Article
Geriatrics & Gerontology
Wenhua Sun, Jinhua Zheng, Jianjun Ma, Zhidong Wang, Xiaoxue Shi, Mingjian Li, Shen Huang, Shiyu Hu, Zhenxiang Zhao, Dongsheng Li
Summary: Plasma HO-1 levels may serve as a promising biomarker for early PD, and a high concentration of the HO-1 protein is associated with a reduction in the right hippocampal volume.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cristina Fernandez-Mendivil, Enrique Luengo, Paula Trigo-Alonso, Nuria Garcia-Magro, Pilar Negredo, Manuela G. Lopez
Summary: The study revealed that overexpression of HO-1 in microglial cells in aged mice leads to neurotoxic iron accumulation, oxidative stress, and cognitive decline. Inhibiting HO-1 or using an iron chelator can prevent these issues, providing new insights for treating age-related neurodegenerative diseases.
Article
Clinical Neurology
Yanyan Jiang, Jing Chen, Yunchuang Sun, Fan Li, Luhua Wei, Wei Sun, Jianwen Deng, Yun Yuan, Zhaoxia Wang
Summary: The combination of salivary miR-29a-3p and miR-29c-3p shows potential as a diagnostic biomarker for idiopathic PD. The expression level of miR-29a-3p in PD patients was significantly lower than ET patients, but higher than MSA patients.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yi-Hsuan Wu, Hsi-Lung Hsieh
Summary: The heme oxygenase system, particularly HO-1 and HO-2, plays an important role in the nervous system. Dysregulation of HO-1 is associated with neurodegenerative diseases.
Article
Medicine, General & Internal
Jia-Ning Jin, Xian Liu, Ming-Juan Li, Xin-Ling Bai, An-Mu Xie
Summary: This meta-analysis study suggests that PD patients have higher levels of total bilirubin and direct bilirubin, with no significant relationship found between indirect bilirubin and PD. Subgroup analysis based on ethnicity indicates that Caucasians with PD have higher serum total bilirubin levels. These findings suggest that bilirubin may play a role in the pathogenesis of PD and could potentially be used as a biochemical marker for diagnosis and treatment.
CHINESE MEDICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Review
Medicine, General & Internal
Yu Hara, Kentaro Nakashima, Ryo Nagasawa, Kota Murohashi, Yoichi Tagami, Ayako Aoki, Koji Okudela, Takeshi Kaneko
Summary: The clinical course and rate of progression of interstitial lung disease (ILD) vary greatly among patients. In the future, heme oxygenase-1 (HO-1) may become a candidate ILD biomarker, as recent research suggests that HO-1 levels in lung tissues of ILD patients can reflect anti-inflammatory M2 macrophage activation. Measurements of HO-1 levels in peripheral blood could be useful for evaluating lung damage severity and predicting fibrosis formation in ILD.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Article
Hematology
Louise L. Dunn, Stephanie M. Y. Kong, Sergey Tumanov, Weiyu Chen, James Cantley, Anita Ayer, Ghassan J. Maghzal, Robyn G. Midwinter, Kim H. Chan, Martin K. C. Ng, Roland Stocker
Summary: The stress-induced enzyme Hmox1 plays a protective role against cardiovascular diseases and ischemic injury by interacting with HIF-1 alpha and regulating cellular metabolism. Lack of Hmox1 leads to impaired blood flow recovery, tissue necrosis, and autoamputation, highlighting its crucial role in ischemic injury protection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Review
Biochemistry & Molecular Biology
Juan A. Parga, Ana I. Rodriguez-Perez, Maria Garcia-Garrote, Jannette Rodriguez-Pallares, Jose L. Labandeira-Garcia
Summary: Reactive oxygen species (ROS) can regulate cellular metabolism and homeostasis, but excessive production leads to oxidative stress, a key mechanism in the progression of neurodegenerative diseases such as Parkinson's. NRF2 is a transcription factor that regulates the cellular response to oxidative stress. Modulating the NRF2 signaling pathway shows promise in controlling the neurodegenerative process associated with Parkinson's disease.
