期刊
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
卷 15, 期 5, 页码 257-273出版社
NATURE RESEARCH
DOI: 10.1038/nrgastro.2018.5
关键词
-
资金
- Burroughs Wellcome Fund
- American Gastroenterology Association Gastric Cancer Foundation Research Scholar Award
- National Institute of Diabetes and Digestive and Kidney Diseases [DK094989, DK105129, DK110406]
- Barnard Trust
- Alvin J. Siteman Cancer Center-Barnes Jewish Hospital Foundation Cancer Frontier Fund
- NIH National Cancer Institute [P30 CA091842]
Subjected to countless daily injuries, the stomach still functions as a remarkably efficient digestive organ and microbial filter. In this Review, we follow the lead of the earliest gastroenterologists who were fascinated by the antiseptic and digestive powers of gastric secretions. We propose that it is easiest to understand how the stomach responds to injury by stressing the central role of the most important gastric secretion, acid. The stomach follows two basic patterns of adaptation. The superficial response is a pattern whereby the surface epithelial cells migrate and rapidly proliferate to repair erosions induced by acid or other irritants. The stomach can also adapt through a glandular response when the source of acid is lost or compromised (that is, the process of oxyntic atrophy). We primarily review the mechanisms governing the glandular response, which is characterized by a metaplastic change in cellular differentiation known as spasmolytic polypeptide-expressing metaplasia (SPEM). We propose that the stomach, like other organs, exhibits marked cellular plasticity: the glandular response involves reprogramming mature cells to serve as auxiliary stem cells that replace lost cells. Unfortunately, such plasticity might mean that the gastric epithelium undergoes cycles of differentiation and de-differentiation that increase the risk of accumulating cancer-predisposing mutations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据