Article
Medicine, Research & Experimental
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Shao Li, Gongbo Fu, Min Zeng, Yi Gao
Summary: The study utilized a fiber scaffold bioreactor for high-density, 3D culture of porcine hepatocytes to construct a bioartificial liver and evaluated its protective effects in an ALF porcine model. The bioartificial liver treatment enhanced liver regeneration, alleviated systemic inflammatory response, and reduced extrahepatic organ injury, leading to prolonged survival in the ALF model.
Article
Pharmacology & Pharmacy
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Summary: This study demonstrates the beneficial effects of exogenous phosphatidic acid in acetaminophen toxicity by activating IL-6 signaling. However, despite the importance of PA in liver repair, exogenous PA did not alter regeneration.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Food Science & Technology
Keisuke Hamada, Ping Wang, Yangliu Xia, Nana Yan, Shogo Takahashi, Kristopher W. Krausz, Haiping Hao, Tingting Yan, Frank J. Gonzalez
Summary: WA has therapeutic effects on alcoholic liver disease by inhibiting hepatic lipogenesis to reduce liver injury caused by alcohol.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Yanyao Liu, Zilun Lei, Hao Chai, Quan Kang, Xiaoyan Qin
Summary: Salidroside alleviates hepatic ischemia-reperfusion injury by modulating the TLR-4/NF-κB/NLRP3 inflammatory pathway.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Xinyu Yang, Di Lu, Rui Wang, Zhengxing Lian, Zuyuan Lin, Jianyong Zhuo, Hao Chen, Modan Yang, Winyen Tan, Mengfan Yang, Xuyong Wei, Qiang Wei, Shusen Zheng, Xiao Xu
Summary: Our study identified 11 different cell types in transplanted livers, with a highly complex ecosystem primarily shaped by myeloid-derived cell subsets that transition between different states and interact mutually. In transplanted steatotic livers, a pro-inflammatory phenotype of Kupffer cells (KCs) with high expression of colony-stimulating factor 3 (CSF3) was found to potentially contribute to fatty graft injury. Additionally, a subset of dendritic cells (DCs) with highly expressing XCR1 was correlated with CD8(+) T cells, mediating severer steatotic liver damage by I/R injury.
CELL PROLIFERATION
(2021)
Article
Gastroenterology & Hepatology
Adriana Perez, Amanda Cantor, Bryan Rudolph, Jonathan Miller, Debora Kogan-Liberman, Qi Gao, Bernardo Da Silva, Kara G. Margolis, Nadia Ovchinsky, Mercedes Martinez
Summary: Elevated ALT in children with SARS-CoV-2 is associated with a more severe disease course, including higher rates of multiorgan dysfunction and longer hospitalizations. Male gender and Black race were more likely to be associated with elevated ALT in MIS-C.
LIVER INTERNATIONAL
(2021)
Article
Biology
Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F. Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A. Elias, William M. Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju
Summary: The study uncovered the critical role of Chi3I1 in mediating APAP-induced hepatic platelet recruitment, signaling through CD44 and C-type lectin-like receptor 2. Inhibiting Chi3I1 effectively attenuated liver injury induced by APAP.
Review
Biochemistry & Molecular Biology
Le Chen, Xiaodong Lv, Min Kan, Ruonan Wang, Hua Wang, Hongmei Zang
Summary: Non-alcoholic fatty liver disease (NAFLD) and acute kidney injury (AKI) are important public health diseases with a heavy burden on healthcare systems worldwide. NAFLD may lead to AKI through the effects of hepatic factors, but the underlying mechanisms are not well understood. Hepatic factors play a crucial role in regulating energy metabolism and maintaining energy homeostasis, and may serve as a potential therapeutic target for preventing the progression of metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Zhang, Chengwu Huang, Tinghui Yin, Xiaoyan Miao, Huan Deng, Rongqin Zheng, Jie Ren, Shigao Chen
Summary: This study aimed to evaluate the feasibility of ultrasensitive US microvessel imaging in visualizing and quantifying hepatic microvessels in healthy and cirrhotic rats. The findings showed that ultrasensitive US microvessel imaging could detect minute vessels below the liver capsule and quantify the perfusion, tortuosity, and integrity of microvessels. Cirrhotic rats had lower vessel density and fractional moving blood volume, and higher tortuosity compared to control rats, which were strongly correlated with pathologically derived vessel density and hepatic tissue hypoxia.
Review
Gastroenterology & Hepatology
Linda Hammerich, Frank Tacke
Summary: This Review provides an extensive overview of the mechanisms of inflammation and fibrosis in the liver, particularly in NAFLD or NASH, and discusses the current advances and therapeutic implications. Chronic liver diseases characterized by persistent inflammation and subsequent liver fibrosis have significant impact on long-term morbidity and mortality. Inflammatory responses involve hepatic cell types and signals related to intrahepatic injury pathways, gut-liver axis, and circulation.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tao Lin, Rilu Feng, Roman Liebe, Hong-Lei Weng
Summary: Liver progenitor cells play a key role in acute liver failure by rapidly proliferating and taking over crucial hepatocyte functions. These findings not only enhance our understanding of liver regenerative capability, but also provide potential new targets for pharmacological management of acute liver failure.
Article
Cell Biology
Yang Wang, Yifan Zhang, Yun Liu, Jun Xu, Yulan Liu
Summary: The study found that LSEC is a crucial barrier in the gut-liver axis, defending the liver against colitis-induced injury. When LSECs are damaged, they can turn into a pro-inflammatory pattern under the stimulation of LPS. LSEC injury and colitis-derived LPS synergistically contribute to the recruitment and activation of hepatic neutrophils. Neutrophils play a pivotal role as a downstream effector in colitis-induced liver injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhui Li, Zhengyi Shi, Xiangli Zhao, Yeting Zhang, Pengfei Bu, Yi Guo, Xiaosheng Tan, Changxing Qi, Yonghui Zhang
Summary: Eight ergosterol-type sterides were isolated from Aspergillus sp. TJ507, among which compound 3 showed protective effects against hepatic ischemia/reperfusion injury and could serve as a lead structure for the development of novel hepatoprotective agents.
BIOORGANIC CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Long Xu, Yang Yang, Yankai Wen, Jong-Min Jeong, Christoph Emontzpohl, Constance L. Atkins, Zhaoli Sun, Kyle L. Poulsen, David R. Hall, J. Steve Bynon, Bin Gao, William M. Lee, Jody Rule, Elizabeth A. Jacobsen, Hua Wang, Cynthia Ju
Summary: This study reveals the recruitment of eosinophils into the liver and their protective function during acetaminophen-induced acute liver injury. The data demonstrate that IL-33-activated eosinophils trigger macrophages to release high amounts of CCL24, which promotes hepatic eosinophil recruitment. Our findings suggest that eosinophils could be an effective cell-based therapy for the treatment of acetaminophen-induced acute liver injury.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Munemasa Nagao, Akihisa Fukuda, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Tomonori Masuda, Osamu Araki, Takaaki Yoshikawa, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Yu Muta, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Makoto Mark Taketo, Jorge Ferrer, Tatsuaki Tsuruyama, Yasuni Nakanuma, Kojiro Taura, Shinji Uemoto, Hiroshi Seno
Summary: This study reveals how dysregulation of canonical cell growth pathways drives precursors to biliary cancers and identifies several molecular vulnerabilities as potential therapeutic targets.