Article
Pharmacology & Pharmacy
Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng, Zhenzhong Zhang, Lei Wang
Summary: The physical properties of nanoparticle-based vaccines, such as their shape, play a crucial role in antigen capture, lymphatic delivery, antigen presentation, and immune response in lymph nodes. Star-shaped gold nanoparticles (AuNPs) were found to capture and retain more repetitive antigen epitopes. Rods and star-shaped nanovaccines primarily drained into the lymph node follicles region, while cage-shaped nanovaccines showed stronger paracortex retention. Surprisingly, star-shaped nanovaccines elicited potent humoral immunity, preventing tumor growth in prophylactic studies. Cage-shaped nanovaccines preferentially presented peptide-MHC I complexes and showed the strongest therapeutic efficacy when combined with PD-1 checkpoint inhibitors in established tumor studies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Cell Biology
Aude De Gassart, Kieu-Suong Le, Patrick Brune, Sophie Agaugue, Jennifer Sims, Armelle Goubard, Remy Castellano, Noemie Joalland, Emmanuel Scotet, Yves Collette, Emmanuel Valentin, Clement Ghigo, Christine Pasero, Magali Colazet, Jaime Guillen, Carla E. Cano, Aurelien Marabelle, Johann De Bonno, Rene Hoet, Alemseged Truneh, Daniel Olive, Paul Frohna
Summary: Gamma delta T cells, when activated by the humanized monoclonal antibody ICT01, show potent cytotoxicity against various tumor cell types in a targeted manner, with promising antitumor effects and acceptable safety profiles in preclinical studies. ICT01 selectively activates V gamma 9V delta 2 T cells, leading to tumor growth inhibition and prolonged survival in animal models, indicating its potential as a targeted therapy for advanced solid tumors.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Alicia Asin, Fayna Garcia-Martin, Jesus Hector Busto, Alberto Avenoza, Jesus Manuel Peregrina, Francisco Corzana
Summary: Immunotherapy, especially using MUC1 glycopeptides as vaccine candidates, has shown promising results in cancer treatment. In this study, the researchers designed three vaccines based on MUC1 glycopeptides with unnatural elements in their structure. The vaccines were found to elicit strong immune responses in mice and produce antibodies that can recognize human cancer cells. The study suggests that effective MUC1-based vaccines should mimic the conformational space of aberrantly glycosylated MUC1 glycopeptides found in tumors.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
Summary: Tumors of melanoma patients who respond to ICI or MAPKi therapies show increased T cell infiltration and IFNγ pathway activation. However, the rate of durable tumor control is higher with ICI therapy, indicating the presence of additional mechanisms beneficial for anti-tumor immunity in ICI responders.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock
Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Han-Ha Chai, Tae-Hun Kim, Young Ran Kim, Dajeong Lim
Summary: The study predicted the structure of the pig TAP transporter and its inhibition complex by the herpes simplex virus-encoded ICP47 inhibitor, revealing the specificity determinants and functional effects of the ICP47 inhibitor on TAP. The research also demonstrated the specialized structure-function relationship of the pig TAP exporter and its implications for antiviral resistance and disease susceptibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Gastroenterology & Hepatology
Marta Canel, Aleksandra Dominika Slawinska, David W. Lonergan, Ashwin Adrian Kallor, Rosie Upstill-Goddard, Catherine Davidson, Alex von Kriegsheim, Andrew Biankin, Adam Byron, Javier Alfaro, Alan Serrels
Summary: In this study, the authors found that focal adhesion kinase (FAK) has an immunoregulatory function in pancreatic ductal adenocarcinoma (PDAC) by promoting the expression of immunoproteasome and MHC-I, leading to increased antigen diversity and antigen presentation. Co-depletion of FAK and STAT3 can further enhance this immune response and inhibit tumor growth. This finding suggests that therapies targeting FAK degradation may provide additional therapeutic benefits for PDAC treatment.
