Article
Chemistry, Physical
Martin Balouch, Marek Soltys, Filip Hladek, Pavel Ulbrich, Frantisek Stepanek
Summary: This study investigates the diffusion control mechanism of lipid-coated silica nanoclusters, revealing the crucial role of electrostatic interactions between the nanoparticle surface and the lipid bilayer in the existence and stability of the clusters. The lipidic membrane acts as a diffusion gate, preventing premature leakage of encapsulated substances during storage but allowing diffusion when the phase transition temperature is exceeded, demonstrating a gating mechanism for controlled release of substances.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Zeynep Burcu Akkus-Dagdeviren, Sema Arisoy, Julian David Friedl, Andrea Fuerst, Ahmad Saleh, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop enzyme-activated charge-reversal lipid nanoparticles (LNPs) as novel gene delivery systems. The researchers successfully anchored a transfection promoter on the surfaces of LNPs to achieve high encapsulation and efficient gene delivery. The experiment results showed that the enzyme-triggered charge reversal of LNPs resulted in significantly increased transfection efficiency in human alveolar epithelial cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Emilia Krok, Agnieszka Batura, Madhurima Chattopadhyay, Hanna Orlikowska, Lukasz Piatkowski
Summary: Many studies have investigated phase separation and formation of lipid domains, crucial in biological processes. This study examined the formation, dynamics, and stability of phase-separated supported lipid membranes under varying pH conditions, finding a strong correlation between L-o domain size and buffer pH. Lipid dynamics are insensitive to buffer pH, and varying pH can induce specific domain formation without external modification. The lipid membrane architecture remains stable even when the aqueous medium is replaced with neutral pH buffer, making this method applicable for studies involving pH-sensitive molecules.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Yining Jiang, Batiste Thienpont, Vinay Sapuru, Richard K. Hite, Jeremy S. Dittman, James N. Sturgis, Simon Scheuring
Summary: The study found that membrane hydrophobic mismatch modulates oligomerization and assembly of membrane proteins, impacting their 2D organization. The experimental and theoretical frameworks revealed how membrane organization can emerge from Brownian diffusion and a minimal set of physical properties of the membrane constituents.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yining Jiang, Batiste Thienpont, Vinay Sapuru, Richard K. Hite, Jeremy S. Dittman, James N. Sturgis, Simon Scheuring
Summary: This study investigates the behavior of a model membrane protein in controlled lipid environments. The results show that membrane hydrophobic mismatch modulates oligomerization and assembly energetics, as well as 2D organization. The findings highlight how membrane organization can emerge from Brownian diffusion and a minimal set of physical properties.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Bijoy Ghosh, Felipe Fantuzzi, Ashwini K. Phukan
Summary: Density functional theory calculations were conducted on metallatranes containing group 13 elements at the bridgehead position to study the M center dot center dot center dot Z interaction and reactivity at the metal center. The strength of the M center dot center dot center dot Z interaction was found to increase with the size and polarizability of the bridgehead group 13 elements. The binding of Lewis bases to the metallatranes was significantly more exergonic for the larger In(III) ions.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Thomas R. Kuech, Nasim Ganji, Caroline Anastasia, Marco D. Torelli, Eric S. Melby, Arielle C. Mensch, Emily R. Caudill, Ralf Zimmermann, Robert J. Hamers, Joel A. Pedersen
Summary: The interactions between cationic polymer-wrapped diamond nanoparticles (PAH-DNPs) and lipid bilayers are influenced by the phospholipid composition and surface charge. Electrostatic attractions and repulsions play key roles in the initial attachment and final extent of nanoparticle adhesion. The formation of a lipid corona on PAH-DNPs reduces the effective charge density and affects the adhesion extent. The inclusion of charged phospholipids decreases the attachment efficiency and extent by reducing the electrostatic attraction between PAH-DNPs and the bilayers.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Tanaz Islam, Olga N. Chesnokov, Andrew V. Oleinikov, Peng Yi
Summary: The interactions between nanoparticles and red blood cell membranes were investigated using characterization methods and techniques. The results showed that the surface charge of the nanoparticles played an important role in their attachment to the red blood cell membranes.
