Cyclization of peptides with two chemical bridges affords large scaffold diversities

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis

(2017) Aleena Banerji et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phage-displayed macrocyclic glycopeptide libraries

(2016) Simon Ng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology

(2016) David Spring et al.   SYNTHESIS-STUTTGART

Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors

(2016) Zhe Li et al.   ACS Medicinal Chemistry Letters

A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization

(2015) Yuanxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

(2015) Naila Assem et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small cyclic agonists of iron regulatory hormone hepcidin

(2015) Kristine Chua et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of fused tricyclic peptides using a reprogrammed translation system and chemical modification

(2015) Nasir Kato Bashiruddin et al.   BIOORGANIC CHEMISTRY

Encoded libraries of chemically modified peptides

(2015) Christian Heinis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Peptide Ligands Stabilized by Small Molecules

(2014) Shiyu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phage Selection of Photoswitchable Peptide Ligands

(2014) Silvia Bellotto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How proteins bind macrocycles

(2014) Elizabeth A Villar et al.   Nature Chemical Biology

Discovery of Light-Responsive Ligands through Screening of a Light-Responsive Genetically Encoded Library

(2013) Mohammad R. Jafari et al.   ACS Chemical Biology

mRNA display: from basic principles to macrocycle drug discovery

(2013) Kristopher Josephson et al.   DRUG DISCOVERY TODAY

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

IL-17 antibodies gain momentum

(2013) Man Tsuey Tse   NATURE REVIEWS DRUG DISCOVERY

In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors

(2012) Yuuki Hayashi et al.   ACS Chemical Biology

Recombinant Human C1 Inhibitor (Conestat Alfa)

(2012) Greg L. Plosker   BIODRUGS

Synthesis and evaluation of disulfide bond mimetics of amylin-(1–8) as agents to treat osteoporosis

(2012) Renata Kowalczyk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases

(2012) Vanessa Baeriswyl et al.   ChemMedChem

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

(2012) Yollete V. Guillen Schlippe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Water-Soluble Scaffolds for Peptide Cyclization, Labeling, and Ligation

(2012) Linde E. J. Smeenk et al.   ORGANIC LETTERS

Phage display libraries of differently sized bicyclic peptides

(2012) Inmaculada Rentero Rebollo et al.   MedChemComm

Bacteriophages and Viruses as a Support for Organic Synthesis and Combinatorial Chemistry

(2011) Simon Ng et al.   ACS Chemical Biology

Towards the systematic exploration of chemical space

(2011) Mark Dow et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ecallantide for the Treatment of Acute Attacks in Hereditary Angioedema

(2010) Marco Cicardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ribosomal Synthesis of Bicyclic Peptides via Two Orthogonal Inter-Side-Chain Reactions

(2008) Yusuke Sako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY