期刊
NATURE BIOTECHNOLOGY
卷 36, 期 2, 页码 152-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.4052
关键词
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资金
- Vaccine Research Center, NIAID, NIH
- NIH [DP5OD023118-01, 5R21CA191239-01, 1R56AI106006]
- Leidos Biomedical Research Inc. [15X219]
- DTRA [HDTRA1-12-C-0105]
We present a technology to screen millions of B cells for natively paired human antibody repertoires. Libraries of natively paired, variable region heavy and light (V-H:V-L) amplicons are expressed in a yeast display platform that is optimized for human Fab surface expression. Using our method we identify HIV-1 broadly neutralizing antibodies (bNAbs) from an HIV-1 slow progressor and high-affinity neutralizing antibodies against Ebola virus glycoprotein and influenza hemagglutinin.
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