期刊
MOLECULES
卷 23, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules23020474
关键词
oridonin; anticancer; antiinflammation; neuroprotection; Alzheimer's disease
资金
- National Institutes of Health, Breast Cancer Research Program (BCRP) Breakthrough Awards from the Department of Defense (DoD) [P30 DA028821, R01 DA038446, BC160038, BC160038P1]
- Cancer Prevention Research Institute of Texas (CPRIT) award
- Gulf Coast Consortia (GCC)
- Center for Addiction Research (NIDA) [T32 DA07287]
- John Sealy Memorial Endowment Fund
- Institute for Translational Sciences (ITS)
Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.
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