Article
Biochemistry & Molecular Biology
Kundan Tayade, Gyu-Seong Yeom, Suban K. Sahoo, Horst Puschmann, Satish Balasaheb Nimse, Anil Kuwar
Summary: This study synthesized Schiff base compound 2 and determined its crystal structure and molecular structure. The antioxidant activity of this compound was confirmed through calculations and experiments. The compound exhibited excellent antioxidant activity and low cytotoxicity.
Article
Biochemistry & Molecular Biology
Wei Wei, Houfan Wu, Yuning Chen, Kunyu Zhong, Li Feng
Summary: A new chitosan 2,4-dihydroxyacetophenone Schiff base @SrFe12O19 (Cs-SB@SrFe12O19) nanocomposite was successfully synthesized and characterized for its properties. It exhibited high magnetization and coercivity, making it a potential hard magnetic material. The nanocomposite was also demonstrated to be an effective sorbent for the removal of Pb(II) ions from aqueous solution. The adsorption process followed pseudo second order kinetics and showed excellent recyclable efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Quang Trung Nguyen, Phuong Nam Pham Thi, Nguyen Tuyen
Summary: Six Fe(III) complexes with unsymmetrical salen-type ligands were synthesized and showed high cytotoxicity and selectivity on human cancer cells. The presence of different substituted groups in the salicyl ring affected the cytotoxicity of the complexes.
JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
P. Manimaran, S. Balasubramaniyan, Mohammad Azam, D. Rajadurai, Saud I. Al-Resayes, G. Mathubala, A. Manikandan, S. Muthupandi, Zishan Tabassum, Imran Khan
Summary: The metal complexes of dinitrophenylhydrazine and thiocyanate ions were synthesized and characterized through various analyses, showing high antimicrobial and antioxidant activities compared to the ligand. The experiments demonstrated the biomedical potential of these metal complexes in fighting bacterial infections and oxidative stress.
Article
Chemistry, Multidisciplinary
Fatemeh Mosalanezhad, Azizeh Asadzadeh, Ali Ghanbariasad, Mahboubeh Naderpour, Razieh Bordbar, Mehdi Ghavamizadeh, Samaneh Zolghadri
Summary: In this study, a series of alpha,alpha-Me-2-salen Schiff base derivatives were investigated for their anti-HDAC, anticancer, antibacterial, and antioxidant activities. The results showed that these compounds exhibited acceptable anticancer and antioxidant activity, with alpha,alpha-Me-2-salen being the most effective against HDAC. However, they did not display antibacterial activity.
IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION
(2022)
Article
Food Science & Technology
Miwa Takatsuka, Satoru Goto, Kenshiro Kobayashi, Yuta Otsuka, Yohsuke Shimada
Summary: This study investigated the radical scavenging reaction of antioxidants in DPPH and ABTS assays using ESR and developed an analytical method. The results demonstrated that the first component in both assays contributed significantly to the radical scavenging reaction.
Article
Biochemistry & Molecular Biology
Samuel Attah Egu, Irfan Ali, Khalid Mohammed Khan, Sridevi Chigurupati, Urooj Qureshi, Uzma Salar, Muhammad Taha, Shatha Ghazi Felemban, Vijayan Venugopal, Zaheer Ul-Haq
Summary: A series of rhodanine-based Schiff bases were synthesized and evaluated for their inhibitory activities against alpha-amylase and radical scavenging. The position and nature of the substituted groups on the phenyl ring were found to play a crucial role in the inhibitory potential, with compounds containing an electron-withdrawing group at the para position showing the highest potency.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Physical
Ajit Kumar Bishoyi, Monalisa Mahapatra, Chita Ranjan Sahoo, Sudhir Kumar Paidesetty, Rabindra Nath Padhy
Summary: Antibiotic resistance has emerged as a potential public health emergency, and there is a need for new drug candidates to combat resistant strains. This study designed and synthesized a series of compounds, and evaluated their antimicrobial activities. Certain structural features of the molecules may enhance their antibacterial and antifungal effects.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Kritika Bajaj, Sarah A. Andres, Dillon T. Hofsommer, Mirza Galib, Mark S. Mashuta, Brian Bennett, Badri Narayanan, Robert M. Buchanan, Paula J. Bates, Craig A. Grapperhaus
Summary: Linkage isomers are coordination compounds with different donor atoms but the same composition. In this study, two linkage isomers derived from phenylglyoxalbis(ethylthiocarbamate) were synthesized and characterized. The antiproliferation activity of these isomers against lung cancer cells and nonmalignant lung fibroblast cells was also evaluated.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Priyanka Devi, Kiran Singh, Bhupender Kumar, Jahnavi Kumari Singh
Summary: Many pyrazoles-based Schiff bases were reported to exhibit high activity against bacterial, parasitic strains, and cancer cells. A new pyrazole based 'NO' bidentate ligand was synthesized and metal complexes with Co+2, Ni+2, Cu+2, and Zn+2 were also prepared. The characterization of the compounds and their metal complexes was performed, and the metal complexes showed enhanced activity compared to the ligand. They exhibited significant anticancer and antibacterial activity, as well as antifungal activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hassan Wafi Garba, Muhammad Sabiu Abdullahi, Mohamad Shazwan Shah Jamil, Nor Azam Endot
Summary: Copper(II) complexes with N,O-chelating Schiff base ligands were synthesized and tested for their catalytic activity in the reduction of 4-nitrophenol to 4-aminophenol. Among the complexes, 3 showed the highest catalytic activity, with 1.0 mol% of the catalyst being the most optimized amount. Recyclability tests confirmed the complexes were active and efficient for repeated use without major decrease in catalytic activity.