Article
Multidisciplinary Sciences
Jared T. Wiemann, Danh Nguyen, Ying Li, Yan Yu
Summary: This study investigates the interaction of amphiphilic Janus nanoparticles with lipid vesicles exhibiting phase-separated microdomains through experiments and simulations. The results show that Janus nanoparticles preferentially bind to and extract lipids from the liquid-disordered domains of the vesicles, causing the vesicles to wrinkle and deform. These deformations are driven by the surface anisotropy of the Janus nanoparticles.
Article
Multidisciplinary Sciences
Lizhi Liu, Dingyi Pan, Sheng Chen, Maria-Viola Martikainen, Anna Karlund, Jing Ke, Herkko Pulkkinen, Hanna Ruhanen, Marjut Roponen, Reijo Kakela, Wujun Xu, Jie Wang, Vesa-Pekka Lehto
Summary: The mechanism underlying partial coating in cell membrane (CM) coating technology has been revealed to be the adsorption of CM fragments or vesicles, which can eventually be ruptured under external force. Partial coating is difficult to self-repair due to limited membrane fluidity. Introducing external phospholipids as a helper can increase CM fluidity and promote the final fusion of lipid patches.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yunyun Xue, Zihao Zhao, Yu Zhao, Chuyao Wang, Shuyang Shen, Zelin Qiu, Ronglu Cui, Shien Zhou, Lifeng Fang, Zhi Chen, Haihong Zhu, Baoku Zhu
Summary: With the emergence of drug-resistant pathogens, new strategies for high antibacterial efficacy are urgently needed. In this study, cationic nano-sized hyperbranched polymers (CNHBPs) were constructed, and one particular type showed the highest antimicrobial and antibiofilm activities. It also exhibited superior therapeutic efficacy in a mouse wound model of MRSA infection.
Article
Chemistry, Medicinal
Barbara Mavroidi, Archontia Kaminari, Elias Sakellis, Zili Sideratou, Dimitris Tsiourvas
Summary: This study investigated the effect of carbon dots on a model cell membrane. The results showed that carbon dots interact with liposomes, affecting the structure and thermodynamic properties of the bilayer. Furthermore, carbon dots increased the membrane's permeability to the anticancer drug doxorubicin.
Article
Chemistry, Multidisciplinary
Zepeng He, Zhicheng Le, Yi Shi, Lixin Liu, Zhijia Liu, Yongming Chen
Summary: We report a powerful strategy using the Ugi four-component reaction to modulate ionizable lipids (ILs) for mRNA delivery. Through a simplified screening process, we identified high-performing ILs for in vivo mRNA delivery. The structure of ILs controls organ-selective mRNA delivery, while the isomeric design of ILs affects the in vivo efficacy. This work provides important insights for the rapid discovery and rational design of IL candidates in mRNA therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Xueyan Huang, Zhi-Bin Fang, Wenhui Feng, Qinfen Tian, Zhiqiang Li, Ping Liu
Summary: Loading cocatalysts on the host photocatalyst surface is an effective strategy for charge separation, but suffers from a large Schottky barrier at the interface. In this study, a series of Pt/PbTiO3 compounds were constructed to modulate the interfacial Schottky barrier height using the piezoelectric field of PbTiO3 under acoustic vibrations, achieving highly efficient piezo-photocatalytic H2 evolution. The manipulation of the Schottky barrier height was validated by conductive AFM measurements, and the enhanced H2 evolution was attributed to the increased electron flow and spatial separation of charge carriers induced by the acoustic-wave-induced piezoelectric field. These findings will contribute to the understanding of the synergistic piezo-photocatalysis mechanism and the rational design of clean energy conversion materials.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Jia-Rui Wu, Dongxia Li, Gengxin Wu, Meng-Hao Li, Ying-Wei Yang
Summary: This study develops a strategy to modulate supramolecular ICT interactions in the solid state by compressing the binding cavity of a macrocyclic host, leading to improved affinities with electron-deficient planar guests.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.