Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Review
Chemistry, Multidisciplinary
Shan Mohanan, Xinwei Guan, Mingtao Liang, Ajay Karakoti, Ajayan Vinu
Summary: The design of novel drug delivery systems is crucial in disease treatments, and mesoporous silica nanoparticles (MSNs) have shown great promise due to their stability, tunable morphologies/sizes, and loading capability. Functionalization of MSNs with drugs, imaging, and targeting agents is enabled by the presence of surface silanol groups, making them versatile and popular among researchers. Stimuli-responsive silanol conjugates have emerged as an effective way to deliver therapeutic drugs precisely and on-demand, and it is important to understand the role of surface silanols in MSN as a drug delivery platform. This review provides an analytical understanding of surface silanols, their chemistry, identification methods, and their correlation with properties and performance.
Article
Pharmacology & Pharmacy
Roshni Iyer, Harish Ramachandramoorthy, Trinh Nguyen, Cancan Xu, Huikang Fu, Tanviben Kotadia, Benjamin Chen, Yi Hong, Debabrata Saha, Kytai Truong Nguyen
Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Conventional clinical therapies have limitations in treating lung cancer, but a new study has developed dual-stimuli nanoparticles that target cancer cells and release chemotherapy drugs and radiation sensitizer, potentially improving treatment efficacy and reducing side effects.
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Review
Chemistry, Multidisciplinary
Weiqi Cai, Tianli Luo, Lanqun Mao, Ming Wang
Summary: Recent innovations in genome editing have led to precise manipulation of genetic information in mammals using stimuli-responsive nanoparticles for the delivery and release of CRISPR/Cas9 genome editing machinery. These approaches can utilize biological signals or external signals to achieve improved genome editing outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
Mohammad Arad Zandieh, Melika Heydari Farahani, Mahshid Daryab, Alireza Motahari, Sarah Gholami, Farshid Salmani, Fatemeh Karimi, Seyedeh Setareh Samaei, Aryan Rezaee, Parham Rahmanian, Ramin Khorrami, Shokooh Salimimoghadam, Noushin Nabavi, Rongjun Zou, Gautam Sethi, Mohsen Rashidi, Kiavash Hushmandi
Summary: The use of phytochemicals in cancer therapy has been accelerated due to tumor cell resistance to conventional chemotherapy drugs. However, the poor bioavailability and lack of specific accumulation at tumor sites pose challenges. The use of nanocarriers for targeted delivery of phytochemicals shows promise in improving pharmacokinetics and therapeutic indices. Stimuli-responsive nanostructures and surface functionalization with ligands further enhance the internalization and cytotoxicity of natural compounds in cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Materials Science, Biomaterials
Takashi Miyata, Takayuki Namera, Yihua Liu, Akifumi Kawamura, Tetsuji Yamaoka
Summary: In this study, zwitterionic polymer particles with photodimerizable groups were designed and photo-assembled using ultraviolet light irradiation. The assembled particles displayed a bioinert surface and exhibited photoresponsive behavior. These polymer particles have potential applications in biosensors, bioseparation, and cell culture, as well as for modifying and repairing biomaterial surfaces in situ.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Medicine, Research & Experimental
Fei Fang, Yinghao Ni, Hongchi Yu, Hongmei Yin, Fan Yang, Chunli Li, Denglian Sun, Tong Pei, Jia Ma, Li Deng, Huaiyi Zhang, Guixue Wang, Song Li, Yang Shen, Xiaoheng Liu
Summary: Targeted and responsive nanoparticles can control the release of drugs and effectively treat atherosclerosis. In vitro experiments showed that these nanoparticles can rapidly release drugs in response to stimulation and effectively inhibit inflammatory responses. In vivo experiments showed that these nanoparticles can slow down the progression of atherosclerosis and reduce inflammation.