Article
Chemistry, Physical
Yasmin M. Ahmed, Gehad G. Mohamed
Summary: A new tetradentate Schiff base ligand was synthesized and characterized, and its complexes were investigated for their antimicrobial activity. The results showed that the ligand could form complexes with metal ions, and the metal chelation enhanced the antimicrobial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Mamta, Subhash, Pinki, Ashu Chaudhary
Summary: Novel synthesised Mn(II) complexes of Schiff base octaazamacrocyclic ligands showed good cytotoxicity against cancerous cell lines and antimicrobial activity against bacterial and fungal strains. The stability and properties of the ligands were determined through experimental and computational studies.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
R. Reshma, R. Selwin Joseyphus, D. Arish, R. Jaya Reshmi Jaya, J. Johnson
Summary: A novel Schiff base was synthesized by condensation of imidazole-2-carboxaldehyde with l-histidine, which was then complexed with a series of 3-d metal(II) ions. The complexes exhibited excellent antibacterial and antifungal activities in vitro, with electronic spectra and magnetic moment data indicating an octahedral geometry for most complexes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed R. Shehata, Ehab M. Abdalla
Summary: In this study, five novel metal ion complexes were synthesized and characterized, showing anticancer potential with antiproliferative effects on cancer cell lines, as well as antioxidant and antibacterial activities. The binding nature of the complexes with CT-DNA was investigated to determine intercalation or replacement mode.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ikechukwu P. Ejidike, Peter A. Ajibade
RESEARCH ON CHEMICAL INTERMEDIATES
(2016)
Article
Chemistry, Analytical
Babalwa Tembeni, Opeoluwa O. Oyedeji, Ikechukwu P. Ejidike, Adebola O. Oyedeji
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2016)
Article
Public, Environmental & Occupational Health
Fanyana M. Mtunzi, Ikechukwu P. Ejidike, Imelda Ledwaba, Aroke Ahmed, Vusumzi E. Pakade, Michael J. Klink, Sekomeng. J. Modise
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2017)
Article
Environmental Sciences
Pardon Nyamukamba, Makwena J. Moloto, Nikita Tavengwa, Ikechukwu P. Ejidike
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2019)
Article
Spectroscopy
Ikechukwu P. Ejidike, Mercy O. Bamigboye, Hadley S. Clayton
Summary: The copper complexes derived from the reaction of copper salts with Schiff base ligand showed crystalline features and excellent thermal stability up to 450 degrees C. The synthesized compounds exhibited potential as potent antiradical and antimicrobial agents, according to the investigated assays.
SPECTROSCOPY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Ikechukwu P. Ejidike, Hadley S. Clayton
Summary: This study utilized a green synthesis method to obtain silver nanoparticles mediated by a carrot leaf extract, and characterized their properties. The nanoparticles showed antimicrobial and antioxidant potentials, as well as cytotoxicity against brain glioblastoma cells.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Omolola E. Fayemi, Onkarabile G. Pooe, Funmilola A. Adesanya, Ikechukwu P. Ejidike
Summary: A successful electrochemical study was conducted on copper oxide nanoparticles (CuO NPs), sulfonated poly (ether ether ketone) polymer (SPEEK), and sulfonated polyether ether ketone-copper oxide (SPEEK/CuO) nanocomposite on bare gold electrodes. The results showed that CuO NPs improved the electrochemical properties of SPEEK, and the SPEEK/CuO nanocomposite exhibited good adsorption and enhanced electrochemical performance compared to SPEEK polymer and CuO NPs alone.
Article
Toxicology
Oluwatoyin O. Ojo, Deborah I. Fatokun, Ikechukwu P. Ejidike, Rachel U. Awolope, Saheed O. Sanni
Summary: The study found that quercetin and its zinc and iron complexes can effectively reduce the damage in rats caused by arsenic poisoning, decrease oxidative stress reactions in the liver and kidney, and reduce the activity of related enzymes. Quercetin-zinc treatment showed better results, and treatment with quercetin-zinc and iron did not cause any damage to the liver and kidney.
JOURNAL OF TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Juliana B. Adetunji, Oluwaseun A. Adebisi, Israel O. Adeyomoye, Sunday I. Oyeleye, Daniel O. Adebayo, Ikechukwu P. Ejidike
Summary: Excessive intake and bioaccumulation of sodium fluoride (NaF) can cause cardiac oxidative stress. This study investigated the effects of Hibiscus sabdariffa (HS) fractions on NaF-induced rats. The results showed that NaF exposure increased oxidative stress markers and decreased antioxidant levels, while HS treatment stimulated antioxidant production and reduced oxidative stress.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2023)
Article
Multidisciplinary Sciences
Mercy Oluwaseyi Bamigboye, Ikechukwu Peter Ejidike, Risikat Nike Ahmed, Misitura Lawal, Ginikachukwu Grace Nnabuike, Kayode Medubi
SURANAREE JOURNAL OF SCIENCE AND TECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sechaba Machedi, Ikechukwu P. Ejidike, Fanyana M. Mtunzi, Vusumzi E. Pakade, Michael J. Klink
ORIENTAL JOURNAL OF CHEMISTRY
(2019)
Article
Nanoscience & Nanotechnology
K. Kotlhao, F. M. Mtunzi, V Pakade, I. P. Ejidike, M. J. Klink
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES
(2018)
Article
Materials Science, Multidisciplinary
Kate Kotlhao, Fanyana M. Mtunzi, Vusumzi Pakade, Neelan Laloo, Ikechukwu P. Ejidike, Sekomeng J. Modise, Richard M. Moutloali, Michael J. Klink
Article
Multidisciplinary Sciences
Victoria Bennett, Ikechukwu P. Ejidike, Nimibofa Ayawei, Donbebe Wankasi, Ezekiel D. Dikio
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES
(2017)