期刊
NANOMEDICINE
卷 13, 期 12, 页码 1405-1416出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0380
关键词
antibacterial agents; gold nanoparticles; multivalent interactions; near infrared (NIR); photothermal; vancomycin; vancomycin-resistant Enterococci
资金
- Ministry of Science and Technology of Taiwan [MOST 105-2113-M-009-022-MY3]
Aim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15 degrees C under irradiation by a near-infrared laser (lambda = 808 nm) within 5 min. Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.
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