Article
Biochemistry & Molecular Biology
Jingjing Ma, Chunhua Lu, Yajie Tang, Yuemao Shen
Summary: An endophytic fungus, Aspergillus sp., isolated from Crassula arborescens, exhibited potent inhibitory activity on the seed germination of Arabidopsis thaliana. Bioactivity-guided fractionation led to the identification of nine compounds, including a newly discovered furanone named aspertamarinoic acid. Compounds 1 and 5 showed significant inhibitory activity on the seed germination of A. thaliana, which is reported for the first time.
Article
Microbiology
Gustavo A. Diaz-Cruz, Jingyu Liu, Kapil Tahlan, Dawn R. D. Bignell
Summary: Streptomyces bacteria are important sources of microbial specialized metabolites with applications in medicine and agriculture. Some species are plant pathogens, causing diseases such as potato scab. The highly pathogenic strain Streptomyces sp. 11-1-2 produces nigericin and geldanamycin, which can cause damage to plant tissues.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
Cyril Balsollier, Roland J. Pieters, Marko Anderluh
Summary: O-GlcNAcylation is a critical posttranslational modification process that has sparked interest in the medical community. While OGA inhibitors are in clinical trials, finding potent OGT inhibitors remains challenging due to complex expression and instability.
Article
Environmental Sciences
Da-Eun Kim, Sung-Chul Hong, Yoonyong Yang, Jaeyoung Choi, Jin-Soo Park
Summary: Streptomyces is a bacterium known for producing pharmaceutically important small molecules. In this study, a marine-derived Streptomyces strain was discovered and its genome analysis suggested its potential for producing novel compounds. Chemical analysis identified several amino acid derivatives and siderophores from the strain.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Physics, Multidisciplinary
H. Keppler, T. Krajewski, T. Muller, A. Tanasa
Summary: In this paper, the results of duality between orthogonal and symplectic random tensor models are generalized to tensor models with non-trivial symmetry under the permutation of the indices.
JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL
(2023)
Article
Biochemistry & Molecular Biology
Sergey Girel, Vadim Schuetz, Laurent Bigler, Peter Doermann, Margot Schulz
Summary: Incubation of microorganisms and plants with 2-acetamido-phenol, a degradation product of 2-benzoxazolinone, resulted in the formation of new compounds and altered gene expression in Arabidopsis thaliana.
Article
Chemistry, Inorganic & Nuclear
Jhonatan R. Guarin, Carlos Frontera, Judith Oro-Sole, Jaume Gazquez, Clemens Ritter, Josep Fontcuberta, Amparo Fuertes
Summary: Europium tantalum perovskite oxynitrides were successfully prepared by a new high-temperature solid-state synthesis method. The crystal structure and magnetic properties of the materials can be tuned by different reactant mixtures and gas atmospheres. Among them, Eu3Ta3O3.66N5.34 is the first example of a triple perovskite oxynitride.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Sharpkate Shaker, Run-Zhu Fan, Hou-Jin Li, Wen-Jian Lan
Summary: Preliminary research on marine fungus Fusarium sp. XBB-9 led to the discovery of a pair of novel bisindole alkaloid enantiomers and 12 diverse compounds. The OSMAC method was used to enhance biosynthetic pathways, with the structures of the compounds elucidated through spectroscopic analysis and X-ray single-crystal diffraction. However, cytotoxicity tests on the compounds showed that they were inactive against HCT-15 and RKO cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ilhan Tomris, Luca Unione, Linh Nguyen, Pouya Zaree, Kim M. Bouwman, Lin Liu, Zeshi Li, Jelle A. Fok, Maria Rios Carrasco, Roosmarijn van der Woude, Anne L. M. Kimpel, Mirte W. Linthorst, Sinan E. Kilavuzoglu, Enrico C. J. M. Verpalen, Tom G. Caniels, Rogier W. Sanders, Balthasar A. . Heesters, Roland J. Pieters, Jesu's Jimenez-Barbero, John S. Klassen, Geert-Jan Boons, Robert P. de Vries
Summary: SARS-CoV-2 viruses use ACE2 as a functional receptor through their spike protein. The NTD of SARS-CoV-2 beta variant strain is capable of binding to Vero E6 cells and has a specific preference for 9-O-acetylated structures, suggesting a potential dual-receptor functionality of the S1 domain.
