期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 35, 期 5, 页码 1266-1283出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msy026
关键词
mixture model; site-specific model; phylogenetics; protein models
资金
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chairs program
As a consequence of structural and functional constraints, proteins tend to have site-specific preferences for particular amino acids. Failing to adjust for heterogeneity of frequencies over sites can lead to artifacts in phylogenetic estimation. Site-heterogeneous mixture-models have been developed to address this problem. However, due to prohibitive computational times, maximum likelihood implementations utilize fixed component frequency vectors inferred from sequences in a database that are external to the alignment under analysis. Here, we propose a composite likelihood approach to estimation of component frequencies for a mixture model that directly uses the data from the alignment of interest. In the common case that the number of taxa under study is not large, several adjustments to the default composite likelihood are shown to be necessary. In simulations, the approach is shown to provide large improvements over hierarchical clustering. For empirical data, substantial improvements in likelihoods are found over mixtures using fixed components.
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