Article
Biochemistry & Molecular Biology
Julita Kulbacka, Grzegorz Chodaczek, Joanna Rossowska, Anna Szewczyk, Jolanta Saczko, Urszula Bazylinska
Summary: The second-generation photosensitizer Ce6 shows efficient delivery into melanoma cells and enhanced photodynamic efficiency through electroporation, making it a promising approach for skin cancer treatment.
BIOELECTROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Caroline Coradi Tonon, Shoaib Ashraf, Alessandra Nara de Souza Rastelli, Goutam Ghosh, Tayyaba Hasan, QianFeng Xu, Alexander Greer, Alan M. Lyons
Summary: Antimicrobial photodynamic therapy is a promising method for controlling biofilms in periodontal diseases. To overcome challenges such as teeth staining and lack of sufficient oxygen, a novel superhydrophobic film that generates airborne singlet oxygen has been developed. This approach shows effectiveness in disinfecting bacterial biofilms and will be further evaluated in animal models.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lin Yue, Meihong Zheng, Imran Mahmood Khan, Zhouping Wang
Summary: The study developed a novel photodynamic antibacterial agent CS-Ce6 conjugates by combining cationic polysaccharide chitosan with photosensitizer Chlorin e6 for combating gram-positive and gram-negative bacteria. The results demonstrated that the photodynamic antibacterial effect of CS-Ce6 conjugates was positively correlated with the degree of substitution (DS). This research highlights the potential of CS-Ce6 conjugates as effective photodynamic bactericidal agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Bei Li, Yi Fu, Maodi Xie, Lei Feng, Xiaoya Niu, Lin Que, Zhen You
Summary: This paper presents a novel nanoparticle for liver cancer treatment, which achieves controlled release and killing of tumors through photothermal conversion and photodynamic therapy. The experimental results demonstrate the efficient anti-tumor effect of these nanoparticles and their ability to alleviate the tumor's anaerobic microenvironment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Milan Paul, Asif Mohd Itoo, Balaram Ghosh, Swati Biswas
Summary: Hypoxia is a key characteristic of the tumor microenvironment and affects various aspects of cancer, including cell proliferation, metastasis, and therapy resistance. A nanomicellar system that generates oxygen through near-infrared light activation was developed for the treatment of oral squamous cell carcinoma. The system showed significant potential in chemo-photodynamic combination therapy, effectively reversing hypoxia in oral cancer models.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Min Nie, Rodrigo Costa e Silva, Kleber Thiago de Oliveira, Vanderlei Salvador Bagnato, Alessandra Nara de Souza Rastelli, Wim Crielaard, Jingmei Yang, Dong Mei Deng
Summary: This study demonstrates that the combination of 33.3 mM H2O2 and Ce6-aPDT significantly enhances antimicrobial efficacy, particularly for biofilm infections thriving in anaerobic microenvironments.
Article
Biochemistry & Molecular Biology
Wei Liu, Xingqun Ma, Yingying Jin, Jie Zhang, Yang Li, Yuxia Tang, Yong Song, Shouju Wang
Summary: Ce6-biotin has higher binding affinity to biotin-receptor-positive tumor cells and exhibits stronger cytotoxicity with lower dark toxicity compared to its precursor, Ce6, making it a promising photosensitizer for BR-positive-tumor-targeting photodynamic therapy.
