期刊
MOLECULES
卷 23, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules23040754
关键词
2-phenyl-benzofuran; antioxidant; moracin; double bond; positional isomeric effect
资金
- National Nature Science Foundation of China [81573558]
- Natural Science Foundation of Guangdong Province [2017A030312009]
- Guangdong Science and Technology Project [2017A050506043]
Two 2-phenyl-benzofurans, moracin C2-[3',5'-dihydroxy-4'-(3-methlbut-2-enyl) phenyl]-6-hydroxybenzofuran and its isomer iso-moracin C{2-[3',5'-dihydroxy-4'-(3-methlbut-1-enyl) phenyl]-6-hydroxybenzofuran}, were comparatively studied using redox-related antioxidant assays and non-redox antioxidant assays. Moracin C always resulted in higher IC50 values than iso-moracin C in the redox-related antioxidant assays, including center dot O-2(-)-inhibition, Cu2+-reducing power, DPPH center dot-inhibition, and ABTS(+)center dot-inhibition assays. In the non-redox antioxidant assay, moracin C and iso-moracin C underwent similar radical-adduct-formation (RAF), evidenced by the peaks at m/z 704 and m/z 618 in HPLC-MS spectra. In conclusion, both moracin C and iso-moracin C can act as 2-phenyl-benzofuran antioxidants; their antioxidant mechanisms may include redox-related ET and H+-transfer, and non-redox RAF. A double bond at the conjugation position can enhance the redox-related antioxidant potential, but hardly affects the RAF potential.
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