Article
Immunology
Marie-Amandine Bonte, Fatima El Idrissi, Bernard Gressier, David Devos, Karim Belarbi
Summary: Parkinson's disease is a progressive neurodegenerative disease associated with neuroinflammation and a loss of dopaminergic neurons. The protein network involved in Parkinson's disease neuroinflammation includes various biological processes, with Toll-like Receptor Cascades and Interleukin 4, 10, and 13 signaling pathways being the most significantly enriched. Through network analysis, 8 key proteins with the highest ability to control the underlying biological processes of neuroinflammation were identified as potential drug targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marisa Cressatti, Julia M. Galindez, Lamin Juwara, Natalie Orlovetskie, Ana M. Velly, Shaun Eintracht, Adrienne Liberman, Mervyn Gornitsky, Hyman M. Schipper
Summary: The study found that EVs in human biofluids mainly contain HO-1 protein, with the majority of HO-1 protein localized in the extracellular vesicles. These findings suggest that a significant proportion of EV HO-1 in peripheral human biofluids is derived from the central nervous system and may contribute to the systemic manifestations of various neurological conditions.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Michele Muller-Bolla, Elody Aiem, Cyril Coulot, Ana Miriam Velly, Sophie Domejean
Summary: The survey showed that dentists treating children in France tend to overtreat in terms of caries management in primary and permanent molars, especially with inappropriate invasive strategies being more commonly chosen for occlusal lesions in permanent molars.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2021)
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Karen Santos Ferreira, Harjot Dhillon, Ana Miriam Velly
Summary: The article discusses potential biomarkers for migraine found in cerebrospinal fluid, blood, and saliva, with a focus on biomarkers related to treatment and clinical outcomes. The authors highlight the importance of identifying reliable biomarkers to improve early disease stage treatment with specific medications. Key biomarkers include CGRP, glutamate, nerve growth factor, inflammatory markers, and oxidative stress markers. New genetic and epigenetic biomarkers are emerging candidates for future research.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Qiman Gao, Geoffroy Noel, Zovinar Der Khatchadourian, Doaa Taqi, Mohammad Abusamak, Anna Henley, Karim Menassa, Ana Velly, Elham Emami, Luc Mongeau, Faleh Tamimi
Summary: This study aimed to develop and evaluate the clinical safety and feasibility of an optimal NFLJI technique for dental anesthesia. Results showed that perpendicular NFLJIs induced more regurgitation and complications, while oblique NFLJIs had lower risks. Oblique NFLJIs could be a promising approach for dental infiltration anesthesia.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, General & Internal
Golnaz Barjandi, Eva Kosek, Britt Hedenberg-Magnusson, Ana Miriam Velly, Malin Ernberg
Summary: The study found that patients with MFP and FM were more similar in comorbidity, and should be differentiated from MYA in clinical settings and pain management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Qiman Gao, Anna Henley, Geoffroy Noel, Zovinar Der Khatchadourian, Doaa Taqi, Mohammad Abusamak, Zixin He, Swen Groen, Rani Taher, Karim Menassa, Ana Velly, Elham Emami, Luc Mongeau, Faleh Tamimi
Summary: The study showed that adjusting the supply pressure of NFLJI can achieve effective Mental Incisive Nerve Blocks with minimal complications and improved success rates. High-pressure NFLJI poses higher risks of discomfort and paresthesia, while low-pressure NFLJI is less likely to cause complications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ana Miriam Velly, Jack Botros, Michele Muller Bolla, Khurram Khan, Oscar Anacleto Teixeira Junior, Antonio Sergio Guimaraes, Mervyn Gornitsky
Summary: The study found that both short- and long-term painful TMD in adolescents are associated with a variety of comorbidities, particularly frequent headaches and back pain. Frequent neck pain and allergies were only associated with short-term TMD, while frequent stomach pain was related to long-term painful TMD.
JOURNAL OF ORAL REHABILITATION
(2022)
Review
Dentistry, Oral Surgery & Medicine
Omar Sabsoob, Sherif M. Elsaraj, Mervyn Gornitsky, Elise Laszlo, James R. Fricton, Eric L. Schiffman, Ana M. Velly
Summary: This study found that psychological factors were more common in chronic TMD pain patients compared to acute patients, but these factors did not increase the transition risk in the multivariable model. Myofascial pain and baseline pain intensity were associated with the transition from acute to chronic TMD pain.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ana Miriam Velly, Gary C. Anderson, John O. Look, Joseph L. Riley, D. Bradley Rindal, Kimberly Johnson, Qi Wang, James Fricton, Kevin Huff, Richard Ohrbach, Gregg H. Gilbert, Eric Schiffman
Summary: This study describes a large prospective cohort study on the management of painful TMDs, including the characteristics of practitioners and patients, as well as initial treatment recommendations. The results show that the practitioners and patients involved in the study have characteristics similar to those of US patients with painful TMDs. Network practitioners typically use conservative treatments to manage TMDs.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Michele Muller-Bolla, Clara Joseph, Nicola Innes, Elody Aiem, Serena Lopez, Lamin Juwara, Ana Miriam Velly
Summary: The objective of this study was to assess the effectiveness of an online case-based learning intervention in training students and paediatric dentistry teachers in radiographic diagnostic accuracy of pulpo-periodontal complications in primary molars. The results showed that all participants' diagnostic accuracy improved over time after receiving feedback. There were similar improvements across sessions between teachers and students, except in session 3.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Letter
Anesthesiology
Karen dos Santos Ferreira, Ana Miriam Velly
Meeting Abstract
Clinical Neurology
Karen Ferreira, Ana Velly
Article
Clinical Neurology
Jack Botros, Mervyn Gornitsky, Firoozeh Samim, Zovinar der Khatchadourian, Ana Miriam Velly
Summary: This study compares the likelihood of back and neck pain between acute and chronic pain-related TMD patients. The results show that compared to acute TMD, chronic TMD patients are twice as likely to report neck pain, but not back pain. Chronic disability is also associated with an increased likelihood of neck pain, but not back pain.
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)
Article
Clinical Neurology
Julia M. Galindez, Lamin Juwara, Marisa Cressatti, Mervyn Gornitsky, Ana M. Velly, Hyman M. Schipper
Summary: The study examined HO-1 protein levels in PD saliva and found elevated concentrations compared to control groups. HO-1 levels in combination with covariates may provide a biomarker signature for distinguishing neurodegenerative conditions, with high accuracy in distinguishing PD and other conditions from controls.
JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE
(2021)