Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Deborah S. Souza, Carla Macheroni, Carolina M. Vicente, Renan P. Cavalheiro, Vanessa L. Campo, Catarina S. Porto
Summary: The aim of this study was to investigate the role of estrogen receptor (ER) alpha and ER beta, and galectin-3 (GAL-3) in migration and invasion of androgen-independent DU-145 prostate cancer cells, and to examine the regulation of the expression of GAL-3 by the activation of these receptors. The results showed that both ER alpha and ER beta play a significant role in regulating the migration and invasion of DU-145 cells, and their activation leads to increased expression and signaling of GAL-3.
Article
Cell Biology
Pablo Carabias, Maria Espelt, Maria L. Bacigalupo, Paola Rojas, Luciana Sarrias, Ayelen Rubin, Nicolas A. Saffioti, Maria T. Elola, Juan P. Rossi, Carlota Wolfenstein-Todel, Gabriel A. Rabinovich, Maria F. Troncoso
Summary: GAL1, abundantly expressed in the tumor microenvironment, may promote chemoresistance in HCC cells by modulating P-gp protein expression.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Fei Fei, Mingfeng Zhang, Somayeh S. Tarighat, Eun Ji Joo, Lu Yang, Nora Heisterkamp
Summary: Galectin-1 and Galectin-3 have a complicated joint contribution to BCP-ALL survival, with stromal Galectin-3 playing an important role in maintaining BCP-ALL fitness during chemotherapy exposure, while stromal Galectin-1 does not significantly contribute to drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bok-Soon Lee, Jeon Yeob Jang, Chorong Seo, Chul-Ho Kim
Summary: Inhibition of CXCL5-CXCR2 signaling pathway can suppress invasion and metastasis of HNSCC cells. Intervening with the signaling pathway between tumor cells and lymphatic endothelial cells may provide a new therapeutic strategy for the clinical management of HNSCC.
Review
Oncology
Li Zhang, Xingyue Chen, Shun Yao, Liming Zheng, Xingyue Yang, Yongfeng Wang, Xin Li, Enqin Wu, Biguang Tuo
Summary: Chloride, as a major intracellular anion, plays a crucial role in maintaining ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1 (CLIC1), besides its function as an ion channel, is involved in cell cycle regulation and intracellular oxidation. It has been found that CLIC1 is highly expressed in tumor cells and associated with malignancy and poor prognosis, suggesting its potential role in systemic diseases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Anna Hillenmayer, Christian M. Wertheimer, Arie Geerlof, Kirsten H. Eibl, Siegfried Priglinger, Claudia Priglinger, Andreas Ohlmann
Summary: This study found that hr-GAL1 and 3 can inhibit the proliferation, migration, and apoptosis of human retinal microvascular endothelial cells, and have inhibitory effects on angiogenesis. However, hr-GAL1 and 3 do not show toxic effects on HRMEC. In addition, hr-GAL1 and 3 treatment can activate the proangiogenic Wnt/β-catenin signaling pathway.
Article
Oncology
Huan Guo, Baozhen Zeng, Liqiong Wang, Chunlei Ge, Xianglin Zuo, Yan Li, Wanbao Ding, Lei Deng, Jie Zhang, Xiaoling Qian, Xin Song, Peixian Zhang
Summary: This study revealed that CYP2S1 is significantly up-regulated in lung cancer tissues and cells, and knockdown of CYP2S1 inhibits cell proliferation, invasion, and migration in vitro. Further analysis showed that CYP2S1 regulates E2F targets and G2M checkpoint pathway in cell cycle. High expression of CYP2S1 is associated with poor prognosis in patients with lung cancer.
