Article
Food Science & Technology
Johannes Grosch, Bernadette Eberlein, Sebastian Waldherr, Mariona Pascal, Clara San Bartolome, Federico De La Roca Pinzon, Michael Dittmar, Christiane Hilger, Markus Ollert, Tilo Biedermann, Ulf Darsow, Maria Beatrice Bilo, Carsten B. Schmidt-Weber, Simon Blank
Summary: Differentiating between Polistes dominula and Vespula spp. venom allergies is crucial, with potential new allergens identified from P. dominula venom to improve diagnostic accuracy for Hymenoptera venom allergies. The characterization of these venom proteins contributes to a better understanding of molecular mechanisms and allergenic potential.
Article
Agriculture, Multidisciplinary
Yeting Wu, Youyou Lu, Yuhao Huang, Junyu Wang, Siyue Li, Mengyao Xu, Hong Lin, Zhenxing Li
Summary: This study investigated the effect of glycosylation on the allergenicity of fish parvalbumin (PV). Glycosylation was found to decrease the binding of immunoglobulin E (IgE) to PV and improve its resistance to digestion. Moreover, glycosylation was shown to reduce cross-reactivity between different species of fish.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Allergy
Moritz M. Hollstein, Silke S. Matzke, Lisa Lorbeer, Stephan Traidl, Susann Forkel, Christian Moebs, Thomas Fuchs, Christiane Lex, Timo Buhl
Summary: The study aimed to evaluate the benefit of measuring venom-induced wheal area in intracutaneous skin tests (ICT) for the diagnosis of severe vespid venom allergy and during follow-up of allergen immunotherapy (AIT). The results showed that wheal area evaluation did not provide additional information over specific IgE analysis, suggesting that ICT should be used only as a secondary measure for confirming serological test results.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Dragana Jovanovic, Aleksandra Peric-Popadic, Vojislav Djuric, Maja Stojanovic, Branislav Lekic, Ognjen Milicevic, Branka Bonaci-Nikolic
Summary: This study analyzed the diagnostic importance of recombinant honeybee allergens and proposed a repositioning of venom immunotherapy for patients with honeybee sting. The results showed that the combination of recombinant honeybee allergens and cross-reactive carbohydrate determinants can diagnose honeybee sting allergy, reducing the testing time and cost for patients with multiple stings.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Letter
Allergy
Wen-Cheng Chao, Wen-Ting Liao, Jing-Rong Wang, Hsiao-Ni Sung, Hsin-Hua Chen, Fang-Ping Lin, Jou-Yu Huang, Kuan-Ting Liu, Tai-Ming Ko
Summary: Through single-cell transcriptomic profiling of HVA patients, we identified previously unknown molecular changes, providing important insights into the mechanism of venom allergy and potential therapeutic targets.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Medicine, General & Internal
Ali Selcuk, Abdullah Baysan, Sait Yesillik, Fevzi Demirel, Ozgur Kartal, Mustafa Gulec, Ugur Musabak, Osman Sener
Summary: This article evaluates the safety of conventional and ultra-rush build-up protocols in patients with honeybee and wasp venom allergy and finds that both protocols are well tolerated. The ultra-rush protocol is preferred due to its advantages in terms of time and costs, making it a suitable option for both patients and clinicians.
ANNALS OF MEDICINE
(2022)
Review
Allergy
Yuma Fukutomi, Yuji Kawakami
Summary: Airborne insect particles are identified as a significant cause of respiratory allergies, not only among occupationally exposed individuals, but also among asthma and rhinitis patients with no occupational exposure to insects. Cockroaches and booklice are common indoor insects associated with asthma development and exacerbation, while moths are considered a significant seasonal outdoor allergen.
ALLERGOLOGY INTERNATIONAL
(2021)
Review
Food Science & Technology
Martin Feindor, Matthew D. Heath, Simon J. Hewings, Thalia L. Carreno Velazquez, Simon Blank, Johannes Grosch, Thilo Jakob, Peter Schmid-Grendelmeier, Ludger Klimek, David B. K. Golden, Murray A. Skinner, Matthias F. Kramer
Summary: This review delves into the important distinctions between allergen-specific immunotherapy for inhalant allergies and venom-specific immunotherapy, focusing on Venomil(R) Bee and Wasp. It discusses historical safety and efficacy studies, characterization and standardization of venom marker allergens, quality differences between products, and considerations for enhancing VIT with depot adjuvants. These discussions highlight the ongoing research and discussions surrounding treatment outcomes and product quality.
Review
Allergy
O. Luengo, M. Labrador-Horrillo
Summary: This article discusses the application of molecular allergy diagnosis (MD) in clinical practice. It emphasizes the importance for clinicians to understand the allergens in allergenic sources before using MD. It also reviews the usefulness of MD and answers frequently asked questions in clinical practice. Additionally, it addresses the interpretation of MD and its integration with other allergy diagnostic tools.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Maria-Roxana Buzan, Lauriana-Eunice Zbircea, Pia Gattinger, Elijahu Babaev, Frank Stolz, Rudolf Valenta, Virgil Paunescu, Carmen Panaitescu, Kuan-Wei Chen
Summary: The study found that ragweed pollen allergic patients have complex IgE reactivity profiles, including Amb a 1 isoforms and cross-reactive carbohydrates. This indicates the importance of Amb a 1 and additional allergens for the diagnosis and treatment of ragweed allergy.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Microbiology
Sunish Shah, Lloyd G. Clarke, Kathleen K. Adams
Summary: Results from a large multicenter study suggest that patients with confirmed hypersensitivity reactions to ciprofloxacin, moxifloxacin, or levofloxacin are likely to tolerate other fluoroquinolones. Avoiding different fluoroquinolones in patients with labeled allergies to ciprofloxacin, moxifloxacin, or levofloxacin may not always be necessary.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Allergy
Wojciech Francuzik, Franziska Rueeff, Andrea Bauer, Maria Beatrice Bilo, Victoria Cardona, George Christoff, Sabine Doelle-Bierke, Luis Ensina, Montserrat Fernandez Rivas, Thomas Hawranek, Jonathan O'b Hourihane, Thilo Jakob, Nicos G. Papadopoulos, Claudia Pfoehler, Iwona Poziomkowska-Gesicka, Xavier Van der Brempt, Kathrin Scherer Hofmeier, Regina Treudler, Nicola Wagner, Bettina Wedi, Margitta Worm
Summary: The study evaluated the phenotype and risk factors of venom-induced anaphylaxis (VIA) using data from the European Anaphylaxis Registry. VIA more frequently involved multiple organ systems and was associated with cardiovascular symptoms, while the absence of skin symptoms during anaphylaxis was correlated with a higher risk of severe reactions. Patients with intermediate baseline serum tryptase levels and without skin involvement had a higher risk of severe VIA. Patients receiving beta-blockers or angiotensin-converting enzyme inhibitors had a higher risk of developing severe cardiovascular symptoms in VIA and non-VIA cases, where patients experiencing VIA received epinephrine less frequently than cases with non-VIA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Julie Wang, David B. K. Golden, David A. Khan
Summary: An accurate diagnosis of IgE-mediated allergies is crucial for managing severe allergic reactions. However, currently available laboratory tests have limitations, especially when it comes to diagnosing drug allergies. Researchers are exploring alternative laboratory testing methods to improve diagnostic accuracy and predict treatment responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Agriculture, Multidisciplinary
Chuang Yu, Xue Ding, Xiang Gao, Hong Lin, Mati Ullah Khan, Hang Lin, Xuewen Dang, Zhenxing Li
Summary: This study investigated the cross-reactivity between marine molluscs and mites, finding that different mollusc groups and mite-mollusc showed varying degrees of cross-reactivity. The most frequently recognized cross-reactive protein was identified as paramyosin, which played an important role in molluscan and mite-molluscan cross-reactivity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Matysiak, Eliza Matuszewska, Kacper Packi, Agnieszka Klupczynska-Gabryszak
Summary: This review discusses the diagnostic challenges of Hymenoptera venom allergy, including a description of insect venoms and diagnostic tests. It also explores common diagnostic issues and the search for new diagnostic capabilities using modern methodologies. Despite recent developments, new testing methods are still needed to address unanswered questions and uncertainties in this field.
