Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

A New Mdr2−/− Mouse Model of Sclerosing Cholangitis with Rapid Fibrosis Progression, Early-Onset Portal Hypertension, and Liver Cancer

(2015) Naoki Ikenaga et al.   AMERICAN JOURNAL OF PATHOLOGY

Connective tissue growth factor and integrin αvβ6: A new pair of regulators critical for ductular reaction and biliary fibrosis in mice

(2015) Liya Pi et al.   HEPATOLOGY

Determining the fate of hepatic cells by lineage tracing: Facts and pitfalls

(2015) Frédéric P. Lemaigre   HEPATOLOGY

The Liver Is a Peculiar Organ When It Comes to Stem Cells

(2014) George K. Michalopoulos   AMERICAN JOURNAL OF PATHOLOGY

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

Extrahepatic Platelet-Derived Growth Factor-β, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice

(2014) Shuhei Yoshida et al.   GASTROENTEROLOGY

Failure of Fibrotic Liver Regeneration in Mice Is Linked to a Severe Fibrogenic Response Driven by Hepatic Progenitor Cell Activation

(2013) Kaori Kuramitsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver regeneration by stem/progenitor cells

(2013) Tohru Itoh et al.   HEPATOLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

(2012) Gabriel A Kwong et al.   NATURE BIOTECHNOLOGY

The biliary tree—a reservoir of multipotent stem cells

(2012) Vincenzo Cardinale et al.   Nature Reviews Gastroenterology & Hepatology

Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

(2011) Yury Popov et al.   GASTROENTEROLOGY

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential

(2011) S. Shin et al.   GENES & DEVELOPMENT

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice

(2011) C. Dorrell et al.   GENES & DEVELOPMENT

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

The αvβ6 integrin is a highly specific immunohistochemical marker for cholangiocarcinoma

(2010) E. Patsenker et al.   JOURNAL OF HEPATOLOGY

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver

(2009) M. Okabe et al.   DEVELOPMENT

Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies

(2009) Yury Popov et al.   HEPATOLOGY

Diagnosis and management of primary sclerosing cholangitis

(2009) Roger Chapman et al.   HEPATOLOGY

Regulation of In Situ to Invasive Breast Carcinoma Transition

(2008) Min Hu et al.   CANCER CELL

Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression

(2008) Eleonora Patsenker et al.   GASTROENTEROLOGY

Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin

(2008) Mina Komuta et al.   HEPATOLOGY

Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

(2008) Yury Popov et al.   JOURNAL OF HEPATOLOGY