ACS CHEMICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Muecahit Varli, Eun-Young Lee, Yi Yang, Rui Zhou, Isa Tas, Sultan Pulat, Chathurika D. B. Gamage, So-Yeon Park, Jae-Seoun Hur, Sang-Jip Nam, Hangun Kim
Summary: A study found that an extract from the endolichenic fungus Jackrogersella sp. EL001672, derived from the lichen Cetraria sp., as well as the isolated compound 1'-O-methyl-averantin, can inhibit the development of colorectal cancer stem cells by regulating sonic Hedgehog and Notch signaling pathways.
SCIENTIFIC REPORTS
(2023)
Article
Zoology
Bindarika Mukherjee, Niladri Hazra
Summary: This article reports the first records of three genera from the Harnischia complex in India and describes two new species. Molecular barcodes and revised world keys to adult males are provided.
Article
Biochemistry & Molecular Biology
Jack Cheeseman, Concepcion Badia, Rebecca Thomson, Gunter Kuhnle, Richard A. Gardner, Daniel I. R. Spencer, Helen M. Osborn
Summary: N-Acetylneuraminic acid is a crucial nine-carbon monosaccharide that plays vital roles in various biological functions. Recent research has identified acetylated sialic acid derivatives as potential biomarkers for specific cancers. This study successfully synthesized and analyzed these derivatives using quantitative NMR spectroscopy.
Article
Astronomy & Astrophysics
U. Jacovella, Jack T. Buntine, Mariah Cotter, Giel Muller, Michael S. Scholz, Emmanuel Dartois
Summary: This study assesses the potential of oxygenated carbon chain ions as explanations for diffuse interstellar bands using density-functional theory and coupled cluster single-double and perturbative triple theory. The results show that the linear structures of these ions are the most stable and their optical absorptions mainly occur in the visible or near-infrared spectral regions. However, based on the known data, the growth rate of O-bearing carbon chains via ion-neutral reaction mechanisms is too low to account for the diffuse interstellar bands.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Mathematics
Bin Xu
Summary: The developed procedure allows for studying the combinatorial structure of Arthur packets for p-adic quasisplit Sp(N) and O(N) following Mceglin's works, and can provide answers to questions such as the size of the packets.
JOURNAL OF THE INSTITUTE OF MATHEMATICS OF JUSSIEU
(2021)
Article
Zoology
Uzma Ishaq, Shahnaz Dawar, Nasira Kazi, Erum Iqbal, Saboohi Raza
Summary: A new species of Oionchus, Oionchus sindhicus n. sp., is described from soil samples collected around the roots of cotton plants in Umerkot, Sindh, Pakistan. Morphological and morphometric data of two other Oionchus species from Pakistan, O. paraobtusus Jairajpuri and Khan, 1982 and O. obtusus Cobb, 1913, are also provided.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
Article
Chemistry, Physical
Srichandan Padhi, Marco Masi, Yugal Kishore Mohanta, Muthupandian Saravanan, Swati Sharma, Alessio Cimmino, Dhivya Shanmugarajan, Antonio Evidente, Kumananda Tayung, Amit Kumar Rai
Summary: Seventy-three anticancer metabolites from different endolichenic fungi previously reported were analyzed for drug likeliness and pharmacokinetic properties. Three compounds, including talaromycin A, pyridoxatin, and terricollene A, showed strong binding affinity and stability, potentially serving as glycolytic inhibitors. These findings contribute to the development of potential glycolytic inhibitors for treating and controlling various forms of cancer, but further experimental investigations are needed to evaluate the efficacy of these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Daniel Pecorari, Emanuele Giuliani, Andrea Mazzanti, Stefano Stagni, Valentina Fiorini, Giulia Vigarani, Francesco Zinna, Gennaro Pescitelli, Michele Mancinelli
Summary: Bis-aryl carbazole borane derivatives with emissive properties and axial chirality were synthesized. The resolution of a thermally stable atropisomeric pair (compound 1b), which has a B-C chiral axis, was achieved using chiral stationary-phase high-performance liquid chromatography (CSP-HPLC). The complete photophysical properties of all compounds were measured and simulated using time-dependent density functional theory (TD-DFT) calculations, and circularly polarized luminescence spectra were obtained for the atropisomers of compound 1b, with their absolute configuration determined by a TD-DFT simulation of the electronic circular dichroism (ECD) spectra.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Antonio Moreno-Robles, Antonio Cala Peralta, Jesus G. Zorrilla, Gabriele Soriano, Marco Masi, Susana Vilarino-Rodriguez, Alessio Cimmino, Monica Fernandez-Aparicio
Summary: This study investigates the inhibitory effects of trans-cinnamic acid and its derivatives on the growth of Cuscuta campestris, a parasitic weed causing significant yield losses in crops. The findings reveal that some derivatives of trans-cinnamic acid exhibit enhanced growth inhibition activity against C. campestris seedlings, with the methyl ester derivative being the most active compound. This structure-activity relationship study provides valuable information for the design of herbicidal treatments targeting parasitic weeds.