Article
Biochemistry & Molecular Biology
Goran Vinterhalter, Jovana J. Kovacevic, Vladimir N. Uversky, Gordana M. Pavlovic-Lazetic
Summary: The research investigates the correlation between protein structure and function using different datasets and functional annotations. Results show consistent findings in protein disorder prediction between Gene Ontology (GO terms) and Swiss-Prot keywords. Additionally, a new method for deriving missing mappings between GO terms and Swiss-Prot keywords is proposed based on protein function similarity measurement.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemical Research Methods
Juntao Deng, Xiao Zhou, Pengyan Zhang, Weibin Cheng, Min Liu, Junzhang Tian
Summary: CD8(+) T cells recognize peptides presented by HLA-I and understanding this mechanism is crucial in cancer immunotherapy. Existing methods for HLA-I binding and antigen presentation prediction lack precision as they do not consider TCR recognition. This article proposes a novel immune epitope prediction method, IEPAPI, which effectively combines antigen presentation and immunogenicity to simulate the connection between T-cell immune responses and provides a valuable tool for T-cell vaccine design.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Fisheries
Valentina Wong-Benito, Jill de Rijke, Brian Dixon
Summary: This article summarizes the structural and functional aspects of antigen presentation pathways in vertebrates, with a focus on MHC receptors and other related proteins.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Maria Rasmussen, Jon Ambaek Durhuus, Mef Nilbert, Ove Andersen, Christina Therkildsen
Summary: This study examines the association between alternative immune evasion mechanisms via the antigen presentation machinery (APM) and resistance towards immune checkpoint inhibitor (ICI) treatments. The research finds that defects in APM significantly predict poor clinical benefits and may explain insensitivity towards ICI therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Valli De Re, Anna Rossetto, Alessandro Rosignoli, Elena Muraro, Vito Racanelli, Maria Lina Tornesello, Aron Zompicchiatti, Alessandro Uzzau
Summary: Ablative and locoregional treatment options are effective therapies for early-stage HCC, enhancing immunogenicity and survival rates. Surgical approaches combined with immune-modulating drugs show promise in maximizing therapeutic outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fengqi Zhou, Jing Gao, Yang Tang, Zhifeng Zou, Shi Jiao, Zhaocai Zhou, Huixiong Xu, Zhi Ping Xu, Haijun Yu, Zhiai Xu
Summary: This research addresses the issue of immune evasion in T-cell-based cancer immunotherapy by developing a multifunctional prodrug nanovesicle. By enhancing tumor antigen presentation and the infiltration of T lymphocytes, the prodrug nanovesicles demonstrate efficacy in overcoming immune resistance and potentiate tumor immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Lousineh Arakelian, Julien Lion, Guillaume Churlaud, Rezlene Bargui, Briac Thierry, Evelyne Mutabazi, Patrick Bruneval, Antonio Jose Alberdi, Christelle Doliger, Maeva Veyssiere, Jerome Larghero, Nuala Mooney
Summary: Endothelial cells play crucial roles in blood transport, vessel homeostasis, inflammatory responses, transendothelial migration, and blood vessel formation. CD34 is commonly used as an endothelial marker, but its expression and function vary in different organs and pathological conditions. This study investigates the expression and function of CD34 in endothelial cells, revealing that CD34(high) cells have lower proliferation but higher expression of IL-33 and Angiopoietin 2 compared to CD34(low) cells. CD34(high) endothelial cells also enhance the proliferation of regulatory T lymphocytes, suggesting their immunogenic ability and potential role in tolerogenic response.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Kenneth Lundstrom, Altijana Hromic-Jahjefendic, Esma Bilajac, Alaa A. A. Aljabali, Katarina Baralic, Nagwa A. Sabri, Eslam M. Shehata, Mohamed Raslan, Ana Claudia B. H. Ferreira, Lidiane Orlandi, Angel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Vasco Azevedo, Khalid J. Alzahrani, Khalaf F. Alsharifm, Ibrahim F. Halawani, Fuad M. Alzahrani, Elrashdy M. Redwan, Debmalya Barhl
Summary: This review summarizes major events of SARS-CoV-2 infection route, immune response following host-cell infection as an important factor for disease outcome, as well as comorbidity issues of various tissues and organs arising due to COVID-19. Investigations on alterations of host-cell machinery and viral interactions with multiple intracellular signaling pathways could represent a major factor in more effective disease management.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Debmalya Barh, Sandeep Tiwari, Lucas Gabriel Rodrigues Gomes, Cecilia Horta Ramalho Pinto, Bruno Silva Andrade, Shaban Ahmad, Alaa A. A. Aljabali, Khalid J. Alzahrani, Hamsa Jameel Banjer, Sk Sarif Hassan, Elrashdy M. Redwan, Khalid Raza, Aristoteles Goes-Neto, Robinson Sabino-Silva, Kenneth Lundstrom, Vladimir N. Uversky, Vasco Azevedo, Murtaza M. Tambuwala
Summary: The Omicron variant of SARS-CoV-2 is highly transmissible with decreased disease severity. It has lower pathogenicity but higher antigenicity compared to other variants. These findings contribute to our understanding of variant dynamics and can help in managing emerging variants.
Retraction
Oncology
Steve Harakeh, Raefa Abou-Khouzam, Ghazi A. Damanhouri, Ahmed Al-Hejin, Taha Kumosani, Aleksandra Niedzwiecki, Mathias Rath, Elie Barbour, Mona Diab-Assaf, Rania Azar
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Hossein Hosseini, Noah Esmaeili, Aref Sepehr, Mahyar Zare, Artur Rombenso, Raied Badierah, Elrashdy M. Redwan
Summary: This study investigated the effects of extruded flaxseed with and without herbs mixture on egg performance, yolk fatty acids, lipid components, blood biochemistry, serological enzymes, antioxidants, and immune system of Hy-Line W-36 hens. The results showed that hens fed herbs mixture had better egg performance and improved antioxidant and immune parameters compared to those fed diets without herbs. High levels of extruded flaxseed without herbs appeared to impair the antioxidant system, immunohematological parameters, and serological enzymes, but the supplementation of herbs mixture corrected these effects.
Article
Cell Biology
Kenneth Lundstrom, Altijana Hromic-Jahjefendic, Esma Bilajac, Alaa A. A. Aljabali, Katarina Baralic, Nagwa A. Sabri, Eslam M. Shehata, Mohamed Raslan, Sara A. Raslan, Ana Claudia B. H. Ferreira, Lidiane Orlandi, Angel Serrano-Aroca, Vladimir N. Uversky, Sk. Sarif Hassan, Elrashdy M. Redwan, Vasco Azevedo, Khalid J. Alzahrani, Khalaf F. Alsharif, Ibrahim F. Halawani, Fuad M. Alzahrani, Murtaza M. Tambuwala, Debmalya Barh
Summary: The COVID-19 pandemic has led to extensive research and development of drugs and vaccines for SARS-CoV-2. Vaccines based on viral vectors, nucleic acids, and whole viral particles have been particularly successful and have received emergency authorization for global mass vaccination. However, emerging variants have raised concerns about vaccine efficacy.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Yousra A. El-Maradny, Alberto Rubio-Casillas, Vladimir N. Uversky, Elrashdy M. Redwan
Summary: The severity of COVID-19 has reduced due to widespread vaccination campaigns and mutations in the virus. However, the long-term side effects of the infection and vaccines, known as long-COVID, are spreading rapidly. The reasons behind this phenomenon are still unclear.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Editorial Material
Geriatrics & Gerontology
Arif Tasleem Jan, Safikur Rahman, Diana K. Sarko, Elrashdy M. Redwan
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Immunology
Vivek P. Chavda, Nidhi Raval, Soham Sheta, Lalitkumar K. Vora, Fatma Elrashdy, Elrashdy M. Redwan, Vladimir N. Uversky, Yavuz Nuri Ertas
Summary: The newly emerged SARS-CoV-2 is highly infectious and rapidly mutating, causing severe effects on various body organs. Multiple approaches, including medications and supportive devices, have been successfully used for the intervention of COVID-19. Hemadsorption devices are discussed in this report as part of supportive treatment for the cytokine storm associated with COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Shaghayegh Khanmohammadi, Sahar Saeedi Moghaddam, Sina Azadnajafabad, Negar Rezaei, Zahra Esfahani, Nazila Rezaei, Mohsen Naghavi, Bagher Larijani, Farshad Farzadfar
Summary: The study aimed to estimate the burden of tracheal, bronchus, and lung cancer and its risk factors in the North Africa and Middle East region from 1990 to 2019. The results showed that TBL cancer caused significant deaths and had increasing incidence rates, especially in women. Tobacco use remained the leading risk factor. Controlling risk factors, particularly tobacco use, could significantly reduce the burden of the disease.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Rasha Ashmawy, Ehab Kamal, Wagdy Amin, Sandy Sharaf, Samar Kabeel, Raed Albiheyri, Yousra A. El-Maradny, Ebtisam Hassanin, Noura Elsaka, Ola Fahmy, Ahmed Awd, Heba Aboeldahab, Mai Nayle, Magda Afifi, Marwa Ibrahim, Raghda Rafaat, Shahinda Aly, Elrashdy M. Redwan
Summary: The study evaluated the safety and efficacy of Egypt's first approved Sinopharm vaccine (BBIBP-CorV) and found it to be effective in protecting healthcare workers from COVID-19. Vaccination was associated with a significant reduction in hospitalization rate and work absenteeism, with mild adverse events reported.
Review
Immunology
Nawal Abd El-Baky, Amro A. Amara, Elrashdy M. Redwan
Summary: The adaptive immune response plays a crucial role in determining the clinical outcome and vaccine efficacy after SARS-CoV-2 infection. T cells recognize viral-derived peptides bound to major histocompatibility complexes (MHCs) to initiate cell-mediated immunity or support high-affinity antibody response. Immunopeptidomics techniques can identify potential vaccine targets or therapeutic approaches and reveal heterogeneity in clinical outcomes by characterizing SARS-CoV-2-derived peptides bound to MHCs.
Review
Immunology
Vladimir N. Uversky, Elrashdy M. Redwan, William Makis, Alberto Rubio-Casillas
Summary: The effectiveness of the COVID-19 vaccines in preventing severe disease and hospitalization in individuals with comorbidities is being questioned. Recent investigations have found abnormally high levels of IgG4 in individuals who received mRNA vaccines, which may suppress natural antiviral responses and promote SARS-CoV2 infection and replication.
Article
Public, Environmental & Occupational Health
Maria Jesus Rios-Blancas, Victoria Pando-Robles, Christian Razo, Cesar P. Carcamo, Walter Mendoza, Kevin Pacheco-Barrios, J. Jaime Miranda, Van Charles Lansingh, Takele Gezahegn Demie, Manika Saha, Osaretin Christabel Okonji, Arzu Yigit, Lucero Cahuana-Hurtado, Pamela R. Chacon-Uscamaita, Eduardo Bernabe, Carlos Culquichicon, Jesus Lorenzo Chirinos-Caceres, Rosario Cardenas, Jacqueline Elizabeth Alcalde-Rabanal, Francisco J. Barrera, Beatriz Paulina Ayala Quintanilla, Seyed Afshin Shorofi, Nuwan Darshana Wickramasinghe, Nuno Ferreira, Louay Almidani, Vivek Kumar Gupta, Hanie Karimi, Daniel Shewaye Alayu, Catherine P. Benziger, Takeshi Fukumoto, Ebrahim Mostafavi, Elrashdy Moustafa Mohamed Redwan, Mesfin Gebrehiwot, Khaled Khatab, Ai Koyanagi, Fiorella Krapp, Seung Lee, Maryam Noori, Ibrahim Qattea, Victor Daniel Rosenthal, Joseph W. Sakshaug, Birhanu Wagaye, Iman Zare, Doris V. Ortega-Altamirano, Efren Murillo-Zamora, Dominique Vervoort, Diego Augusto Santos Silva, Abderrahim Oulhaj, Brenda Yuliana Herrera-Serna, Rahul Mehra, Mehrdad Amir-Behghadami, Nasrin Adib, Sandra Cortes, Anh Kim Dang, Binh Thanh Nguyen, Ali H. Mokdad, Simon I. Hay, Christopher J. L. Murray, Rafael Lozano, Patricia J. Garcia
Summary: Using data from the Global Burden of Disease Study (2019), this study assessed mortality and disability trends in Peru from 1990 to 2019. Significant improvements were observed in life expectancy and child survival, but there was an increase in the burden of non-communicable diseases. Peru had one of the highest rates of lower respiratory infections in the Latin American region before the COVID-19 pandemic.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Mohammad-Reza Malekpour, Mohsen Abbasi-Kangevari, Seyyed-Hadi Ghamari, Javad Khanali, Mahsa Heidari-Foroozan, Sahar Saeedi Moghaddam, Mohammadreza Azangou-Khyavy, Sahba Rezazadeh-Khadem, Negar Rezaei, Parnian Shobeiri, Zahra Esfahani, Nazila Rezaei, Ali H. Mokdad, Mohsen Naghavi, Bagher Larijani, Farshad Farzadfar
Summary: This study investigated the trends of exposure and burden attributable to the four main metabolic risk factors in North Africa and the Middle East from 1990 to 2019. The findings showed a decrease in death rates attributable to high-LDL and high-SBP, but an increase in death rates attributable to high-BMI and high-FPG. Exposure to all four risk factors increased over the past three decades.
Review
Biochemistry & Molecular Biology
Altijana Hromic-Jahjefendic, Abas Sezer, Alaa A. A. Aljabali, Angel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Elrashdy M. Redwan, Debmalya Barh, Kenneth Lundstrom
Summary: COVID-19 vaccines have been widely used to reduce the incidence and disease severity of COVID-19. Recent concerns have been raised about a possible association between COVID-19 vaccines and myocarditis. Myocarditis can be caused by infections, immune reactions, or toxic exposure. The incidence rate of myocarditis after vaccination is lower than that after SARS-CoV-2 infection, and it is more common in adolescent males following mRNA vaccination.