Article
Oncology
Kajal Rajput, Mohammad Nafees Ansari, Somesh K. Jha, Trishna Pani, Nihal Medatwal, Somdeb Chattopadhyay, Avinash Bajaj, Ujjaini Dasgupta
Summary: This study compares the sphingolipid profiles of triple-positive and triple-negative breast cancer patients and correlates them with cell proliferation and migration properties. Results show that targeting ceramide kinase (CERK) can slow down tumor progression, suggesting CERK as a potential therapeutic target for breast cancer.
Article
Oncology
Chia-Che Chang, Chien-Chih Chiu, Pei-Feng Liu, Chih-Hsuan Wu, Yen-Chiang Tseng, Cheng-Hsin Lee, Chih-Wen Shu
Summary: The study identified DYRK1B as a potential gene essential for cell proliferation and mobility of triple-negative breast cancer (TNBC) cells, particularly in those with high DYRK1B expression, which was associated with poor overall survival. CCDC97 and ZNF581 were positively correlated with DYRK1B expression. The results suggest DYRK1B as a potential therapeutic target for TNBC patients.
Article
Pharmacology & Pharmacy
Yuzhou Shen, Haitao Ma
Summary: This study evaluated the feasibility of using novel anisamide-lipid calcium phosphate nanoparticles (AS-LCPs) as a nanocarrier for biologically active oridonin (ORD) delivery in lung cancer models. The AS-ORD LCPs demonstrated stability, sustained release in vivo, and faster release in acidic environments. Additionally, the degree of cell internalization of the AS-ORD LCPs varied depending on surface modification.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Anna Epanchintseva, Julia E. Poletaeva, Ilya S. Dovydenko, Boris P. Chelobanov, Dmitrii Pyshnyi, Elena Ryabchikova, Inna A. Pyshnaya
Summary: The study aimed to improve the quality of preparations of gold nanoparticle-based multilayer nanoconstructs (MLNCs) by finding optimal conditions for their fabrication, verifying all steps and purification processes, and ultimately optimizing the fabrication of target MLNCs bearing small interfering RNA.
Article
Chemistry, Multidisciplinary
Simona Sapino, Giulia Chindamo, Daniela Chirio, Maela Manzoli, Elena Peira, Chiara Riganti, Marina Gallarate
Summary: The study aims to prepare and characterize lipid nanoparticles coated with calcium phosphate, which showed higher cell accumulation in human osteosarcoma cells compared to uncoated nanoparticles. This indicates the potential of calcium phosphate-coated lipid nanoparticles as vehicles for selective drug delivery to bone tissue in the treatment of bone diseases.
Review
Biotechnology & Applied Microbiology
Rushikesh Fopase, Chinmaya Panda, Amarnath P. Rajendran, Hasan Uludag, Lalit M. Pandey
Summary: The use of small interfering RNA (siRNA) in mRNA degradation has shown its potential in treating difficult-to-treat genetic disorders and related diseases. The recent COVID-19 pandemic has highlighted the importance of mRNA-based vaccination strategies and RNA interference (RNAi) using siRNA as a complementary approach for managing the disease. However, challenges such as the stability of siRNA in the physiological environment, targeted delivery, and evasion of the immune system need to be addressed. Nanotechnology offers solutions to these challenges through the design of siRNA targeted towards specific regions of the viral genome and the development of nanoformulations for efficient delivery. This review provides insights into the potential of siRNA and nanotechnology in managing SARS-CoV-2, and discusses in silico design and nanoparticle carriers for siRNA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yomna S. Abd El-Aziz, Josef Gillson, Patric J. Jansson, Sumit Sahni
Summary: This review discusses the critical role of autophagy in the progression of triple negative breast cancer (TNBC) and introduces recent therapeutic approaches that target autophagy.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Rahul Chadar, Afsana, Prashant Kesharwani
Summary: Triple negative breast cancer is characterized by absence of estrogen receptor, progesterone receptor, and HER-2 receptor, leading to poor prognosis and chemoresistance. Advanced therapy using genes and nanocarrier can improve therapeutic outcomes with reduced side effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Wataru Sato, Kazuhiro Ikeda, Noriko Gotoh, Satoshi Inoue, Kuniko Horie
Summary: Efp plays a tumor-promotive role in TNBC and may serve as a potential therapeutic target for this aggressive disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yongpeng Li, Yanan Tan, Lijuan Wen, Zhihao Xing, Changxu Wang, Liuhui Zhang, Kai Wu, Haiyan Sun, Yuqing Li, Qifang Lei, Song Wu
Summary: TNBC is a highly aggressive and lethal disease lacking targeted therapies, with high BIRC6 expression correlated with poor patient survival. Mechanistically, EGF-JNK signaling stabilizes BIRC6 by preventing ubiquitination and degradation, promoting TNBC cell growth. Targeted delivery of BIRC6 siRNA using pCLN nanoparticles effectively suppresses TNBC cell growth, showing superior antitumor activity compared to gefitinib.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Long Zhang, Chaofeng Mu, Tinghong Zhang, Dejun Yang, Chenou Wang, Qiong Chen, Lin Tang, Luhui Fan, Cong Liu, Jianliang Shen, Huaqiong Li
Summary: By assembling RNase resistant RNA nanoparticles (NPs) based on the 3WJ structure from Phi29 DNA packaging motor, we successfully developed RNA NPs equipped with epidermal growth factor receptor (EGFR) targeting aptamer and XBP1 siRNA, which could deplete XBP1 expression, suppress tumor growth, sensitize TNBC to chemotherapy, and inhibit angiogenesis in vivo, demonstrating the potential of RNA NPs as an effective platform for siRNA delivery and therapy for chemotherapy-resistant TNBC.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Tian-Jiao Zhou, Xing Wan, Meng-Meng Zhang, Dan-Meng Liu, Li-Ling Huang, Lei Xing, Yi Wang, Hu-Lin Jiang
Summary: This study proposes a novel strategy for ROS explosion induced by tumor microenvironment-initiated lipid redox cycling. The strategy utilizes soybean phosphatidylcholine (SPC) to encapsulate lactate oxidase (LOX) and sorafenib (SRF) self-assembled nanoparticles (NPs), named LOX/SRF@Lip. Compared to traditional treatment methods, this strategy shows great potential for treating aggressive malignancies with low toxicity in normal tissues, enabling excellent and safe tumor-specific therapy.
Review
Pharmacology & Pharmacy
Xuemei Ge, Lijuan Chen, Bo Zhao, Weien Yuan
Summary: RNA interference technology holds great potential for clinical application by unraveling disease mechanisms; the challenge lies in improving stability, bioactivity, and efficiency of delivering therapeutic agents to target sites. PEGylated lipid-based delivery system, with its advantages of long circulating half-life, low toxicity, and biocompatibility, provides a promising platform for targeted delivery of nucleic acids and is advancing towards clinical trials for siRNA delivery.
FRONTIERS IN PHARMACOLOGY
(2021)
Letter
Oncology
Yizhao Xie, Biyun Wang, Yannan Zhao, Zhonghua Tao, Ye Wang, Guangliang Chen, Xichun Hu
Summary: In this study, a co-culture system of mammary adipocytes and breast cancer cells was established, showing that adipocytes can protect triple-negative breast cancer cells from ferroptosis. Lipidomics analysis revealed that oleic acid secreted from adipocytes inhibits lipid peroxidation and ferroptosis of breast cancer cells through ACSL3.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Jie Li, Dejiao He, Sicheng Li, Jun Xiao, Zhanyong Zhu
Summary: This review discusses the role of ferroptosis in TNBC and explores its potential value in the progression, diagnosis, and treatment of TNBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Aiden C. Beauglehole, Dinora Roche Recinos, Cassandra L. Pegg, Yih Yean Lee, Victor Turnbull, Susann Herrmann, Esteban Marcellin, Christopher B. Howard, Benjamin L. Schulz
Summary: Appropriate treatment of Hemophilia B is crucial, and advancements in recombinant technologies have allowed for the production of Factor IX. However, the complex post-translational modifications of Factor IX have posed challenges for large-scale recombinant production. Further research is needed to optimize the production methods.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Pizzi, James Humphries, Joshua P. Morrow, Ayaat M. Mahmoud, Nicholas L. Fletcher, Stefan E. Sonderegger, Craig A. Bell, Kristofer J. Thurecht, Kristian Kempe
Summary: In this study, we synthesized a new water-soluble polymer and compared it with control polymers. The new polymer demonstrated a lower critical solution temperature behavior and a chiral secondary structure. Cellular association and mouse biodistribution studies confirmed the biocompatibility of this polymer and its higher immune cell association and organ accumulation compared to control polymers.
Article
Chemistry, Medicinal
Karine Mardon, Jayendra Z. Patel, Juha R. Savinainen, Damion H. R. Stimson, Caitlin R. M. Oyagawa, Natasha L. Grimsey, Mary-anne Migotto, Grace F. M. Njiru, Brett R. Hamilton, Gary Cowin, Jari Yli-Kauhaluoma, Wim Vanduffel, Idriss Blakey, Rajiv Bhalla, Christopher Cawthorne, Sofie Celen, Guy Bormans, Kristofer J. Thurecht, Muneer Ahamed
Summary: Multimodal imaging, through PET and MALDI imaging, is used to discover and validate a new probe targeting the ABHD6 enzyme. The PET ligand [18F]JZP-MA-11 is reported to have specific uptake in ABHD6-rich tissues and major brain regions, with brain uptake confirmed in a nonhuman primate study. In vivo pharmacological response upon ABHD6 inhibition is observed using MALDI imaging. These synergistic imaging efforts hold promise for improving our understanding of ABHD6-mediated endocannabinoid metabolism in peripheral and central nervous system disorders.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Saikat Ghosh, Nicholas L. Fletcher, Pie Huda, Zachary H. Houston, Christopher B. Howard, Maria E. Lund, Yanling Lu, Douglas H. Campbell, Bradley J. Walsh, Kristofer J. Thurecht
Summary: This study developed an antibody-based positron emission tomography (PET) tracer for noninvasive detection of glypican-1 (GPC-1) positive glioblastoma (GBM) tumors. The results show that 89Zr-DFO-Miltuximab is an effective immuno-PET imaging agent for detecting GPC-1positive tumors such as GBM.
MOLECULAR PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Maria C. C. Arno, Joshua D. D. Simpson, Lewis D. D. Blackman, Ruairi P. Brannigan, Kristofer J. J. Thurecht, Andrew P. P. Dove
Summary: Polymer-drug conjugates can enhance the selectivity of therapeutic drugs to cancer cells and improve the circulation lifetime and solubility of poorly soluble drugs. This study reports a simple method to generate biodegradable nanoparticles that efficiently conjugate and release S-(+)-camptothecin, a commonly used inhibitor in cancer therapy. The drug-polymer conjugate shows strong efficacy in inhibiting cell proliferation in various cancer cell lines.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Weijing Chu, Zachary H. Houston, Nicholas L. Fletcher, Pie Huda, Muneer Ahamed, Ting Xiang Lim, Bryan W. Day, Mark Pinkham, Kristofer J. Thurecht
Summary: This study developed a multifunctional polymer platform for treating treatment-resistant glioblastoma (GBM) by using targeted nanomedicine. The polymer was synthesized via reversible addition fragmentation chain transfer polymerization and included temozolomide (TMZ) as a polymerizable monomer, PEG units for biocompatibility, and hydrazide moieties for attaching a secondary drug. The polymer showed improved therapeutic efficacy in overcoming resistance to TMZ when attached with a DNA repair protein inhibitor. Targeted delivery to GBM tumors using a specific antibody further enhanced the therapeutic effect of the polymer. The study highlights the potential benefit of this formulation for delivering multi-drug combinations to resistant GBM tumor cells.
Article
Medicine, Research & Experimental
Aditya Ardana, Saikat Ghosh, Pie Huda, Nicholas L. Fletcher, Kristofer J. Thurecht, Charlotte C. Williams
Summary: Covalent conjugation of a biologically stable polymer to a therapeutic protein, such as an antibody, can enhance its stability, improve tumor targeting, and ensure reproducibility in manufacturing. By using stable reactive groups and site-selective conjugation methods, high-purity conjugates can be obtained, preserving the efficacy and specificity of the protein.
MOLECULAR PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Junrong Li, Christopher B. Howard, Shuvashis Dey, Kym Lowry, David M. Whiley, Simon Puttick, Stephen Rose, Richard J. Lobb, Alain Wuethrich, Selvakumar Edwardraja, Matt Trau
Summary: Accurate and early detection of biomarkers is crucial for disease management, and programmable and multifunctional nanoprobes have been developed for rapid, specific and highly sensitive detection of emerging diseases. These nanoprobes, composed of synthetic bionanofragments (SynBioNFs), display multiple copies of biomolecules for high-affinity target binding and optimized molecular orientation on diagnostic platform surfaces. The SynBioNFs have been successfully used for the capture and detection of SARS-CoV-2 using various diagnostic systems with sensitivity comparable to the gold-standard reverse-transcription quantitative polymerase chain reaction.