Article
Chemistry, Multidisciplinary
Krzysztof Nowak, Olaf Morawski, Francesco Zinna, Gennaro Pescitelli, Lorenzo Di Bari, Marcin Gorecki, Marek Grzybowski
Summary: Chiral fluorescent macrocycles, consisting of dimethyl 2,5-diaminoterephthalate units, can be easily synthesized from inexpensive building blocks. Depending on the concentration, the reaction mainly produces a paracyclophane-like dimer or a triangular trimer. These macrocycles exhibit fluorescence in solution and the solid state, with red-shifted maxima as the size of the macrocyclic ring decreases. Chirality affects their absorption and emission of circularly polarized light.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Editorial Material
Chemistry, Multidisciplinary
Gianluigi Albano, Francesco Zinna, Andrea Taddeucci, Maria Annunziata M. Capozzi, Gennaro Pescitelli, Angela Punzi, Lorenzo Di Bari, Gianluca M. Farinola
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Shurooq Ismail, Rosa Gaglione, Marco Masi, Srichandan Padhi, Amit K. Rai, Ghadeer Omar, Alessio Cimmino, Angela Arciello
Summary: This study purified extracts from Ephedra foeminea and identified bioactive compounds with antimicrobial and antibiofilm properties. The compound kaempferol-3-O-alpha-L-(2 '',4 ''-di-E-p-coumaroyl)-rhamnopyranoside exhibited strong antibacterial and antibiofilm activity against S. aureus strains. Molecular docking studies suggested its potential applicability in biomedical and biotechnological fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Yi-Jie Zhai, Zhen-Zhen Zhou, Lin-Lin Gao, Jian-Nan Li, Gennaro Pescitelli, Jin-Ming Gao, Wen-Bo Han
Summary: Six new dimeric spiciferones (1-6) and four known metabolites (7-10) were produced by the lichen-associated fungus Phaeosphaeria sp. The new structures were determined through spectroscopic analysis, and their absolute configurations were established using electronic circular dichroism calculations. Compounds 1 and 3-6 represent the first instances of ethylidene-bridged dimers from the building blocks 4H-chromene-4,7(8H)-dione and alpha-pyrone, and compound 2 is a unique homodimer of spiciferone. Compounds 1, 2, and 5-9 exhibited significant growth inhibition on the dicot weed-like plant Arabidopsis thaliana at a concentration of 100.0 μM. Notably, compound 8 showed the strongest inhibitory activity against the fresh weight and root elongation of A. thaliana, with IC50 values of 32.04 and 26.78 μM, respectively, while compounds 1, 8, and 9 promoted the growth of A. thaliana at lower concentrations. Additionally, compounds 2 and 6 exhibited weak inhibition on the root elongation of the monocot rice, while compounds 1 and 8 exhibited dose-dependent growth-promoting effects on the shoot and root elongation of rice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Microbiology
Antonio Evidente
Summary: Weeds, including parasite plants, have become a serious problem for farmers, causing significant losses in agricultural and herding production and hindering reforestation practices and important infrastructure. To combat these pests, synthetic herbicides have been widely used, leading to environmental pollution and risks to human and animal health. This review explores the potential of fungal phytotoxins as bioherbicides, as well as the commercial availability and future perspectives of bioherbicides based on microbial toxic metabolites.
