Article
Anesthesiology
Isabella M. Fuentes, Brittni M. Jones, Aaron D. Brake, Angela N. Pierce, Olivia C. Eller, Rachel M. Supple, Douglas E. Wright, Julie A. Christianson
Summary: Studies suggest that voluntary exercise can alleviate the negative impact of a history of early life stress exposure on patients with chronic pain and mood disorders, with evidence showing that voluntary wheel running may improve outcomes related to urologic chronic pelvic pain syndrome.
Article
Neurosciences
Carolina Luft, Isadora Perez Levices, Mariana Severo da Costa, Jarbas Rodrigues de Oliveira, Marcio Vinicius Fagundes Donadio
Summary: The study found that pregestational exercise can prevent the effects of maternal stress on hippocampal BDNF IV gene expression in females, but has no effect on stress-induced memory impairment in males.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R. Homberg, Francesca Calabrese
Summary: Peripheral serotonin levels have an influence on brain functions under basal and dynamic situations. The lack of peripheral serotonin can reduce anxiety-like behavior, as well as neuronal activation and the expression of brain plasticity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuki Tomiga, Kazuya Sakai, Song-Gyu Ra, Masaki Kusano, Ai Ito, Yoshinari Uehara, Hirokazu Takahashi, Kentaro Kawanaka, Hidenobu Soejima, Yasuki Higaki
Summary: This study found that relatively short-term running exercise can reduce anxiety-like behaviors, increase brain-derived neurotrophic factor (BDNF), and decrease neuronal nitric oxide synthase (nNOS) levels through epigenetic modifications in the brain. These effects mainly occur in the ventral hippocampal region, suggesting a potential mechanism for mood regulation via alterations in epigenetic mechanisms after a brief period of exercise.
Article
Biochemistry & Molecular Biology
Mauritz Frederick Herselman, Liying Lin, Shayan Luo, Akihiro Yamanaka, Xin-Fu Zhou, Larisa Bobrovskaya
Summary: Anxiety and depressive disorders are closely linked, but their pathophysiology is poorly understood. This study explored the mechanisms involved in anxiety and depression by subjecting mice to chronic stress. The results showed that female mice exhibited more anxiety-like behavior and had reduced synaptic proteins in the hippocampus, while all female mice showed increased synaptic proteins in the prefrontal cortex. These findings highlight the importance of considering sex differences in future studies on chronic stress and depression mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Liu
Summary: In this study, the role of the 8 opioid receptor (8OR) system in chronic-restraint-stress-induced depression was evaluated. The agonist SNC80 was found to exert antidepressant effects by up-regulating the BDNF/TrkB signaling pathway in the hippocampus and amygdala. This suggests that 8OR agonists may have potential therapeutic value for depression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Clinical Neurology
Megan Dutton, Adem T. Can, Jim Lagopoulos, Daniel F. Hermens
Summary: The experience of stress is linked to the development of mental disorders through neurobiological systems. Chronic stress and prolonged exposure to glucocorticoids affect brain regions involved in regulating the hypothalamic-pituitary-adrenal axis, which is associated with psychiatric disorders. This review explores the neurobiological and neurochemical systems that modulate stress-related changes in brain structure and function. Stress-related psychopathology is considered the cause of these disorders, and this review examines the potential of ketamine as an emerging treatment. Ketamine enhances synaptic strength and connectivity in key brain regions and can modulate the hypothalamic-pituitary-adrenal axis and associated pathways.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing-Jing Chen, Jun-Xian Shen, Zong-Hao Yu, Chuan Pan, Fei Han, Xiu-Ling Zhu, Hui Xu, Rui-Ting Xu, Tong-Yao Wei, Ya-Ping Lu
Summary: This study investigated the antidepressant effects of resveratrol and its mechanism using a chronic restraint stress-induced mouse depression model. Results showed that resveratrol attenuated depression-like behavior by affecting the BDNF/cofilin1 pathway, leading to an improvement in dendrite and dendritic spine density loss.
NEUROCHEMICAL RESEARCH
(2021)
Article
Immunology
Kiersten Scott, Thien Trong Phan, Nabila Boukelmoune, Cobi J. Heijnen, Robert Dantzer
Summary: Chronic restraint stress affects the behavior of mice, specifically their voluntary wheel running but not working for food. This indicates a dissociation between energy demanding and energy procuring activities, possibly due to adaptive response to mitochondrial dysfunction caused by chronic restraint stress.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Behavioral Sciences
Ning Jiang, Kezhu Wang, Yiwen Zhang, Hong Huang, Jing-wei Lv, Qiong Wang, Hai-xia Wang, Tian-ji Xia, Xin-min Liu
Summary: The study showed that Rb1 rescued cognitive deficits induced by CRS partially through antagonizing oxidative stress and apoptosis, improving synaptic plasticity, and restoring the BDNF/TrkB signaling pathway.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Clinical Neurology
Weifen Li, Tahir Ali, Shengnan Mou, Qichao Gong, Ningning Li, Liangliang Hao, Zhi-Jian Yu, Shupeng Li
Summary: Dopamine and serotonin signaling are associated with major depressive disorder, and targeting their signaling pathway is crucial for improving depression treatment. A study found that serotonin receptor 2A (5-HT2AR) abundantly forms a protein complex with dopamine receptor 1 (D1R), which regulates synaptic regulation through CREB/ERK/AKT modulation and affects depressive symptoms.
