A stocked toolbox for understanding the role of astrocytes in disease

The role of aquaporin-4 in synaptic plasticity, memory and disease

(2018) Jacqueline A. Hubbard et al.   BRAIN RESEARCH BULLETIN

Human astrocytes in the diseased brain

(2018) Elena Dossi et al.   BRAIN RESEARCH BULLETIN

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

High content analysis in amyotrophic lateral sclerosis

(2017) Federica Rinaldi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling

(2017) Marco Brancaccio et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence

(2017) Dörthe F. Bebensee et al.   Oxidative Medicine and Cellular Longevity

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

New Tools to Study Astrocyte Ca2+ Signal Dynamics in Brain Networks In Vivo

(2017) Gabriele Losi et al.   Frontiers in Cellular Neuroscience

Aberrant iPSC-derived human astrocytes in Alzheimer's disease

(2017) V C Jones et al.   Cell Death & Disease

Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging

(2017) Kazuki Harada et al.   Scientific Reports

Reactive gliosis in the pathogenesis of CNS diseases

(2016) Milos Pekny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NewIn VitroModels to Study Amyotrophic Lateral Sclerosis

(2016) Monika Myszczynska et al.   BRAIN PATHOLOGY

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats

(2016) Kelsey C. Patterson et al.   HUMAN MOLECULAR GENETICS

Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors

(2016) J. V. Raimondo et al.   JOURNAL OF NEUROSCIENCE

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes

(2016) Mei-Chen Liao et al.   JOURNAL OF NEUROSCIENCE

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

(2016) Jerome Mertens et al.   NATURE REVIEWS NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

(2016) Tal Iram et al.   NEUROBIOLOGY OF DISEASE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Review: Roles for astrocytes in epilepsy: insights from malformations of cortical development

(2016) M. Kielbinski et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Astrocytes regulate cortical state switching in vivo

(2016) Kira E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

(2016) Abinaya Chandrasekaran et al.   Frontiers in Cellular Neuroscience

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes

(2016) Youngpyo Nam et al.   Cell Reports

Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes

(2016) E Tian et al.   Cell Reports

The Use of DREADDs to Deconstruct Behavior

(2016) Paul D. Whissell et al.   Frontiers in Genetics

Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

(2016) Takayuki Kondo et al.   Acta Neuropathologica Communications

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

(2015) Michael D. Scofield et al.   BIOLOGICAL PSYCHIATRY

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Induced pluripotent stem cells from ALS patients for disease modeling

(2015) Jean-Philippe Richard et al.   BRAIN RESEARCH

Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

(2015) Zhi-Gang Ji et al.   BRAIN RESEARCH BULLETIN

Astrocyte development: A Guide for the Perplexed

(2015) Anna Victoria Molofsky et al.   GLIA

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes

(2015) Chloé Delépine et al.   HUMAN MOLECULAR GENETICS

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling

(2015) M. L. Olsen et al.   JOURNAL OF NEUROSCIENCE

Impaired CO2sensitivity of astrocytes in a mouse model of Rett syndrome

(2015) Egor Turovsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

(2015) Eyal Vardy et al.   NEURON

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors

(2015) Massimiliano Caiazzo et al.   Stem Cell Reports

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

(2014) Emily Cunningham Williams et al.   HUMAN MOLECULAR GENETICS

Abnormal Intracellular Calcium Signaling and SNARE-Dependent Exocytosis Contributes to SOD1G93A Astrocyte-Mediated Toxicity in Amyotrophic Lateral Sclerosis

(2014) H. Kawamata et al.   JOURNAL OF NEUROSCIENCE

Astrocytic TDP-43 Pathology in Alexander Disease

(2014) A. K. Walker et al.   JOURNAL OF NEUROSCIENCE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage

(2014) Kaoru Beppu et al.   NEURON

Review: Hippocampal sclerosis in epilepsy: a neuropathology review

(2014) Maria Thom   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A Novel Optical Intracellular Imaging Approach for Potassium Dynamics in Astrocytes

(2014) Theresa S. Rimmele et al.   PLoS One

Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

(2014) Gertrudis Perea et al.   Nature Communications

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Gene Profiling of Human Induced Pluripotent Stem Cell-Derived Astrocyte Progenitors Following Spinal Cord Engraftment

(2014) Amanda M. Haidet-Phillips et al.   Stem Cells Translational Medicine

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Modulation of the autonomic nervous system and behaviour by acute glial cell Gqprotein-coupled receptor activationin vivo

(2013) Cendra Agulhon et al.   JOURNAL OF PHYSIOLOGY-LONDON

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

(2013) Nicholas G. Horton et al.   Nature Photonics

Altered Kir and gap junction channels in temporal lobe epilepsy

(2013) Peter Bedner et al.   NEUROCHEMISTRY INTERNATIONAL

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

(2013) K. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent molecular approaches to understanding astrocyte function in vivo

(2013) David Davila et al.   Frontiers in Cellular Neuroscience

Truncated N-terminal huntingtin fragment with expanded-polyglutamine (htt552-100Q) suppresses brain-derived neurotrophic factor transcription in astrocytes

(2012) L. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-Null Mouse Model of Rett Syndrome

(2012) Yasunori Okabe et al.   PLoS One

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate

(2011) C. X. Bittner et al.   JOURNAL OF NEUROSCIENCE

A role for glia in the progression of Rett’s syndrome

(2011) Daniel T. Lioy et al.   NATURE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters

(2011) Eiji Shigetomi et al.   Neuron Glia Biology

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo

(2011) S. T. Papadeas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1

(2010) J Aebischer et al.   CELL DEATH AND DIFFERENTIATION

Optogenetic experimentation on astrocytes

(2010) M. Figueiredo et al.   EXPERIMENTAL PHYSIOLOGY

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Mitochondrial bioenergetics and dynamics in Huntington’s disease: tripartite synapses and selective striatal degeneration

(2010) Jorge M. A. Oliveira   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition

(2010) Guomei Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early defect of transforming growth factor β1 formation in Huntington’s disease

(2010) Giuseppe Battaglia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

(2010) Mandi Gandelman et al.   Journal of Neuroinflammation

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

(2010) M. Valenza et al.   JOURNAL OF NEUROSCIENCE

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Imaging extrasynaptic glutamate dynamics in the brain

(2010) Y. Okubo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients

(2009) Noriyuki Shibata et al.   ACTA NEUROPATHOLOGICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy

(2009) Kjell Heuser et al.   EPILEPSY RESEARCH

Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions

(2009) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

(2009) Nurit Ballas et al.   NATURE NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Focal degeneration of astrocytes in amyotrophic lateral sclerosis

(2008) D Rossi et al.   CELL DEATH AND DIFFERENTIATION

Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes

(2008) S.-Y. Chou et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE