Article
Chemistry, Medicinal
Ya Li, Xingzhi Jiao, Tinghong Lv, Meili Yang, Kun Gao
Summary: Four new diterpenoids and 18 known ones were isolated from the roots of Euphorbia fischeriana Steud. These compounds showed inhibitory activity against the interferon regulatory factors (IRFs) involved pathway. The structures of the new diterpenoids were characterized using spectroscopic techniques and X-ray crystallography.
Article
Chemistry, Medicinal
Rihan Xie, Guiyang Xia, Jianxun Zhu, Pengcheng Lin, Xiaona Fan, Jiachen Zi
Summary: Two new daphnane-type diterpenoids, fischerianin A and fischerianin B, as well as two known ones, langduin A and langduin A(6), were isolated from Euphorbia fischeriana Steud dry roots. These compounds showed moderate inhibitory activities against various human cancer cell lines, indicating their potential as anticancer agents.
Article
Biochemistry & Molecular Biology
Cheng-Peng Sun, Yi-Bo Chang, Chao Wang, Xia Lv, Wei-Yu Zhou, Xiang-Ge Tian, Wen-Yu Zhao, Xiao-Chi Ma
Summary: Two undescribed ent-abietane-type diterpenoid dimers with nonacyclic backbone, bisfischoids A and B, were identified, along with a known compound fischdiabietane A, from Euphorbia fischeriana Steud. These compounds showed promising anti-inflammatory activities by inhibiting soluble epoxide hydrolase, with bisfischoid B exhibiting the strongest inhibitory effect. Further molecular docking studies revealed the key amino acid residue Tyr343 in the catalytic cavity of sEH for their inhibitory function.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Qin Cai, Hong-Jing Zha, Shi-Ying Yuan, Xing Sun, Xin Lin, Xin-Yu Zheng, Ying-Xian Qian, Ru-Feng Xia, Yue-Shan Luo, Zhimian Shi, Jun-Cheng Su, Luo-Sheng Wan
Summary: In this study, diterpenoids from Euphorbia fischeriana were found to possess inhibitory effects on the Kv1.3 ion channel. Macrocyclic jatrophanes and lathyranes exhibited selective blocking activity on the Kv1.3 channel, indicating their potential as therapeutic agents for autoimmune diseases.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Gang Chen, Tiancheng Ma, Yukun Ma, Cuicui Han, Jinling Zhang, Yu Sun
Summary: Ent-abietane diterpenoids from Euphorbia fischeriana exhibit varying degrees of growth inhibition against breast cancer cell lines, with some compounds being novel or first-time discoveries. Extraction is crucial for obtaining valuable compounds from natural plants, and optimizing the salting-out-assisted liquid-liquid extraction process can maximize yields.
Article
Biochemistry & Molecular Biology
Jia Meng, Bo-Ting Li, Gang Sheng, An-Ling Zhang, Xing-Cong Li, Jun-Mian Tian
Summary: Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Euphorfischerin A and euphorfischerin B showed cytotoxicity against human cancer cell lines.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Applied
Ye Zhao, Hui-Hui Huang, Jiang-Chun Wei, Qing Wang, Guo-Qing Long, An-Hua Wang, Jing-Ming Jia
Summary: Two previously undescribed ent-abietane diterpenoids, Euphorfinoids M and N, along with seven known analogues, were isolated from the roots of wild Euphorbia fischeriana. Their structures were determined by spectroscopic analysis and comparison with structurally related known analogues. Compound 1 exhibited the highest activity with an IC50 value of 3.62 +/- 0.31 mu M against the proliferative effects of HeLa cell line.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qin-Feng Zhu, Guo-Bo Xu, Shang-Gao Liao, Xue-Long Yan
Summary: In this study, diterpenoids from the roots of Euphorbia fischeriana were investigated for their cytotoxic effects against cancer cells. Two new diterpenoids were isolated from this plant source and showed significant inhibitory effects against human prostate cancer cells.
Article
Chemistry, Multidisciplinary
Yulin Peng, Yibo Chang, Chengpeng Sun, Weiyi Wang, Chao Wang, Yan Tian, Baojing Zhang, Sa Deng, Wenyu Zhao, Xiaochi Ma
Summary: A novel compound with a unique structure was isolated from Euphorbia fischeriana, and its structure was determined using various techniques. It was found to exhibit antiproliferative activity.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Nan -Fang Zhong, Hui -Hui Huang, Jiang -Chun Wei, Yong-Cheng Yang, Xiao-Xu Gao, Xiu-Yan Wei, An-Hua Wang, Jing-Ming Jia
Summary: Nine previously undescribed diterpenoids and seven known diterpenoids were isolated from the roots of wild Euphorbia fischeriana. The structures were analyzed and determined, and their configuration was confirmed. These compounds were tested for their antitumor effects, and some of them showed inhibitory effects on tumor cells.
Review
Plant Sciences
Ya-Nan Li, Jun He, Jia Zhang, Ying-Xue Shi, Lin-Bo Guo, Zhong-Can Peng, Ting Yang, Kang Ding, Wei-Ku Zhang, Jie-Kun Xu
Summary: Euphorbia fischeriana has been identified as a toxic herb with medicinal uses for various conditions. A total of 241 chemical constituents have been found in its roots, exhibiting various pharmacological activities, especially anti-tumor, antibacterial, anti-inflammatory, antiviral, and anti-leukemia activities. Further research on its toxicity and pharmacological mechanisms may contribute to the development of more effective lead compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Da-Wei Li, Xiao-Peng Deng, Xin He, Xiu-Yan Han, Yu-Fang Ma, Hui-Lian Huang, Zhen-Long Yu, Lei Feng, Chao Wang, Xiao-Chi Ma
Summary: The roots of Euphorbia fischeriana contain 15 diterpenoids that show moderate inhibitory effects on the proliferation of Mycobacterium tuberculosis, with eupholides F-H being the most effective. Additionally, some of these compounds significantly inhibit the lyase activity of human carboxylesterase 2.
Article
Biochemistry & Molecular Biology
Jiang-Chun Wei, Xiao-Yu Zhang, Yu-Ning Gao, Dong-Dong Wang, Xue-Lai He, Xiao-Xu Gao, Gao-Sheng Hu, An-Hua Wang, Jing-Ming Jia
Summary: This study isolated eight new diterpenoids from the roots of wild Euphorbia fischeriana, identified their structures and absolute configurations, and proposed a plausible biosynthetic pathway. These compounds showed moderate inhibitory activity against acetylcholinesterase, with IC50 values ranging from 6.23 to 192.38 µM.
Review
Biochemistry & Molecular Biology
Zha-jun Zhan, Shen Li, Wang Chu, Sheng Yin
Summary: This review provides an in-depth and extensive coverage of the latest research progress on Euphorbia diterpenoids reported from 2013 to the end of 2021, including 997 new compounds and 78 known compounds. The review covers the occurrences, chemical structures, bioactivities, and syntheses of Euphorbia diterpenoids, and discusses the structure-activity relationship and biosynthesis of this class for the first time.
NATURAL PRODUCT REPORTS
(2022)
Article
Chemistry, Applied
Tiancheng Ma, Yu Sun, Lei Liu, Jia Sun, Yukun Ma, Lina Guo, Qi Liu
Summary: The optimal conditions for the simultaneous extraction of four diterpenoids from Euphorbia Fischeriana were determined using response surface methodology with Box-Behnken design. Under these conditions, 51 peaks were identified in the extract, including two tentatively identified as new compounds. The compounds detected were diterpenoids, fatty oil, phenolics, and others.
NATURAL PRODUCT RESEARCH
(2021)