α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
出版年份 2018 全文链接
标题
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
作者
关键词
Parkinson’s disease, GBA, MPTP, Mitochondrial dysfunction, α-synuclein
出版物
Molecular Neurodegeneration
Volume 13, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-01-08
DOI
10.1186/s13024-017-0233-5
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice
- (2017) Ina Tesseur et al. JOURNAL OF NEUROSCIENCE
- Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice
- (2016) Anna Migdalska-Richards et al. ANNALS OF NEUROLOGY
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A
- (2015) Ting-Ting Du et al. Autophagy
- Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease
- (2015) Carmen Noelker et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration
- (2015) Daniel A. Stevens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse
- (2015) Lian-Kun Song et al. PLoS One
- Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity
- (2015) Seulah Choi et al. PLoS One
- Glucocerebrosidase is shaking up the synucleinopathies
- (2014) Marina Siebert et al. BRAIN
- Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
- (2014) Ianai Fishbein et al. BRAIN
- The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
- (2014) Senthilkumar S. Karuppagounder et al. Scientific Reports
- Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
- (2013) Laura D. Osellame et al. Cell Metabolism
- The Association Between ß-Glucocerebrosidase Mutations and Parkinsonism
- (2013) Matthew Swan et al. Current Neurology and Neuroscience Reports
- Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss
- (2013) Yunjong Lee et al. NATURE NEUROSCIENCE
- Inactivation ofPink1Genein VivoSensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes,ParkinorDJ-1
- (2012) M. Emdadul Haque et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endoplasmic Reticulum Stress Is Important for the Manifestations of -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- MutantGBA1Expression and Synucleinopathy Risk: First Insights from Cellular and Mouse Models
- (2012) S. Pablo Sardi et al. Neurodegenerative Diseases
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Caspase signalling controls microglia activation and neurotoxicity
- (2011) Miguel A. Burguillos et al. NATURE
- Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
- (2011) Bobby Thomas et al. PLoS One
- A Lysosomal Lair for a Pathogenic Protein Pair
- (2011) T. M. Dawson et al. Science Translational Medicine
- The Role of Glucocerebrosidase Mutations in Parkinson Disease and Lewy Body Disorders
- (2010) Arash Velayati et al. Current Neurology and Neuroscience Reports
- Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis
- (2010) Derrick Sek Tong Ong et al. Nature Chemical Biology
- Glucocerebrosidase mutations in diffuse Lewy body disease
- (2010) Kenya Nishioka et al. PARKINSONISM & RELATED DISORDERS
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Brain-Specific Deletion of Extracellular Signal-Regulated Kinase 2 Mitogen-Activated Protein Kinase Leads to Aberrant Cortical Collagen Deposition
- (2009) Daniel S. Heffron et al. AMERICAN JOURNAL OF PATHOLOGY
- Association of Glucocerebrosidase Mutations With Dementia With Lewy Bodies
- (2009) Lorraine N. Clark et al. ARCHIVES OF NEUROLOGY
- Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
- (2009) Juliane Neumann et al. BRAIN
- Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
- (2009) E. Andres-Mateos et al. JOURNAL OF NEUROSCIENCE
- LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease
- (2009) Z. Gan-Or et al. NEUROGENETICS
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
- (2009) Han Seok Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset
- (2008) Z. Gan-Or et al. NEUROLOGY
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