Article
Biochemistry & Molecular Biology
V. Bharath Kumar, Jen-Tsun Lin, B. Mahalakshmi, Yi-Ching Chuang, Hsin-Yu Ho, Chia-Chieh Lin, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: The study demonstrates that platyphyllenone significantly inhibits the motility, migration, and invasion of oral cancer cells by modulating specific proteins and signaling pathways, indicating its potential as an anti-metastatic agent in oral cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Meisi Huo, Kangkang Yu, Yahui Zheng, Lu Liu, Hao Zhao, Xiaoqi Li, Chong Huang, Jubo Zhang
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, with metastasis accounting for the majority of cases. Angiogenesis is crucial for cancer metastasis, however, the mechanism by which tumor cells influence endothelial cell function through microRNA (miRNA) expression remains largely unknown. Through analyzing differentially expressed miRNAs (DEMs) identified from the Gene Expression Omnibus (GEO) database, this study found that miR-302c-3p was the most down-regulated miRNA in human umbilical vein endothelial cells (HUVECs) when co-cultured with HCC-LM3 cells. Functional enrichment analysis revealed that the candidate targets were involved in epigenetic gene regulation, particularly cytosine methylation. Furthermore, the protein-protein interaction (PPI) network showed distinct roles of genes targeted by miR-302c-3p. In vitro experiments confirmed that the most down-regulated miR-302c-3p in HUVECs inhibited angiogenesis, migration, and permeability. These findings offer new insights into how HCC cells regulate angiogenesis and provide potential targets for therapeutic strategies.
BIOSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kuiyuan Hou, Jie Liu, Jianyang Du, Shan Mi, Shuai Ma, Yixu Ba, Hang Ji, Bo Li, Shaoshan Hu
Summary: Combining PDT with DHA significantly enhances total ROS levels, suppresses NHE1 expression in vitro and in vivo, weakens GC invasion and migration, and abolishes GC resistance to PDT. This synergistic therapy represents a more effective and safe strategy for comprehensive glioma treatment.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chan Huang, Xuan Su, Da-Lei Zhou, Bo-Heng Xu, Qing Liu, Xiao Zhang, Tao Tang, Xin-Hua Yang, Zu-Lu Ye, Cai-Yun He
Summary: This study identified several lncRNAs as diagnostic biomarkers for papillary thyroid cancer (PTC) and developed a nomogram model to predict lymph node metastasis (LN) in PTC patients. Additionally, a pathway involving lncMPEG1-1:1/miR-766-5p was discovered to be associated with thyroid cancer progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biotechnology & Applied Microbiology
Min Feng, Ningfei Dong, Xin Zhou, Lihong Ma, Rui Xiang
Summary: MYL9 promotes the proliferation, invasion, migration, and angiogenesis of colorectal cancer cells by binding to YAP1 and activating Hippo signaling.
Review
Biochemistry & Molecular Biology
Eleonora Sarantelli, Apostolis Mourkakis, Lefteris C. Zacharia, Andreas Stylianou, Vasiliki Gkretsi
Summary: As metastasis is a major cause of cancer-related deaths, understanding the cellular and molecular events involved in cancer cell migration and invasion is crucial for developing novel anti-metastatic therapies. Fascin-1, an actin-bundling protein, plays a fundamental role in cell migration processes. It is significantly elevated in most cancers and its high expression is associated with aggressive disease and poor prognosis. Recent studies show that Fascin-1 is critically involved in metastasis and suggest it as a promising target for anti-metastatic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Lingling Jiang, Xuexin Wang
Summary: miR-133b inhibits the proliferation, invasion, and migration of cervical cancer cells by suppressing the expression of ARFGEF1, suggesting that miR-133b/ARFGEF1 could be a potential therapeutic target for cervical cancer.
Article
Computer Science, Information Systems
Zhipeng Liu, Yinghui Ye, Guangyue Lu, Rose Qingyang Hu
Summary: This article investigates the joint impact of residual hardware impairments (RHIs) and residual self-interference (RSI) on the system outage performance of a full-duplex two-way decode-and-forward relay network. The system outage probability is derived in a closed-form, and the overall system ceiling (OSC) effect caused by only RHIs is identified. It is shown that the diversity gain of the considered network is always zero due to the existence of RHIs and RSI.
IEEE SYSTEMS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Pengxu Chen, Hongwu Liu, Yinghui Ye, Liang Yang, Kyeong Jin Kim, Theodoros A. Tsiftsis
Summary: In this paper, a rate-splitting multiple access (RSMA) scheme is proposed to aid a mobile edge computing (MEC) system where multiple randomly deployed users offload their computation tasks to a MEC server. The proposed cognitive radio (CR)-inspired rate-splitting enables paired users to simultaneously offload to the MEC server. The study investigates the impact of user locations on the offloading performance and provides closed-form expressions for the successful computation probability (SCP) achieved by different user pairing schemes.
IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
(2023)
Article
Engineering, Electrical & Electronic
Yinghui Ye, Jiajia Zhao, Xiaoli Chu, Sumei Sun, Guangyue Lu
Summary: In this paper, the symbol detection in ambient backscatter communications (AmBC) under IQ imbalances is studied. The bit error rate (BER) and the near-optimal detection threshold are derived in closed forms, considering a differential encoding scheme at the transmitter and an energy difference based detector at the receiver. A simple and practical method to estimate the near-optimal detection threshold is proposed, by exploiting the received signal samples at the receiver. Simulation results validate the accuracy of the derived BER and detection threshold, and show that the studied detector is more robust to amplitude imbalance than to phase imbalance.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu-jia Xu, Kun Zeng, Ying Ren, Chen-yu Mao, Ying-hui Ye, Xiao-ting Zhu, Zi-ying Sun, Bi-yin Cao, Zu-bin Zhang, Guo-qiang Xu, Zhen-qian Huang, Xin-liang Mao
Summary: In this study, the deubiquitinase USP10 is identified as the first deubiquitinase of CCND3, and it stabilizes CCND3 and activates the CCND3/CDK4/6 signaling pathway in multiple myeloma cells. Inhibition of USP10 results in CCND3 degradation, and combined with a CDK4/6 inhibitor, it induces cell apoptosis, suggesting it as a potential therapeutic modality for myeloma.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Endocrinology & Metabolism
Long Cui, Li Fang, Lili Zhuang, Biwei Shi, Chao-Po Lin, Yinghui Ye
Summary: Studies have shown that sperm-borne microRNAs (miRNAs) are involved in mammalian preimplantation embryonic development. In humans, miR-34c levels in spermatozoa are correlated with in vitro fertilization outcomes. However, the mechanisms underlying the regulation of embryonic development by miR-34c remain unknown.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Cell Biology
Xiaoya Zhao, Zhenwu Zhang, Qian Zhu, Yurui Luo, Qinying Ye, Shuxiang Shi, Xueyang He, Jing Zhu, Duo Zhang, Wei Xia, Yiqin Zhang, Linlin Jiang, Long Cui, Yinghui Ye, Yangfei Xiang, Junhao Hu, Jian Zhang, Chao-Po Lin
Summary: Ruptured ectopic pregnancy (REP) occurs when embryos aberrantly implant, invade deeply, and overgrow in the fallopian tubes, resulting in tube rupture and accounting for 4%-10% of pregnancy-related deaths. The lack of ectopic pregnancy phenotypes in rodents hinders our understanding of its pathological mechanisms. This study utilized cell culture and organoid models to investigate the interaction between human trophoblast development and intravillous vascularization in REP. The findings demonstrate the crucial role of WNT-mediated angiogenesis and provide insights into the intricate communication between trophoblasts and endothelial/endothelial progenitor cells using an organoid co-culture model.
Article
Environmental Sciences
Bingxue Zhu, Shengbo Chen, Zhengyuan Xu, Yinghui Ye, Cheng Han, Peng Lu, Kaishan Song
Summary: The objective of this study was to explore an effective assimilation approach for estimating maize grain protein content and yield using a canopy remote sensing data and crop growth model. Based on two years of field experiment data, a remote sensing inversion model using assimilation intermediate variables was constructed with good accuracy. The results show that using multiple variables in the assimilation process improves the accuracy of estimations compared to using a single variable.
Article
Immunology
Yulou Luo, Yinghui Ye, Yan Chen, Chenguang Zhang, Yutian Sun, Chengwei Wang, Jianghua Ou
Summary: This study aimed to assess the clinical utility of a prognostic signature based on degradome-related genes in breast cancer. The results showed that this signature could predict prognosis, stratify risk, and guide treatment for patients with breast cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Biwei Shi, Yinghui Ye
Summary: Preimplantation genetic testing (PGT) is an effective method to select embryos free of disease-causing genes and chromosome abnormalities, and this study applied PGT to a challenging case with a maternal subchromosomal reciprocal translocation (RecT) and heterozygous mutations in dual oxidase 2 (DUOX2). By verifying the mutations, pedigree haplotypes for DUOX2 and chromosomal translocation were constructed. A healthy female infant was born through embryo transfer of a blastocyst without RecT but carrying the paternal gene mutation in DUOX2. This case report contributes significantly to the literature and highlights the usefulness of NGS-based PGT strategy for complex pedigrees.
FRONTIERS IN GENETICS
(2023)
Article
Telecommunications
Guangyue Lu, Zhipeng Liu, Yinghui Ye, Xiaoli Chu
Summary: This paper investigates the system outage performance of a SWIPT-based two-way DF relay network under potential HIs. The system outage probability is derived, showing an OSC effect determined by the levels of HIs. The diversity gain of the network is also derived, indicating different behaviors compared with the AF strategy.
CHINA COMMUNICATIONS
(2023)
Article
Engineering, Civil
Jian Su, Shiming Yu, Bin Li, Yinghui Ye
Summary: This paper focuses on task offloading in an aerial edge network assisted by a UAV, aiming to minimize the energy consumption of all user equipment by optimizing task offloading decisions and the position of the UAV. The proposed ADMM algorithm effectively reduces energy consumption and ensures continuous operation of user equipment.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Liqin Shi, Yinghui Ye, Xiaoli Chu, Sumei Sun, Guangyue Lu
Summary: In this paper, we propose a novel energy-efficient resource allocation scheme for a backscatter-assisted wireless powered mobile edge computing (MEC) network. By jointly optimizing various parameters such as offloading decisions, computing frequencies and times, backscatter time and reflection coefficients, and transmit power and time, we are able to minimize the energy consumption of the MEC server. The proposed low-complexity iterative algorithm demonstrates fast convergence and outperforms baseline schemes in terms of energy consumption.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Bin Li, Wancheng Xie, Yinghui Ye, Lei Liu, Zesong Fei
Summary: This paper studies the integration of unmanned aerial vehicles (UAVs) into digital twin driven vehicular edge computing networks, showing their high potentials in handling intensive computing tasks.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yinghui Ye, Yulou Luo, Tong Guo, Chenguang Zhang, Yutian Sun, Anping Xu, Ling Ji, Jianghua Ou, Shang Ying Wu
Summary: A predictive model based on senescence-oxidative stress co-relation genes (SOSCRGs) was developed and evaluated for its clinical utility in breast cancer. The model showed promise in predicting prognosis, aiding clinical decision making, and risk stratification for patients with breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Yinghui Ye, Guangyue Lu, Yujia Tian, Yingting Liu
Summary: This paper investigates the outage performance of the primary and secondary systems in a commensal symbiotic radio network with energy harvesting. The signal-to-noise ratios for decoding the primary and secondary systems are given based on the energy-causality constraint of the secondary user, and the outage probabilities of both systems are defined. The closed-form expressions for the outage probability under the Rayleigh channel fading model are derived, and the diversity gain of both systems is obtained. It is shown that the access of secondary users can increase the diversity gain of the primary system from 1 to 2. The theoretical analysis is verified through simulations, and the effects of different system parameters on the outage probabilities are investigated.
JOURNAL OF ELECTRONICS & INFORMATION TECHNOLOGY
(2023)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
