Article
Multidisciplinary Sciences
Yashraj Bhosale, Giridar Vishwanathan, Gaurav Upadhyay, Tejaswin Parthasarathy, Gabriel Juarez, Mattia Gazzola
Summary: Viscous streaming can be effectively manipulated with multicurvature designs, leading to rich flow repertoires and potential applications in fluid and particle manipulation, filtering, and separation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Lei Zhao, Mengqi Gao, Yanbing Niu, Jianchun Wang, Shaofei Shen
Summary: A novel microchannel structure was developed for flow-rate and particle-size insensitive inertial focusing; efficient focusing of particles and tumor cells at different flow rates was achieved through enhanced secondary flow; providing important reference for the development of portable inertial microfluidic devices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Chemical
Maira Shakeel Syed, Christopher Marquis, Robert Taylor, Majid Ebrahimi Warkiani
Summary: The advancement of cell separation techniques has brought efficiency to cell culture processes, but cost and reliability issues persist. A proposed integrated system utilizing two membrane-less microfiltration techniques is able to achieve efficient cell separation in a cost-effective and reliable manner.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Yueyue Zhang, Tingting Zheng, Li Wang, Liang Feng, Min Wang, Zhenchao Zhang, Huanhuan Feng
Summary: The significance of achieving high-efficiency sorting of microfluidics in various fields is discussed, along with the introduction of recent sorting methods. The research status and progress are categorized into active and passive sorting systems, which can control microfluidics for more selective separation to obtain higher resolution and selection rate. The paper analyzes and discusses these methods and prospects the future of microfluidic sorting.
REVIEWS ON ADVANCED MATERIALS SCIENCE
(2021)
Article
Chemistry, Analytical
Uihwan Kim, Byeolnim Oh, Jiyeon Ahn, Sangwook Lee, Younghak Cho
Summary: In this study, an integrated microfluidic device was proposed for non-contact, label-free separation of particles and cells using a combination of inertial microfluidics and acoustophoresis. The device demonstrated excellent separation performance and high recovery ratio, making it a potential alternative to current cell separation methods.
Article
Multidisciplinary Sciences
Siddhansh Agarwal, Fan Kiat Chan, Bhargav Rallabandi, Mattia Gazzola, Sascha Hilgenfeldt
Summary: This literature introduces an analytical method in inertial microfluidics to derive and quantify the theory of inertial effects, which has been verified through full-scale, three-dimensional direct numerical simulations and revealed previously unexplained experimental phenomena.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Aliaa I. Shallan, Yakini Tavares, Moein Navvab Kashani, Michael C. Breadmore, Craig Priest
Summary: The study developed a continuous in situ sampler that can extract particle-free solution from a turbulent high solids content stream without needing to be close to a solid surface. Two applications were demonstrated: monitoring Fe-III in a stirred slurry of mixed ore particles and dissolution profiles of paracetamol tablets with different formulations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Hua Gao, Jian Zhou, Mohammad Moein Naderi, Zhangli Peng, Ian Papautsky
Summary: Particle migration dynamics in viscoelastic fluids in spiral channels for 3D focusing and label-free sorting has been studied extensively, but the underlying mechanism is not fully understood. In this work, we experimentally demonstrate the evolution of particle focusing behavior in spiral microchannels with high blockage ratio and reveal the important roles of flow rate, device curvature, and medium viscosity. Our results provide insights into the design of elasto-inertial microfluidics devices for improved efficiency in cell sorting and cytometry applications.
