Article
Neurosciences
Carolina Tecuatl, Diek W. Wheeler, Nate Sutton, Giorgio A. Ascoli
Summary: A systematic pipeline is presented to estimate local connection parameters between different neuron types in the hippocampal formation, greatly increasing the available quantitative assessments. The study also provides approximate measurements of synaptic distances, filling substantial gaps in the knowledge and offering useful model specifications for neural network simulations.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jinhu Kim, Dongseok Park, Na-Young Seo, Taek-Han Yoon, Gyu Hyun Kim, Sang-Hoon Lee, Jinsoo Seo, Ji Won Um, Kea Joo Lee, Jaewon Ko
Summary: Synaptic cell-adhesion molecules (CAMs) play a crucial role in organizing the structure and properties of neural circuits. This study found that Leucine-rich repeat transmembrane protein 3 (LRRTM3) is important for the development of excitatory synapses in hippocampal dentate gyrus (DG) granule neurons. The deletion of LRRTM3 leads to reduced synapse density and synaptic strength in specific projections involving the medial entorhinal cortex (MEC) and DG granule neurons. Additionally, LRRTM3 loss affects neurotransmitter release, excitability of granule neurons, and long-term potentiation of mossy fiber synapses in DG neurons. Silencing the MEC-DG circuits protects against the negative effects of LRRTM3 deficiency on excitatory synapse inputs, granule neuron excitability, and mossy fiber long-term potentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Ain Chung, Claudia Jou, Alejandro Grau-Perales, Eliott R. J. Levy, Dino Dvorak, Nida Hussain, Andre A. Fenton
Summary: Research suggests that cognitive control training can persistently alter hippocampal neural circuit function, facilitating learning of new tasks in novel environments and enhancing signal-to-noise ratio.
Article
Neurosciences
Sachin S. Deshmukh
Summary: The study shows that the inputs from different regions in the proximal and distal CA1 areas cause differential representation responses. While pCA1 representation splits when faced with conflicting inputs, dCA1 is more influenced by global cues. Overall spatial selectivity is not significantly different, possibly due to the richer sensory information available in the behavioral environment.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
George Andrew Reid, Sultan Darvesh
Summary: The study on the Atlantic white-sided dolphin's hippocampal formation revealed similarities and differences compared to terrestrial mammals, particularly in terms of acetylcholinesterase distribution, indicating possible alterations in connectivity. Overall, the cholinergic innervation and function of the hippocampal formation in the dolphin appears to be conserved like in other mammals.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Shayan Aliakbari, Mohammad Sayyah, Hadi Mirzapourdelavar, Niloufar Amini, Naser Naghdi, Hamid Gholami Pourbadie
Summary: EC amyloidopathy leads to impaired synaptic transmission and memory deficits, while overexpression of PKM zeta in DG enhances synaptic responses and improves memory performance, suggesting PKM zeta may serve as a potential therapeutic target for early stage AD.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Jennifer M. Yonan, Oswald Steward
Summary: Deletion of the PTEN gene leads to neuronal hypertrophy and formation of abnormal neural networks, resulting in spontaneous seizures. This study demonstrates that PTEN deletion in mature neurons causes growth of cell bodies and dendrites, disrupting connectivity in mature circuits.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Osung Kwon, Hayoung Yang, Seung-Chan Kim, Juhyun Kim, Jaewon Sim, Jiyoun Lee, Eun-Mi Hwang, Sungbo Shim, Jae-Yong Park
Summary: TWIK-1 BAC-GFP Tg mice expressing GFP under TWIK-1 promoter control show high GFP expression in various brain areas, including the DG, LEC, and Cb, with particularly high expression in immature granule cells in the DG. These mice also mimic the upregulation of TWIK-1 mRNA expression in the hippocampus following KA injection, providing a useful animal model for studying TWIK-1 gene expression regulation and its physiological roles in the brain.
