Article
Biochemistry & Molecular Biology
Olga Abramova, Yana Zorkina, Timur Syunyakov, Eugene Zubkov, Valeria Ushakova, Artemiy Silantyev, Kristina Soloveva, Olga Gurina, Alexander Majouga, Anna Morozova, Vladimir Chekhonin
Summary: The study found that ultrasound stress can lead rats to exhibit depressive-like behavior, while treatment with clomipramine can have an antidepressant effect. Different routes of drug administration can influence the drug's impact on the metabolic profiles in the frontal cortex and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Piotr Plichta, Ernest Tyburski, Maksymilian Bielecki, Monika Mak, Jolanta Kucharska-Mazur, Piotr Podwalski, Katarzyna Rek-Owodzin, Katarzyna Waszczuk, Leszek Sagan, Anna Michalczyk, Blazej Misiak, Jerzy Samochowiec
Summary: This study compared cognitive domains between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS) patients and healthy controls (HC), analyzing relationships between psychopathological dimensions and cognitive domains. The results showed that clinical groups performed poorer than HC groups in various cognitive domains, and DS patients scored poorer than NDS patients in all cognitive domains except for reasoning and problem solving. Psychopathological symptoms were only related to cognitive functions in NDS patients. The findings suggest that the MCCB battery is sensitive to detecting cognitive dysfunctions in both deficit and non-deficit schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Caio Fernando Ferreira Coelho, Ivana Leticia Santos Souza, Vinicyus Teles Chagas, Nathalee Liberal Xavier Ribeiro, Bruno Araujo Serra Pinto, Lucas Martins Franca, Antonio Marcus de Andrade Paes
Summary: The research showed that Myricetin can reduce elevated glucose and triglyceride levels in MSG obese mice, improve peripheral insulin sensitivity and liver steatosis, but has limited effect on cognitive deficits.
Article
Biochemistry & Molecular Biology
Yang Zhou, Monica K. Chawla, Jose L. Rios-Monterrosa, Lingzhi Wang, Marc A. Zempare, Victor J. Hruby, Carol A. Barnes, Minying Cai
Summary: The study found significant correlations between the expression of MCR subtypes in the frontal cortex/hypothalamus and hippocampus regions and the performance of spatial learning and memory in aged rats, supporting the hypothesis that aging has a direct impact on MCR expression and function.
Article
Biochemistry & Molecular Biology
Jiaxian Zhang, Yu Jing, Hu Zhang, Ping Liu
Summary: This study revealed significant differences in levels of l-arginine in the brain and blood between female and male rats, with variations also observed based on the estrous cycle. The findings suggest that sex and estrous cycle can influence the metabolic profile of arginine, which is important to consider in experimental research involving female rodents when using blood as a biomarker for brain pathology.
Article
Medicine, Research & Experimental
Ali Heidarianpour, Fereshteh Mohammadi, Maryam Keshvari, Naser Mirazi
Summary: Diabetes mellitus is associated with cognitive deficits due to degeneration of the central nervous system. This study found that endurance training combined with Matricaria chamomilla extract can improve cognitive impairment in diabetic rats by reducing neuronal necrosis and increasing antioxidant levels.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biology
Tarek Amer, Lila Davachi
Summary: Pattern separation is the process by which highly similar stimuli or experiences in memory are represented by non-overlapping neural ensembles. It has been traditionally attributed to the hippocampus, but recent evidence suggests that it involves a network of brain regions. The 'cortico-hippocampal pattern separation' (CHiPS) framework proposes that cognitive control regions play a significant role in pattern separation, either by resolving interference in sensory regions or by directly modulating hippocampal processes.
Article
Pharmacology & Pharmacy
Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming Ma
Summary: This study found that Osthole (OST) can improve ovariectomy-induced cognitive impairment, alleviate anxiety and depression-like behaviors, and reverse alterations in hippocampal protein levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Mehreen Arif, Khalid Rauf, Naeem Ur Rehman, Ahmed Tokhi, Muhammad Ikram, Robert Sewell
Summary: This study found that 6-MOF and donepezil have neuroprotective effects in chronic ethanol-induced cognitive impairment, improving cognitive performance and neurochemical markers in animals.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Environmental Sciences
Wenlan Yu, Xiaoyue Chang, Jianzhao Liao, Jinwen Quan, Siying Liu, Ting He, Gaolong Zhong, Jilei Huang, Zhonghua Liu, Zhaoxin Tang
Summary: Long-term ingestion of tribasic copper chloride may result in cognitive dysfunction and disrupt mitochondrial metabolism by inhibiting mitophagy.
ENVIRONMENTAL POLLUTION
(2023)
Article
Geriatrics & Gerontology
Francesco Bellanti, Vidyasagar Naik Bukke, Archana Moola, Rosanna Villani, Caterina Scuderi, Luca Steardo, Gianmauro Palombelli, Rossella Canese, Sarah Beggiato, Mario Altamura, Gianluigi Vendemiale, Gaetano Serviddio, Tommaso Cassano
Summary: This study investigated the therapeutic potential of ultramicronized palmitoylethanolamide (um-PEA) in 3 x Tg-AD mice. The results showed that um-PEA can improve the complex-I respiration rate and ATPase activity, as well as ATP content in the cortical mitochondria of the mice. However, um-PEA treatment did not improve the mitochondrial bioenergetics impairments and glutamate release in the hippocampus.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Milda Sarkinaite, Rymante Gleizniene, Virginija Adomaitiene, Kristina Dambrauskiene, Nijole Raskauskiene, Vesta Steibliene
Summary: Structural brain changes are found in suicide attempters and patients with mental disorders, with atrophy of frontal, temporal cortex, and hippocampus parts significantly higher in repeated suicide attempters compared to those with first suicide attempt.
Article
Biology
Avinash R. Vaidya, Henry M. Jones, Johanny Castillo, David Badre
Summary: The study uncovered how the human brain adapts flexibly to new conditions without feedback, confirming the existence of a neural instantiation of an abstract task representation. This representation can support massive expansions of behavioral flexibility in human cognition.
Article
Multidisciplinary Sciences
Naoki Miura, Satsuki Noguchi
Summary: Hyperscanning, which measures neural signals in multiple individuals simultaneously, is a useful tool for understanding social interactions. This study investigates the impact of the presence of others without explicit social interaction on neural signals during a self-paced addition task. The results show that being adjacent to another participant enhances interpersonal neural synchronization in the left forehead region, but decreases synchronization in the center of the forehead region. This suggests that the presence of others influences cognitive processing differently from explicit social interaction.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Adriana Boettcher, Saskia Wilken, Nico Adelhoefer, Markus Raab, Sven Hoffmann, Christian Beste
Summary: Sensorimotor integration is a crucial process in daily life, involving the integration of different sensory information. The role of theta- and beta-band activities in this process and the neuroanatomical structures involved were examined. The study found that beta-band activity in parietal cortices plays a role in the initial specification of indicator dynamics. When information about the goal was not accessible, higher theta-band activity in the superior frontal cortex was observed, indicating an increased need for control. Later, theta- and beta-band activities encoded different information within the ventral processing stream. Complex sensorimotor integration is achieved through a cascade of theta- and beta-band activities in a ventral-stream-parieto-frontal network.
Article
Nutrition & Dietetics
Juan C. Laguna, Marta Alegret, Montserrat Cofan, Ana Sanchez-Tainta, Andres Diaz-Lopez, Miguel A. Martinez-Gonzalez, Jose V. Sorli, Jordi Salas-Salvado, Montserrat Fito, Angel M. Alonso-Gomez, Lluis Serra-Majem, Jose Laperra, Miquel Fiol, Enrique Gomez-Gracia, Xavier Pinto, Miguel A. Munoz, Olga Castaner, Judith B. Ramirez-Sabio, Jose J. Portu, Ramon Estruch, Emilio Ros
Summary: This study found an association between intake of simple sugars in drinks and fruit juice and increased risk of overall cancer incidence and mortality, suggesting that sugary beverages may be a modifiable risk factor for cancer and all-cause mortality.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Ana Magdalena Velazquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lazaro, Jose Rodriguez-Morato, Rosa M. Sanchez, Marta Alegret, Nuria Roglans, Juan Carlos Laguna
Summary: This study aims to determine the role of dietary saturated fatty acids (FA) versus liquid fructose in the development of fatty liver and hypertriglyceridemia. The results show that adding liquid fructose to the diet plays a decisive role in the accumulation of liver fat and production of high triglycerides, through increased de novo lipogenesis and reduced fatty acid catabolism.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Cell Biology
J. Roig-Soriano, C. Grinan-Ferre, J. F. Espinosa-Parrilla, C. R. Abraham, A. Bosch, M. Pallas, Miguel Chillon
Summary: This study investigated the expression of Klotho (KL) isoforms using AAV9 to prevent age-related features in a senescence-accelerated mouse model. The results showed that both secreted and transmembrane KL isoforms improved cognitive performance, physical state parameters, and various molecular variables associated with aging. The study also revealed the potential role of KL isoforms in epigenetic regulation and age-related bone structure alteration.
Article
Biochemistry & Molecular Biology
Andrea Bagan, Jose A. Morales-Garcia, Christian Grinan-Ferre, Caridad Diaz, Jose Perez del Palacio, Maria C. Ramos, Francisca Vicente, Belen Perez, Jose Brea, Maria Isabel Loza, Merce Pallas, Carmen Escolano
Summary: The research indicates that modulating imidazoline I-2 receptors can improve cognitive impairment and behavioral condition in patients with neurodegenerative diseases, with representative compound B06 showing potential as a drug candidate for advancing in drug discovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Sandra Codony, Caterina Pont, Christian Grinan-Ferre, Ania Di Pede-Mattatelli, Carla Calvo-Tusell, Ferran Feixas, Silvia Osuna, Julia Jarne-Ferrer, Marina Naldi, Manuela Bartolini, Maria Isabel Loza, Jose Brea, Belen Perez, Clara Bartra, Coral Sanfeliu, Jordi Juarez-Jimenez, Christophe Morisseau, Bruce D. Hammock, Merce Pallas, Santiago Vazquez, Diego Munoz-Torrero
Summary: The advent of multitarget drug discovery has brought hope for the treatment of multifactorial diseases. A new dual inhibitor has shown positive effects on neuroinflammation and memory impairment and exhibits favorable drug properties.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Cristina Rosell-Cardona, Concepcio Amat, Christian Grinan-Ferre, Javier Polo, Merce Pallas, Anna Perez-Bosque, Miquel Moreto, Lluisa Miro
Summary: Supplementation with spray-dried porcine plasma (SDP) reduces Alzheimer's disease (AD) hallmarks in aging mice, potentially through the gut microbiota-gut-brain axis. SDP promotes the proliferation of probiotic species while reducing inflammation-associated bacteria, resulting in anti-inflammatory effects and neuroprotection.
Article
Biochemistry & Molecular Biology
Alejandro Sanchez-Melgar, Pedro J. Izquierdo-Ramirez, Christian Grinan-Ferre, Merce Pallas, Mairena Martin, Jose Luis Albasanz
Summary: Age is a prominent factor for dysregulation of cholesterol metabolism in the brain of SAMP8 mice, and resveratrol exhibits different neuroprotective effects on Aβ processing or cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana Magdalena Velazquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lazaro, Jose Rodriguez-Morato, Rosa Maria Sanchez, Juan Carlos Laguna, Nuria Roglans, Marta Alegret
Summary: The study investigated the anti-steatotic effect of Bempedoic acid (BemA) in a rat model of fatty liver induced by a high-fat diet supplemented with liquid fructose. The results showed that BemA-treated rats exhibited lower body weight, higher liver/body weight, and reduced hepatic steatosis compared to the control group. In addition to inhibiting ATP-citrate lyase (ACLY), BemA was found to have three novel mechanisms, including reducing fructose intake and de novo lipogenesis, increasing liver triglyceride export, and promoting hepatic fatty acid beta-oxidation. These findings suggest that BemA may be a potential approach for treating hepatic steatosis and preventing the progression of non-alcoholic fatty liver disease.
Article
Chemistry, Medicinal
Julia Jarne-Ferrer, Christian Grinan-Ferre, Aina Bellver-Sanchis, Santiago Vazquez, Diego Munoz-Torrero, Merce Pallas
Summary: Alzheimer's disease is a progressive neurological disorder with limited treatment options. However, this study suggests that chronic low-dose co-treatment with sEH and AChE inhibitors may have neuroprotective effects and improve cognition in mouse models.
Article
Cell Biology
Foteini Vasilopoulou, Aina Bellver-Sanchis, Julia Companys-Alemany, Julia Jarne-Ferrer, Alba Irisarri, Veronica Palomera-Avalos, Celia Gonzalez-Castillo, Daniel Ortuno-Sahagun, Coral Sanfeliu, Merce Pallas, Christian Grinan-Ferre
Summary: This study investigates the molecular mechanisms underlying the behavioural and psychological symptoms of dementia (BPSD) in Alzheimer's Disease (AD) patients. It suggests that epigenetic modulation, particularly through G9a methyltransferase and its histone mark (H3K9me2), plays a key role in shaping learning and memory. The study also reveals the association between increased levels of G9a, autophagic deficits, and alterations in synaptic plasticity, providing further understanding of the cognitive decline and BPSD exhibited by the AD model.
Review
Cell Biology
Daniel Ortuno-Sahagun, Julia Enterria-Rosales, Vanesa Izquierdo, Christian Grinan-Ferre, Merce Pallas, Celia Gonzalez-Castillo
Summary: This article discusses the important role of the miR-17-92 cluster in regulating cellular metabolism and autophagy, as well as its potential involvement in the pathogenesis of lysosomal storage diseases.
Article
Biochemistry & Molecular Biology
Clara Bartra, Alba Irisarri, Ainhoa Villoslada, Ruben Corpas, Samuel Aguirre, Elisa Garcia-Lara, Cristina Sunol, Merce Pallas, Christian Grinan-Ferre, Coral Sanfeliu
Summary: Maternal treatment with TPPU during gestation and lactation can prevent or delay memory loss and AD pathology, possibly by modulating the brain's epigenetic machinery and marks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Abhisek Jana, Rahul Naga, Sougata Saha, Christian Grinan-Ferre, Deb Ranjan Banerjee
Summary: In this study, a new natural lead against Protein Lysine Methyltransferase 2 (EHMT2/G9a) was identified using a blended ligand and structure-based pharmacophore screening approach. EHMT2/G9a is associated with cancer, Alzheimer's, and aging, and is considered an emerging drug target. Two pharmacophores, based on the common features of known inhibitors and the interaction profile of crystal structures, were developed and validated. These pharmacophores were used in combination to screen over 741,543 compounds. The screening process also included tests for drug-likeness and toxicity, and the potential inhibitors were further analyzed through docking, simulation, and comparative analysis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Abhisek Jana, Aina Bellver-Sanchis, Christian Grinan-Ferre, Deb Ranjan Banerjee
Summary: In this study, we report for the first time the inhibition of G9a/EHMT2 and the anti-Alzheimer's activities of the drug raltitrexed. Raltitrexed inhibits G9a directly and reduces the levels of H3K9me2/ H3K9 in an AD transgenic worm model. Furthermore, raltitrexed exhibits a safe toxicity/function range and enhances locomotive function in worms, while reducing amyloid beta aggregates.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Andrea Bagan, Sergio Rodriguez-Arevalo, Teresa Taboada-Jara, Christian Grinan-Ferre, Merce Pallas, Iria Brocos-Mosquera, Luis F. Callado, Jose A. Morales-Garcia, Belen Perez, Caridad Diaz, Rosario Fernandez-Godino, Olga Genilloud, Milan Beljkas, Slavica Oljacic, Katarina Nikolic, Carmen Escolano
Summary: This study aims to find molecular entities that modulate imidazoline I-2 receptors (I-2-IRs) as potential therapeutic targets for Alzheimer's disease. The findings demonstrate that the new I-2-IR ligands have beneficial effects in neuroprotection, anti-inflammation, and improvement of cognitive impairment, suggesting their potential as a promising therapeutic strategy for neurodegenerative diseases.