Article
Pharmacology & Pharmacy
Kangkang Li, Xinlong Zang, Mingyang Cheng, Xuehong Chen
Summary: Recent progresses in fighting against cancer include better understanding of tumor microenvironment and rapid development in nanoscale drug delivery system. Nanocarriers based on polymeric acrylic derivatives have shown high drug encapsulation rate and satisfactory therapeutic outcome in tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Sachin Bhaladhare, Sulagna Bhattacharjee
Summary: The development of nanotechnology has had a significant impact on biomedical and pharmaceutical fields, particularly in the design and formulation of stimuli-responsive nano-drug delivery systems. These systems, known as smart drug delivery systems, are able to respond to various external and internal stimuli and deliver drugs to targeted sites in a controlled manner. They offer improved patient compliance, treatment efficiency, and reduced side effects on healthy tissue. Polymeric nanogels with stimuli-responsive characteristics have shown great potential in biomedical, tissue engineering, and pharmaceutical applications due to their small size, biocompatibility, stimuli-triggered drug deliverability, high payload capacity, and tailored functionality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Nanoscience & Nanotechnology
Ruixin Jia, Lesheng Teng, Lingyu Gao, Ting Su, Lu Fu, Zhidong Qiu, Ye Bi
Summary: Nanomedicines offer unique advantages in tumor therapy, but traditional nanomedicines are hindered by complex physiological fluids and tumor microenvironments. Stimuli-responsive drug-delivery systems have emerged as a promising tool to overcome these barriers and deliver therapeutic agents to target sites effectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Peng Yang, Fang Zhu, Zhengbiao Zhang, Yiyun Cheng, Zhao Wang, Yiwen Li
Summary: PDA is a promising candidate for stimuli-responsive smart materials, with excellent photo-responsive properties and active surface functionality for loading various responsive motifs. This review summarizes recent advances in design strategies, responsive mechanisms, and diverse applications of stimuli-responsive PDA-based materials, covering stimuli such as light, pH, chemicals, temperature, etc.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Muhammad Bilal, Maimoona Qindeel, Ali Raza, Shahid Mehmood, Abbas Rahdar
Summary: This review discusses the advantages and mechanisms of nanoliposomes for targeted drug delivery, as well as the stimulation-responsive targeting approaches for efficient cancer therapy. Various targeting strategies and challenges associated with these systems are also detailed in this review.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Keli An, Xuqian Deng, Hongli Chi, Yuchao Zhang, Yan Li, Ming Cheng, Zhigang Ni, Zhi Yang, Chao Wang, Jinling Chen, Jianbo Bai, Chunyan Ran, Yong Wei, Juan Li, Penghui Zhang, Feng Xu, Weihong Tan
Summary: Proteolysis Targeting Chimeras (PROTACs) are a promising therapeutic modality for tackling undruggable and resistant issues in drug discovery. Researchers have developed a generalized caging strategy to synthesize stimuli-responsive PROTACs (sr-PROTACs) that can be activated and released in response to specific pathological cues and external triggers. These sr-PROTACs showed high solubility, long plasma exposure, and efficient protein degradation in tumor cells, making them potential candidates for personalized treatment and tissue engineering.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Jinzhao Liu, Weirong Kang, Weiping Wang
Summary: This review summarizes recent applications of photocleavage technologies in nanoparticle-based drug delivery for precise targeting and controlled drug release, with a focus on strategies to achieve long-wavelength light excitation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Chemistry, Physical
Yang Zhou, Yifan Gao, Li Pang, Weirong Kang, Kwan Man, Weiping Wang
Summary: The development of cytosolic protein delivery platforms has opened up new possibilities for the treatment of various incurable diseases. This study reports a versatile and photo-controlled platform based on self-assembly for the efficient cytosolic delivery of proteins. The researchers achieved high serum stability by coating hyaluronic acid and human serum albumin on the surface of nanoparticles. Under green light irradiation, these nanoparticles showed efficient intracellular delivery of multiple cargo proteins with different characteristics and promoted endosome escape.
Article
Chemistry, Multidisciplinary
Tianyi Wang, Yaming Zhang, Kang Chen, Yi Huang, Yuwei Liu, Shuting Xu, Weiping Wang
Summary: Cell cycle progression is highly activated in cancer cells, and CDK4/6 inhibition-based cell cycle arrest is a potent cancer treatment strategy. Combining CDK4/6 PROTAC with Chlorin e6-based photodynamic therapy has a synergistic anti-cancer effect, mediated by mitochondria accumulation and activation, resulting in increased production of reactive oxygen species and apoptosis.
Review
Oncology
Changchun Zhou, Yuanbo Wu, Zeyu Wang, Yanli Liu, Jiaqi Yu, Weiping Wang, Sunrui Chen, Weihua Wu, Jidong Wang, Guowei Qian, Aina He
Summary: Establishing a valid in vitro model that represents tumor heterogeneity and biology is critical but challenging. Tumor organoids, self-assembled three-dimensional cell clusters, have emerged as an attractive in vitro platform for tumor biology research and high-throughput drug screening. However, the lack of standardized methods for organoid culture leads to confusion in organoid studies, potentially affecting accurate judgments of tumor biology. This review summarizes the shortcomings of current organoid culture methods, presents the latest research on organoid standardization, and proposes an outlook for organoid modeling.
