Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Review
Pharmacology & Pharmacy
Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min
Summary: Nanomedicine has provided effective approaches for improving the efficiency of radiotherapy and reducing its side effects, with metal nanoparticles proving to be ideal radiosensitizers. The use of nanoparticles can help facilitate the delivery of radiosensitizing drugs to tumor sites, enhancing anti-tumor responses.
Review
Pharmacology & Pharmacy
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei, Xinrong Guo
Summary: Cancer immunotherapy is a novel approach to enhance the immune system's ability to detect and eliminate cancer cells. Gold nanoparticles (AuNPs) have been explored as drug carriers in immunotherapy due to their stability, surface versatility, and optical properties. This review summarizes the synthesis routes and utilization of AuNPs as drug carriers, focusing on drug loading, targeting strategies, and drug release mechanisms in AuNP-based immunotherapy. The application and therapeutic efficacy of AuNPs in combination with cancer immunotherapy are also briefly discussed.
Article
Instruments & Instrumentation
Carmine D'Amico, Flavia Fontana, Ruoyu Cheng, Helder A. Santos
Summary: The ongoing pandemic has brought vaccines into focus again, with traditional vaccines facing challenges in immunogenicity, stability, and storage. Research delves into past, present, and future vaccine formulations, highlighting the use of nanoparticles and microneedle patches as alternative options. The analysis compares injectable solutions, nanovaccines, and microneedles in terms of efficacy, stability, and patient-friendly design.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Nanoscience & Nanotechnology
Tobias Achu Muluh, Zhuo Chen, Yi Li, Kang Xiong, Jing Jin, ShaoZhi Fu, JingBo Wu
Summary: In recent years, there has been a significant increase in research on abnormal cell growth, particularly focusing on the management, treatment, and prevention of tumor recurrence. Cancer immunotherapy aims to educate the body's defensive system to prevent, control, and eliminate tumor cells, with the use of nanoparticles enhancing its effectiveness. By utilizing nanoparticles for precise delivery of immunotherapies to targeted neoplasms, immunotherapy can be a promising approach for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Jonas Kaltbeitzel, Peter R. Wich
Summary: Proteins and enzymes are versatile biomaterials with high specificity, degradability, low toxicity, and good biocompatibility, making them ideal for various medical applications. Protein nanoparticles, formed by arranging native or modified proteins into nanometer-sized assemblies, have emerged as a promising nanosystem for drug delivery, imaging, nanocatalysis, and protein therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Nanoscience & Nanotechnology
Saji Uthaman, Gabriel Cutshaw, Saman Ghazvini, Rizia Bardhan
Summary: This tutorial review summarizes the recent advances in using nanoparticles to label NK cells for immunoimaging or deliver treatment to activate NK cells and induce long-term immunity against tumors. The key properties of nanoparticles for overcoming challenges in NK cell-based diagnostics and therapeutics are discussed. The review concludes with an outlook on future directions in NP-NK cell hybrid interfaces and the need to address their overall clinical impact and patient response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Madeleine R. Landry, Joshua M. Walker, Conroy Sun
Summary: Recent interest in cancer immunotherapy has largely focused on adaptive immune system, particularly adoptive T-cell therapy and immune checkpoint blockade. However, targeting immune evasion signals in tumors can enhance phagocytosis of cancer cells, but may also lead to negative off-target effects on normal cells.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Yongxin Zhang, Hao Fu, Jiajing Chen, Linlin Xu, Yingli An, Rujiang Ma, Chunlei Zhu, Yang Liu, Feihe Ma, Linqi Shi
Summary: This article introduces a holdase/foldase mimetic nanochaperone (H/F-nChap) for co-delivery of multiple mAbs, which significantly improves cancer immunotherapy. The nanochaperone exhibits holdase activity in blood and normal tissues, protecting mAbs and reducing side effects. In the tumor microenvironment, it switches to foldase activity, enhancing immune activation.
Article
Oncology
Mengdan Xu, Shenglong Li
Summary: This comprehensive review provides an overview of current research on nano-drug delivery systems for melanoma treatment, with a focus on liposomes, polymeric nanoparticles, and inorganic nanoparticles. It discusses the potential of these nanoparticles for targeted drug delivery, as well as their ability to enhance the efficacy of conventional drugs while minimizing toxicity. Furthermore, this review emphasizes the significance of interdisciplinary collaboration in advancing the development of nanomedicines.
Review
Pharmacology & Pharmacy
Palaniyandi Muthukutty, Hyun Young Woo, Murali Ragothaman, So Young Yoo
Summary: Immunotherapy is crucial in fighting cancer and achieving successful remission. Recent advances in cancer immunotherapy delivery techniques have been discussed, along with their future prospects. Meticulously designed delivery methods are necessary to effectively attack cancer cells and expose immune cells to the immune system, while maintaining high therapeutic efficacy and minimizing adverse events.
Review
Pharmacology & Pharmacy
Kyeong Jin Cho, Young-Eun Cho, Jihoon Kim
Summary: The lymphatic system is a crucial target in controlling cancer progression and adaptive immune response. Nano-sized materials have shown advantages in delivering drugs to lymph nodes and overcoming barriers associated with lymphatic physiology. Sustained drug delivery systems have the potential to improve the therapeutic index of immune modulating agents.
Article
Materials Science, Biomaterials
Shuying Li, Yanjuan Wu, Siyuan Liu, Ting Wu, Guozheng Liu, Tianduo Li, Zhaowei Chen
Summary: This work developed an innovative nanoplatform based on a Pt(iv) prodrug and a near-infrared photosensitizer, which can achieve multifunctional cancer therapy and diagnosis. The nanoplatform allows real-time tracking of nanodrugs and has dual effects of photothermal therapy and chemotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Nazim Nasir, Shadma Wahab, Mallikarjuna Rao Pichika, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Breast cancer is a common type of cancer with significant side effects after therapy. Nanoparticle-based drug delivery systems, particularly natural polysaccharide-based nanoparticles, have gained attention for their ability to achieve targeted drug delivery. Dextran and its derivatives have shown potential in breast cancer therapy. This review provides insights into dextran and its modification, discusses the role of dextran-based nanoparticles in breast cancer treatment and imaging, and presents clinical trials and future perspectives.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Albert Yu, Xiaoyong Dai, Zixian Wang, Huaqing Chen, Bing Guo, Laiqiang Huang
Summary: Immunotherapy is a promising treatment modality for cancer, using the body's immune response to fight against cancer. Mesoporous silica, as a nanomaterial, can facilitate the advancement of immunotherapy with its high porosity and biocompatibility.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
