期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 88, 期 -, 页码 1-6出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2017.12.003
关键词
Alzheimer's disease; trans epsilon-viniferin; Amyloid fibrils; Inflammation; Multi-target molecule
资金
- French Ministry of Education and Research and Technology [EA3808]
- country Poitou Charentes (VinOx project)
Alzheimer's disease (AD) is marked by several cellular and molecular damage. Therefore, the therapeutic interest of multi-target molecules is increasingly justified. Polyphenols presenting multiple pharmacological effects would be more efficient. In this study, beneficial effects of trans epsilon-viniferin, a natural polyphenol were thus evaluated. This study reported that this stilbenoid (1) induced the disaggregation of amyloid beta (A beta) peptide and (2) rescued inflammation in murine primary neuronal cultures. These both effects are higher than those of resveratrol, and so, trans epsilon-viniferin could be a good therapeutic multi-target candidate.
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