Article
Veterinary Sciences
Hironari Osada, Maiko Nagashima-Fukui, Taiga Okazawa, Miki Omura, Koichi Makimura, Keitaro Ohmori
Summary: This study reports a case of subcutaneous phaeohyphomycosis caused by E. dermatitidis in a cat. By performing pathological and molecular biological analyses on the case, it provides definitive evidence of subcutaneous phaeohyphomycosis caused by E. dermatitidis in cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Dermatology
Xianzhong Zhu, Jianchi Ma, Bowen Zheng, Wenying Cai, Jiahao Li, Li Lin, Liyan Xi, Xiqing Li, Sha Lu
Summary: This article reports a case of cutaneous, subcutaneous, and disseminated phaeohyphomycosis caused by Exophiala spinifera in a Chinese male, who showed significant clinical improvement after receiving oral itraconazole and terbinafine treatment. A detailed review was conducted to evaluate the antifungal therapy for phaeohyphomycosis caused by E. spinifera.
Article
Chemistry, Medicinal
Ming-Jun Hong, Meng-Jiao Hao, Guang-Yu Zhang, Hou-Jin Li, Zong-Ze Shao, Xiu-Pian Liu, Wen-Zhe Ma, Jun Xu, Taifo Mahmud, Wen-Jian Lan
Summary: A new compound, exophilone, isolated from a deep-sea-derived fungus, showed potential in inhibiting collagen accumulation and exhibited low toxicity.
Review
Mycology
Chongyang Wu, Ling Shu, Zhixing Chen, Qianrong Hu, Lijun Tao, Chao He
Summary: In this report, we present a case of cutaneous phaeohyphomycosis caused by E. jeanselmei in a farmer. The patient had suffered from this disease three years ago but it had not been definitively diagnosed until he was admitted to our hospital. After histopathological examination and sequencing, the pathogen was identified as E. jeanselmei. The patient's condition improved after 4 weeks of antifungal treatment. We also reviewed 84 published cases to investigate the susceptibility of E. jeanselmei isolates to antifungal agents and compare the characteristics of infections in immunocompetent and immunocompromised patients.
Article
Chemistry, Applied
Alef dos Santos, Edson Rodrigues-Filho
Summary: Three pregnene steroids, including two newly discovered Delta(8,9)-pregnenes, were isolated from liquid cultivation of the extremophyle fungus Exophiala oligosperma in a pH 1.5 hydrochloric acid aqueous solution. Their molecular structures were determined using NMR and HRMS, marking the first description of these compounds in the literature.
NATURAL PRODUCT RESEARCH
(2021)
Article
Microbiology
Colin T. McDermott, Charles J. Innis, Akinyi C. Nyaoke, Kathryn A. Tuxbury, Julie M. Cavin, E. Scott Weber, Deana Edmunds, Stephane Lair, Jill Spangenberg, Amy L. Hancock-Ronemus, Catherine A. Hadfield, Leigh A. Clayton, Thomas B. Waltzek, Connie F. Canete-Gibas, Nathan P. Wiederhold, Salvatore Frasca
Summary: This study summarizes the clinical findings and diagnosis of Exophiala infections in aquarium-housed fish, providing insights for the management of these infections in public aquaria.
