期刊
NANOMEDICINE
卷 13, 期 9, 页码 1067-1085出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0389
关键词
biological microenvironment; material properties; nanoscaffold; nerve guidance conduits; nerve regeneration; peripheral nerve system
资金
- National Key Research and Development Program of China [2016YFC1102605, 2016YFC1102603]
- National Natural Science Foundation of China [51672122]
- Natural Science Foundation of Guangdong Province of China [2016A030313673, 2015A030313299]
The ability to surgically repair peripheral nerve injuries is urgently needed. However, traditional tissue engineering techniques, such as autologous nerve transplantation, have some limitations. Therefore, tissue engineered autologous nerve grafts have become a suitable choice for nerve repair. Novel tissue engineering techniques derived from nanostructured conduits have been shown to be superior to other successful functional neurological structures with different scaffolds in terms of providing the required structures and properties. Additionally, different biomaterials and growth factors have been added to nerve scaffolds to produce unique biological effects that promote nerve regeneration and functional recovery. This review summarizes the application of different nanoscaffolds in peripheral nerve repair and further analyzes how the nanoscaffolds promote peripheral nerve regeneration.
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