期刊
NATURE NEUROSCIENCE
卷 21, 期 6, 页码 803-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-018-0151-z
关键词
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资金
- Max Planck Society
- Volkswagen Foundation
- German Federal Ministry of Education and Research [01ZX1314H]
- Helmholtz Alliance ICEMED
- Chica and Heinz Schaller Foundation
- DFG [SFB 1134]
- FAPESP [2013/03445-3]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/03445-3] Funding Source: FAPESP
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
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