Article
Dermatology
Ricardo Guerra, Darren Guffey, Mark Russell
Summary: Deep cutaneous fungal infections (DCFI) can occur in cases of skin trauma and immunosuppression. Chromoblastomycosis is often characterized by pseudoepitheliomatous hyperplasia histologically, which can be mistaken for squamous cell carcinoma. Phaeohyphomycosis, on the other hand, exhibits circumscribed pseudocysts or abscesses on histopathology.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Review
Veterinary Sciences
Daniel Felipe Barrantes Murillo, Stephanie Anderson, Christian Capobianco, Gregory A. Lewbart, Nathan P. Wiederhold, Connie F. Canete-Gibas, Tatiane Terumi Negrao Watanabe
Summary: Phaeohyphomycosis is an infection caused by melanized fungi. This study presents a case of phaeohyphomycosis in an Eastern box turtle, providing important insights into the pathology and etiology of melanized fungal infections in animals.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Xiujiao Xia, Zehu Liu, Hong Shen
Summary: A woman with nephrotic syndrome developed purulent infiltrating plaques on her hands and arms, and was diagnosed with subcutaneous phaeohyphomycosis caused by Alternaria section Alternaria. Antifungal treatment led to complete resolution of the lesions after 2 months. The case report emphasizes the difficulty in distinguishing subcutaneous phaeohyphomycosis from chromoblastomycosis based solely on pathological findings and highlights the variation of parasitic forms of dematiaceous fungi in immunosuppressed hosts with different sites and environments.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Mohanad Aljundi, Sophie Brun, Mohammad Akhoundi, Morgane Didier, Roula Jabbour, Arezki Izri, Frederic Caux, Gerome Bohelay
Summary: We reported a case of subcutaneous phaeohyphomycosis caused by Medicopsis romeroi in a 56-year-old Malian woman residing in France for 20 years. The infection recurred after antifungal therapy discontinuation but was successfully treated with wide excision and prolonged antifungal treatment.
Article
Dermatology
Alice Cortes de Castro Lima, Daniel Wagner de C. L. Santos, Angela Satie Nishikaku, Milvia Maria Simoes E. Silva Enokihara, Marilia Marufuji Ogawa
Summary: Melanized fungi infections can pose challenges in kidney transplant recipients, with a lack of clear treatment guidelines, and management depends on factors such as dermatologic lesion, immunosuppression condition, and anatomical cleavage plane. The small sample size limits the ability to establish definitive recommendations for treatment.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Ana Taibo, Alejandro Seoane Estevez, Nieves Martinez Campayo, Maria Rodriguez Mayo, Maria del Pilar Arevalo Bermudez, Eduardo Fonseca
Summary: This retrospective study analyzed cases of subcutaneous mycoses caused by opportunistic filamentous fungi between 2017 and 2022. The most common fungi were Alternaria spp., followed by Scedosporium apiospermum and Fusarium solani. The main clinical presentation was suppurative nodules in lower limbs. Risk factors for infection included immunosuppressants, corticosteroids, previous trauma, and transplantation. Positive blood culture was significantly associated with mortality. It is crucial to raise awareness among physicians about the severity of these infections to ensure prompt and appropriate treatment.
Article
Dermatology
Hiromitsu Noguchi, Tadahiko Matsumoto, Utako Kimura, Masataro Hiruma, Rui Kano, Takashi Yaguchi, Masahide Kubo, Kayo Kashiwada-Nakamura, Satoshi Fukushima
Summary: This study reported two cases of phaeohyphomycosis caused by Exophiala jeanselmei and E. oligosperma. The patients were successfully treated with fosravuconazole and terbinafine, respectively. A summary of 32 cases of cutaneous and subcutaneous phaeohyphomycosis caused by Exophiala species in Japan was included, with different antifungal treatments and their success rates discussed.
JOURNAL OF DERMATOLOGY
(2022)
Article
Fisheries
Abigail R. Armwood, Connie F. Canete-Gibas, Jennifer A. Dill-Okubo, Nathan P. Wiederhold, Alvin C. Camus
Summary: A study on phaeohyphomycosis cases in a diverse range of aquarium-housed fish species found that the disease mostly affects bony fish, particularly marine species. The most common fungal genus identified was Exophiala, with two new species described for the first time in fish. Pathologically, lesions were most frequently observed in the skin/fin, skeletal muscle, and kidneys.
JOURNAL OF FISH DISEASES
(2021)
Article
Medicine, Research & Experimental
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S. P. Viall, Christa S. Zerbe, Elise M. N. Ferre, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis
Summary: The study explores the immune protection mechanisms against subcutaneous phaeohyphomycosis caused by viral particles. The researchers found that CLEC7A gene mutations are associated with susceptibility to the disease. Animal experiments further confirmed the importance of this gene in immune defense against phaeohyphomycosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
