Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic

Identification of a Functionally Unique Family of Penicillin-Binding Proteins

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Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections

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Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site

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Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

(2017) Yuan Qiao et al.   Nature Chemical Biology

In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

(2017) Kaitlin Schaefer et al.   Nature Chemical Biology

Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics

(2017) Kelly M. Hines et al.   mSphere

Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries

(2016) Mithila Rajagopal et al.   mBio

Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci

(2016) William R. Miller et al.   Cold Spring Harbor Perspectives in Medicine

A new platform for ultra-high density Staphylococcus aureus transposon libraries

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The Mechanism of Action of Lysobactin

(2015) Wonsik Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

(2015) Lincoln Pasquina et al.   Nature Chemical Biology

Intrinsic Antimicrobial Resistance Determinants in the Superbug Pseudomonas aeruginosa

(2015) Justine L. Murray et al.   mBio

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning

(2015) Jan Wildenhain et al.   Cell Systems

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

(2014) Sascha Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction

(2014) Yuan Qiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane

(2014) Hiroshi Hamamoto et al.   Nature Chemical Biology

Cystomanamides: Structure and Biosynthetic Pathway of a Family of Glycosylated Lipopeptides from Myxobacteria

(2014) Lena Etzbach et al.   ORGANIC LETTERS

MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

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ARTIST: High-Resolution Genome-Wide Assessment of Fitness Using Transposon-Insertion Sequencing

(2014) Justin R. Pritchard et al.   PLoS Genetics

Moenomycin Resistance Mutations in Staphylococcus aureus Reduce Peptidoglycan Chain Length and Cause Aberrant Cell Division

(2013) Yuriy Rebets et al.   ACS Chemical Biology

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

(2013) P. Nonejuie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning Defense into Offense: Defensin Mimetics as Novel Antibiotics Targeting Lipid II

(2013) Kristen M. Varney et al.   PLoS Pathogens

Daptomycin-Mediated Reorganization of Membrane Architecture Causes Mislocalization of Essential Cell Division Proteins

(2012) J. Pogliano et al.   JOURNAL OF BACTERIOLOGY

Menaquinone biosynthesis potentiates haem toxicity inStaphylococcus aureus

(2012) Catherine A. Wakeman et al.   MOLECULAR MICROBIOLOGY

High-frequency transposition for determining antibacterial mode of action

(2011) Hao Wang et al.   Nature Chemical Biology

Identifying microbial fitness determinants by insertion sequencing using genome-wide transposon mutant libraries

(2011) Andrew L Goodman et al.   Nature Protocols

A simple plasmid-based system that allows rapid generation of tightly controlled gene expression in Staphylococcus aureus

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Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

(2010) Jeremy Goecks et al.   GENOME BIOLOGY

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds

(2009) Robert G.K. Donald et al.   CHEMISTRY & BIOLOGY

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

(2009) Joann Huber et al.   CHEMISTRY & BIOLOGY

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Antibiotics for Emerging Pathogens

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