Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Chemistry, Medicinal
Thuy Le Lam Nguyen, Yujin Jin, Lila Kim, Kyung-Sun Heo
Summary: This study found that 6'SL, a human milk oligosaccharide, can reverse abnormal function of vascular smooth muscle cells stimulated by Ang II, inhibit cell proliferation and migration, and reduce osteogenic switching. 6'SL works by inhibiting the ERK1/2/p90RSK and NF-kappa B signaling pathways, as well as reducing AP-1 activity.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Peripheral Vascular Disease
Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, Satoru Eguchi
Summary: Smooth muscle AT(1A) receptors mediate Ang II-induced vascular remodeling in both hypertensive and non-hypertensive conditions, contributing to medial hypertrophy and perivascular fibrosis. These findings indicate an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lucie Pothen, Roxane Verdoy, Delphine De Mulder, Hrag Esfahani, Charlotte Farah, Lauriane Y. M. Michel, Flavia Dei Zotti, Bertrand Bearzatto, Jerome Ambroise, Caroline Bouzin, Chantal Dessy, Jean-Luc Balligand
Summary: This study evaluated the long-term effects of transient exposure to Ang II on the mouse heart and arterial tissue. It was found that transient exposure to Ang II leads to prolonged vascular remodeling and downregulation of ACTA2, which is independent of blood pressure normalization and associated with systemic oxidative stress.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Luckika Panthiya, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: This study found that hexahydrocurcumin (HHC) can suppress the proliferation, migration, and inflammation of vascular smooth muscle cells (VSMCs) in the development of atherosclerosis and hypertension. HHC can exert its protective effects by inhibiting NADPH oxidase-mediated ROS generation and increasing the expression of PPAR-gamma and PGC-1 alpha.
Article
Biochemistry & Molecular Biology
Haiying Yang, Jie Liu, Xue Chen, Guobin Li
Summary: Angptl2 expression is elevated in hypertension and Ang II-stimulated VSMCs. Knockdown of Angptl2 suppresses VSMC proliferation, migration, and invasion, suggesting it as a potential target for vascular remodeling in hypertension.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kinga Bernadett Kovacs, Laura Szalai, Pal Szabo, Janka Borbala Gem, Szilvia Barsi, Bence Szalai, Bernadett Perey-Simon, Gabor Turu, Andras David Toth, Peter Varnai, Laszlo Hunyady, Andras Balla
Summary: Angiotensin II (AngII) and 25-hydroxycholesterol (25-HC) both play detrimental roles in cardiovascular health. AngII stimulation was found to significantly upregulate Ch25h mRNA levels in vascular smooth muscle cells (VSMCs), with the upregulation being dependent on type 1 angiotensin II receptor and G(q/11) activity. The production of 25-HC in VSMCs was observed to peak 4 hours after AngII stimulation. These findings provide insights into the connection between AngII stimulus and 25-HC production, potentially leading to new understandings of vascular impairments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Vishnu Amaram Samara, Sadhan Das, Marpadga A. Reddy, Vinay Singh Tanwar, Kenneth Stapleton, Amy Leung, Maryam Abdollahi, Rituparna Ganguly, Linda Lanting, Rama Natarajan
Summary: This study identified a novel AngII-induced lncRNA, Alivec, which plays a crucial role in the chondrogenic transformation of VSMCs. Alivec is co-regulated by AngII, growth factors, and inflammatory cytokines, and its knockdown attenuated the expression of chondrogenic marker genes in VSMCs. These findings suggest that AngII-regulated lncRNA Alivec is involved in the vascular dysfunction and hypertension caused by the chondrogenic transformation of VSMCs.
Article
Hematology
Jung-Min Park, Van Quan Do, Yoon-Seok Seo, Hyun Jong Kim, Joo Hyun Nam, Ming Zhe Yin, Hae Jin Kim, Sung Joon Kim, Kathy K. Griendling, Moo-Yeol Lee
Summary: This study reveals that NOX1 mediates the generation of Ca2+ signals and contributes to vascular contraction and blood pressure elevation induced by Ang II.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hisashi Sawada, Yuriko Katsumata, Hideyuki Higashi, Chen Zhang, Yanming Li, Stephanie Morgan, Lang H. Lee, Sasha A. Singh, Jeff Z. Chen, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Debra L. Rateri, Ying H. Shen, Scott A. LeMaire, Masanori Aikawa, Mark W. Majesky, Hong S. Lu, Alan Daugherty
Summary: The study revealed that SHF-derived cells play a critical role in thoracic aortopathies by maintaining vascular integrity through LRP1 and transforming growth factor-beta signaling associated with increased levels of aortic PAI1.
Article
Medicine, Research & Experimental
Yishu Luo, Chen Huang
Summary: The study showed that circSFMBT2 is upregulated in neointimal tissue and PDGF-BB-treated VSMCs, and its knockdown inhibits VSMC proliferation and migration while enhancing the expression of contractile markers. CircSFMBT2 was found to regulate VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis, suggesting a potential novel target for treating proliferative vascular diseases.
Article
Biotechnology & Applied Microbiology
Buxiong Tuo, Jie Xu, Wenqiang Zhang, Xiaomiao Li, Lijing Peng, Qian Zou, Ying Deng, Junning Lei, Hui Li
Summary: Angiotensin II-induced vascular smooth muscle cell (VSMC) remodeling and dysfunction play a significant role in hypertension development. Angiotensin II reduces the expression of Bcl-xL, resulting in mitochondrial uncoupling in VSMCs. miR-140-5p upregulation targets Bcl-xL, leading to mitochondrial uncoupling, suggesting that miR-140-5p and Bcl-xL could be potential targets in the treatment of vascular dysfunction.
Article
Cell Biology
Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen
Summary: This study reveals the defective mechanosensation of vascular smooth muscle cells (VSMCs) during aging, leading to a decline in their ability to sense and adapt to mechanical perturbations. Aged VSMCs exhibit a relatively inert mechanobiological state with altered actin cytoskeletal integrity, resulting in impaired mechanosensitivity and dynamic mechanoresponse. This decline in mechanosensation is mediated by hyperactivity of Piezo1-dependent calcium signaling. Inhibition of Piezo1 can alleviate vascular aging and partially restore the loss in dynamic contractile properties in aged cells.
Article
Biochemistry & Molecular Biology
Diem Thi Ngoc Huynh, Yujin Jin, Dung Van Nguyen, Chang-Seon Myung, Kyung-Sun Heo
Summary: This study found that ginsenoside Rh1 inhibits the migration and proliferation of rat aortic smooth muscle cells (RASMCs) induced by angiotensin II by suppressing the ROS-mediated ERK1/2/p90RSK signaling pathway.