Article
Medicine, General & Internal
Chun-Ju Chiang, Jing-Rong Jhuang, Ya-Wen Yang, Bo-Zhi Zhuang, San-Lin You, Wen-Chung Lee, Chien-Jen Chen
Summary: The national hepatitis B vaccination program and antiviral therapy program in Taiwan have significantly reduced the burden of end-stage liver disease (ESLD).
Article
Immunology
Huahao Fan, Junfen Fan, Suming Chen, Yangzhen Chen, Huiru Gao, Liying Shan, Xue Li, Fengjun Gu, Hui Zhuang, Lijun Sun
Summary: The study found that not all pre-existing chronic liver diseases exacerbate clinical manifestations of acute hepatitis E, while end-stage liver diseases, respiratory tract infections, and chronic kidney diseases may significantly increase the mortality of patients with symptomatic HEV infection. Additionally, HEV patients with underlying comorbidities had worse severity evaluation indexes compared to those without relevant comorbidities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyung Woo Kim, Young Su Joo, Shin Chan Kang, Hee Byung Koh, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Summary: This study found that statin use is associated with a lower risk of incident hepatocellular carcinoma (HCC) in dialysis patients with chronic hepatitis B or C infection.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Alaya Koneru, Nancy Fenlon, Sarah Schillie, Charnetta Williams, Mark K. Weng, Noele Nelson
Summary: This study assessed trends and programmatic outcomes among infants born to HBsAg-positive women from 2009 to 2017, finding an increase in achievement of objectives related to infant hepatitis B postexposure prophylaxis, vaccine series completion, and PVST. However, there is a need to strengthen management mechanisms to bridge the gap between estimated and identified numbers, improve vaccine series completion rates, and increase the proportion of case-managed infants receiving recommended PVST.
Article
Immunology
Jaiprasath Sachithanandham, Ashwin Balagopal, Julia Leep-Lazar, Jeffrey Quinn, Kenneth Bowden, Kathleen Ward, Ruy M. Ribeiro, Mark S. Sulkowski
Summary: Using single-cell methods, the proportion of HCV-infected hepatocytes significantly decreased after initiating direct-acting antivirals (DAAs), proving that the second-phase viral dynamics derive from the loss of infected cells.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Henu Kumar Verma, Kiran Prasad, Pramod Kumar, Bhaskar Lvks
Summary: Viral hepatitis is a liver disease caused by different viruses, which can lead to liver damage. Early diagnosis, pathologizing, and treatment are crucial for patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Erkin Musabaev, Chris Estes, Shakhlo Sadirova, Shokhista Bakieva, Krestina Brigida, Rick Dunn, Shyamasundaran Kottilil, Poonam Mathur, Ameer Abutaleb, Kathryn Razavi-Shearer, Tim Anstiss, Bakhodir Yusupaliev, Homie Razavi
Summary: Chronic infection with HBV and HCV is a major cause of liver disease and mortality in Uzbekistan. This study demonstrated the feasibility of large-scale simplified testing and treatment to implement a national viral hepatitis elimination program.
LIVER INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Deepika Shrestha, Sally Picciotto, Michael P. LaValley, Sa Liu, S. Katharine Hammond, Daniel E. Weiner, Ellen A. Eisen, Katie M. Applebaum
Summary: Despite increasing prevalence of end-stage renal disease, this study found no overall association between metalworking fluids (MWF) and ESRD. However, there were modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. Differences by race suggest that black males may have higher disease rates following MWF exposure, indicating a need for further examination of this relationship.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ming-Yen Lin, Min-Yu Chang, Pei-Yu Wu, Ping-Hsun Wu, Ming-Huang Lin, Chih-Cheng Hsu, Jer-Ming Chang, Shang-Jyh Hwang, Yi-Wen Chiu
Summary: The study found that the universal pay-for-performance program implemented by the Taiwanese government has achieved certain effectiveness in providing better care for patients with late-stage CKD, including more appropriate medication prescriptions and improved survival outcomes. Further efforts are needed to expand the program's coverage and enrollment.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Fang Wang, Dingtao Hu, Hongyu Sun, Ziye Yan, Yuhua Wang, Linlin Wang, Tingyu Zhang, Nana Meng, Chunxia Zhai, Qiqun Zong, Wanqin Hu, Guanghui Yu, Yanfeng Zou
Summary: In the past 30 years, the global burden of digestive diseases has been increasing, requiring further investigation into incidence rates, deaths, and disability-adjusted life-years. According to data from the Global Burden of Diseases 2019 website, there has been a significant increase in the incidence, deaths, and DALYs of digestive diseases worldwide. Variations in burden have been observed across different countries and sexes.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Wei-Cheng Lee, Tzen-Kwan Chen, Hwa-Fa Han, Yu-Chun Lin, Ya-Min Hwang, Jia-Horng Kao, Pei-Jer Chen, Chun-Jen Liu
Summary: The study aimed to investigate the prevalence and clinical impact of HDV infection in Taiwan's communities, finding a low prevalence rate of HDV in district hospitals in Taiwan and no influence on the clinical manifestation of patients with chronic HBV infection. Further research with more sensitive methods may be needed for reliable prevalence data due to the small number of HDV RNA cases and the current sensitivity limitations of anti-HDV kits.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Giorgio Maria Saracco, Alfredo Marzano, Mario Rizzetto
Summary: Chronic viral hepatitis, caused by Hepatitis B Virus, Hepatitis C Virus, and Hepatitis D Virus, is a significant global health issue. Different viruses require different treatment approaches. Long-term suppressive therapy has had a dramatic impact on chronic hepatitis B, but complete clearance of the virus remains difficult. The unique virology of Hepatitis D Virus makes its treatment challenging, but combination therapy with specific antivirals shows promise. The introduction of Direct Acting Antiviral Agents has revolutionized the treatment of chronic hepatitis C, achieving high cure rates.
Article
Public, Environmental & Occupational Health
Yi Huang, Yongan Li, Haiyan Pan, Liyuan Han
Summary: This study aimed to determine the incidence and DALYs of neurological disorders worldwide. The highest incidence rates were observed in East Asia, tropical Latin America, Southern Latin America, and Western Europe. Control measures are needed to address the increasing incidence rates in China, Ecuador, and Italy.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Gastroenterology & Hepatology
Dan-Yi Zeng, Jing-Mao Li, Su Lin, Xuan Dong, Jia You, Qing-Qing Xing, Yan-Dan Ren, Wei-Ming Chen, Yan-Yan Cai, Kuangnan Fang, Mei-Zhu Hong, Yueyong Zhu, Jin-Shui Pan
Summary: The burden of acute viral hepatitis is associated with the socio-economic development status of countries or regions, with incidence rates and DALY rates varying according to the SDI.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Meng-Hsuan Hsieh, Ming-Jong Bair, Pei-Chien Tsai, Kuo-Chih Tseng, Ching-Chu Lo, Chi-Yi Chen, Hsing-Tao Kuo, Chao-Hung Hung, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi-Ming Tai, Chih-Wen Lin, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Ming-Lun Yeh, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Ming-Lung Yu, Wan-Long Chuang
Summary: This study revealed that diabetes history and impaired baseline renal function, instead of achieving sustained virological response (SVR), were significant risk factors for developing end-stage renal diseases (ESRD) under maintenance dialysis among chronic HCV-infected patients after antiviral therapy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jiyoon Park, An K. Le, Tai-Chung Tseng, Ming-Lun Yeh, Dae Won Jun, Huy Trinh, Grace L. H. Wong, Chien-Hung Chen, Cheng-Yuan Peng, Sung Eun Kim, Hyunwoo Oh, Min-Sun Kwak, Ka Shing Cheung, Hidenori Toyoda, Yao-Chun Hsu, Jae Yoon Jeong, Eileen L. Yoon, Teerapat Ungtrakul, Jian Zhang, Qing Xie, Sang Bong Ahn, Masaru Enomoto, Jae-Jun Shim, Chris Cunningham, Soung Won Jeong, Yong Kyun Cho, Eiichi Ogawa, Rui Huang, Dong-Hyun Lee, Hirokazu Takahashi, Pei-Chien Tsai, Chung-Feng Huang, Chia-Yen Dai, Cheng-Hao Tseng, Satoshi Yasuda, Ritsuzo Kozuka, Jiayi Li, Christopher Wong, Clifford C. Wong, Changqing Zhao, Joseph Hoang, Yuichiro Eguchi, Chao Wu, Yasuhito Tanaka, Ed Gane, Tawesak Tanwandee, Ramsey Cheung, Man-Fung Yuen, Hyo-Suk Lee, Ming-Lung Yu, Jia-Horng Kao, Hwai-I Yang, Mindie H. Nguyen
Summary: This study aimed to determine the rates of cirrhosis and hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB), stratified by age, sex, treatment status, and disease activity. The results show that there is significant variability in CHB disease progression rates even among lower-risk populations.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hui-Han Hu, Wen-Juei Jeng, Mei-Hung Pan, Wun-Sheng Luo, Chia-Ling Chang, Yen-Tsung Huang, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Yu-Chuan Chien, Shen-Nan Lu, Li-Yu Wang, Li-Rung Huang, Mei-Hsuan Lee, Jessica Liu, Mindie H. Nguyen, Chien-Jen Chen, Hwai- Yang
Summary: sPD-1 level is a novel marker that predicts spontaneous HBsAg seroclearance in patients with HBeAg-negative chronic hepatitis B with undetectable HBV DNA.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
An-Shun Tai, Yen-Tsung Huang, Hwai- Yang, Lauren V. Lan, Sheng-Hsuan Lin
Summary: Regression-based approaches are commonly used in causal mediation analysis, but they may not be efficient in cases with multiple mediators. Therefore, a flexible simulation-based approach was developed to address estimation issues and increase flexibility in model selection. The method was evaluated using a Taiwanese Cohort Study dataset and showed promising results in investigating the mediating role of HBV viral load in the effect of HCV infection on hepatocellular carcinoma.
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Gastroenterology & Hepatology
Wen-Juei Jeng, Mei-Hung Pan, Hwai- Yang
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Yu-Ju Chu, Wen-Juei Jeng, Mei-Hung Pan, Hui-Han Hu, Wen-Sheng Luo, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Chien-Jen Chen, Hwai- Yang
Summary: Serum sPD-1 levels may serve as a novel immunological predictor for spontaneous HBeAg seroclearance in patients with chronic hepatitis B. Lower baseline sPD-1 levels and long-term decline in sPD-1 levels were independent predictors for HBeAg seroclearance, particularly significant in patients with genotype C infection.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Virology
Wen-Juei Jeng, Chien-Hung Chen, Yi-Wen Wang, Mei-Hung Pan, Chia-Wei Lin, Chun-Yen Lin, Hwai- Yang
Summary: There is no correlation between sPD-1 levels measured by MyBioSource (MB) and R&D (RD) kits. The sPD-1 measured by MB showed strong correlations with HBsAg, HBV DNA, and ALT levels, while an opposite trend was seen with the RD kit. Multivariate linear regression analysis indicated that HBsAg and ALT levels were the major factors associated with sPD-1 levels measured by MB and RD, respectively.
