Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals
出版年份 2018 全文链接
标题
Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals
作者
关键词
-
出版物
Nature Chemistry
Volume 10, Issue 7, Pages 724-731
出版商
Springer Nature
发表日期
2018-06-14
DOI
10.1038/s41557-018-0062-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Recent Developments in Ruthenium-Catalyzed C–H Arylation: Array of Mechanistic Manifolds
- (2017) Pradeep Nareddy et al. ACS Catalysis
- Late Stage CH Activation of a Privileged Scaffold; Synthesis of a Library of Benzodiazepines
- (2016) Raysa Khan et al. ADVANCED SYNTHESIS & CATALYSIS
- Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?
- (2016) Daniel J. Foley et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
- (2016) Tim Cernak et al. CHEMICAL SOCIETY REVIEWS
- Ru-Catalyzed C–H Arylation of Fluoroarenes with Aryl Halides
- (2016) Marco Simonetti et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Microwave-assisted regioselective direct C–H arylation of thiazole derivatives leading to increased σ1 receptor affinity
- (2016) Artur Kokornaczyk et al. MedChemComm
- Understanding Our Love Affair with p-Chlorophenyl: Present Day Implications from Historical Biases of Reagent Selection
- (2015) Dean G. Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
- (2015) Dean G. Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pd(ii)-catalyzed, controllable C–H mono-/diarylation of aryl tetrazoles: concise synthesis of Losartan
- (2015) Yan-Jun Ding et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- What does the aromatic ring number mean for drug design?
- (2014) Simon E Ward et al. Expert Opinion on Drug Discovery
- Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures
- (2014) Brandon R. Smith et al. JOURNAL OF MEDICINAL CHEMISTRY
- Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
- (2014) Edon Vitaku et al. JOURNAL OF MEDICINAL CHEMISTRY
- Iridium-Catalyzed C–H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism
- (2014) Matthew A. Larsen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Overcoming the limitations of directed C–H functionalizations of heterocycles
- (2014) Yue-Jin Liu et al. NATURE
- An organic cation as a silver(i) analogue for the arylation of sp2 and sp3 C–H bonds with iodoarenes
- (2014) Carlos Arroniz et al. Chemical Science
- Non-directed allylic C–H acetoxylation in the presence of Lewis basic heterocycles
- (2014) Hasnain A. Malik et al. Chemical Science
- Improvement of σ1 receptor affinity by late-stage C–H-bond arylation of spirocyclic lactones
- (2013) Christina Meyer et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors
- (2013) Xiaofei Liang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
- (2013) Elizabeth A. Ilardi et al. JOURNAL OF MEDICINAL CHEMISTRY
- C–H bond activation enables the rapid construction and late-stage diversification of functional molecules
- (2013) Joanna Wencel-Delord et al. Nature Chemistry
- Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry
- (2012) Alan Nadin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
- (2012) Junichiro Yamaguchi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Expanding medicinal chemistry space
- (2012) Andy Barker et al. DRUG DISCOVERY TODAY
- Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
- (2011) Lutz Ackermann CHEMICAL REVIEWS
- The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
- (2011) Stephen D. Roughley et al. JOURNAL OF MEDICINAL CHEMISTRY
- Autocatalysis for C–H Bond Activation by Ruthenium(II) Complexes in Catalytic Arylation of Functional Arenes
- (2011) Emmanuel Ferrer Flegeau et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- CH Bond Functionalization in Water Catalyzed by Carboxylato Ruthenium(II) Systems
- (2010) Percia B. Arockiam et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)
- (2010) Tony W. J. Cooper et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types
- (2010) Timothy J. Ritchie et al. DRUG DISCOVERY TODAY
- Mechanistic Insight into Direct Arylations with Ruthenium(II) Carboxylate Catalysts
- (2010) Lutz Ackermann et al. ORGANIC LETTERS
- The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
- (2009) Timothy J. Ritchie et al. DRUG DISCOVERY TODAY
- Direct Arylation of Arene C−H Bonds by Cooperative Action of NHCarbene−Ruthenium(II) Catalyst and Carbonate via Proton Abstraction Mechanism
- (2008) Ismail Özdemir et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Assisted Ruthenium-Catalyzed C−H Bond Activation: Carboxylic Acids as Cocatalysts for Generally Applicable Direct Arylations in Apolar Solvents
- (2008) Lutz Ackermann et al. ORGANIC LETTERS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started