Review
Plant Sciences
Yanbo Mao, Shutang Tan
Summary: Phosphatidylinositol is a crucial phospholipid that can be phosphorylated into phosphoinositides to regulate cellular functions. Recent studies have highlighted the importance of the SAC family of phosphoinositide phosphatases in growth and development processes in plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Physics, Fluids & Plasmas
Paul C. Bressloff
Summary: In this paper, the relaxation to steady state of intracellular diffusion in a pair of cells with gap junction coupling is analyzed. The local accumulation time is calculated and it is found to be a monotonically increasing function of spatial position. Both static and dynamic gap junction models are considered.
Article
Microbiology
Jingqi Chen, Auke J. van Heel, Oscar P. Kuipers
Summary: A membrane-associated lanthipeptide synthetase complex was studied in rod-shaped cells, revealing the spatial distribution and dynamics of NisT, NisB, and NisC along the cell periphery, with highly colocalized NisBTC proteins. Isolation of the biosynthetic complex corroborated that the bright foci were sites for nisin maturation and transportation.
Article
Neurosciences
Stefan Hardt, Dario Tascio, Stefan Passlick, Aline Timmermann, Ronald Jabs, Christian Steinhaeuser, Gerald Seifert
Summary: In white matter, synaptic and axonal glutamatergic signaling to NG2 glia is critical for differentiation and myelination, whereas in gray matter the impact of neuron-to-NG2 glia signaling remains unclear. NG2 glia in hippocampus express AMPA receptors early in postnatal development, but the expression of TARP proteins changes during maturation. Adult NG2 glia receptors show increased sensitivity to blockers of Ca2+ permeable AMPA receptors, particularly near the soma.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Magdalena Pereyra, Jorge H. Medina
Summary: Retrieval is a highly regulated and dynamic phase in memory processing, where AMPA receptors play a crucial role in supporting transient memory trace reactivation. The dynamic movements and changes in receptor number and subunit composition of AMPAR during retrieval greatly impact memory recall through their differential regulations in plasticity processes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Magdalena Pereyra, Ana Belen de Landeta, Juliana Fatima Dalto, Cynthia Katche, Jorge H. Medina
Summary: The study shows that the activity of mTORC1 signaling pathway is crucial for the normal expression of aversive and non-aversive long-term memories during memory retrieval. Specifically, the de novo synthesis of GluA1 and GluA2 AMPAR subunits plays an important role in memory retrieval, with mTORC1 potentially regulating AMPAR trafficking during this process.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miranda Mele, Pasqualino De Luca, Ana Rita Santos, Marta Vieira, Ivan L. Salazar, Paulo S. Pinheiro, Carlos B. Duarte
Summary: This study investigated the regulation of the synaptic protein GRASP1 by ubiquitin-dependent mechanisms, revealing an impact on the surface distribution and activity of AMPA receptors. Ubiquitination was found to decrease dendritic levels of GRASP1 and surface expression of GluA1 subunits, leading to a reduction in mEPSC amplitudes, effects that were partially reversed by cotransfection with GRASP1.
Article
Cell Biology
May Bakr, Damien Jullie, Julia Krapivkina, Vincent Paget-Blanc, Lou Bouit, Jennifer D. Petersen, Natacha Retailleau, Christelle Breillat, Etienne Herzog, Daniel Choquet, David Perrais
Summary: The study identifies VAMP4 as the vesicular SNARE that mediates most dendritic recycling endosome exocytosis, while VAMP2 plays a minor role in this process. Knock down of VAMP4 reduces TfR recycling but increases AMPAR recycling, leading to increased AMPAR-mediated synaptic transmission and occlusion of LTP expression. The opposing changes in AMPAR and TfR recycling upon VAMP4 knock down reveal their sorting into separate endosomal populations.
Article
Neurosciences
Yao Q. Wang, Yanhua H. Huang, Saju Balakrishnan, Lidong Liu, Yu Tian Wang, Eric J. Nestler, Oliver M. Schluter, Yan Dong
Summary: This study elucidates the dynamic interactions between AMPARs and NMDARs during the generation and maturation of silent synapses in the NAc after cocaine experience. The findings provide a mechanistic basis for manipulating new synaptic contacts and potentially new neural network patterns created by these synapses for therapeutic benefit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Longfei Cheng, Keen Chen, Jiong Li, Jiaming Wu, Jiaqi Zhang, Li Chen, Guoqing Guo, Jifeng Zhang
Summary: CRMP2 can promote the surface expression of AMPA receptor GluA1 subunit in hippocampal neurons and in HEK293T cells expressing GluA1 subunits, through interaction with GluA1 and regulation by Cdk5 phosphorylation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Doris Wennagel, Barbara Yael Braz, Mariacristina Capizzi, Monia Barnat, Sandrine Humbert
Summary: Compelling evidence suggests that the mutation of huntingtin in Huntington's disease affects early brain development, particularly in spine formation. Loss of huntingtin leads to enlarged spines but reduced excitatory synaptic function due to its role in actin dynamics. The decoupling of spine structure from synaptic function may contribute to the development of HD symptoms.
Article
Biochemistry & Molecular Biology
Tomoko Hirano, Kazuo Ebine, Takashi Ueda, Takumi Higaki, Takahiro Watanabe-Nakayama, Hiroki Konno, Hisako Takigawa-Imamura, Masa H. Sato
Summary: This study demonstrates that the SYP123-VAMP727-dependent secretion pathway plays a crucial role in delivering secondary cell wall components for the hardening of the subapical zone and shank of Arabidopsis root hairs. The localization of SYP123 at the plasma membrane is dependent on the production of phosphatidylinositol (PtdIns)(3,5)P2, and this pathway is involved in maintaining the tubular morphology of root hairs by transporting secondary cell wall components. The study highlights the importance of SYP123-VAMP727-mediated secretion in root hair elongation and maintenance.
Article
Cell Biology
Emily E. Maverick, Ashley N. Leek, Michael M. Tamkun
Summary: Kv2 channels encode delayed rectifier currents that regulate membrane potential and also form stable junctions with AMIGO proteins to modulate conducting and non-conducting channel properties. Among the AMIGO family, AMIGO2 significantly slows inactivation and deactivation of Kv2 channels, leading to a prolonged open state. The co-regulatory effects of Kv2s and AMIGOs likely fine-tune both the electrical and non-electrical properties of expressed cells.
JOURNAL OF CELL SCIENCE
(2021)
Review
Neurosciences
Jeremy M. Henley, Jithin D. Nair, Richard Seager, Busra P. Yucel, Gavin Woodhall, Benjamin S. Henley, Karolina Talandyte, Hope I. Needs, Kevin A. Wilkinson
Summary: Epilepsy is caused by abnormal neuronal network activity. The review focuses on the role and regulation of kainate and AMPA receptors in seizure activity, discussing the impact of GluK2 and GluA2 subunits on their respective receptors' properties.
Article
Cell Biology
Anagh Sinha Ravi, Menglong Zeng, Xudong Chen, Gerardo Sandoval, Javier Diaz-Alonso, Mingjie Zhang, Roger A. Nicoll
Summary: Recent research suggests that the TARP/PSD-95 complex is an essential interaction underlying AMPAR trafficking and LTP. The interaction between PSD-95 and AMPAR auxiliary subunits TARPs can capture AMPARs and enhance synaptic transmission and LTP.
Article
Biochemistry & Molecular Biology
Navneet A. Vasistha, Maria Pardo-Navarro, Janina Gasthaus, Dilys Weijers, Michaela K. Mueller, Diego Garcia-Gonzalez, Susmita Malwade, Irina Korshunova, Ulrich Pfisterer, Jakob von Engelhardt, Karin S. Hougaard, Konstantin Khodosevich
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Annika Mehr, Meike Hick, Susann Ludewig, Michaela Mueller, Ulrike Herrmann, Jakob von Engelhardt, David P. Wolfer, Martin Korte, Ulrike C. Mueller
Review
Neurosciences
Eric Jacobi, Jakob von Engelhardt
Summary: AMPAR auxiliary subunits play a pivotal role in modulating AMPAR function, influencing synaptic strength, temporal precision, and integrative properties, as well as participating in synaptic plasticity.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
NATURE COMMUNICATIONS
(2020)
Correction
Multidisciplinary Sciences
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Muhammad Aslam, Nirosiya Kandasamy, Anwar Ullah, Nagarajan Paramasivam, Mehmet Ali Ozturk, Saima Naureen, Abida Arshad, Mazhar Badshah, Kafaitullah Khan, Muhammad Wajid, Rashda Abbasi, Muhammad Ilyas, Roland Eils, Matthias Schlesner, Rebecca C. Wade, Nafees Ahmad, Jakob von Engelhardt
Summary: Rare variants in the GBA1 gene are common genetic risk factors for alpha synucleinopathy, and in this study, rare genetic variants of DNAJB6 and PSAP were identified as additional factors possibly influencing PD risk in families with PD-associated GBA1 variants. The altered functions of variant DNAJB6 and PSAP proteins in cellular alpha-synuclein homeostasis suggest a possible association with PD, and the occurrence of second hits or additional rare variants in PD families with GBA1 variants has implications for genetic counseling and treatment selection.
NPJ GENOMIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Vicky Steubler, Susanne Erdinger, Michaela K. Back, Susann Ludewig, Dominique Faessler, Max Richter, Kang Han, Lutz Slomianka, Irmgard Amrein, Jakob von Engelhardt, David P. Wolfer, Martin Korte, Ulrike C. Mueller
Summary: This study identifies the essential functions of the APP family during development, for normal hippocampal function and circuits important for learning and social behavior. Lack of the APP family leads to altered brain morphology, reduced synaptic transmission, and impairments in behavior related to learning and social interactions.
Article
Biochemistry & Molecular Biology
Michaela K. Back, Sonia Ruggieri, Eric Jacobi, Jakob von Engelhardt
Summary: The pathophysiology of Alzheimer's disease varies between brain regions, with the neocortex being affected early in the disease. NMDA receptors are involved in mediating amyloid beta toxicity, and may be influenced by amyloid beta. This study found that neocortical neurons' vulnerability to amyloid beta toxicity may be due to specific NMDAR expression profiles or regulation by amyloid beta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Jakob von Engelhardt
Summary: Repetitive synapse activity induces short-term plasticity, affecting both presynaptic and postsynaptic mechanisms, with a focus on the contribution of AMPA receptor desensitization. The review discusses how short-term plasticity in retinogeniculate synapses plays a role in visual information processing by LGN relay neurons, highlighting the interaction of AMPA receptors with auxiliary proteins such as CKAMP44.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Cell Biology
Robert Luck, Andromachi Karakatsani, Bhavin Shah, Geza Schermann, Heike Adler, Janina Kupke, Nathalie Tisch, Hyun-Woo Jeong, Michaela Kerstin Back, Florian Hetsch, Anna D'Errico, Michele De Palma, Ellen Wiedtke, Dirk Grimm, Amparo Acker-Palmer, Jakob von Engelhardt, Ralf H. Adams, Hellmut G. Augustin, Carmen Ruiz de Almodovar
Summary: The neuro-vascular signaling axis of Angiopoietin/Tie2 is crucial for proper dendritic morphogenesis in Purkinje cells, requiring intercellular communication between neural cells, endothelial cells, and Purkinje cells. Deletion of Tie2 or its ligands results in altered dendritic arborization and gene expression, impacting cytoskeleton organization and cell functionality.
Article
Medicine, General & Internal
Florian Freudenberg, Esin Candemir, Xufeng Chen, Li-Li Li, Dilhan Esen-Sehir, Nicole Schenk, Makoto Kinoshita, Lena Gruenewald, Veronika Frerichs, Nikolai Fattakhov, Jessica Manchen, Solmaz Bikas, Anita Kumar, Aet OLeary, David A. Slattery, Jakob von Engelhardt, Michael J. Courtney, Andreas Reif
Summary: The study revealed the function of NOS1AP in the hippocampus, showing that its overexpression resulted in various changes, including increased interaction of nNOS with PSD-95, reduced dendritic spine density, and altered morphology. Behaviorally, impairments in social memory and spatial working memory capacity were observed.
Article
Biochemistry & Molecular Biology
Michaela K. Back, Johanna Kurzawa, Sonia Ruggieri, Jakob von Engelhardt
Summary: Mouse models are commonly used in the study of Huntington's disease (HD). The severity and onset of neuronal and behavioral pathologies in HD mouse models vary greatly due to differences in huntingtin expression levels and CAG repeat length. Strain background also plays a role in HD pathology, with behavioral deficits being more severe in certain backgrounds. Despite mild cellular phenotypes, deficits in motor performance were still observed. The study highlights the importance of strain background in the manifestation of mHTT toxicity in HD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Elisa Colombo, Guilherme Horta, Mona K. Roesler, Natascha Ihbe, Stuti Chhabra, Konstantin Radyushkin, Giovanni Di Liberto, Mario Kreutzfeldt, Sven Schumann, Jakob von Engelhardt, Doron Merkler, Christian Behl, Thomas Mittmann, Albrecht M. Clement, Ari Waisman, Michael J. Schmeisser
Summary: Studies have shown that CYLD plays an important role in synaptic function and autism spectrum disorder, with its deficiency leading to autism-like behaviors and phenotypes. The absence of CYLD results in a reduction in synaptic spine numbers in neurons, as well as decreased hippocampal network excitability and long-term potentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Florian Hetsch, Danni Wang, Xufeng Chen, Jiong Zhang, Muhammad Aslam, Marcel Kegel, Henrik Tonner, Franz Grus, Jakob von Engelhardt
Summary: In relay neurons of the dorsal lateral geniculate nucleus (dLGN), CKAMP44 plays a role in the maturation and modulation of retinogeniculate synapses during early development, without affecting input segregation.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