Article
Microbiology
Jesus G. Zorrilla, Marco Masi, Suzette Clement, Alessio Cimmino, Susan Meyer
Summary: (10S,11S)-(-)-epi-pyriculol is a phytotoxic metabolite produced by Pyricularia grisea, a fungus that infects the invasive weed species buffelgrass. This study developed a high-pressure liquid chromatography (HPLC) method for quantifying (10S,11S)-(-)-epi-pyriculol in complex mixtures. The results showed that the production of (10S,11S)-(-)-epi-pyriculol varied among different P. grisea isolates and was strongly correlated with phytotoxic activity. The HPLC method could be used for selecting the best strain and cultural conditions for mass production of (10S,11S)-(-)-epi-pyriculol, thus providing a new bioherbicide for the control of buffelgrass.
Article
Microbiology
Stefany Castaldi, Jesus G. Zorrilla, Claudia Petrillo, Maria Teresa Russo, Patrizia Ambrosino, Marco Masi, Alessio Cimmino, Rachele Isticato
Summary: Alternaria alternata is a devastating phytopathogenic fungus that causes black spots in many fruits and vegetables. In this study, the pathogenicity mechanisms and competitive exclusion of A. alternata were investigated, with a focus on its interaction with Botrytis cinerea. The fungus was found to produce strong enzymatic activities and four different toxins, which showed varying levels of necrotic activity on different hosts. Interestingly, A. alternata exhibited competitive exclusion of B. cinerea in host and non-host pear fruits, inhibiting its growth by 70% and 65%, respectively. The toxins Alteichin and alternariol 4-methyl ether showed the strongest inhibition activity against B. cinerea.
Review
Chemistry, Multidisciplinary
Gianluigi Albano, Andrea Taddeucci, Gennaro Pescitelli, Lorenzo Di Bari
Summary: This review provides an overview of electronic circular dichroism imaging (ECDi), circularly polarized luminescence imaging (CPLi), and vibrational circular dichroism imaging (VCDi) and their applications in thin films, with a focus on chiral organic dye case studies. These instrumental techniques are valuable for mapping and understanding the supramolecular structures in thin films of chiral organic materials.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Ciro A. Guido, Francesco Zinna, Gennaro Pescitelli
Summary: Any device based on materials exhibiting circularly polarized luminescence (CPL) requires a high degree of circular polarization, quantified through the dissymmetry factor g(lum) and related quantities such as the CPL brightness. However, maximizing |g(lum)| is not an easy task. Computational tools able to predict dissymmetry values in an accurate way are therefore of utmost importance. Our study tests the predictive power of time-dependent density functional theory (TD-DFT) combined with solvation effects in determining large g(abs) and g(lum) values for specific helicene-based materials.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Gianluigi Albano, Francesco Zinna, Andrea Taddeucci, Maria Annunziata M. Capozzi, Gennaro Pescitelli, Angela Punzi, Lorenzo Di Bari, Gianluca M. Farinola
Summary: We have investigated the effect of achiral substituents on the chiral supramolecular architectures of diketopyrrolo[3,4-c]pyrrole-1,2,3-1H-triazole (DPP) dyes. By decorating the same chiral DPP motif with different substituent groups, we observed significant differences in optical, chiroptical, electrochemical and thermal properties among the three dyes. Our findings provide valuable insights for the development of chiral organic opto-electronics and other innovative technological applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Alessio Gabbani, Andrea Taddeucci, Marco Bertuolo, Francesco Pineider, Laura Antonella Aronica, Lorenzo Di Bari, Gennaro Pescitelli, Francesco Zinna
Summary: Magnetic circular dichroism can elucidate the molecular interactions and structural parameters of organic chiral materials, making it a valuable tool for studying supramolecular order and structure-property relationships.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)