NATURE NANOTECHNOLOGY
(2023)
Article
Cell Biology
Ernest Moles, Christopher B. Howard, Pie Huda, Mawar Karsa, Hannah McCalmont, Kathleen Kimpton, Alastair Duly, Yongjuan Chen, Yizhou Huang, Melinda L. Tursky, David Ma, Sonia Bustamante, Russell Pickford, Patrick Connerty, Sofia Omari, Christopher J. Jolly, Swapna Joshi, Sylvie Shen, John E. Pimanda, Alla Dolnikov, Laurence C. Cheung, Rishi S. Kotecha, Murray D. Norris, Michelle Haber, Charles E. de Bock, Klaartje Somers, Richard B. Lock, Kristofer J. Thurecht, Maria Kavallaris
Summary: High-risk childhood leukemia has a poor prognosis due to treatment failure and toxic side effects. Encapsulation of drugs in liposomal nanocarriers improves biodistribution and tolerability, but lacks selectivity for cancer cells. In this study, bispecific antibodies were generated to target PEGylated liposomal drugs to leukemic cells. These antibodies improved targeting and cytotoxic activity, with minimal harm to normal cells. Targeted delivery using bispecific antibodies enhanced leukemia suppression and extended overall survival, representing a promising platform for improved treatment of high-risk leukemia.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Courtney Vedelago, Junrong Li, Kym Lowry, Christopher Howard, Alain Wuethrich, Matt Trau
Summary: Variants of SARS-CoV-2 play a crucial role in predicting patient outcomes, hence the need for variant detection. This study proposes a multiplex SERS microassay for detecting both the spike and nucleocapsid structural proteins. The microassay combines gold-silver hollow nanobox barcodes and electrohydrodynamically induced nanomixing to achieve highly specific and sensitive detection of the virus and S-protein epitopes. The assay can detect as low as 20 virus/mu L and 50 pg/mL RBD protein in nasopharyngeal swabs and can differentiate between different variants.
Article
Pharmacology & Pharmacy
Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: Despite the clinical benefits of chemotherapeutics, drug resistance remains a major challenge in breast cancer treatment. Nanomedicines, such as porous silicon nanoparticles (pSiNPs), offer a targeted and effective approach by delivering multiple therapeutics and minimizing drug resistance. In this study, breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs) were engineered. The combination of hyperthermia and chemotherapy using targeted pSiNPs showed higher cell-killing efficacy compared to monotherapy and a nontargeted system with combined therapeutics. These findings highlight the potential of targeted pSiNPs as a versatile platform for personalized medicine.
Article
Engineering, Biomedical
Arunpandian Balaji, Craig A. Bell, Zachary H. Houston, Kim R. Bridle, Berit Genz, Nicholas L. Fletcher, Grant A. Ramm, Kristofer J. Thurecht
Summary: Nanoparticle-based drug delivery systems have shown promise in reversing hepatic fibrosis in preclinical animal models, but there are challenges in transitioning them to clinical usage and developing FDA-approved drugs for liver fibrosis.
Article
Medicine, Research & Experimental
Malcolm Lim, Nicholas L. Fletcher, Jodi M. Saunus, Amy E. McCart Reed, Haarika Chittoory, Peter T. Simpson, Kristofer J. Thurecht, Sunil R. Lakhani
Summary: This study demonstrates the potential of a HER3-targeted hyperbranched polymer (HBP) nanomedicine for the treatment of breast cancer brain metastases. The HBP carrier can selectively deliver and release the chemotherapy drug doxorubicin (DOX) in a pH-responsive manner. The nanomedicine shows effective drug release and cytotoxicity against breast cancer cells, and in a mouse model, it inhibits tumor proliferation, reduces tumor size, and prolongs overall survival. Furthermore, the nanomedicine exhibits lower toxicity compared to free DOX.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Pie Huda, James Humphries, Nicholas L. Fletcher, Christopher B. Howard, Kristofer J. Thurecht, Craig A. Bell
Summary: This article showcases the development of protein functionalisation methods for the development of imaging agents and antibody drug conjugates. By incorporating noncanonical amino acids into the protein structure, site-specific labelling and functionalisation can be achieved. The study shows that the coupling of model compounds onto the protein does not significantly impact binding affinity, making it a powerful tool for the development of customisable targeted antibody-drug conjugates.
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
