Article
Oncology
Lamis Yehia, Charis Eng
Summary: The study of characteristics of breast cancer in young women has important implications for personalized genomics-driven management.
CLINICAL CANCER RESEARCH
(2022)
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. While they can evade the immune system, they are recognized by the innate immune system, leading to inflammation. Recent studies have found that inflammasome signaling plays a role in herpesvirus innate immune activation and impacts disease outcomes.
Review
Microbiology
Ayush Kumar, Georgia Stavrakis, Andrew H. Karaba
Summary: Herpesviruses are common DNA viruses that cause lifelong infections and are associated with various diseases. They activate the innate immune system by inflammasome signaling, leading to inflammation and potential disease outcomes.
Article
Obstetrics & Gynecology
Lan N. Vuong
Summary: Freeze-all strategy has emerged as an alternative approach in in vitro fertilization (IVF) to reduce the negative effects of controlled ovarian stimulation. However, current studies have inconsistent results and a personalized approach should be taken based on individual patient characteristics and preference.
HUMAN REPRODUCTION
(2022)
Review
Ophthalmology
Mohit Parekh, Davide Romano, Rintra Wongvisavavit, Giulia Coco, Giuseppe Giannaccare, Stefano Ferrari, Carlos Rocha-de-Lossada, Hannah J. Levis, Francesco Semeraro, Marina Rodriguez Calvo-de-Mora, Vincenzo Scorcia, Vito Romano
Summary: Descemet membrane endothelial keratoplasty (DMEK) is a popular surgical procedure for treating Fuchs endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK). The size of the graft is crucial for the success of the procedure, with smaller grafts being preferred. However, larger diameter grafts pose challenges due to higher detachment rates.
ACTA OPHTHALMOLOGICA
(2023)
Article
Gastroenterology & Hepatology
Camille Danne, Nathalie Rolhion, Harry Sokol
Summary: Faecal microbiota transplantation (FMT) shows varying efficacy in treating different diseases. Sokol and colleagues discuss the relevance of recipient factors, such as inflammation, immunity, and genetics, in influencing the success of FMT.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Immunology
Shruti Naik
Summary: This article provides an overview of the skin's complex architecture and the distinct microniches in which immune cells reside and function. It reviews the synchronized immune, stromal, epithelial, and neuronal cell responses in healthy and inflamed skin. It also delves into the requirement and mechanisms of long-term immune surveillance and tissue adaptation at the cutaneous frontier, and discusses the constellation of noncanonical functions undertaken by the skin immune system.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Cell Biology
Cristiana Barone, Roberto Orsenigo, Raffaella Meneveri, Silvia Brunelli, Emanuele Azzoni
Summary: Our understanding of the complexity of the developing hematopoietic system has greatly increased in recent decades. We now know that multiple HSC-independent progenitor populations during fetal development play vital roles that can affect adult physiology and lead to disease. Ontogeny has been shown to be a primary determinant of the function of critical cell types.
Article
Computer Science, Hardware & Architecture
Xiaomeng Zhai, Hong Zhang, Xu Huang, Shouhua Zhang
Summary: This paper focuses on the problem of graph partitioning in distributed graph computing. The existing graph partitioning methods do not consider the relationship between partition strategies and graph algorithm characteristics, resulting in significant performance differences. To address this issue, the paper proposes a distributed graph partitioning framework based on program analysis, which can select the optimal partitioning strategy based on the characteristics of the graph algorithm. Additionally, the paper introduces a triangle-based partitioning strategy and redesigns the PageRank algorithm to reduce shuffling operations. Experimental results show that the proposed adaptive graph partitioning framework outperforms the original framework, especially in triangle counting and PageRank algorithms, on both real-world and synthetic graphs.
JOURNAL OF SUPERCOMPUTING
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Tolga Aksu, Carlos A. Morillo, Richard Sutton
Summary: This article describes a practical decision pathway for managing vasovagal syncope, including the locations of autonomic ganglia and methods for evaluating the response to treatment.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dirk Van Raemdonck, Laurens J. Ceulemans, Robin Vos, Geert M. Verleden
Summary: Lung transplantation may involve lobar transplantation and graft reduction to better match the recipient. Some patients may be given priority for transplantation based on their condition.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Neurosciences
Pavel Prado, Sebastian Moguilner, Jhony A. Mejia, Agustin Sainz-Ballesteros, Monica Otero, Agustina Birba, Hernando Santamaria-Garcia, Agustina Legaz, Sol Fittipaldi, Josephine Cruzat, Enzo Tagliazucchi, Mario Parra, Ruben Herzog, Agustin Ibanez
Summary: Brain functional connectivity in dementia has been assessed using various EEG connectivity metrics, and joint analyses integrating information from different metrics can provide a more comprehensive characterization of brain interactions. In this study, rsEEG was recorded in individuals with AD, bvFTD, and HCs, and whole-brain functional connectivity was estimated using 101 different types of connectivity metrics. The multi-metric analysis revealed patterns of hypoconnectivity in frontotemporal regions in both patient groups, which were differently captured by frequency- and time-domain metrics. These joint analyses contribute to a more reliable and interpretable description of atypical functional connectivity in neurodegeneration.
NEUROBIOLOGY OF DISEASE
(2023)
Editorial Material
Rheumatology
Andreas Kronbichler, Milena Bond, Christian Dejaco
Summary: This editorial discusses the reclassification of previously diagnosed GPA patients using the 2022 ACR/EULAR classification criteria.
Editorial Material
Biochemistry & Molecular Biology
Izhar Karbat, Eitan Reuveny
Summary: Ion channels can adjust their activity by incorporating auxiliary subunits, and this study reveals that a voltage-gated K+ channel auxiliary subunit can also modulate the gating of Ca2+-activated Cl- channels.
Editorial Material
Biochemistry & Molecular Biology
Nancy E. Sealover, Robert L. Kortum
Summary: The specific amino acid substitution substantially affects the biological activity and oncogenicity of mutant KRAS, creating challenges for the development of effective treatments for RAS-mutated cancers.
Article
Critical Care Medicine
Nadir Yehya, Julie C. Fitzgerald, Katie Hayes, Donglan Zhang, Jenny Bush, Natalka Koterba, Fang Chen, Florin Tuluc, David T. Teachey, Fran Balamuth, Simon F. Lacey, Jan Joseph Melenhorst, Scott L. Weiss
Summary: Trajectory-defined sub-phenotypes based on temperature can help categorize critically ill septic children, with hypothermic patients exhibiting lower levels of inflammatory cytokines and chemokines.
Article
Oncology
Nadine H. Abdallah, Moritz Binder, S. Vincent Rajkumar, Patricia T. Greipp, Prashant Kapoor, Angela Dispenzieri, Morie A. Gertz, Linda B. Baughn, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, David Dingli, Ronald S. Go, Yi L. Hwa, Amie L. Fonder, Miriam A. Hobbs, Yi Lin, Nelson Leung, Taxiarchis Kourelis, Rahma Warsame, Mustaqeem A. Siddiqui, Robert A. Kyle, P. Leif Bergsagel, Rafael Fonseca, Rhett P. Ketterling, Shaji K. Kumar
Summary: Risk stratification is crucial in multiple myeloma for predicting prognosis, selecting patients for clinical trials, and comparing treatment approaches. A new staging system has been developed that incorporates additional high-risk disease features and improves upon the current risk stratification system. This system is easy to implement and provides valuable prognostic information.
BLOOD CANCER JOURNAL
(2022)
Article
Hematology
Joselle Cook, Kah-Whye Peng, Thomas E. Witzig, Stephen M. Broski, Jose C. Villasboas, Jonas Paludo, Mrinal Patnaik, Vincent Rajkumar, Angela Dispenzieri, Nelson Leung, Francis Buadi, Nora Bennani, Stephen M. Ansell, Lianwen Zhang, Nandakumar Packiriswamy, Baskar Balakrishnan, Bethany Brunton, Marissa Giers, Brenda Ginos, Amylou C. Dueck, Susan Geyer, Morie A. Gertz, Rahma Warsame, Ronald S. Go, Suzanne R. Hayman, David Dingli, Shaji Kumar, Leif Bergsagel, Javier L. Munoz, Wilson Gonsalves, Taxiarchis Kourelis, Eli Muchtar, Prashant Kapoor, Robert A. Kyle, Yi Lin, Mustaqeem Siddiqui, Amie Fonder, Miriam Hobbs, Lisa Hwa, Shruthi Naik, Stephen J. Russell, Martha Q. Lacy
Summary: This study investigated the safety and efficacy of intravenous oncolytic virotherapy in patients with relapsed/refractory hematologic malignancies. The results showed that VSV-IFN beta-NIS had significant therapeutic effects in patients with TCL, possibly through a combination of oncolytic tumor destruction and immune response.
