Article
Neurosciences
P. Komirishetty, K. Zubkow, A. Areti, H. Ong, D. W. Zochodne
Summary: The study found that local delivery of Rb1 siRNA can promote nerve regeneration at the outset, enhancing reinnervation of epidermal axons. Combining intrinsic Rb1 knockdown with exogenous insulin can significantly improve growth patterns of adult sensory neurons in vitro and enhance regeneration outcomes in vivo. Overall, the findings highlight the responsiveness of regrowing peripheral neurons to both intrinsic and exogenous approaches that improve their recovery, as well as a novel local approach to manipulate gene expression and outcome in regrowing axons.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Physics, Multidisciplinary
Huanxin Zhang, Kaixuan Zhang, Min Li, Yue Shao, Xi-Qiao Feng
Summary: In this study, a theoretical framework was developed to investigate the force-regulated states and transitions in growing axons. A unique negative feedback mechanism was discovered, defining four distinct kinetic states in the axon growth process. This research provides valuable insights into the understanding of axonal development.
PHYSICAL REVIEW LETTERS
(2022)
Article
Biology
Narrendar Ravichandran, James Hope, Kean Aw, Andrew Mcdaid
Summary: Computational models provide a safe and convenient method to study the excitation of nerve fibers under external stimulation. This study developed a multi-scale model using finite element methods to couple electric fields within macroscopic tissue layers and microscopic nerve fibers. The model captures the excitability of nerve fibers and their interactions with nerve tissue under transcutaneous stimulation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francesco De Nuccio, Marianna Kashyrina, Francesca Serinelli, Florent Laferriere, Dario Domenico Lofrumento, Francesca De Giorgi, Francois Ichas
Summary: alpha-Synucleinopathies are neurodegenerative disorders characterized by the accumulation of insoluble alpha-Synuclein fibrils. These fibrils can form Lewy bodies in somata and Lewy neurites in neuronal processes. In multiple system atrophy, alpha-Synuclein aggregates are found in mature oligodendrocytes, but the origin of these aggregates is still unknown.
Review
Cell Biology
Bruna Andrade Aguiar Koga, Leticia Alves Fernandes, Paula Fratini, Mari Cleide Sogayar, Ana Claudia Oliveira Carreira
Summary: Mesenchymal stem cells (MSCs) secrete vesicles known as extracellular vesicles (EVs), which play a crucial role in tissue homeostasis, repair, and therapeutic applications. MSC-derived EVs have advantages such as low immunogenicity and the ability to pass through barriers, making them potential drug delivery agents for various diseases. Extensive in vitro studies have been conducted to understand the mechanisms and signaling pathways of EVs. Clinical trials are underway to explore the therapeutic potential of EVs in Alzheimer's disease, retina degeneration, and COVID-19. This review provides an overview of different EV isolation methods and highlights their therapeutic applications in tissue repair and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Alexander M. Hilla, Annemarie Baehr, Marco Leibinger, Anastasia Andreadaki, Dietmar Fischer
Summary: Regenerative failure in the optic nerve is attributed to a chemoattractive CXCL12/CXCR4-dependent mechanism that prevents growth-stimulated axons from regenerating distally. Depletion of CXCR4 or CXCL12 reduces aberrant axonal growth and enables long-distance regeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Xiaorong Pan, Jie Li, Wei Li, Haofei Wang, Nela Durisic, Zhenyu Li, Yu Feng, Yifan Liu, Chun-Xia Zhao, Tong Wang
Summary: Researchers have successfully modeled DAI and monitored instant cellular responses using an "axon-on-a-chip" (AoC) model. They found that the severity of DAI is correlated with the intensity of the mechanical impact. Additionally, they observed periodic disruption of the axonal cytoskeleton after the impact. These findings provide insights into the early mechanisms of DAI and offer a platform for screening effective treatments for TBI.
Review
Medicine, General & Internal
Tito Sumarwoto, Heri Suroto, Ferdiansyah Mahyudin, Dwikora Novembri Utomo, Romaniyanto, Damayanti Tinduh, Hari Basuki Notobroto, Cita Rosita Sigit Prakoeswa, Fedik Abdul Rantam, Sholahuddin Rhatomy
Summary: The use of stem cells, especially Mesenchymal Stem Cells (MSCs), has become a breakthrough in medical biotechnology, bringing regenerative therapy to a new era. Stem cells have shown effectiveness in treating various diseases through their tissue protective and repair mechanisms, particularly in the case of peripheral nerve injury where surgical procedures are unable to fully restore function. Adipose mesenchymal stem cells (AdMSCs) have emerged as a promising option for regenerating peripheral nerves.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Cell Biology
Supraja G. Varadarajan, Fei Wang, Onkar S. Dhande, Phung Le, Xin Duan, Andrew D. Huberman
Summary: The wiring of visual circuits involves signaling between retinal axons and postsynaptic targets. Damage to these connections from the eye to the brain can result in vision loss. This study shows that enhancing neural activity in the postsynaptic visual target neurons promotes axon regeneration and target reinnervation, leading to the restoration of optomotor function. Targeted activation of retinorecipient neuron subsets is sufficient to promote axon regeneration. These findings highlight the importance of postsynaptic neuronal activity in neural circuit repair and the potential for restoring damaged sensory inputs through proper brain stimulation.
Article
Biology
Mohsen Khedr, Nashwa Barakat, Ibrahem Mohey El-Deen, Faten Zahran
Summary: The study investigated the effects of preconditioning adipose-derived stem cells (ADMSCs) with all-trans retinoic acid (ATRA) on cisplatin-induced acute kidney injury (AKI). The results showed that preconditioning ADMSCs with ATRA improved cell viability and ameliorated kidney functions after cisplatin injection. ATRA reduced serum creatinine, microalbuminuria, and NO levels, while increasing creatinine clearance, SOD activity, and the expression of HIF1, VEGF, and CD31. Additionally, ATRA down-regulated caspase-3, IL-6, and TGF01 expression, indicating its protective effects against apoptosis and inflammation.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Engineering, Biomedical
Lorella Giovannelli, Elia Bari, Claudio Jommi, Fulvio Tartara, Daniele Armocida, Diego Garbossa, Fabio Cofano, Maria Luisa Torre, Lorena Segale
Summary: Neurodegenerative diseases are a growing healthcare burden globally. Mesenchymal stem cells (MSCs) have potential as a therapy due to their neuroregenerative, neuroprotective, and immunomodulatory properties through their secretome. This paper provides an overview of recent research on the safety and efficacy of MSC-derived secretome and extracellular vesicles (EVs) in various neurodegenerative diseases, and discusses the challenges and potential future directions for translating them into clinical use.
BIOACTIVE MATERIALS
(2023)
Article
Neurosciences
Mustafa M. Siddiq, Carlos A. Toro, Nicholas P. Johnson, Jens Hansen, Yuguang Xiong, Wilfredo Mellado, Rosa E. Tolentino, Kaitlin Johnson, Gomathi Jayaraman, Zaara Suhail, Lauren Harlow, Jinye Dai, Kristin G. Beaumont, Robert Sebra, Dianna E. Willis, Christopher P. Cardozo, Ravi Iyengar
Summary: This study reveals the importance of axonal RNA in neurorepair after spinal cord injury. The circRNA Rims2 is identified as a regulator of axonal translation and regeneration. The inhibition of circRNA formation by ADAR1 promotes axonal outgrowth in cortical neurons, suggesting the significance of axonal regulatory pathways in neurorepair.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Agnieszka Miklosz, Barbara Emilia Nikitiuk, Adrian Chabowski
Summary: Obesity is a critical risk factor for metabolic diseases, but adipose-derived mesenchymal stem cells (ADMSCs) have shown potential in improving pancreatic islet cell function and reducing inflammation and oxidative stress in experimental studies. However, there is a lack of clinical studies using ADMSCs for treating metabolic complications, and further research is needed to establish their safety and efficacy in humans.
Article
Neurosciences
Sierra D. Kauer, Kathryn L. Fink, Elizabeth H. F. Li, Brian P. Evans, Noa Golan, William B. J. Cafferty
Summary: The failure of CNS neurons to grow significantly after trauma is a contributing factor to chronic functional deficits. This study identified several candidates that stimulate axon growth in both in vitro and in vivo models through activator and repressor screening and transcriptional profiling. Inpp5k was found to be a novel CST growth activator capable of driving compensatory axon growth in multiple complex CNS injury environments.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Justin C. Burrell, Suradip Das, Franco A. Laimo, Kritika S. Katiyar, Kevin D. Browne, Robert B. Shultz, Vishal J. Tien, Phuong T. Vu, Dmitriy Petrov, Zarina S. Ali, Joseph M. Rosen, D. Kacy Cullen
Summary: Surgical repair of nerve injuries often leads to poor functional recovery due to the limited ability of host axons to regenerate and form connections with target muscles. This study introduces tissue engineered neuromuscular interfaces (TE-NMIs) as an injectable microtissue containing motor and sensory neurons, aiming to enhance regenerative capacity and functional recovery. The results demonstrate that TE-NMIs can support Schwann cell maintenance, integrate with distal muscles, and preserve muscle response even without innervation from host axons. Additionally, repopulating the distal sheath with exogenous axons enables delayed fusion with proximal host axons, improving axon maturation and muscle reinnervation.
BIOACTIVE MATERIALS
(2022)
Article
Surgery
Clement J. Staud, Maximilian Zaussinger, Dominik Duscher, Christine Radtke, Raphael Wenny, Manfred Schmidt, Georg M. Huemer
Summary: This study presents a modified tube-in-tube concept combining a radial forearm free flap and an anterolateral thigh flap for phalloplasty in female-to-male transsexuals. The study aims to assess the outcome of this surgical approach.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Nutrition & Dietetics
Arabella Fischer, Anatol Hertwig, Ricarda Hahn, Martin Anwar, Timo Siebenrock, Maximilian Pesta, Konstantin Liebau, Isabel Timmermann, Jonas Brugger, Martin Posch, Helmut Ringl, Dietmar Tamandl, Michael Hiesmayr
Summary: This study aimed to investigate the feasibility of ultrasound in predicting skeletal muscle area. The results showed that one single ultrasound measuring point at the thigh, along with sex, height, and weight, can effectively predict CT L3 SMA, which is important for assessing muscle mass.
CLINICAL NUTRITION
(2022)
Article
Oncology
Maryana Teufelsbauer, Clemens Lang, Adelina Plangger, Barbara Rath, Doris Moser, Clement Staud, Christine Radtke, Christoph Neumayer, Gerhard Hamilton
Summary: Metformin is found to inhibit the proliferation of BM-MSCs and reduce the migration of breast cancer cell lines. The effects of conditioned media from drug-pretreated BM-MSCs on breast cancer cell lines vary depending on the specific combinations. Metformin may affect metastasis by altering the expression of adipokines and increasing osteogenic signaling in BM-MSCs' conditioned media.
Letter
Surgery
Paul Supper, Lorenz Semmler, Christine Radtke
Article
Multidisciplinary Sciences
Maria Laggner, Marie-Therese Lingitz, Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Alfred Gugerell, Bernhard Moser, Christine Radtke, Stefan Hacker, Michael Mildner, Hendrik Jan Ankersmit, Thomas Haider
Summary: Burn injuries elicit a unique stress response and can lead to burn injury progression. This study found that levels of neutrophil-derived factors were significantly elevated in burn victims, and leukocyte and neutrophil counts were increased while lymphocytes were decreased. These factors did not predict mortality, but were associated with higher burn severity scores in patients with third-degree burns.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Olivia Aschacher, Alexandra Kaider, Nikolaus Sternat, Ines Ana Ederer, Simona Stievano, Christine Radtke, Stefan Hacker, Reinhard Pauzenberger
Summary: According to the International Diabetes Federation, the number of people with diabetes mellitus worldwide is expected to double in the next 20 years. Data on diabetic patients in burn intensive care units are limited, and the effects on mortality rate are unclear. A retrospective study evaluated risk factors, clinical outcomes, and patient population of diabetic patients after severe burn injuries over a 21-year period. Results showed stable ratio of diabetic burn patients and identified risk factors for mortality. Diabetes was not directly associated with higher mortality rate after burn injury, but had a significant effect when considering burn area percentage. The study highlighted the higher mortality rates of diabetic patients with larger burn areas in severely burned patients.
Editorial Material
Dermatology
Doha Obed, Nicco Krezdorn, Elissa Harik-Chraim, Christian Freystaetter, Christine Radtke, Peter M. Vogt
Summary: Self-attempted liquid body contouring through injection of site-enhancing oils (SEOs) can lead to serious health complications, including pain, infection, and systemic complications. Timely surgical treatment may be necessary.
CLINICS IN DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anton Borger, Sarah Stadlmayr, Maximilian Haertinger, Lorenz Semmler, Paul Supper, Flavia Millesi, Christine Radtke
Summary: miRNAs play a crucial role in peripheral nerve injuries by regulating specific pathways and proteins, which is essential for understanding the molecular mechanisms of nerve regeneration and providing targets for precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Martin Direder, Tamara Weiss, Dragan Copic, Vera Vorstandlechner, Maria Laggner, Karin Pfisterer, Caterina Selina Mildner, Katharina Klas, Daniel Bormann, Werner Haslik, Christine Radtke, Matthias Farlik, Lisa Shaw, Bahar Golabi, Erwin Tschachler, Konrad Hoetzenecker, Hendrik Jan Ankersmit, Michael Mildner
Summary: This study identifies a unique population of Schwann cells in keloids and highlights the interaction between Schwann cells and macrophages in keloid formation.
Article
Neurosciences
Anda Mann, Bibiane Steinecker-Frohnwieser, Aida Naghilou, Flavia Millesi, Paul Supper, Lorenz Semmler, Sonja Wolf, Lena Marinova, Lukas Weigl, Tamara Weiss, Christine Radtke
Summary: This study investigated the effect of low nuclear magnetic resonance therapy (NMRT) on cells involved in peripheral nerve regeneration. The results showed that NMRT stimulated Schwann cell proliferation and promoted dorsal root ganglion neuron regeneration. Furthermore, the medium obtained from NMRT treated Schwann cell cultures supported neuron survival and neurite outgrowth.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Clement J. Staud, Maximilian Zaussinger, Matthias Holzbauer, Alexandra Christ, Hannes Beiglboeck, Karin Unterberger, Christine Radtke
Summary: This study evaluated the impact of age, comorbidities, and sex on plastic and reconstructive patients aged 75 years and older admitted to the intensive care unit (ICU). The results showed that age and number of operations were significant predictors for death in the ICU.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Letter
Surgery
Annika Resch, Christine Radtke
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Immunology
Felix Bergmann, Lena Pracher, Rebecca Sawodny, Amelie Blaschke, Georg Gelbenegger, Christine Radtke, Markus Zeitlinger, Anselm Jorda
Summary: The study showed that adjunctive systemic corticosteroid therapy in adult patients hospitalized with community-acquired pneumonia was associated with a reduction in all-cause mortality by day 30, without increasing the risk of adverse events.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Materials Science, Biomaterials
Felix Bergmann, Sarah Stadlmayr, Flavia Millesi, Markus Zeitlinger, Aida Naghilou, Christine Radtke
Summary: Spider silk has unique characteristics and a wide range of applications, with its high strength, extensibility, and biocompatibility making it a promising natural material for biomedical applications. It has been the focus of scientific research in recent decades.
BIOMATERIALS ADVANCES
(2022)
Article
Medicine, General & Internal
Zuzana Simkova Gabrielova, Pavol Macho, Jozef Fedeles, Lukas Simko, Christine Radtke, Lucia Demesova
Summary: This retrospective study evaluated the results of four different surgical approaches to palatoplasty, finding that patients with complete cleft palate had a significantly higher rate of secondary correction. The Bardach procedure had a higher rate of additional surgery, while the von Langenbeck procedure had the lowest revision rate.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2022)