MICROSYSTEMS & NANOENGINEERING
(2023)
Review
Engineering, Chemical
Karin Schroen, Izabella Bouhid de Aguiar
Summary: Membrane filtration plays a crucial role in food ingredient production, but there is a lack of consideration for the specific properties of food ingredients. This review focuses on the processes of concentration and fractionation, highlighting the importance of deformability in membrane filtration.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Chemistry, Analytical
Navya Rastogi, Pranjal Seth, Ramray Bhat, Prosenjit Sen
Summary: The novel orthogonal vortex chip enables size-based cell separation at lower velocities to avoid cell damage caused by high flow speeds. The device utilizes shear-gradient lift, centrifugal, and Dean flow drag forces to selectively trap particles of different sizes, showing promising results for gentle isolation of rare cells from blood.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Malihe Farasat, Ehsan Aalaei, Saeed Kheirati Ronizi, Atin Bakhshi, Shaghayegh Mirhosseini, Jun Zhang, Nam-Trung Nguyen, Navid Kashaninejad
Summary: Separation and detection of cells and particles in a suspension are essential for various applications, including biomedical investigations and clinical diagnostics. Microfluidics has enabled the miniaturization of analytical devices by controlling the motion of fluid in micrometer-sized channels and chambers. Among different microfluidic methods, dielectrophoresis (DEP) offers advantages for manipulating neutral bioparticles using unique dielectric characteristics. This review focuses on signal-based DEP methods that utilize signal parameters such as frequency, amplitude, phase, and shape for cell/particle separation and manipulation.
Article
Chemistry, Analytical
Kazem Akbarnataj, Sasan Maleki, Masoud Rezaeian, Mohammad Haki, Amir Shamloo
Summary: This study proposes novel microfluidic devices based on size-dependent cell-sorting for label-free, ultra-fast enrichment of circulating tumor cells (CTCs). The devices were evaluated through numerical simulation and demonstrated optimal separation efficiency at a flow rate of 2.5 mL/min, achieving CTC purity values between 88% and 90%.
Article
Mechanics
Mehryar Jannesari Ghomsheh, Azadeh Jafari, Denis Funfschilling
Summary: Direct three-dimensional Numerical Simulations (DNS) are used to study the inertial lift forces on a single particle in a straight rectangular microchannel filled with Newtonian fluid and xanthan gum solutions. The shear-thinning behavior of xanthan gum solutions is experimentally demonstrated and mathematically represented using power-law and Carreau-Yasuda models. The simulations reveal the dominant region of shear gradient and wall-induced lift forces for both power-law and Carreau-Yasuda fluids, similar to Newtonian fluids. The variable viscosity of non-Newtonian fluids allows for better control of particle motion, particularly in the inertial focusing method.
JOURNAL OF NON-NEWTONIAN FLUID MECHANICS
(2023)
Article
Optics
Shashi Prakash, Subrata Kumar
Summary: The article introduces different strategies for fabricating microchannels using CO2 lasers and conducts experimental studies to compare them in terms of surface quality, cross-sectional profile, and other parameters.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Physics, Applied
Di Jiang, Chen Ni, Wenlai Tang, Nan Xiang
Summary: Numerical simulation was used to explore particle elasto-inertial focusing in straight microchannels, revealing that increased flow intensity and particle diameter can accelerate focusing migration, while flow elasticity weakens particle rotation and lateral focusing towards the channel centerline. The competition mechanisms of forces were elucidated under different Reynolds and Weissenberg numbers.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Review
Immunology
Habib Sadeghirad, Tayyeb Bahrami, Sepideh M. Layeghi, Hassan Yousefi, Meysam Rezaei, Seyed R. Hosseini-Fard, Payar Radfar, Majid E. Warkiani, Ken O'Byrne, Arutha Kulasinghe
Summary: This review discusses the immunotherapeutic targets in non-small cell lung cancer (NSCLC) tumors and how the tumor microenvironment (TME) can influence the response to immunotherapy.
Review
Urology & Nephrology
Dale M. Goss, Steven A. Vasilescu, Gavin Sacks, David K. Gardner, Majid E. Warkiani
Summary: In this study, Goss et al. explore the diagnostic potential of male reproductive small extracellular vesicles (S-EVs) and the practical approaches of implementing point-of-need and multianalyte diagnostics in infertility treatment. They find that S-EVs have the potential to influence sperm physiology therapeutically and diagnostically. However, the isolation of pure populations of S-EVs from bodily fluids with current conventional methods presents a substantial hurdle. Microfluidic technology has the potential to simplify and improve S-EV isolation and detection.
