Is there a role for MR-guided focused ultrasound in Parkinson's disease?

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

(2018) Robert F. Dallapiazza et al.   JOURNAL OF NEUROSURGERY

Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study

(2018) Raul Martínez-Fernández et al.   LANCET NEUROLOGY

Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume

(2017) Meaghan A. O'Reilly et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Current applications and limitations of surgical treatments for movement disorders

(2017) Paul Krack et al.   MOVEMENT DISORDERS

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model

(2017) Brian P. Mead et al.   NANO LETTERS

MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes

(2017) Alfonso Fasano et al.   NEUROLOGY

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

(2017) Charissa Poon et al.   NEUROPHARMACOLOGY

Comparative Evaluation of Magnetic Resonance-Guided Focused Ultrasound Surgery for Essential Tremor

(2017) Minsoo Kim et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease

(2017) Aaron E. Bond et al.   JAMA Neurology

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

(2016) Chung-Yin Lin et al.   JOURNAL OF CONTROLLED RELEASE

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound

(2016) Brian P. Mead et al.   JOURNAL OF CONTROLLED RELEASE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

(2016) Kullervo Hynynen et al.   PHYSICS IN MEDICINE AND BIOLOGY

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

(2016) Alexandre Carpentier et al.   Science Translational Medicine

Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor

(2016) Hong Chen et al.   Scientific Reports

Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

(2016) Ching-Hsiang Fan et al.   Scientific Reports

Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial

(2015) C. Warren Olanow et al.   ANNALS OF NEUROLOGY

Current disease modifying approaches to treat Parkinson’s disease

(2015) Dan Lindholm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

Enhanced Delivery and Bioactivity of the Neurturin Neurotrophic Factor through Focused Ultrasound—Mediated Blood—Brain Barrier Opening in vivo

(2015) Gesthimani Samiotaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies

(2015) R.T. Bartus et al.   NEUROBIOLOGY OF DISEASE

Unilateral magnetic resonance–guided focused ultrasound pallidotomy for Parkinson disease

(2015) Young Cheol Na et al.   NEUROLOGY

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment

(2015) Analiz Rodriguez et al.   Pharmaceutics

Osmotic nephrosis with mannitol: review article

(2014) Ali Zohair Nomani et al.   RENAL FAILURE

Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients

(2013) R. T. Bartus et al.   NEUROLOGY

Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

(2013) Po-Hung Hsu et al.   PLoS One

Therapies in Parkinsonʼs disease

(2012) Joseph Jankovic et al.   CURRENT OPINION IN NEUROLOGY

Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles

(2012) Babak Baseri et al.   PHYSICS IN MEDICINE AND BIOLOGY

A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys

(2012) Sachiko Ohshima-Hosoyama et al.   PLoS One

Targeted Delivery of GDNF through the Blood–Brain Barrier by MRI-Guided Focused Ultrasound

(2012) Feng Wang et al.   PLoS One

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier

(2011) Alison Burgess et al.   PLoS One

Influence of Exposure Time and Pressure Amplitude on Blood−Brain-Barrier Opening Using Transcranial Ultrasound Exposures

(2010) Rajiv Chopra et al.   ACS Chemical Neuroscience

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor

(2009) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease

(2009) Jens Volkmann et al.   MOVEMENT DISORDERS

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY