Article
Endocrinology & Metabolism
Zhongli Chen, A. S. Elise van der Sman, Stefan Groeneweg, Linda Johanna de Rooij, W. Edward Visser, Robin P. Peeters, Marcel E. Meima
Summary: Using pharmacological inhibitors, this study identified that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears to be independent of known TH transporters, suggesting the presence of alternative transporter(s) that are currently unknown.
Article
Environmental Sciences
Xuan Li, Tao Yu, Muxin Zhai, Yongyuan Wu, Baojing Zhao, Cancan Duan, Huiru Cheng, Han Li, Zhaolian Wei, Yuanyuan Yang, Zhen Yu
Summary: This study found that cadmium exposure reduces placental angiogenesis in preeclampsia by decreasing the expression of PLGF and VEGF and increasing the expression of sFlt1. Cadmium exposure also decreases the expression of thyroid hormone receptor alpha and Dio2. These results suggest that cadmium exposure impairs placental angiogenesis in preeclampsia by disturbing thyroid hormone receptor signaling.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi
Summary: CD36 plays an important role in podocyte injury in lupus nephritis by activating NLRP3 inflammasome and inhibiting autophagy, and enhancing autophagy can decrease NLRP3 inflammasome and alleviate podocyte injury.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Robin A. F. Verwilligen, Lindsay Mulder, Pedro M. Araujo, Miguel Carneiro, Jeroen Bussmann, Menno Hoekstra, Miranda Van Eck
Summary: Scavenger receptor class B1 (SCARB1) is a multi-ligand scavenger receptor that is primarily expressed in liver and steroidogenic organs. This study created two stable scarb1 knockout zebrafish lines and found that SCARB1 deficiency in zebrafish leads to disruption of carotenoid-based pigmentation, reduced fertility, and decreased larvae survival rate. It also affects the uptake of HDL in the liver, but this is attributed to reduced perfusion.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Environmental Sciences
Xinwen Dong, Weidong Wu, Sanqiao Yao, Haibin Li, Zhichun Li, Li Zhang, Jing Jiang, Jie Xu, Fengquan Zhang
Summary: PM2.5 exposure induced pathological changes in the thyroid and liver of rats, decreased TH levels, and led to oxidative stress responses. Activation of the HPT axis and altered hepatic transthyretin levels appear to crucially contribute to PM2.5-induced thyroid dysfunction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Jian Li, Ying Xu, Na Li, Rui Zuo, Yuanzheng Zhai, Haiyang Chen
Summary: Through integrated in vitro, in vivo, and in silico assays, the study investigated the thyroid hormone-disrupting effects and mechanisms of 8 typical organophosphate esters (OPEs). It was found that these chemicals competitively bound to the membrane thyroid hormone receptor (mTR) and some OPEs also interacted with the nuclear thyroid hormone receptor (nTR). Molecular docking simulation supported these findings. In addition, in vivo analyses using zebrafish embryo development demonstrated the thyroid hormone-disrupting effects of OPEs and their possible association with mTR.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Peripheral Vascular Disease
Liming Yu, Yao Dai, Chieko Mineo
Summary: SR-BI plays a key role in reverse cholesterol transport as the high-affinity receptor for HDL in the liver, but recent studies have also revealed its novel functions in regulating transcellular transport of LDL and HDL in endothelial cells, which may have both anti-atherogenic and pro-atherogenic effects.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Ophthalmology
Haixiang Huang, Zhuang Li, Jun Huang, Yanyan Xie, Zhiqiang Xiao, Yunwei Hu, Guanyu Chen, Minzhen Wang, Zuoyi Li, Qian Chen, Wenjie Zhu, Wenru Su, Yan Luo, Xiaoqing Chen, Dan Liang
Summary: In this study, researchers investigated the role of apolipoprotein A1 (APOA1) in experimental autoimmune uveitis (EAU), a representative animal model of human uveitis. They found that APOA1 administration ameliorated EAU by regulating the expansion and infiltration of pathogenic T cells, as well as the production of inflammatory cytokines. The results suggest that APOA1 could be a therapeutic alternative for autoimmune uveitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Limei Li, Yan Song, Yongquan Shi, Liangliang Sun
Summary: Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disease without a known cause or FDA-approved drug treatment. Hypothyroidism has been identified as a risk factor for NAFLD, as thyroid hormone (TH) is important for metabolism regulation in adults. Thyroxine, a synthetic TH, has been shown to reduce liver fat in animal models with NAFLD, but it has side effects, especially in the heart. To overcome these side effects, agonists specific to the TR beta, a subtype of the TH receptor mainly expressed in the liver, have been developed and shown positive therapeutic effects in NAFLD animal models and clinical trials. This review aims to provide an updated reference and explore the future therapeutic potential of TR beta-specific agonists in the treatment of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Fisheries
Yinan Jiang, Yuting Wang, Yingying Zhang, Hui Yang
Summary: A novel scavenger receptor B (PcSRB) was identified in the Chinese mitten crab, which plays an important role in immune defense, particularly in the recognition and binding of pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huei-Pin Lai, Mei-Hsiu Chen
Summary: This study reports a family with resistance to thyroid hormone (RTH) caused by a rare point mutation in the thyroid hormone receptor beta (THR beta) gene. The proband developed atrial fibrillation and life-threatening heart failure with pulmonary edema, which differs from previously reported mutations. This study contributes to a better understanding and management of patients with RTH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Stefan Groeneweg, Ferdy S. van Geest, Zhongli Chen, Stefania Farina, Ramona E. A. van Heerebeek, Marcel E. Meima, Robin P. Peeters, Heike Heuer, Marco Medici, W. Edward Visser
Summary: The study demonstrates that SLC17A4 facilitates the transport of T3 and T4, as well as less efficiently rT3 and 3,3’-T2. Further research should reveal the physiological role of SLC17A4 in TH regulation.
Article
Plant Sciences
Kiyoshi Mashiguchi, Yoshiya Seto, Shinjiro Yamaguchi
Summary: Strigolactones are plant hormones that regulate developmental processes and environmental responses, also acting as root-derived chemical signals. Recent advances in SL research have provided breakthroughs in understanding biosynthesis, transport and perception of these hormones.
Article
Endocrinology & Metabolism
Gregory A. Brent
Summary: Thyroid hormone plays a vital role in development and has diverse effects on various tissues and organs in the body. Early markers of thyroid hormone action included oxygen consumption, basal metabolic rate, serum cholesterol, and deep tendon reflex time. Research has focused on understanding the nuclear and cellular mechanisms of thyroid hormone action, including the role of thyroid hormone receptors, coactivators, DNA response elements, and transportation defects.
Article
Agriculture, Dairy & Animal Science
C. B. Steinhauser, K. Askelson, K. C. Hobbs, F. W. Bazer, M. C. Satterfield
Summary: Maternal nutrient restriction during pregnancy can affect fetal growth and thyroid hormone levels, leading to lower thyroid hormone concentrations in NR SGA fetuses. Changes in thyroid hormone-associated proteins in placentomes of ewes having SGA fetuses suggest adaptations to and potential effects of nutritional restrictions.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Jenny A. Doust, Paul P. Glasziou, Michael C. d'Emden
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Cell Biology
Melanie J. Young, Ming Tang, Derek J. Richard, Donald S. A. McLeod, Michael C. d'Emden, Kerry Richard
Summary: The study found that nicotine inhibits the uptake of transthyretin-T4 complex by human placental trophoblast cells, and reduces the expression of the scavenger receptor class B type 1 (SR-B1) that plays a role in transthyretin-T4 uptake. Molecular dynamic simulations suggest that nicotine binding increases tetramer stability, which decreases the ability of the transthyretin-T4 complex to enter trophoblast cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Oncology
Donald S. A. McLeod, Sheryl A. Bedno, David S. Cooper, Susan M. Hutfless, Silvia Ippolito, Susan J. Jordan, Peter G. Matos, Rachel E. Neale, Elena Sabini, David C. Whiteman, Paul W. Ladenson, Patrizio Caturegli
Summary: This case-control study conducted within the US active-duty personnel cohort found an association between longstanding prior thyroid autoimmunity and the risk of papillary thyroid cancer. The association was not mediated by the diagnosis of thyroid autoimmunity and thyroid cancers were often diagnosed at an early stage when autoimmunity had been identified.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Immunology
Hai Pham, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study analyzed the effect of vitamin D supplementation on infection risk and found that vitamin D may reduce the number of antibiotic prescriptions, especially in individuals with low vitamin D levels.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Ophthalmology
Sabbir T. Rahman, Mary Waterhouse, Briony Duarte Romero, Catherine Baxter, Dallas English, David A. Mackey, Peter R. Ebeling, Bruce K. Armstrong, Donald S. A. McLeod, Gunter Hartel, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Supplementing high-dose vitamin D may not significantly reduce the incidence of cataract surgery, regardless of age, sex, body mass index, serum vitamin D concentration, or ambient ultraviolet radiation.
