Signalling from the periphery to the brain that regulates energy homeostasis

Activation of murine pre-proglucagon–producing neurons reduces food intake and body weight

(2017) Ronald P. Gaykema et al.   JOURNAL OF CLINICAL INVESTIGATION

AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons

(2017) Rachel A. Essner et al.   JOURNAL OF NEUROSCIENCE

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB

(2017) Robert E. Steinert et al.   PHYSIOLOGICAL REVIEWS

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

(2017) Yumei Xiong et al.   Science Translational Medicine

Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors

(2016) Ai-Jun Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Parabrachial CGRP Neurons Control Meal Termination

(2016) Carlos A. Campos et al.   Cell Metabolism

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice

(2016) Melissa A. Burmeister et al.   DIABETES

Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

(2016) Lili Ding et al.   HEPATOLOGY

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Genetically and functionally defined NTS to PBN brain circuits mediating anorexia

(2016) Carolyn W. Roman et al.   Nature Communications

Fibroblast Growth Factor Signaling in Metabolic Regulation

(2016) Vera J. M. Nies et al.   Frontiers in Endocrinology

Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor

(2015) Amber L. Alhadeff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes

(2015) Randy J. Seeley et al.   Cell Metabolism

Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia

(2015) Jean-Philippe Krieger et al.   DIABETES

An Analysis of Cosecretion and Coexpression of Gut Hormones From Male Rat Proximal and Distal Small Intestine

(2015) Berit Svendsen et al.   ENDOCRINOLOGY

TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice

(2015) Anne K McGavigan et al.   GUT

Gut chemosensing mechanisms

(2015) Arianna Psichas et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

(2015) Darleen A. Sandoval et al.   PHYSIOLOGICAL REVIEWS

Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy

(2015) D. Ripken et al.   PHYSIOLOGY & BEHAVIOR

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

(2015) Virginie Mansuy-Aubert et al.   eLife

Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors

(2014) Rebecca A. Darling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Leptin receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake

(2014) Amber L. Alhadeff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents

(2014) Jianping Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

SnapShot: Neural Pathways that Control Feeding

(2014) Martin G. Myers et al.   Cell Metabolism

PPARγ in Vagal Neurons Regulates High-Fat Diet Induced Thermogenesis

(2014) Chen Liu et al.   Cell Metabolism

GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6-Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

(2014) F. Kahles et al.   DIABETES

Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect

(2014) Stephanie Sisley et al.   JOURNAL OF CLINICAL INVESTIGATION

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Presynaptic Partners of Dorsal Raphe Serotonergic and GABAergic Neurons

(2014) Brandon Weissbourd et al.   NEURON

Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

(2014) Tevye J. Stachniak et al.   NEURON

Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Parabrachial Nucleus Contributes to the Control of Food Intake and Motivation to Feed

(2014) Amber L Alhadeff et al.   NEUROPSYCHOPHARMACOLOGY

Rapid gastric and intestinal transit is a major determinant of changes in blood glucose, intestinal hormones, glucose absorption and postprandial symptoms after gastric bypass

(2014) Nam Q. Nguyen et al.   Obesity

Vagal Innervation of Intestine Contributes to Weight Loss After Roux-en-Y Gastric Bypass Surgery in Rats

(2014) Zheng Hao et al.   OBESITY SURGERY

Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity

(2014) Guillaume de Lartigue et al.   Molecular Metabolism

Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy

(2013) Adam P. Chambers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty

(2013) Astrid Plamboeck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

(2013) H. E. Wilson-Perez et al.   DIABETES

Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse

(2013) L Gautron et al.   INTERNATIONAL JOURNAL OF OBESITY

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

The endocrinology of food intake

(2013) Denovan P. Begg et al.   Nature Reviews Endocrinology

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner

(2013) Andriy Myronovych et al.   Obesity

Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans

(2013) Ahmed Yousseif et al.   OBESITY SURGERY

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency

(2013) Mohamad Mokadem et al.   Molecular Metabolism

Metabolic signals and food intake. Forty years of progress

(2012) Stephen C. Woods   APPETITE

Neurochemical Characterization of Body Weight-Regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract

(2012) Alastair S. Garfield et al.   ENDOCRINOLOGY

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

(2012) Karen K. Ryan et al.   ENDOCRINOLOGY

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

The effect of vertical sleeve gastrectomy on food choice in rats

(2012) H E Wilson-Pérez et al.   INTERNATIONAL JOURNAL OF OBESITY

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

Glucose-dependent trafficking of 5-HT3 receptors in rat gastrointestinal vagal afferent neurons

(2012) T. Babic et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

(2012) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1

(2011) Matthew R. Hayes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Vagal Innervation of the Hepatic Portal Vein and Liver Is Not Necessary for Roux-En-Y Gastric Bypass Surgery-Induced Hypophagia, Weight Loss, and Hypermetabolism

(2011) Andrew C. Shin et al.   ANNALS OF SURGERY

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

(2011) Gina M. Leinninger et al.   Cell Metabolism

CCK Stimulation of GLP-1 Neurons Involves α 1 -Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

(2011) Kazunari Hisadome et al.   DIABETES

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

Role of central serotonin and melanocortin systems in the control of energy balance

(2011) Oliver J. Marston et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structure, regulation and function of ghrelin

(2011) T. Sato et al.   JOURNAL OF BIOCHEMISTRY

Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice

(2011) Michael M. Scott et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function

(2011) J. G. Barrera et al.   JOURNAL OF NEUROSCIENCE

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius

(2010) Kazunari Hisadome et al.   DIABETES

Effects of albumin-conjugated PYY on food intake: the respective roles of the circumventricular organs and vagus nerve

(2010) Elena-Dana Baraboi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hepatic-Portal Vein Infusions of Glucagon-Like Peptide-1 Reduce Meal Size and Increase c-Fos Expression in the Nucleus Tractus Solitarii, Area Postrema and Central Nucleus of the Amygdala in Rats

(2010) I. Baumgartner et al.   JOURNAL OF NEUROENDOCRINOLOGY

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

(2009) A. Pocai et al.   DIABETES

Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia

(2009) Gintautas Grabauskas et al.   JOURNAL OF PHYSIOLOGY-LONDON

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

The effects of GLP-1 infusion in the hepatic portal region on food intake

(2009) Dong-Hoon Kim et al.   REGULATORY PEPTIDES

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

(2008) D. A. Sandoval et al.   DIABETES

Acyl and Total Ghrelin Are Suppressed Strongly by Ingested Proteins, Weakly by Lipids, and Biphasically by Carbohydrates

(2008) Karen E. Foster-Schubert et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production

(2008) Penny Y. T. Wang et al.   NATURE

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY