Review
Plant Sciences
Maria Jose Garcia, Macarena Angulo, Carlos Lucena, Rafael Perez-Vicente, Francisco Javier Romera
Summary: To cope with nutrient scarcity, plants employ two main strategies - stopping growing to reduce nutrient demand, and searching for nutrients through physiological and morphological responses in roots. The interconnection between these strategies is not well understood, but recent research suggests that the plant hormone ethylene may play a crucial role in connecting them. The TOR system is known to be a central regulator of growth in response to nutrients, and ethylene activation is involved in many nutrient deficiency responses.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Alicja B. Kunkowska, Fabrizia Fontana, Federico Betti, Raphael Soeur, Gerold J. M. Beckers, Christian Meyer, Geert De Jaeger, Daan A. Weits, Elena Loreti, Pierdomenico Perata
Summary: Plants respond to oxygen deprivation by activating a set of hypoxia-responsive genes through a group of transcription factors. However, the activity of these factors is greatly reduced when the plant has limited sugar reserves, suggesting the involvement of another sensing pathway related to energy availability. The energy sensor target of rapamycin (TOR) is responsible for the oxygen sensing in plants, and its inhibition leads to a lower induction of hypoxia-responsive genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Plant Sciences
Anthony Artins, Camila Caldana
Summary: Plants capture light energy to convert carbon dioxide into essential substances for growth and development. The Target Of Rapamycin (TOR) signalling pathway plays a crucial role in sensing and regulating energy and nutrient availability. Recent research has highlighted the importance of this pathway in maintaining metabolic homeostasis and controlling growth and development across different tissues and organs in plants.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenjia Xu, Hikaru Sato, Heinrich Bente, Juan Santos-Gonzalez, Claudia Koehler
Summary: During seed maturation, endosperm cellularization is required for the embryo to establish dehydration tolerance and survive. Triploid Arabidopsis thaliana embryos surrounded by uncellularized endosperm show an osmotic stress response related to increased levels of abscisic acid (ABA). Impairing ABA biosynthesis and signaling aggravates triploid seed abortion, while increasing endogenous ABA levels or applying exogenous ABA induces endosperm cellularization and suppresses embryo growth arrest.
Review
Plant Sciences
Yoshiaki Kamiyama, Sotaro Katagiri, Taishi Umezawa
Summary: Recent studies have shown that SnRK2s play a central role in modulating plant growth and osmotic stress signaling through various pathways, including activation mechanisms independent of ABA and regulation through TOR signaling. These findings provide important insights for further research on plant growth and stress responses.
Article
Plant Sciences
Sotaro Katagiri, Yoshiaki Kamiyama, Kota Yamashita, Sara Iizumi, Risa Suzuki, Yuki Aoi, Fuminori Takahashi, Hiroyuki Kasahara, Toshinori Kinoshita, Taishi Umezawa
Summary: Plants adopt different strategies in response to drought stress depending on its intensity and duration. This study reveals that SNF1-related protein kinase 2 substrate 1 plays a role in growth regulation under drought conditions. It contributes to maintaining growth and promoting flowering by repressing stress-responsive genes and inducing FLOWERING LOCUS T expression. The phosphorylation and accumulation of SNS1 in plants reflect the intensity and duration of stress and can serve as a molecular scale for maintaining growth and adopting optimal drought tolerance strategies.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Ecology
Jingyi Ding, Samantha K. Travers, David J. Eldridge
Summary: The study in Eastern Australia found that as aridity increased, plant height decreased while branching, canopy width, and canopy depth increased. Different genera of woody plants responded differently to dryness, with resource availability affecting Eucalyptus and Callitris spp., and aboveground competition regulating Acacia and Allocasuarina spp.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2021)
Article
Plant Sciences
Chao Han, Yan Qiao, Lianmei Yao, Wei Hao, Yue Liu, Wen Shi, Min Fan, Ming-Yi Bai
Summary: This study reveals the crucial roles of SnRK1 and TOR in regulating stomatal development under different sugar availability. SnRK1 promotes stomatal development by stabilizing SPCH under low sucrose conditions, while high accumulation of Tre6P inhibits SnRK1 activity, leading to degradation of SPCH and inhibition of stomatal development under high sucrose conditions.
Article
Multidisciplinary Sciences
Fumiyuki Soma, Fuminori Takahashi, Satoshi Kidokoro, Haruka Kameoka, Takamasa Suzuki, Yusaku Uga, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki
Summary: Osmotic stresses such as drought and high salinity have negative effects on plant growth and productivity. Abscisic acid (ABA) accumulates in response to osmotic stress and enhances stress tolerance by triggering physiological responses through ABA signaling. B2-RAFs are essential for activating SnRK2s in an ABA-dependent manner under mild osmotic stress, while B3-RAFs enhance SnRK2 activity under severe stress conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Xinjie Shen, Hong Nan, Yuzhuang Jiang, Yujia Zhou, Xuejun Pan
Summary: As a crucial oil crop species, soybean plays a key role in supplying edible oil, plant protein, and animal fodder worldwide. Studies have found that the GmSnRK2s and GmPP2C-As genes play important roles in response to drought stress, including their expression patterns, functions, and interactions with the abscisic acid (ABA) signal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Hao Chen, David A. Bullock, Jose M. Alonso, Anna N. Stepanova
Summary: Plants have developed specialized mechanisms to adapt to adverse environmental conditions, allowing them to continue to grow and reproduce. Ethylene, in collaboration with other plant hormones, plays a key role in regulating plant growth and development in response to abiotic stresses.
Article
Biology
Charlotte Seydel, Julia Biener, Vladimir Brodsky, Svenja Eberlein, Thomas Naegele
Summary: This study suggests that Fourier polynomials can be used to predict plant responses in varied environmental conditions and quantify and analyze metabolism and its reaction towards environmental fluctuations.
COMMUNICATIONS BIOLOGY
(2022)
Article
Plant Sciences
Ariel M. Hughes, H. Tucker Hallmark, Lenka Plackova, Ondrej Novak, Aaron M. Rashotte
Summary: Research shows that Clade III CRFs play a significant role in oxidative stress response, regulating the expression of genes related to oxidative stress in Arabidopsis and tomato. Additionally, they impact cytokinin signaling and gene regulation in response to oxidative stress.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Aigerim Soltabayeva, Nurbanu Dauletova, Symbat Serik, Margulan Sandybek, John Okoth Omondi, Assylay Kurmanbayeva, Sudhakar Srivastava
Summary: This article reviews the recent research progress on the role of LRR-RLK receptors in biotic and abiotic stresses in plants, focusing on the model plant Arabidopsis thaliana. It also discusses the homologous LRR-RLKs in other plants and their involvement in stress response processes, as well as the interactions and combinations among LRR-RLK receptors. Furthermore, potential LRR-RLK genes involved in specific stresses are predicted based on GENEINVESTIGATOR microarray database analysis.
Article
Biochemistry & Molecular Biology
Tsukasa Toriyama, Akihisa Shinozawa, Yuki Yasumura, Masashi Saruhashi, Mayuka Hiraide, Shiori Ito, Hideyuki Matsuura, Keiko Kuwata, Mika Yoshida, Tadashi Baba, Izumi Yotsui, Teruaki Taji, Daisuke Takezawa, Yoichi Sakata
Summary: To survive fluctuating water availability, terrestrial plants need to sense water stresses and respond accordingly. The plant hormone ABA and the SnRK2 protein kinase play crucial roles in osmostress responses. In the moss Physcomitrium patens, it was discovered that ABA and osmostress-dependent SnRK2 activation require phosphorylation by an upstream kinase called ARK. Surprisingly, ARK is also involved in regulating the submergence response in P. patens through its ortholog CTR1. However, the activation mechanism of the ARK/SnRK2 module in response to water stress is still unknown. This study found that a group of ethylene-receptor-related sensor histidine kinases (ETR-HKs) is essential for ABA and osmostress responses in P. patens, and the intracellular kinase domain of an ETR-HK physically interacts with ARK. The HK disruptants fail to activate SnRK2 in response to ABA and osmostress due to the lack of ABA-dependent autophosphorylation of ARK's critical serine residue. These findings suggest that the HK/ARK module functions as an integration unit for water availability responses in P. patens.
Article
Microbiology
Ik-Jung Kim, Jeongmin Lee, Seung J. Oh, Mee-Sup Yoon, Sung-Soo Jang, Robin L. Holland, Michael L. Reno, Mohammed N. Hamad, Tatsuya Maeda, Hee Jung Chung, Jie Chen, Steven R. Blanke
CELL HOST & MICROBE
(2018)
Article
Multidisciplinary Sciences
Xiaoguang Li, Marc Edwards, Kristen F. Swaney, Nilmani Singh, Sayak Bhattacharya, Jane Borleis, Yu Long, Pablo A. Iglesias, Jie Chen, Peter N. Devreotes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Geriatrics & Gerontology
Qing Zhang, Agnes Duplany, Vincent Moncollin, Sandrine Mouradian, Evelyne Goillot, Laetitia Mazelin, Karine Gauthier, Nathalie Streichenberger, Celine Angleraux, Jie Chen, Shuzhe Ding, Laurent Schaeffer, Yann-Gael Gangloff
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Medicine, Research & Experimental
Kook Son, Jae-Sung You, Mee-Sup Yoon, Chong Dai, Jong Hyun Kim, Nidhi Khanna, Aditi Banerjee, Susan A. Martinis, Gyoonhee Han, Jung Min Han, Sunghoon Kim, Jie Chen
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Nilmani Singh, Adriana Reyes-Ordonez, Michael Compagnone, Jesus Moreno, Lucy Yao, Jie Chen
Article
Oncology
Dongwook Kim, Nilmani Singh, Rachel J. Waldemer-Streyer, Mee-Sup Yoon, Jie Chen
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Cell Biology
Jae-Sung You, Nilmani Singh, Adriana Reyes-Ordonez, Nidhi Khanna, Zehua Bao, Huimin Zhao, Jie Chen
Summary: ARHGEF3 deficiency enhances muscle regeneration by promoting muscle quality and function, independently of the Akt signaling pathway. Furthermore, ARHGEF3 KO promotes muscle regeneration through activation of autophagy, which is critical for maintaining muscle strength and preventing muscle weakness.
Editorial Material
Cell Biology
Jae-Sung You, Jie Chen
Summary: Macroautophagy plays a critical role in maintaining skeletal muscle function, but declines with aging leading to muscle deterioration. ARHGEF3 negatively regulates skeletal muscle autophagy during injury-induced regeneration and normal aging, and its knockout enhances muscle regeneration and prevents age-related muscle weakness. The GEF activity of ARHGEF3 toward ROCK mediates its function in muscle regeneration, suggesting it as a potential therapeutic target for impaired muscle regeneration, age-related muscle weakness, and other diseases related to aberrant regulation of autophagy.
Article
Biochemistry & Molecular Biology
Kuan-Yu Lai, Sebastien R. G. Galan, Yibo Zeng, Tianhui Hina Zhou, Chang He, Ritu Raj, Jitka Riedl, Shi Liu, K. Phin Chooi, Neha Garg, Min Zeng, Lyn H. Jones, Graham J. Hutchings, Shabaz Mohammed, Satish K. Nair, Jie Chen, Benjamin G. Davis, Wilfred A. van der Donk
Summary: LanCL catalyzes the addition of glutathione to Dha/Dhb in proteins, driving irreversible C-glutathionylation to repair damages in proteins, indicating its physiological importance in removing reactive electrophiles and dysregulatory effects from the proteome.
Article
Cell Biology
Jae-Sung You, Kookjoo Kim, Nathaniel D. Steinert, Jie Chen, Troy A. Hornberger
Summary: The study shows that mTORC1 signaling is activated during denervation and plays a crucial role in mitigating atrophy of non-type IIB muscle fibers, thereby regulating protein synthesis. Denervation induces a significant increase in phosphorylated ribosomal S6 protein levels in non-type IIB muscle fibers. mTORC1 plays a novel role in mediating fiber type-specific regulation of muscle size and protein synthesis during denervation.
CELL DEATH DISCOVERY
(2021)
Article
Multidisciplinary Sciences
Nilmani Singh, Adriana Reyes-Ordonez, Michael A. Compagnone, Jesus F. Moreno Castillo, Benjamin J. Leslie, Taekjip Ha, Jie Chen
Summary: This study explores the specific interactions of human PH domain-containing proteins with PIPs and reveals unexpected lipid-binding specificity among these proteins. By analyzing the structural requirements and functional relevance of PIP binding, as well as using a prediction algorithm, the researchers demonstrate widespread PIP binding among human PH domains.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Chong Dai, Adriana Reyes-Ordonez, Jae-Sung You, Jie Chen
Summary: Aminoacyl-tRNA synthetases play essential roles in protein synthesis, with some also exhibiting non-translational functions. Threonyl-tRNA synthetase (ThrRS) has been found to negatively regulate myoblast differentiation through a non-catalytic mechanism involving new domains UNE-T and TGS. ThrRS interacts with Axin1, inhibiting JNK signaling and affecting skeletal myogenesis through the MEKK4-MKK4-JNK pathway.
Review
Biochemistry & Molecular Biology
Rachel J. Waldemer-Streyer, Dongwook Kim, Jie Chen
Summary: Regeneration of adult skeletal muscle in mammals is a complex process regulated by multiple proteins and signaling pathways. Cytokines play a crucial role in skeletal myogenesis, with both infiltrating immune cells and the muscle itself secreting these signaling molecules. This review focuses on muscle-secreted cytokines that have been shown to be involved in myogenic differentiation and muscle regeneration.
Editorial Material
Cell Biology
Jie Chen
NATURE CELL BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Jae-Sung You, Yongdeok Kim, Soohyun Lee, Rashid Bashir, Jie Chen
Summary: The RhoA/ROCK signaling pathway plays a critical role in the pathology of Duchenne muscular dystrophy (DMD), and inhibiting ROCK can improve muscle strength and quality in DMD by rescuing autophagy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
