. MiRNAs have shown promise as biomarkers for early detection and monitoring of the disease. Further research is needed to validate their effectiveness in diagnosing and treating diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
James Meehan, Mark Gray, Carlos Martinez-Perez, Charlene Kay, Duncan McLaren, Arran K. Turnbull
Summary: Prostate cancer is the second most common male cancer worldwide, diagnosed based on clinical signs and PSA levels, although the lack of specificity in PSA levels is a concern. Current biomarker research focuses on disease diagnosis, but there is a need for novel biomarkers for prognosis, prediction, and treatment response to enhance precision medicine approach in managing prostate cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shingo Nakayamada, Yoshiya Tanaka
Summary: The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythematosus is a disease with high heterogeneous immune abnormalities, and diverse cells or molecules can be treatment targets. Thus, the identification of subpopulations based on immune abnormalities is essential for the development of effective treatment.
Review
Biochemistry & Molecular Biology
Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Eloisa Romano, Mirko Manetti
Summary: Systemic sclerosis (SSc, scleroderma) is a rare connective tissue disease characterized by immune dysregulation, small vessel vasculopathy, impaired angiogenesis, and fibrosis. Microvascular impairment is the initial event of the disease and is linked to disabling and life-threatening clinical manifestations. Despite available treatment options, managing SSc-related vascular disease remains challenging. Vascular biomarkers have shown promise in assessing disease progression, predicting prognosis, and guiding therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth
Summary: In the era of precision medicine, drug discovery and development are undergoing unprecedented opportunities and challenges. By adopting new technologies and methods, the transition from serendipity-driven to data-driven approach is achieved, promoting the development of modern Translational Precision Medicine methods.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Zuzanna Gogulska, Zaneta Smolenska, Jacek Turyn, Adriana Mika, Zbigniew Zdrojewski
Summary: This review summarized studies on lipidomics in systemic sclerosis, focusing on lipoproteins, fatty acids, cholesterol, and other components, highlighting their potential role in the disease pathology.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Immunology
Aline G. Souza, Leandro M. Colli
Summary: Tumor cells use extracellular vesicles as a vital pathway for communication with non-malignant cells, employing various strategies for survival and dissemination in the tumor environment. These vesicles carry different molecules that, when internalized by target cells, activate signaling pathways and molecular processes, promoting and disseminating neoplastic cells. Proteins, nucleic acids, and cytokines, such as interleukins, are the main types of molecules carried by extracellular vesicles, and their association reveals potential approaches for the diagnosis and therapeutics of various neoplasms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Peter J. Wermuth, Sonsoles Piera-Velazquez, Sergio A. Jimenez
Article
Medicine, Research & Experimental
Peter J. Wermuth, Fabian A. Mendoza, Sergio A. Jimenez
LABORATORY INVESTIGATION
(2019)
Review
Physiology
Sonsoles Piera-Velazquez, Sergio A. Jimenez
PHYSIOLOGICAL REVIEWS
(2019)
Article
Rheumatology
Fabian A. Mendoza, Cathy Lee-Ching, Sergio A. Jimenez
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Article
Rheumatology
Christopher W. Wasson, Giuseppina Abignano, Heidi Hermes, Maya Malaab, Rebecca L. Ross, Sergio A. Jimenez, Howard Y. Chang, Carol A. Feghali-Bostwick, Francesco del Galdo
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Review
Immunology
Peter J. Wermuth, Sergio A. Jimenez
AUTOIMMUNITY REVIEWS
(2020)
Review
Dermatology
Edward J. Macarak, Peter J. Wermuth, Joel Rosenbloom, Jouni Uitto
Summary: Keloid disorder is a fibroproliferative skin disease characterized by the accumulation of extracellular matrix in skin, mainly collagen, with a strong genetic predisposition in individuals of African and Asian ancestry. The activation of biosynthetic pathways leading to ECM accumulation is driven by several cytokines, notably TGF-beta signaling, and the mechanical properties of the cellular microenvironment also play a critical role in the cell's response to these signals. Studies have shown that fibroblasts derived from keloids demonstrate different biosynthetic capacities when cultured on substrata with different degrees of stiffness, highlighting the complexity of factors involved in keloid pathogenesis.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Rheumatology
Sonsoles Piera-Velazquez, Peter J. Wermuth, Juan J. Gomez-Reino, John Varga, Sergio A. Jimenez
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Review
Rheumatology
Fabian A. Mendoza, Sergio A. Jimenez
Summary: Serine/threonine kinases mediate phosphorylation of intracellular protein targets and play a crucial role in regulating cellular functions, including fibrosis development and maintenance in diseases. Drugs targeting and inhibiting these kinases have been developed and may serve as potential therapeutic agents for fibrotic diseases.
Review
Rheumatology
Sergio A. Jimenez, Sonsoles Piera-Velazquez
Summary: SSc is a systemic autoimmune disease characterized by progressive fibrosis that affects the skin and internal organs, leading to severe disability and high mortality. Recent research suggests that the extension of fibrosis may be mediated by exosome microvesicles released from SSc-affected cells.
Article
Multidisciplinary Sciences
Sonsoles Piera-Velazquez, Simon T. Dillon, Xuesong Gu, Towia A. Libermann, Sergio A. Jimenez
Summary: The analysis of serum exosomes using aptamer proteomics can help identify differentially expressed proteins between patients with Raynaud's Phenomenon at high risk of evolving into Systemic Sclerosis (SSc) and those with Primary Raynaud's Phenomenon. Some of these proteins are involved in relevant biological pathways related to SSc pathogenesis, including inflammatory responses, immune cell activation, and vascular abnormalities.
Article
Cell Biology
Joseph P. Flemming, Brianna L. Hill, Mohammed W. Haque, Jessica Raad, Claudine S. Bonder, Larry A. Harshyne, Ulrich Rodeck, Adam Luginbuhl, James K. Wahl, Kenneth Y. Tsai, Peter J. Wermuth, Andrew M. Overmiller, My G. Mahoney
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Rheumatology
S. Piera-Velazquez, S. A. Jimenez
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2018)