NATURE REVIEWS UROLOGY
(2023)
Article
Immunology
Maryam Shojaei, Amir Shamshirian, James Monkman, Laura Grice, Minh Tran, Chin Wee Tan, Siok Min Teo, Gustavo Rodrigues Rossi, Timothy R. McCulloch, Marek Nalos, Maedeh Raei, Alireza Razavi, Roya Ghasemian, Mobina Gheibi, Fatemeh Roozbeh, Peter D. Sly, Kirsten M. Spann, Keng Yih Chew, Yanshan Zhu, Yao Xia, Timothy J. Wells, Alexandra Cristina Senegaglia, Carmen Lucia Kuniyoshi, Claudio Luciano Franck, Anna Flavia Ribeiro dos Santos, Lucia de Noronha, Sepideh Motamen, Reza Valadan, Omolbanin Amjadi, Rajan Gogna, Esha Madan, Reza Alizadeh-Navaei, Liliana Lamperti, Felipe Zuniga, Estefania Nova-Lamperti, Gonzalo Labarca, Ben Knippenberg, Velma Herwanto, Ya Wang, Amy Phu, Tracy Chew, Timothy Kwan, Karan Kim, Sally Teoh, Tiana M. Pelaia, Win Sen Kuan, Yvette Jee, Jon Iredell, Ken O'Byrne, John F. Fraser, Melissa J. Davis, Gabrielle T. Belz, Majid E. Warkiani, Carlos Salomon Gallo, Fernando Souza-Fonseca-Guimaraes, Quan Nguyen, Anthony Mclean, Arutha Kulasinghe, Kirsty R. Short, Benjamin Tang
Summary: This study found that the IFI27 gene is associated with COVID-19 infection and that its expression levels in the respiratory tract and blood are correlated with viral load and infection severity. IFI27 gene family biomarkers may supplement conventional diagnostic tools in future virus pandemics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Sajad Razavi Bazaz, Sareh Zhand, Robert Salomon, Elham Hosseini Beheshti, Dayong Jin, Majid Ebrahimi Warkiani
Summary: This study used the ImmunoInertial microfluidics approach to isolate specific subpopulations of cancer-specific small extracellular vesicles (sEVs), demonstrating high efficiency and selectivity. The method has the advantages of high sensitivity, low cost, and ability to process samples of varying volumes, making it a promising strategy for cancer diagnosis and prognosis in liquid biopsies.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemical Research Methods
Mingyuan Yang, Yi Zhou, Wenqin Chen, Weihao Wang, Chun Yang
Summary: This study examines the thermophoresis of colloidal spheroids in aqueous media by considering the thermal conductivity effect. A numerical model is developed to analyze the temperature distribution around the spheroid. The results show that the thermal conductivity mismatch between the particle and the liquid leads to a nonlinear temperature region, and the influence of thermal conductivity on thermophoresis depends on various parameters.
Review
Immunology
Azadeh Haghighitalab, Massimo Dominici, Maryam M. Matin, Faezeh Shekari, Majid Ebrahimi Warkiani, Rebecca Lim, Naghmeh Ahmadiankia, Mahdi Mirahmadi, Ahmad Reza Bahrami, Hamid Reza Bidkhori
Summary: Conventional immune suppressive therapies for autoimmune diseases have limitations and complications. Tolerogenic therapeutic strategies based on stem cells, immune cells, and their extracellular vesicles (EVs) are promising for managing these diseases. Mesenchymal stem/stromal cells (MSCs), dendritic cells, and regulatory T cells (Tregs) are the main cell types used, with MSCs playing a more beneficial role. EV-based therapies are gaining attention as cell-free therapeutic paradigms and have unique properties as smart immunomodulators. This review discusses the advantages and disadvantages of cell-based and EV-based methods and the future outlook of EVs in autoimmune disease treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Steven A. Vasilescu, Lin Ding, Farin Yazdan Parast, Reza Nosrati, Majid Ebrahimi Warkiani
Summary: This article presents a 3D printed microfluidic sperm selection device (MSSP) that mimics the behavior of sperm selection and has higher sperm motility and lower DNA fragmentation and apoptosis. It demonstrates that MSSP is easy to use and mimics the biological function of the female reproductive tract during conception.