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
Julie Faitg, Clay Lacefield, Tracey Davey, Kathryn White, Ross Laws, Stylianos Kosmidis, Amy K. Reeve, Eric R. Kandel, Amy E. Vincent, Martin Picard
Summary: This study used quantitative three-dimensional electron microscopy to map mitochondrial network morphology and complexity in the mouse brain. Differences in mitochondrial morphology across different cell types and ages were identified, providing a foundation for further research on the role of neuronal mitochondria in the aging brain.
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Suchitra Joshi, Cedric L. Williams, Jaideep Kapur
Summary: Progesterone and its receptors play a role in mating and reproduction, and this study investigates their role in spatial declarative memory. The results show that PRs are expressed in brain regions related to spatial memory in male mice. By examining the performance of PRKO mice in various cognitive tasks, including object recognition and spatial tasks, the authors found that PR deletion impaired spatial memory but did not affect fear conditioning. These findings provide new insights into the role of PRs in facilitating spatial memory in males.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Kelsey D. McDermott, M. Agustina Frechou, Jake T. Jordan, Sunaina S. Martin, J. Tiago Goncalves
Summary: Aging is associated with cognitive deficits, especially in spatial memory. The hippocampal dentate gyrus (DG) is important for processing spatial information but is vulnerable to aging. Using two-photon calcium imaging, researchers found that neuronal activity and spatial representations in the DG were impaired in aged mice. However, with repeated exposure to the same environment, spatial tuning and information levels in aged mice improved, while activity remained elevated.
Article
Neurosciences
Oswald Steward, Jennifer M. Yonan, Paula M. Falk
Summary: The Wld(s) mutation significantly delays axon degeneration in mice, leading to prolonged synaptic terminal degeneration time and hypertrophy of dendritic spine heads with formation of spinules. This suggests the presence of yet to be characterized signaling processes between amputated but non-degenerating axons and their postsynaptic targets.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Heather C. Ratigan, Seetha Krishnan, Shai Smith, Mark E. J. Sheffield
Summary: The NR-CA1 pathway actively suppresses fear by disrupting contextual fear memory retrieval in CA1 during fearful freezing behavior, which also reduces fear generalization and accelerates extinction.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Neurosciences
Laura E. M. Wisse, Ana M. Daugherty, Rosanna K. Olsen, David Berron, Valerie A. Carr, Craig E. L. Stark, Robert S. C. Amaral, Katrin Amunts, Jean C. Augustinack, Andrew R. Bender, Jeffrey D. Bernstein, Marina Boccardi, Martina Bocchetta, Alison Burggren, M. Mallar Chakravarty, Marie Chupin, Arne Ekstrom, Robin de Flores, Ricardo Insausti, Prabesh Kanel, Olga Kedo, Kristen M. Kennedy, Geoffrey A. Kerchner, Karen F. LaRocque, Xiuwen Liu, Anne Maass, Nicolai Malykhin, Susanne G. Mueller, Noa Ofen, Daniela J. Palombo, Mansi B. Parekh, John B. Pluta, Jens C. Pruessner, Naftali Raz, Karen M. Rodrigue, Dorothee Schoemaker, Andrea T. Shafer, Trevor A. Steve, Nanthia Suthana, Lei Wang, Julie L. Winterburn, Michael A. Yassa, Paul A. Yushkevich, Renaud la Joie
Article
Neurosciences
Ana M. Daugherty, Naftali Raz
Article
Clinical Neurology
Brianne Mohl, Noa Ofen, Lara L. Jones, Joseph E. Casey, Jeffrey A. Stanley
APPLIED NEUROPSYCHOLOGY-CHILD
(2018)
Article
Psychology, Developmental
Noa Ofen, Lingfei Tang, Qijing Yu, Elizabeth L. Johnson
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
E. L. Johnson, L. Tang, Q. Yin, E. Asano, N. Ofen
Article
Neurosciences
Jonathan D. Lynn, Chaitali Anand, Muzamil Arshad, Roya Homayouni, David R. Rosenberg, Noa Ofen, Naftali Raz, Jeffrey A. Stanley
Summary: The myeloarchitecture of the corpus callosum was studied using magnetic resonance imaging, revealing age and region-related patterns in myelin water fraction and intra-/extracellular water T-2, which were consistent with histology. These two indicators were associated with axon diameter and density, showing different patterns across age groups.
