Hexadirectional coding of visual space in human entorhinal cortex

Entorhinal grid cells map the local environment, but their involvement beyond spatial navigation remains elusive. We examined human functional MRi responses during a highly controlled visual tracking task and show that entorhinal cortex exhibited a sixfold rotationally symmetric signal encoding gaze direction. Our results provide evidence for a grid-like entorhinal code for visual space and suggest a more general role of the entorhinal grid system in coding information along continuous dimensions.