MICROSYSTEMS & NANOENGINEERING
(2023)
Correction
Chemistry, Analytical
Sareh Zhand, Ying Zhu, Hojjatollah Nazari, Mohammad Sadraeian, Majid Ebrahimi Warkiani, Dayong Jin
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yan Dong, Weifeng Meng, Fuqiang Wang, Han Han, Huaxu Liang, Xiang Li, Yanan Zou, Chun Yang, Zenghui Xu, Yuying Yan, Ziming Cheng
Summary: This study combines temperature-adaptive solar absorption and passive daytime radiative cooling (PDRC) technology to achieve warm in winter and cool in summer. The temperature-adaptive radiative cooling coating (TARCC) with color variability is designed and fabricated, showing high solar reflectance and atmospheric transmission window emittance in summer, and heat absorption in winter. It has the potential to save energy and increase suitable human hours.
Article
Chemistry, Multidisciplinary
Wenyao Zhang, Xinxi Liu, Kai Jiao, Qiuwang Wang, Chun Yang, Cunlu Zhao
Summary: This study reveals a new thermoelectric mechanism that significantly enhances the thermoelectric response in nanoconfined electrolytes by coupling the ion steric effect and ion thermodiffusion in electric double layers.
Article
Pharmacology & Pharmacy
Bikash Manandhar, Keshav Raj Paudel, Dvya Delilaa Clarence, Gabriele De Rubis, Thiagarajan Madheswaran, Jithendra Panneerselvam, Flavia C. Zacconi, Kylie A. Williams, Lisa G. Pont, Majid Ebrahimi Warkiani, Ronan MacLoughlin, Brian Gregory Oliver, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer is a common and deadly form of cancer, especially non-small-cell lung cancer (NSCLC). Zerumbone (ZER) is a natural compound with anti-cancer properties, but its effectiveness is hindered by low solubility and poor absorption. This study developed ZER-loaded liquid crystalline nanoparticles (LCNs) and found that they effectively inhibited the growth and migration of NSCLC cells. The underlying mechanisms involved the regulation of tumor suppressor genes and metastasis-associated genes. This research suggests that ZER-LCNs could be a promising treatment strategy for NSCLC.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Physics, Multidisciplinary
Benjamin Owen, Konstantinos Kechagidis, Sajad Razavi Bazaz, Romain Enjalbert, Erich Essmann, Calum Mallorie, Fatemehsadat Mirghaderi, Christian Schaaf, Krishnaveni Thota, Rohan Vernekar, Qi Zhou, Majid Ebrahimi Warkiani, Holger Stark, Timm Krueger
Summary: Inertial Particle Microfluidics (IPMF) is a technology used for manipulating and separating microparticles and biological cells. This tutorial review provides a guide for researchers interested in simulating IPMF applications using the lattice-Boltzmann (LB) method, including the state of the art of LB-based IPMF modelling, physics of IPMF, related methods used in LB models, case studies of LB simulations for different IPMF scenarios, and proposed research directions.
ADVANCES IN PHYSICS-X
(2023)
Review
Cell & Tissue Engineering
Malihe Lotfi, Dorsa Morshedi Rad, Samaneh Sharif Mashhadi, Atefeh Ashouri, Majid Mojarrad, Sina Mozaffari-Jovin, Shima Farrokhi, Maryam Hashemi, Marzieh Lotfi, Majid Ebrahimi Warkiani, Mohammad Reza Abbaszadegan
Summary: The CRISPR/Cas9 system offers potential for treating various diseases, and hPSCs have great potential in stem cell-based therapy. However, effective delivery of CRISPR/Cas9 into hPSCs is still an ongoing challenge.
STEM CELL REVIEWS AND REPORTS
(2023)
Meeting Abstract
Developmental Biology
Sahar Ghorbanpour, Claire Richards, Louise Cole, Kristine McGrath, Majid E. Warkiani, Lana McClements
Meeting Abstract
Cell & Tissue Engineering
P. Radfar, L. Ding, S. Oh, M. Ebrahimi Warkiani