Article
Neurosciences
Felipe A. Olave, Felipe Aguayo, Luciano P. Roman-Albasini, Wladimir A. Corrales, Juan P. Silva, Pablo Gonzalez, Sara Lagos, Maria A. Garcia, Matias Alarcon-Mardones, Paulina S. Rojas, Xiaojiang Xu, John A. Cidlowski, Esteban Aliaga, Jenny Fiedler
Summary: Stress-related disorders display differences between males and females. This study found that chronic restraint stress produces different somatic responses in adult male and female rats. The molecular responses in the hippocampus also showed sex-specific differences, with the signaling pathways mainly influenced by sex rather than stress. The study suggests that female rats are resilient and males are susceptible to stress exposure, while the activity of canonical signaling pathways is primarily determined by sex in the hippocampus.
NEUROBIOLOGY OF STRESS
(2022)
Article
Biochemistry & Molecular Biology
Hunter Franks, Ruishan Wang, Mingqi Li, Bin Wang, Ashton Wildmann, Tyler Ortyl, Shannon O'Brien, Deborah Young, Francesca-Fang Liao, Kazuko Sakata
Summary: The study reveals the direct regulation of the brain-derived neurotrophic factor (BDNF) gene by heat shock factor 1 (HSF1) in the brain in response to neuronal stress stimuli. This regulation plays a crucial role in neuronal protection and plasticity in the hippocampus during acute stress.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Xiaoyue Wei, Kezhu Wang, Jinfeng Gao, Shijian Chen, Siying Zeng, Yuhong Zhao
Summary: By using FG7142 combined with restraint stress, an anxiety animal model was established, which induced anxiety-like behavior in behavior tests and showed increased c-fos expression in the hippocampus and amygdala, as well as decreased expression of GABA receptor and serotonin receptors in the hippocampus.
Article
Neurosciences
Laura Gerosa, Barbara Grillo, Chiara Forastieri, Alessandra Longaretti, Emanuela Toffolo, Alessandra Mallei, Silvia Bassani, Maurizio Popoli, Elena Battaglioli, Francesco Rusconi
MOLECULAR NEUROBIOLOGY
(2020)
Article
Cell Biology
Alessandro Ieraci, Silvia S. Barbieri, Chiara Macchi, Patrizia Amadio, Leonardo Sandrini, Paolo Magni, Maurizio Popoli, Massimiliano Ruscica
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Immunology
Alessandro Ieraci, Sarah Beggiato, Luca Ferraro, Silvia S. Barbieri, Maurizio Popoli
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Biochemistry & Molecular Biology
Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli, Alessandro Ieraci
Summary: Anxiety disorders are common mental health diseases, with stress being a major risk factor. The study found that apocynin can prevent the development of anxiety-like phenotype, reduce histone acetylation decrease, and block the upregulation of specific biochemical molecules.
Article
Medicine, Research & Experimental
Leonardo Sandrini, Patrizia Amadio, Alessandro Ieraci, Alessandro Malara, Jose P. Werba, Paolo M. Soprano, Alessandra Balduini, Marta Zara, Alice Bonomi, Fabrizio Veglia, Gualtiero Colombo, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia S. Barbieri
Summary: Depression is associated with thrombotic risk and arterial events, and its management is recommended in coronary artery disease patients. The BDNF Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice and acute myocardial infarction in humans. Finding show desipramine rescues behavioral impairments and reduces arterial thrombosis risk by normalizing norepinephrine levels in BDNFMet/Met mice, suggesting the potential use of alpha(2A)-ADR inhibitors in treating depression-associated thrombotic conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Geriatrics & Gerontology
Giulia Carini, Laura Musazzi, Francesco Bolzetta, Alberto Cester, Chiara Fiorentini, Alessandro Ieraci, Stefania Maggi, Maurizio Popoli, Nicola Veronese, Alessandro Barbon
Summary: Frailty and cognitive impairment are common in older individuals, with age being the main risk factor for both conditions. MicroRNAs have been proposed as potential biomarkers and molecular effectors in physiological and pathological aging processes, with some miRNAs showing promise in being associated with frailty and cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Giulia Carini, Jessica Mingardi, Francesco Bolzetta, Alberto Cester, Andrea Bolner, Giampietro Nordera, Luca La Via, Alessandro Ieraci, Isabella Russo, Stefania Maggi, Stefano Calza, Maurizio Popoli, Nicola Veronese, Laura Musazzi, Alessandro Barbon
Summary: The study aimed to identify potential frailty biomarkers and candidate mechanisms, finding two miRNAs that significantly differentiate frail patients from robust subjects. The potential molecular mechanisms and cellular pathways regulated by these miRNAs in frailty were further explored using bioinformatics tools.