Letter
Hematology
Radhika Bansal, Mattia Novo, Abdullah S. Al Saleh, Anatilde Gonzalez Guerrico, Henan Zhang, Zuoyi Shao, Elham Babadi, Kodi E. Martinez, Gabrielle A. McCoy, Matthew A. Hathcock, Arushi Khurana, Nabila Nora Bennani, Jonas Paludo, Yucai Wang, Stephen M. Ansell, Patrick B. Johnston, Jose C. Villasboas, Yi Lin
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Lauren K. Meyer, Cristina Delgado-Martin, Phillip P. Sharp, Benjamin J. Huang, Dustin McMinn, Tiffaney L. Vincent, Theresa Ryan, Terzah M. Horton, Brent L. Wood, David T. Teachey, Jack Taunton, Christopher J. Kirk, Michelle L. Hermiston
Summary: In this study, it was found that a novel Sec61 inhibitor, KZR-445, can overcome glucocorticoid resistance in T-cell acute lymphoblastic leukemia (T-ALL) and attenuate the dexamethasone-induced increase in cell surface IL-7R. This finding is of significant importance in addressing glucocorticoid resistance.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Sumit Gupta, David T. Teachey, Zhiguo Chen, Karen R. Rabin, Kimberly P. Dunsmore, Eric C. Larsen, Kelly W. Maloney, Leonard A. Mattano, Stuart S. Winter, Andrew J. Carroll, Nyla A. Heerema, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Elizabeth A. Raetz, Naomi J. Winick, Mignon L. Loh, Stephen P. Hunger, Meenakshi Devidas
Summary: Boys with acute lymphoblastic leukemia continue to have lower survival rates compared to girls. This study found that the sex-based disparities still exist in contemporary therapy, with boys experiencing inferior event-free survival and overall survival, primarily due to higher rates of relapse, particularly involving the central nervous system.
Review
Oncology
Arushi Khurana, Yi Lin
Summary: Allogeneic CAR-T therapies have advantages over autologous CAR-T therapies, such as easier accessibility and more stable quality, but they also have complications and require genomic editing. Further research and clinical trials are needed.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Oncology
Kimberly Bodaar, Natsuko Yamagata, Anais Barthe, Jack Landrigan, Triona Ni Chonghaile, Melissa Burns, Kristen E. Stevenson, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Brent Wood, Lewis B. Silverman, David T. Teachey, Jules P. Meijerink, Anthony Letai, Alejandro Gutierrez
Summary: Resistance to mitochondrial apoptosis is associated with activating mutations of JAK3 in patients with diverse tumor types, including T-ALL. Inhibition of JAK3 reverses the apoptotic blockade and shows synergy with glucocorticoids in JAK3-mutant T-ALL.
Article
Oncology
Thomas Martin, Saad Z. Usmani, Jesus G. Berdeja, Mounzer Agha, Adam D. Cohen, Parameswaran Hari, David Avigan, Abhinav Deol, Myo Htut, Alexander Lesokhin, Nikhil C. Munshi, Elizabeth O'Donnell, A. Keith Stewart, Jordan M. Schecter, Jenna D. Goldberg, Carolyn C. Jackson, Tzu-Min Yeh, Arnob Banerjee, Alicia Allred, Enrique Zudaire, William Deraedt, Yunsi Olyslager, Changwei Zhou, Lida Pacaud, Deepu Madduri, Andrzej Jakubowiak, Yi Lin, Sundar Jagannath
Summary: PURPOSECARTITUDE-1, a phase Ib/II study, evaluated the safety and efficacy of Ciltacabtagene Autoleucel in heavily treated patients with relapsed/refractory multiple myeloma. The study showed early, deep, and durable responses at 12 months, with updated results at 2 years. Patients received a single infusion of Ciltacabtagene Autoleucel and responses were assessed.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi Lin, Noopur S. Raje, Jesus G. Berdeja, David S. Siegel, Sundar Jagannath, Deepu Madduri, Michaela Liedtke, Jacalyn Rosenblatt, Marcela V. Maus, Monica Massaro, Fabio Petrocca, Ashish Yeri, Olivia Finney, Andrea Caia, Zhihong Yang, Nathan Martin, Timothy B. Campbell, Julie Rytlewski, Jaymes Fuller, Kristen Hege, Nikhil C. Munshi, James N. Kochenderfer
Summary: This study conducted a post hoc analysis of the use of Idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma and found that it is safe and well-tolerated, with a positive impact on response rates. Additionally, the study identified a correlation between the state of T cells and durable responses.