Article
Neuroimaging
Catherine E. Lewis, Kevin G. F. Thomas, Noa Ofen, Christopher M. R. Warton, Frances Robertson, Nadine M. Lindinger, Christopher D. Molteno, Ernesta M. Meintjes, Joseph L. Jacobson, Sandra W. Jacobson
Summary: Prenatal alcohol exposure is associated with neurobehavioral deficits and declarative memory impairment in individuals with Fetal Alcohol Spectrum Disorders (FASD). A study found that children with FAS or PFAS recruit more extensive neural resources to achieve successful memory formation compared to heavily exposed and control groups, despite similar recognition accuracy.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Roya Homayouni, Qijing Yu, Sruthi Ramesh, Lingfei Tang, Ana M. Daugherty, Noa Ofen
Summary: The study demonstrated high test-retest consistency of hippocampal subfield volumes in two independent developmental samples, indicating reliable measurements over time. Additionally, significant variability in hippocampal subfield volume changes was detected over a 2-year delay, suggesting high sensitivity of the method in detecting individual differences.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth L. Johnson, Qin Yin, Nolan B. O'Hara, Lingfei Tang, Jeong-Won Jeong, Eishi Asano, Noa Ofen
Summary: Understanding the development of complex brain functions is crucial for understanding how the human brain works. In this study, rare direct recordings from children and adolescents were used to fill a gap in models of human memory. The results show that memory relies on interactions between the medial temporal lobe (MTL) and prefrontal cortex (PFC), and the maturation of these interactions plays a key role in supporting memory development.
Article
Neurosciences
Hilary Sweatman, C. Paula de los Angeles, Jiahe Zhang, Carlo de los Angeles, Noa Ofen, John D. E. Gabrieli, Xiaoqian J. Chai
Summary: The study found differences in the brain basis for recollection between adults and children. Adults exhibited higher recall activations in certain brain regions compared to children, while the medial prefrontal cortex (mPFC) played similar roles in recollection in both age groups.
Article
Neurosciences
Kelsey L. Canada, Roya Homayouni, Qijing Yu, Da' Jonae Foster, Sruthi Ramesh, Sarah Raz, Ana M. Daugherty, Noa Ofen
Summary: This study investigated the relationship between socioeconomic status (SES) and specific subfield volumes in the hippocampus. The results showed that lower SES was associated with larger volumes of CA3-DG and CA1-2, while Sub volume was not influenced by SES.
Article
Psychology, Developmental
Qin Yin, Elizabeth L. Johnson, Noa Ofen
Summary: This paper discusses the importance of studying cognitive development by recording neural activity from the developing brain. It focuses on the development of episodic memory and its relationship with neural oscillations, emphasizing the need to isolate different frequency oscillations in research. Through this approach, we can gain a better understanding of brain development and the improvement of cognitive functions.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Qijing Yu, Ana M. Daugherty, Dana M. Anderson, Mayu Nishimura, David Brush, Amanda Hardwick, William Lacey, Sarah Raz, Noa Ofen
DEVELOPMENTAL SCIENCE
(2018)
Article
Psychology, Multidisciplinary
Ljiljana Progovac, Natalia Rakhlin, William Angell, Ryan Liddane, Lingfei Tang, Noa Ofen
FRONTIERS IN PSYCHOLOGY
(2018)
Article
Psychology, Multidisciplinary
Ljiljana Progovac, Natalia Rakhlin, William Angell, Ryan Liddane, Lingfei Tang, Noa Ofen
FRONTIERS IN PSYCHOLOGY
(2018)