Correction
Cell Biology
Oualid Sbai, Mehdi Djelloul, Antonia Auletta, Alessandro Ieraci, Carlo Vascotto, L. Perrone
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Oualid Sbai, Mehdi Djelloul, Antonia Auletta, Alessandro Ieraci, Carlo Vascotto, L. Perrone
Summary: This study explores the role of the RAGE-TXNIP axis in neuroinflammation in relation to A beta burden. The results show that TXNIP is associated with A beta and RAGE, and that its inhibition can prevent neuroinflammation and restore mitochondrial functionality. The findings shed new light on the mechanism of action of RAGE-TXNIP axis in microglia and suggest TXNIP as a potential therapeutic target for AD.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Laura Musazzi, Paolo Tornese, Nathalie Sala, Francis S. Lee, Maurizio Popoli, Alessandro Ieraci
Summary: Stressful life events are major risk factors for psychiatric disorders, and individual response to stress varies. The BDNF Val66Met SNP knock-in mice showed altered biological response to acute restraint stress, which may partly explain the increased vulnerability to stressful events in Met carriers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Patrizia Amadio, Chiara Macchi, Chiara Favero, Marta Zara, Giulia Solazzo, Laura Dioni, Leonardo Sandrini, Luisella Vigna, Maria Francesca Greco, Massimiliano Buoli, Cesare R. Sirtori, Angela Cecilia Pesatori, Alessandro Ieraci, Massimiliano Ruscica, Silvia Stella Barbieri, Valentina Bollati
Summary: Obesity and depression are often associated with an increased risk of cardiovascular complications. The present study investigated the relationship among peripheral Brain-Derived Neurotrophic Factor (BDNF), depression, and extracellular vesicle (EV)-derived miRNAs related to atherothrombosis in a large Italian cohort of obese individuals. The results revealed a negative association between depression and BDNF levels, which was modified by raised levels of IFN-gamma. BDNF levels were also found to be linked to an increase in EV-derived miRNAs related to atherosclerosis and thrombosis, suggesting a possible link among BDNF, depression, and miRNAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Psychiatry
Sarah Beggiato, Alessandro Ieraci, Mariachiara Zuccarini, Patrizia Di Iorio, Robert Schwarcz, Luca Ferraro
Summary: This study investigates the effects of chronic cannabis use during adolescence on cognition and KYNA metabolism. The results show that chronic THC exposure during adolescence increases KYNA levels in the prefrontal cortex in adulthood and negatively affects short-term memory. Additionally, blockade of KYNA neosynthesis can restore the cognitive impairment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Tiziana Bonifacino, Jessica Mingardi, Roberta Facchinetti, Nathalie Sala, Giulia Frumento, Elona Ndoj, Marta Valenza, Caterina Paoli, Alessandro Ieraci, Carola Torazza, Matilde Balbi, Michele Guerinoni, Nadeem Muhammad, Isabella Russo, Marco Milanese, Caterina Scuderi, Alessandro Barbon, Luca Steardo, Giambattista Bonanno, Maurizio Popoli, Laura Musazzi
Summary: Stress is a major risk factor for psychiatric disorders, but little is known about the mechanisms of vulnerability to acute stressors. In this study, a new animal model of resilience/vulnerability to acute footshock stress in rats was generated and used to identify early determinants of maladaptive response related to behavioral vulnerability to stress.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Federico Ravanelli, Laura Musazzi, Silvia Stella Barbieri, Gianenrico Rovati, Maurizio Popoli, Alessandro Barbon, Alessandro Ieraci
Summary: Alzheimer's disease is a neurodegenerative disease that causes memory loss and cognitive impairment in elderly people. The causes of this disease are not well understood and involve genetic, environmental, and epigenetic factors. In the study, SAMP8 mice were used as a model to investigate epigenetic changes in the dorsal hippocampus. The results showed differential regulation of epigenetic markers between male and female SAMP8 mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. S. Barbieri, P. Amadio, C. Macchi, M. Zara, C. Favero, G. Solazzo, L. Vigna, M. F. Greco, M. Buoli, C. R. Sirtori, A. Ieraci, M. Ruscica, V. Bollati