Article
Nutrition & Dietetics
Hai Pham, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Recent studies have suggested that vitamin D supplementation may reduce the severity of infections, but its effect on hospitalization for infection has not been confirmed. This study found that vitamin D supplementation had no effect on the incidence of hospitalization for any infection, but it reduced the number of extended hospitalizations lasting more than 6 days.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Aninda Rahman, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Observational studies suggest an inverse association between 25-hydroxy vitamin D (25(OH)D) concentration and pain, but intervention trials have inconsistent findings. In this large placebo-controlled trial, vitamin D supplementation with 60000 IU of vitamin D-3/month had negligible effect on bodily pain.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Sabbir T. Rahman, Mary Waterhouse, Briony Duarte Romero, Catherine Baxter, Dallas R. English, Osvaldo P. Almeida, Michael Berk, Peter R. Ebeling, Bruce K. Armstrong, Donald S. A. McLeod, Gunter Hartel, Rachel L. O'Connell, Hai Pham, James G. Scott, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: The study investigated whether vitamin D supplementation reduces depressive symptoms and incidence of antidepressant use. The results showed that high-dose monthly supplementation with vitamin D-3 did not have overall benefit for measures of depression, but there was some evidence of benefit in subgroup analyses.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Hai Pham, Mary Waterhouse, Sabbir Rahman, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Osvaldo P. Almeida, Rachel E. Neale
Summary: A randomized controlled trial found that monthly bolus doses of vitamin D supplementation for 5 years did not improve cognitive function in older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Cell Biology
Melanie Young, Ming Tang, Huika Li, Derek J. Richard, Donald S. A. McLeod, Michael C. d'Emden, Kerry Richard
Summary: Preeclampsia is a life-threatening condition caused by poor placentation during pregnancy. The study suggests that transthyretin, a thyroid hormone binding protein, binds to soluble endoglin (sEng) and enhances its uptake by hepatocytes. This finding may lead to potential treatment options for reducing sEng-induced vascular dysfunction.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Debbie W. Chen, Brian H. H. Lang, Donald S. A. McLeod, Kate Newbold, Megan R. Haymart
Summary: The past 5-10 years have seen significant advancements in the diagnosis and management of thyroid cancer, including ultrasound-based risk stratification systems, less invasive alternatives to surgery, and the availability of new systemic therapies for advanced cases. However, disparities in thyroid cancer care still exist, highlighting the importance of population-based studies and inclusive research to address barriers to equitable care.
Article
Endocrinology & Metabolism
Mary Waterhouse, Peter R. Ebeling, Donald S. A. McLeod, Dallas English, Briony Duarte Romero, Catherine Baxter, Bruce K. Armstrong, Gunter Hartel, Michael Kimlin, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study investigated whether supplementing Australian adults with monthly doses of 60,000 IU vitamin D3 for up to 5 years altered the rate of fractures. The results showed that vitamin D supplementation did not increase fracture risk, and long-term supplementation might reduce the incidence of total fractures. However, further research is needed to confirm this effect.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Oncology
Vu Tran, Monika Janda, Robyn M. M. Lucas, Donald S. A. McLeod, Bridie S. S. Thompson, Mary Waterhouse, David C. C. Whiteman, Rachel E. E. Neale
Summary: Sun exposure in Australia has both negative and positive effects. It is a major cause of skin cancer, but also promotes vitamin D production. However, despite high levels of UV radiation, a significant portion of the population is vitamin D deficient. Balancing the risks and benefits requires effective communication.
Letter
Endocrinology & Metabolism
Rachel E. Neale, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Gunter Hartel, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Mary Waterhouse
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