Review
Pharmacology & Pharmacy
Weirong Kang, Yuwei Liu, Weiping Wang
Summary: Immunotherapy has revolutionized cancer treatments by activating the immune system to effectively inhibit cancer progression. Recent advances in cancer immunotherapy, such as checkpoint blockades and adoptive cellular therapy, have shown remarkable clinical outcomes. However, low response rates and side effects limit the widespread use of immunotherapy. Nanomedicine, specifically light-responsive nanoplatforms, show promise in enhancing immunotherapy by precise drug delivery and modulation of the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Yaming Zhang, Lu Liu, Tianyi Wang, Cong Mao, Pengfei Shan, Chak Sing Lau, Zhongyu Li, Weisheng Guo, Weiping Wang
Summary: The development of a novel nanoparticle system, ROS-CA-NPs, which is responsive to reactive oxygen species, provides a solution to the limited efficacy and systemic side effects of traditional anti-inflammatory drugs. The ROS-CA-NPs exhibit excellent drug stability, tissue selectivity, and controlled drug release upon oxidative stress activation. Mouse models of chronic rheumatoid arthritis and acute ulcerative colitis demonstrate that the systemic administration of ROS-CA-NPs results in their accumulation at inflamed lesions and leads to greater therapeutic efficacy compared to traditional drugs. The findings suggest that ROS-CA-NPs have the potential to be developed as safe and effective nanotherapeutic agents for a broad range of inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuting Xu, Kaixuan Cui, Kaiqi Long, Jia Li, Ni Fan, Wai-Ching Lam, Xiaoling Liang, Weiping Wang
Summary: This study reports a novel approach for combined anti-angiogenic and photodynamic therapy of wet age-related macular degeneration (wAMD) by intravenous administration of a photoactivatable nanosystem. The nanosystem, composed of a reactive oxygen species (ROS)-sensitive drug and a photosensitizer, showed promising therapeutic efficacy against CNV with minimized systemic toxicity.
Review
Chemistry, Multidisciplinary
Yuwei Liu, Shuting Xu, Qingyang Lyu, Yi Huang, Weiping Wang
Summary: This article provides a comprehensive overview of the recent advancements in using self-assembled nanoparticles based on the photosensitizer chlorin e6 (Ce6) for effective photodynamic therapy (PDT) and precise delivery of functional molecules. These nanoparticles exhibit enhanced pharmacokinetic profiles and excellent biocompatibility.
Article
Chemistry, Multidisciplinary
Fei Wang, Po-Yu Ho, Chuen Kam, Quanzhi Yang, Jinzhao Liu, Weiping Wang, Engui Zhao, Sijie Chen
Summary: Researchers have developed a novel fluorescent probe called OTM for the detection of bacterial outer membrane vesicles (OMVs). OTM can provide quantitative information on bacterial membrane remodeling and OMV secretion, and can be used for high-throughput screening of OMV-inducing agents.
Article
Chemistry, Multidisciplinary
Tianyi Wang, Yaming Zhang, Yuwei Liu, Yi Huang, Weiping Wang
Summary: This study demonstrates that under amino acid starvation, macropinocytosis and ubiquitin-proteasome system are activated as a nutrient supply route. Therefore, amino acid deprivation also sensitizes cancer cells to proteasome inhibition. By blocking macropinocytosis and proteasome simultaneously, an innovative approach is presented to exacerbate amino acid starvation in cancer therapy. A pH-responsive polymersome nanocarrier is developed to maximize therapeutic efficacy and minimize systemic side effects.
Article
Chemistry, Multidisciplinary
Yuwei Liu, Kaiqi Long, Tianyi Wang, Weirong Kang, Weiping Wang
Summary: The study prepared a carrier-free nanodrug MKCe6 NPs for effective tumor growth repression, which sensitized CSCs to PDT and demonstrated good performance in vitro and in vivo.
Article
Nanoscience & Nanotechnology
Lang Wang, Zhongmin Geng, Yannis Y. L. Ho, Jiayu Zhou, Nicola Judge, Yafei Li, Weiping Wang, Jinyao Liu, Yufeng Wang
Summary: Metal-organic cage (MOC) materials are integrated with amphiphilic block copolymers (BCPs) to fabricate stable block co-polyMOC micellar nanoparticles (BCPMMs). BCPMMs exhibit extended blood circulation, favorable biodistribution, and improved treatment efficacy for anticancer drugs.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yuwei Liu, Kaiqi Long, Weirong Kang, Tianyi Wang, Weiping Wang
Summary: Blockading PD-1/PD-L1 has the potential to be a promising approach for treating malignancies, but its systemic immune-related side effects reduce its therapeutic efficacy. To address this issue, a photoactivatable and biocompatible prodrug cBMS-1 based on the concept of photopharmacology has been developed. The prodrug exhibits minimal toxicity but effectively inhibits the PD-1/PD-L1 axis upon light irradiation, offering promising potential for locally activating immune responses in clinical settings.
ADVANCED NANOBIOMED RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Kaiqi Long, Yang Yang, Zhanfeng Du, Weirong Kang, Wen Lv, Yafei Li, Yusheng Xie, Hongyan Sun, Changyou Zhan, Weiping Wang
Summary: This study develops a H2S-responsive nanocarrier based on self-assembly, which can be used for controlled drug release in cancer therapy. The results show that the nanocarrier exhibits efficient H2S-responsive drug release in colon cancer cells and effectively inhibits tumor growth in animal models.
ADVANCED THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Tianyi Wang, Kaiqi Long, Yang Zhou, Xiaoding Jiang, Jinzhao Liu, John H. C. Fong, Alan S. L. Wong, Wai-Lung Ng, Weiping Wang
Summary: mTOR signaling is a crucial regulator of cell metabolism, proliferation, and survival. The photoactivatable OSI-027 prodrug offers a novel strategy for cancer treatment by inhibiting the mTOR signaling pathway and inducing cell death upon light irradiation.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