Article
Hematology
Uday R. Popat, Oren Pasvolsky, Roland Bassett Jr, Rohtesh S. Mehta, Amanda Olson, Julianne Chen, Amin M. Alousi, Gheath Al-Atrash, Qaiser Bashir, Alison M. Gulbis, Chitra M. Hosing, Jin S. Im, Partow Kebriaei, Issa Khouri, David Marin, Yago Nieto, Betul Oran, Neeraj Saini, Terri Lynn Shigle, Samer A. Srour, Jeremy L. Ramdial, Katayoun Rezvani, Muzaffar H. Qazilbash, Borje S. Andersson, Richard E. Champlin, Elizabeth J. Shpall
Summary: A fractionated myeloablative busulfan regimen was found to be effective in reducing nonrelapse mortality without increasing relapse rate for patients undergoing allogeneic hematopoietic cell transplantation, especially for older patients and those with comorbidities.
Article
Hematology
Caron A. Jacobson, Frederick L. Locke, Long Ma, Julius Asubonteng, Zhen-Huan Hu, Tanya Siddiqi, Sairah Ahmed, Armin Ghobadi, David Bernard Miklos, Yi Lin, Miguel-Angel Perales, Matthew Alexander Lunning, Megan M. Herr, Brian T. Hill, Siddhartha Ganguly, Hua Dong, Sarah Nikiforow, Michele Hooper, Jun Kawashima, Hairong Xu, Marcelo C. Pasquini
Summary: This study evaluated the outcomes of axi-cel therapy in real-world settings. The results showed that patients ineligible for the ZUMA-1 trial had durable responses with axi-cel treatment. Despite higher rates of side effects, elderly patients had favorable efficacy outcomes.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Letter
Pharmacology & Pharmacy
Kamakshi V. Rao, Alison M. Gulbis, Zahra Mahmoudjafari
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)
Article
Hematology
Surbhi Sidana, Amylou C. Dueck, Gita Thanarajasingam, Joan M. Griffin, Carrie Thompson, Urshila Durani, Michelle Burtis, Rahma Warsame, Jonas Paludo, Morie A. Gertz, Angela Dispenzieri, Stephen M. Ansell, S. Vincent Rajkumar, Kathleen Yost, Nora Bennani, Yi Lin, Shaji Kumar
Summary: Limited data on patient experience after CAR-T cell therapy, especially compared to autologous and allogeneic transplantation. Prospective evaluation of patient-reported QoL, symptom burden and cognition after CAR-T therapy compared to autoSCT and alloSCT. Short-term QoL, including physical and functional domains, was better in the CAR-T group, but all groups experienced an initial decline coinciding with peak symptoms. These findings serve as a guide for patient education, symptom management, and future studies in CAR-T cell therapy.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Pharmacology & Pharmacy
Kamakshi Rao, Alison M. Gulbis, Zahra Mahmoudjafari
Summary: Hospital departments of pharmacy are facing challenges in recruiting and retaining trained hematology-oncology pharmacists, with the growing attrition of clinically-trained pharmacists being a consistent challenge. A survey of oncology pharmacists in the United States revealed that the workforce is highly trained and capable, with a high level of satisfaction. However, over 60% of respondents were actively seeking or open to alternate employment outside of the patient care environment. Factors contributing to attrition risk include work burdens, burnout, lack of work-life integration, and ineffective leadership. Commitments to clinical work were associated with improved job satisfaction and decreased attrition risk.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)