Article
Chemistry, Physical
Asim Mushtaq, Han Zhang, Mingyue Cui, Xiaoqing Lin, Shuqi Huang, Zhe Tang, Yike Hou, M. Zubair Iqbal, Xiangdong Kong
Summary: In this study, ultrathin magnetic hydroxyapatite nanorods loaded with ROS-responsive chlorin e6 and silk fibroin were successfully synthesized for T1-magnetic resonance imaging and photodynamic therapy. These self-assembled nanoparticles showed excellent biocompatibility, cellular uptake, and ROS generation ability, making them a promising strategy for cancer diagnosis and treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Lin Yue, Zhouping Wang, Meihong Zheng, Min Wang, Imran Mahmood Khan, Xiaowei Ding, Yin Zhang
Summary: In this study, Hydroxypropyl chitosan was used as a carrier of the photosensitizer chlorin e6 to develop a photodynamic antibacterial agent with good water solubility, high biocompatibility, and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Ting-Ting Yu, Xue-Yu Sang, Ning Han, Xing-Chun Peng, Qi-Rui Li, Xiang Xu, Rong-Cheng Xiao, Hua-Zhen Xu, Xiao Chen, Mei-Fang Wang, Tong-Fei Li
Summary: Photodynamic therapy (PDT) using photosensitizer chlorin e6 (Ce6) to selectively target lung cancer cells has shown potential, and in this study, tumor associated macrophages (TAM) were utilized as carriers to deliver Ce6 and reprogrammed to the M1 phenotype through photodynamic action. The reprogrammed macrophages exhibited anti-lung cancer effects by inhibiting proliferation and promoting apoptosis of lung cancer cells, suggesting a novel approach for combining photodynamic therapy with anti-tumor immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Ekaterina Rychikhina, Svetlana S. Ivanova, Yulia V. Romanenko, Oskar I. Koifman, Pavel A. Stuzhin
Summary: In this study, complexes of chlorin e6 trimethyl ester and methylpyropheophorbide a with indium (III) were obtained and their photophysical properties were studied. It was found that insertion of the indium atom into the macrocyclic core decreased the fluorescence lifetimes and quantum yields, but facilitated the conversion to the triplet state. Therefore, these complexes can be considered as promising photosensitizers for photodynamic therapy.
Article
Engineering, Chemical
Zhenzhou Wang, Shan Hu, Fang Deng, Hongxin Shi, Xibao Li, Shuqu Zhang, Jianping Zou, Xubiao Luo
Summary: In this study, a BiPO4/CdS type-II heterojunction with oxygen vacancy was successfully fabricated. The BiPO4/Bi/CdS heterojunction exhibited stronger phosphorescence emission than BiPO4/Bi, indicating higher efficiency of intersystem crossing. The effective intersystem crossing promoted the activation of O2 to singlet oxygen (1O2), and the synergies between oxygen vacancy, surface plasmon resonance of Bi, and heterojunction construction enhanced charge carrier separation and 1O2 generation, leading to excellent photocatalytic activity.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Chemistry, Physical
Yunshan Fan, Yara Aceta, Esther Hessong, Athena Bengston, Laris A. Biageyian, Quan P. Huynh, Robert M. Corn
Summary: Diffraction patterns observed in SPRI microscopy measurements of single gold nanorods exhibit complex behavior near the longitudinal plasmonic resonance band, with a unitless ratio parameter M-R created to describe the diffraction pattern distribution. Results show that this behavior only occurs in the anomalous dispersion region, when the laser wavelength used is shorter than the AuNR plasmonic resonance maxima.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Ga-Hee Hur, A-Reum Ryu, Yong-Wan Kim, Mi-Young Lee
Summary: This study suggests that Ce6-PEG-Cur-mediated PDT can delay and improve skin photoaging, potentially serving as a more effective treatment.
Article
Chemistry, Multidisciplinary
Oleg A. Yeshchenko, Nataliya Kutsevol, Anastasiya Tomchuk, Pavlo S. Khort, Pavlo A. Virych, Vasyl A. Chumachenko, Yulia Kuziv, Andrey Marinin, Lili Cheng, Guochao Nie
Summary: The thermoresponsive ZnTPP/D-g-PNIPAM/AuNPs triple hybrid nanosystem was synthesized for thermally driven and controlled photodynamic therapy applications. The nanosystem demonstrated excellent stability and plasmonic enhancement of electronic processes in the photosensitizer molecules. In vitro experiments on Staphylococcus aureus proved the high potential of the nanosystem for rapid photodynamic inactivation of microorganisms in wounds or ulcers.