Article
Gastroenterology & Hepatology
Shanshan Wu, Jialing Zhou, Xiaoning Wu, Yameng Sun, Bingqiong Wang, Yuanyuan Kong, Siyan Zhan, Jidong Jia, Hwai- Yang, Hong You
Summary: This study assessed the comparative performance of 14 hepatocellular carcinoma prediction models in chronic hepatitis B patients and found that several models performed best when using on-treatment values within the first 2 years.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi-Chung Hsieh, Mei-Hung Pan, Wen-Juei Jeng, Hui-Han Hu, Jessica Liu, Masashi Mizokami, Chien-Jen Chen, Hwai- Yang
Summary: The study found an association between hepatitis B core-related antigen (HBcrAg) and hepatocellular carcinoma (HCC) in chronic hepatitis B patients. The relationship between HBcrAg and HCC was also investigated in individuals seronegative for hepatitis B surface antigen and anti-hepatitis C virus (NBNC) in Taiwan. The results showed that HBcrAg positivity was significantly associated with higher risk of HCC, indicating that it might serve as a marker for identifying individuals at a higher risk of HCC in hepatitis B virus endemic areas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chien-Wei Peng, Wen-Juei Jeng, Hwai- Yang, Yen-Chun Liu, Rong-Nan Chien, Yun-Fan Liaw
Summary: In HBeAg negative chronic hepatitis B (CHB) patients, stopping tenofovir and other nucleos(t)ide analogues (Nucs) is associated with more frequent and severe clinical relapse. This study found that switching to entecavir more than 12 weeks prior to stopping treatment can delay and reduce the occurrence of clinical relapse and flares.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Ilona Argirion, Jalen Brown, Sarah Jackson, Ruth M. Pfeiffer, Tram Kim Lam, Thomas R. O'Brien, Kelly J. Yu, Katherine A. McGlynn, Jessica L. Petrick, Ligia A. Pinto, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang, Mei-Hsuan Lee, Jill Koshiol
Summary: This study investigated the role of circulating immunologic markers in predicting the progression of liver disease in individuals chronically infected with hepatitis C virus (HCV). The findings suggest that these markers play an important role in predicting HCV-related cirrhosis even 11 years after enrollment.
Article
Virology
Kwong-Ming Kee, Chien-Hung Chen, Jui-Ting Hu, Yi-Hsiang Huang, Tsang-En Wang, Gar-Yang Chau, Kuo-Hsin Chen, Yao-Li Chen, Chih-Che Lin, Chien-Fu Hung, Shiu-Feng Huang, Tsang-Wu Liu, Hsiu-Ying Ku, Bing-Shen Huang, Yi-Pin Wang, Hui-Ping Tseng, Chun-Ju Chiang, Sheng-Nan Lu
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death in Taiwan. This study aimed to investigate the secular trends of HCC characteristics and survival in recent decades. The overall survival of HCC in Taiwan has been improving, possibly due to increased early-stage patients and the aging population. The proportion of viral-related HCC is decreasing, while nonviral-related HCC is increasing.
Article
Oncology
Yu-Hsuan Chang, Wan-Lun Hsu, Yu-Kwang Lee, Chun-Ju Chiang, Ya-Wen Yang, San-Lin You, Yong-Chen Chen, Tai-Shuan Lai
Summary: Taiwan has a high incidence of UTUC, especially in women. A long-term follow-up study using national cancer registry data from 1985 to 2019 showed a 3.5% increase in renal pelvis cancer incidence in men and a 5.3% increase in women. The incidence of renal pelvis cancer gradually increased with age among women, and younger cohorts had a higher risk of UTUC compared to older cohorts.
Meeting Abstract
Gastroenterology & Hepatology
Rachel Wen-Juei Jeng, Chien-Hung Chen, Hwai-I Yang, Yi-Cheng Chen, Yen-Chun Liu, Chia-Ying Wu, Rong-Nan Chien, Yun-Fan Liaw
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Rachel Wen-Juei Jeng, Yu-Ju Chu, Mei-Hung Pan, Hui-Han Hu, Wun-Sheng Luo, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Sheng-Nan Lu, Li-Yu Wang, Chien-Jen Chen, Hwai-I Yang
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hui-Chen Wu, Wen-Juei Jeng, Mei-Hung Pan, Yi-Chung Hsieh, Sheng-Nan Lu, Chien-Jen Chen, Hwai- Yang
Summary: This study examined the cumulative risk of hepatocellular carcinoma (HCC) and mortality from liver-related disease among a non-hepatitis virus-infected population. It found that modifiable risk factors such as alcohol consumption, heart disease, diabetes, and abnormal liver function tests were strongly associated with an increased risk of HCC and mortality.