Article
Ornithology
Roxiris A. Azuaje-Rodriguez, Jason D. Weckstein, Janice H. Dispoto, Swati Patel, Joseph A. Cacioppo, John M. Bates, Sofia Marques Silva, Alexandre Aleixo
Review
Zoology
Murilo N. L. Pastana, Flavio A. Bockmann, Alessio Datovo
ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2020)
Article
Biochemical Research Methods
Marcel Pratavieira, Anally Ribeiro da Silva Menegasso, Thaisa Roat, Osmar Malaspina, Mario Sergio Palma
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Cell Biology
Caroline Natania de Souza-Araujo, Claudia Rodrigues Tonetti, Marcella Regina Cardoso, Liliana Aparecida Lucci de Angelo Andrade, Rodrigo Fernandes da Silva, Luis Gustavo Romani Fernandes, Fernando Guimaraes
Article
Biochemistry & Molecular Biology
Danubia Batista Martins, Carolina Colombelli Pacca, Annielle Mendes Brito da Silva, Bibiana Monson de Souza, Margarete Teresa Gottardo de Almeida, Mario Sergio Palma, Manoel Arcisio-Miranda, Marcia Perez dos Santos Cabrera
Article
Biotechnology & Applied Microbiology
Amilcar Perez-Riverol, Alexis Musacchio-Lasa, Luis Gustavo Romani Fernandes, Jose Roberto Aparecido dos Santos-Pinto, Franciele Grego Esteves, Murilo Luiz Bazon, Ricardo de Lima Zollner, Mario Sergio Palma, Marcia Regina Brochetto-Braga
Review
Entomology
Dirk C. de Graaf, Marcia Regina Brochetto Braga, Rusleyd Maria Magalhaes de Abreu, Simon Blank, Chris H. Bridts, Luc S. De Clerck, Bart Devreese, Didier G. Ebo, Timothy J. Ferris, Margo M. Hagendorens, Debora Lais Justo Jacomini, Iliya Kanchev, Zenon J. Kokot, Jan Matysiak, Christel Mertens, Vito Sabato, Athina L. Van Gasse, Matthias Van Vaerenbergh
Summary: Honey bees possess a sting used to inject venom, sparking interest in its potential therapeutic and allergenic properties. This paper provides insight into standardized methods for researching honey bee venom, covering collection techniques, biological activity determination, and application in biomedical research.
JOURNAL OF APICULTURAL RESEARCH
(2021)
Article
Cell Biology
Ana Maria Costa-Leonardo, Iago Bueno da Silva, Vanelize Janei, Silvana Beani Poiani, Jose Roberto Aparecido dos Santos-Pinto, Franciele Grego Esteves, Mario Sergio Palma
Summary: Salivary glands in termites play important roles in feeding and defense, with complex structures and distinct characteristics. Proteomic analysis of the salivary glands revealed various functional groups of proteins, indicating their potential roles in social aspects of different termite species.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell Biology
Claudia Rodrigues Tonetti, Caroline Natania de Souza-Araujo, Adriana Yoshida, Rodrigo Fernandes da Silva, Paulo Cesar Martins Alves, Tais Nitsch Mazzola, Sophie Derchain, Luis Gustavo Romani Fernandes, Fernando Guimaraes
Summary: Ovarian cancer, particularly the serous histotype, is a deadly malignancy with frequent comorbidity of peritoneal ascites. Ascites from EOC patients provide a valuable sampling source for studying lymphocytes, revealing an inflammatory and immunosuppressive environment with altered signaling pathways. NK and T lymphocytes in EOC-associated ascites exhibit distinct phenotypic changes compared to blood samples, suggesting a complex interplay between the tumor microenvironment and immune cells.
Article
Biochemistry & Molecular Biology
Nayara Simon Gonzalez Schumacher, Lus Gustavo Romani Fernandes, Ricardo de Lima Zollner
Summary: A study found that the use of extract from Passiflora alata leaves can modulate bone marrow-derived professional antigen-presenting cells, reducing the proliferation of CD4 and CD8 T cells in diabetic mice and decreasing cytokine release in cell cultures. In addition, an increase in CD4(+)CD25(+)FoxP3(+) Tregs was observed in cell cultures from diabetic mice.
Article
Immunology
Marcos Vinicius de Sousa, Luis Gustavo Romani Fernandes, Leandro Luiz Lopes de Freitas, Ricardo de Lima Zollner, Marilda Mazzali
Summary: This study retrospectively analyzed membranous nephropathy (MN) associated with antibody-mediated rejection in kidney transplant recipients and found that de novo MN is characterized by antibody-mediated activation despite the use of maintenance immunosuppression.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Biochemistry & Molecular Biology
Talita Cristina Colomeu, Daniella de Figueiredo, Priscila de Matos da Silva, Luis Gustavo Romani Fernandes, Ricardo de Lima Zollner
Summary: The presence of polyphenols in the Passiflora alata Curtis plant gives it antioxidant, anti-inflammatory, and antiproliferative properties. However, depending on their concentration and interaction with other molecules, these polyphenols may also have a pro-oxidant effect. This study evaluated the effects of the aqueous leaf extract of P. alata and its polyphenols on lymphocyte proliferation, viability, cell cycle, and oxidative stress. The results showed that these substances inhibited lymphocyte proliferation, caused cell injury and death.
Article
Chemistry, Analytical
AnaIly Ribeiro da Silva Menegasso, Marcel Pratavieira, Lucilene Delazari dos Santos, Flavio de Oliveira Lima, Marcelo Padovani T. Moraes, Marco Antonio Zanini, Mario Sergio Palma
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Applied
Gema Nunez-Lopez, Sandrine Morel, Lazaro Hernandez, Alexis Musacchio, Lorena Amaya-Delgado, Anne Gschaedler, Magali Remaud-Simeon, Javier Arrizon
CARBOHYDRATE POLYMERS
(2020)