Article
Environmental Sciences
Nima Shiry, Seyed Jalil Alavinia, Federica Impellitteri, Seyed Jamal Alavinia, Caterina Faggio
Summary: This research looked at the consequences of MTBE contamination on rainbow trout, focusing on oxidative stress, genotoxicity, and histopathological damage. The results showed that MTBE exposure caused significant alterations in rainbow trout, including increased oxidative stress, dose-dependent DNA damage, and abnormalities in liver and gill tissues. The study highlights the possible sub-lethal effects of MTBE contamination on rainbow trout and emphasizes the need to address this issue.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Islam El-Garawani, Heba Khodary Allam, Yasser A. Shehata, Khaldoun Fadel, Ahmed El Kattan
Summary: The study investigated the potential health hazards faced by Egyptian uranium miners, focusing on the biological effects of radiation exposure. Findings included an increase in dead cells, fragmented DNA, and levels of Granzyme B protein in the exposed groups compared to controls. These results highlight the importance of health education and effective hazard management for preserving the health of all mining industry employees.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Diane A. Mielewczyk, Chris N. Glover, Chantelle E. Klaczek, Greg G. Goss, Gavin N. Saari
Summary: Fish mortality is linked to harmful algal blooms, but the relationship between toxicity, cyanotoxins, and water chemistry remains unclear. This study examined the impact of waterborne microcystin-LR exposure on rainbow trout and found that it specifically affected calcium metabolism without general effects on ion regulation. The mechanism underlying this effect is still unknown.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Fisheries
Rebecca A. Dupre, Ryan Ardoin, Jesse Trushenski, Chris Jackson, Casey Grimm, Brennan Smith
Summary: The present research demonstrates that dietary exposure is an alternative route of geosmin uptake in Rainbow Trout fillets, leading to a significant increase in geosmin concentrations. This finding is important for further investigation of sensory quality and off-flavor mitigation strategies for farm-raised fish.
Article
Marine & Freshwater Biology
Aline Ferain, Eva Delbecque, Ineke Neefs, Helene Dailly, Nancy De Saeyer, Melusine Van Larebeke, Valerie Cornet, Yvan Larondelle, Jean-Francois Rees, Patrick Kestemont, Karel A. C. De Schamphelaere, Cathy Debier
Summary: The study found that both dietary lipids and Cd exposure influenced fatty acid metabolism in fish. The hepatic fatty acid profile mostly reflected that of the diet, with selective retention of certain long chain polyunsaturated fatty acids (LC-PUFAs) and active bioconversion of dietary LA and ALA.
AQUATIC TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
David Boyle, Nathaniel J. Clark, Benjamin P. Eynon, Richard D. Handy
Summary: The study evaluated the dietary bioaccumulation of copper from copper oxide nanomaterials and dissolved copper exposure in fish. Both forms of copper caused an increase in tissue copper concentrations and induced MT expression in the hind intestine, as well as affecting total GSH levels in the liver. Post-exposure, there was evidence of copper depuration from the mid and hind intestine, as well as the carcass, but not the brain or kidney.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Fisheries
Elisabeth Holen, Maren Hoff Austgulen, Marit Espe
Summary: The study showed that both LPS and RNA from baker's yeast have distinct but also common effects on gene transcription in this intestinal cell line.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Roghayeh Chekani, Reza Akrami, Zahra Ghiasvand, Hossein Chitsaz, Sara Jorjani
Summary: The study showed that dietary supplementation of 1.5% dehydrated lemon peel powder can reduce crowding stress and stimulate most of the antioxidant and immune characteristics of rainbow trout, without affecting the fish growth performance.
Article
Fisheries
Julia Mougin, Victor Lobanov, Morgane Danion, Roxane Roquigny, Lionel Goardon, Thierry Grard, Thierry Morin, Laurent Labbe, Alyssa Joyce
Summary: Misuse and overuse of antibiotics in aquaculture leads to bacterial resistance. Using immunostimulants in fish diets, specifically fungal and herbal compounds, is a sustainable alternative. This study evaluates the effects of fungal and herbal additives on rainbow trout, showing positive immune and gut microbiota responses without adverse effects on growth and survival. The findings contribute to the understanding and potential commercial use of immunostimulant compounds as feed supplements.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Diana Martin, Pedro Perdiguero, Esther Morel, Irene Soleto, J. German Herranz-Jusdado, Luis A. Ramon, Beatriz Abos, Tiehui Wang, Patricia Diaz-Rosales, Carolina Tafalla
Summary: CD38 has diverse expressions in different species, with high levels in mouse B cell subsets and transient expression on early lymphocyte precursors in humans while consistently expressed on terminally differentiated plasma cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Morteza Yousefi, Hamed Ghafarifarsani, Seyyed Morteza Hoseini, Seyed Hossein Hoseinifar, Behrooz Abtahi, Yury Anatolyevich Vatnikov, Evgeny Vladimirovich Kulikov, Hien Van Doan
Summary: The combination of thyme essential oil and Immunogen has positive effects on the growth performance, hematological parameters, immunity, and oxidative status of rainbow trout, enhancing their growth performance and immune capabilities.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biology
Naveed Akhtar, Muhammad Fiaz Khan, Sadia Tabassum, Eman Zahran
Summary: This study evaluated the adverse effects of atrazine on snow trout, showing significant changes in hematological, biochemical parameters, and genotoxicity. Exposure to atrazine resulted in alterations in blood parameters, as well as DNA damage, indicating potential toxicity in the tested fish species.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Yiwen Wu, Manman Zhao, Yuting Xia, Weiqing Sun, Guangquan Xiong, Liu Shi, Yu Qiao, Wenjing Wu, Anzi Ding, Lang Chen, Lan Wang, Sheng Chen
Summary: In order to study the deterioration of rainbow trout muscle quality caused by ammonia exposure, experiments with different concentrations of ammonia stress were conducted. The results showed that higher ammonia exposure led to increased bitterness and decreased umami and sweetness of the muscle, as well as decreased polyunsaturated fatty acids (PUFA) content. The expression of lipid metabolism-related genes was also affected, inhibiting lipid synthesis and promoting lipid oxidation. These findings are important for understanding the relationship between muscle quality, lipid metabolism, and environmental adaptability of rainbow trout (O. mykiss).
Article
Fisheries
Sajad Nazari, Mohammad Pourkazemi, Hamed Paknejad, Esmaeil Kazemi, Mostafa Ghaderi, Khalil Eslamloo
Summary: This study investigated the effects of different sources of zinc supplements on the transcriptome profiling of male rainbow trout broodstocks. The results revealed a strong inhibitory effect of mineral zinc supplement on the gene expression of O. mykiss.
Article
Fisheries
Rocio Simon, Patricia Martinez, Lucia Gonzalez, M. Camino Ordas, Carolina Tafalla
Summary: Mucosal surfaces are the main route for pathogens to enter the host. This study investigated the immune response of mucosal epithelial cells from the gastrointestinal tract and gills of rainbow trout to a viral mimic and two important viral pathogens. The results provide valuable information on the different responses of these cell lines to viral stimuli and their usefulness in studying mucosal responses in fish.
JOURNAL OF FISH DISEASES
(2023)
Article
Environmental Sciences
Raegyn B. Taylor, Bridgett N. Hill, Laura M. Langan, C. Kevin Chambliss, Bryan W. Brooks
Summary: The research indicates that prymnesins present in Prymnesium parvum blooms exposed to sunlight are the major cause of acute toxicity to fish, and these toxins are light-sensitive, which can reduce their toxicity to fish through light exposure treatment.
Article
Biology
Carmel E. Mothersill, Deborah H. Oughton, Paul N. Schofield, Michael Abend, Christelle Adam-Guillermin, Kentaro Ariyoshi, Nicholas A. Beresford, Andrea Bonisoli-Alquati, Jason Cohen, Yuri Dubrova, Stanislav A. Geras'kin, Tanya Helena Hevroy, Kathryn A. Higley, Nele Horemans, Awadhesh N. Jha, Lawrence A. Kapustka, Juliann G. Kiang, Balazs G. Madas, Gibin Powathil, Elena Sarapultseva, Colin B. Seymour, Nguyen T. K. Vo, Michael D. Wood
Summary: This paper presents the outcomes of discussions on the importance of an ecosystem approach in radioecology and radiation protection of the environment, which took place at an international conference. The interaction between radioecologists and radiobiologists is vital for addressing the challenges of field versus laboratory research and the integration of a pan-ecosystem approach into radiation protection guidelines. The application of novel tools such as machine learning can aid in the development of this ecosystem approach.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biology
Emily L. Vernon, Michael N. Moore, Tim P. Bean, Awadhesh N. Jha
Summary: This study evaluated the interactive effects of radionuclides and metals on freshwater and marine bivalve species. The results showed that copper had a slight additive effect on phosphorus-32-induced damage in certain species, cell types, and dose rates. Genetic and molecular biomarkers were generally unchanged in response to contaminant exposures.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Environmental Sciences
Nashami Alnajar, Awadhesh N. Jha, Andrew Turner
Summary: The results of the study suggest that tumble dryer lint may have adverse effects on marine mussels, including reduced clearance rate, tissue abnormalities, and DNA damage. These effects are likely due to both the fibrous material itself and chemicals released from the polymers.
Article
Environmental Sciences
Michael N. Moore, Susanna Sforzini, Aldo Viarengo, Audrey Barranger, Yann Aminot, James W. Readman, Andrei N. Khlobystov, Volker M. Arlt, Mohamed Banni, Awadhesh N. Jha
Summary: The hypothesis that C-60 fullerene nanoparticles exert an antagonistic interactive effect on the toxicity of benzo[a]pyrene was supported by this investigation. The combination treatment of C-60 and BaP was found to reduce cellular damage caused by BaP alone, and the scavenging property of C-60 against reactive oxygen species was identified as a key factor in reducing oxidative damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biotechnology & Applied Microbiology
Tirukalikundram S. Kumaravel, Tiruvathipuram N. Sathya, Ramalingam Balaje, Pitchaipillai Pradeepa, Desikan Yogaraj, Malliga R. Murali, K. R. Navaneethakrishnan, Sivasubramanian Murugan, Awadhesh N. Jha
Summary: This review critically evaluates the current understanding and assessment of genotoxicity in medical devices. It highlights the existing methods and standards, as well as the potential uses of recent advances in achieving robust genotoxicity assessment. However, it also points out the gaps in genotoxicity risk assessment and suggests possible approaches to address them.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Article
Environmental Sciences
Megan O'Brien, Zachary C. Rundell, Michelle D. Nemec, Laura M. Langan, Jeffrey A. Back, Joaquin N. Lugo
Summary: For smaller population densities, the most effective kits are pellet based and include steps such as homogenization, inhibitor removal, and RNA preservation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Emily L. Vernon, Awadhesh N. Jha, Maria F. Ferreira, Danielle L. Slomberg, Veronique Malard, Christian Grisolia, Mickael Payet, Andrew Turner
Summary: This study investigates the tissue-specific bioaccumulation, release, and genotoxic response of tritiated stainless steel particles in marine mussels. The study finds that the particles rapidly accumulate in the mussel tissues, especially in the digestive gland, but are readily rejected and expelled over longer periods of time. The absence of genotoxicity suggests that the rapid processing of the particles and limited dissolution of steel components prevent chemical toxicity effects.
Review
Environmental Sciences
Maria Florencia Ferreira, Andrew Turner, Emily L. Vernon, Christian Grisolia, Laurence Lebaron-Jacobs, Veronique Malard, Awadhesh N. Jha
Summary: This review examines the sources and characteristics of tritium in the environment, as well as its biological effects on non-human biota. Despite an increasing number of publications, the available data is heavily biased towards certain taxonomic groups and species, with limited information on forms of tritium other than tritiated water. However, studies have reported various responses to tritiated water exposure, from molecular to behavioral, though the potential transgenerational effects remain unclear. The application of omics techniques and the development of adverse outcome pathways could help fill these knowledge gaps and improve environmental risk assessments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha
Summary: This study aims to establish in silico models capable of classifying structurally diverse biocidal chemicals into different toxicity categories and predict acute chemical toxicity (LC50) in marine crustaceans. These models showed the potential to replace animal testing for the chemical hazard assessment of untested biocides.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Infectious Diseases
Hanan A. Al-Sarawi, Nazima Habibi, Saif Uddin, Awadhesh N. Jha, Mohammed A. Al-Sarawi, Brett P. Lyons
Summary: In this study, the prevalence of antibiotic-resistance genes (ARGs) in Escherichia coli isolated from mollusks and coastal water samples in Kuwait's marine environment was investigated using a genome-based approach. The study also examined the plasmids and integron genes associated with the spread of ARGs. The findings revealed the presence of various genes conferring resistance to different classes of antibiotics, including those commonly found in E. coli plasmids. Additionally, a significant correlation was observed between integron genes and antibiotic resistance. These results are valuable for monitoring horizontal gene transfer of antibiotic resistance in Kuwait's marine environments.
Article
Environmental Sciences
Laura M. Langan, Megan O'Brien, Zach C. Rundell, Jeffrey A. Back, Benjamin J. Ryan, C. Kevin Chambliss, R. Sean Norman, Bryan W. Brooks
Summary: Wastewater-based epidemiology (WBE) is an early warning and trend analysis approach for determining the presence of COVID-19 in a community. This study evaluated different wastewater concentration methods, RNA extraction modifications, and nucleic acid extraction kits to find the most efficient and sensitive combination. The results showed that the composite supernatant-solid method with pre-RNA extraction consisting of water concentration and RNA/DNA shield performed the best. Additionally, the variability of results was highest with the Qiagen kit. The viral concentrations in wastewater were generally related to positive clinical cases, but the relationship depended on various factors such as method, modification, kit, target, and normalization.
Article
Medicine, Research & Experimental
Laura M. Langan, Bryan W. Brooks
Summary: Animal testing has been an important method for chemical safety assessments, but fish embryo assays offer an alternative. This study examines the effect of sample pool size on protein identification results in fish models and finds that there is no significant difference in protein expression among different pool sizes. The findings suggest that using pool sizes of less than 5 organisms per replicate can achieve comparable protein identifications.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2022)
Article
Engineering, Environmental
Jill S. McClary-Gutierrez, Zachary T. Aanderud, Mitham Al-faliti, Claire Duvallet, Raul Gonzalez, Joe Guzman, Rochelle H. Holm, Michael A. Jahne, Rose S. Kantor, Panagis Katsivelis, Katrin Gaardbo Kuhn, Laura M. Langan, Cresten Mansfeldt, Sandra L. McLellan, Lorelay M. Mendoza Grijalva, Kevin S. Murnane, Colleen C. Naughton, Aaron Packman, Sotirios Paraskevopoulos, Tyler S. Radniecki, Fernando A. Jr Jr Roman, Abhilasha Shrestha, Lauren B. Stadler, Joshua A. Steele, Brian M. Swalla, Peter Vikesland, Brian Wartell, Carol J. Wilusz, Judith Chui Ching Wong, Alexandria B. Boehm, Rolf U. Halden, Kyle Bibby, Jeseth Delgado Vela
Summary: Detection of SARS-CoV-2 RNA in wastewater is rapidly expanding globally as a public health monitoring tool. To ensure accurate interpretation and use of data, it is essential to include appropriate meta-information in collected and shared data. While common globally-adopted data standards have not been established within the research community, establishing such standards will require national and international consensus.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2021)
Article
Biology
Giorgio Baiocco, Isabelle George, Sebastien Garcia-Argote, Isabella Guardamagna, Leonardo Lonati, Yordenca Lamartiniere, Thierry Orsiere, Bernard Rousseau, Andrea Ottolenghi, Awadhesh Jha, Laurence Lebaron-Jacobs, Christian Grisolia, Veronique Malard
Summary: Tritium has raised global concerns due to its production and use in various nuclear technologies, which could lead to environmental release. Studying the effects of low-dose tritium exposure on human health presents challenges, but using three-dimensional models of the human airway epithelium can provide valuable insights into its potential toxicity.
RADIATION RESEARCH
(2021)