Article
Biology
Jingbo Ma, Yang Gu, Peng Xu
Summary: This study reports a systematic approach to improve the biosynthesis of the cannabinoid precursor olivetolic acid in yeast, leading to a significant increase in the production of the acid. The findings provide a baseline for engineering cannabinoids biosynthesis in oleaginous yeast species.
COMMUNICATIONS BIOLOGY
(2022)
Article
Plant Sciences
Mingming Yang, Linda S. Thomashow, David M. Weller
Summary: Pseudomonas brassicacearum Q8r1-96 and DAPG have differing effects on the germination of wheat cultivars, with certain cultivars showing higher tolerance to these factors. Wheat cultivars vary widely in their interaction with P. brassicacearum and the biocontrol antibiotic DAPG.
Article
Pharmacology & Pharmacy
Brian J. Kirby, Justin D. Lutz, Mun Sang Yue, Kimberly L. Garrison, Ann Ran-Ran Qin, Lorraine Ampaw, Carine Beysen, Robert P. Myers, Brian P. Kearney, Anita Mathias
Summary: The study investigated the impact of Firsocostat on hepatic de novo lipogenesis and found that the drug maintained the same hepatic efficacy even when affected by an OATP inhibitor. These findings provide practical guidance for drug administration in settings of reduced OATP function.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Yifan Zhong, Xiaoli He, Wenlan Tao, Jizhou Feng, Ruixue Zhang, Hongzhi Gong, Ziyi Tang, Chao Huang, Yun He
Summary: MRSA, a multi-drug resistant bacterium, poses a severe global public health challenge. In this study, a derivative of natural compound DAPG, 7g, showed strong antibacterial activity against MRSA without resistance development. Mechanistic studies revealed that 7g targets bacterial cell membranes. Additionally, 7g exhibited significant synergistic effects with oxacillin and had the potential to eradicate MRSA biofilms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Multidisciplinary Sciences
Waheed Miran, Divya Naradasu, Akihiro Okamoto
Summary: The article discusses the role of electron transfer in the metabolic activity of biofilms, as well as the new method of using electrical currents produced by biofilm cells to evaluate the effects of antimicrobial agents. It also explores the mechanisms of EET in pathogens and environmental bacteria, along with addressing the current limitations and future research directions in the assessment of biofilm metabolic activity.
Article
Agriculture, Multidisciplinary
Qingqing Yang, Qing Yan, Bo Zhang, Li-qun Zhang, Xiaogang Wu
Summary: Carbon metabolism plays a critical role in the production of the bacterial secondary metabolite 2,4-diacetylphloroglucinol (2,4-DAPG) and the biocontrol capacity of Pseudomonas fluorescens 2P24. The citrate synthase gene gltA regulates the expression of 2,4-DAPG biosynthesis genes and is essential for biocontrol activity. Mutation of gltA decreases 2,4-DAPG synthesis and impairs biocontrol capacity against bacterial wilt disease, while citrate addition enhances 2,4-DAPG production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Microbiology
Qiuling Dong, Qing Yan, Bo Zhang, Li-qun Zhang, Xiaogang Wu
Summary: Pseudomonas fluorescens 2P24, a plant root-associated bacterium, produces the antibiotic 2,4-diacetylphloroglucinol (2,4-DAPG) to suppress soilborne plant diseases. In this study, a new genetic element grxD was identified, which plays a crucial role in the production of 2,4-DAPG. Mutation of grxD significantly reduced 2,4-DAPG production and affected the function of other regulatory factors.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Qiuling Dong, Qing Yan, Bo Zhang, Li-qun Zhang, Xiaogang Wu
Summary: The monothiol glutaredoxin GrxD plays a crucial role in regulating the production of 2,4-diacetylphloroglucinol (2,4-DAPG) in Pseudomonas fluorescens 2P24. This study reveals the interaction between GrxD and the BolA-like protein IbaG, which is necessary for the regulation of 2,4-DAPG production. The findings also highlight the important role of IbaG in gene regulation, motility, biofilm formation, siderophore production, and acid resistance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Qiuling Dong, Qing Yan, Bo Zhang, Li-qun Zhang, Xiaogang Wu
Summary: The monothiol glutaredoxin GrxD plays an essential role in the biosynthesis of the antibiotic 2,4-diacetylphloroglucinol (2,4-DAPG) and the biocontrol capacity of Pseudomonas fluorescens 2P24. This study reveals that GrxD directly interacts with the BolA protein family member IbaG, and IbaG is required for the regulation of 2,4-DAPG production by GrxD. Transcriptome sequencing analyses also demonstrate that IbaG plays a global role in gene regulation and has important functions in various cellular processes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Thermodynamics
Ece Polat, Mahmut Altinbas
Summary: Mutagenesis using EMS and tralkoxydim treatment resulted in mutant microalgae strains with enhanced biofuel properties, including higher lipid content and improved biodiesel fuel properties compared to the wild type strain.
INTERNATIONAL JOURNAL OF GREEN ENERGY
(2023)
Article
Microbiology
Carole Balthazar, Renee St-Onge, Genevieve Leger, Simon G. Lamarre, David L. Joly, Martin Filion
Summary: Pseudomonas protegens Pf-5 is an effective biocontrol agent that protects Cannabis sativa crops against the fungal pathogen Botrytis cinerea causing gray mold disease. The antibiotics pyoluteorin (PLT) and 2,4-diacetylphloroglucinol (DAPG) play an important role in Pf-5-mediated biocontrol. The biosynthesis pathways for PLT and DAPG are required for the optimal antagonistic activity of Pf-5 against B. cinerea.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Urology & Nephrology
Gary C. W. Chan, Helen Zhi, Pamela J. Hicks, Barry Freedman, Sydney C. W. Tang
Summary: This study found no significant association between the ACACB gene rs2268388 SNP and cardiovascular outcomes in Chinese individuals with type 2 diabetes.
Article
Biotechnology & Applied Microbiology
Chen Gao, Yin Chen, Xin Cheng, Yi Zhang, Yueyue Zhang, Ying Wang, Zhiyuan Cui, Yaling Liao, Ping Luo, Weihui Wu, Cheng Wang, Hao Zeng, Quanming Zou, Jiang Gu
Summary: This study identified a novel immunogenic epitope from the outer membrane protein PilY1 of Pseudomonas aeruginosa. A macrophage membrane-coated nanoparticle vaccine carrying this epitope induced an immune response and conferred protection in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Qiao, Max Purro, Zhi Liu, May P. Xiong
Summary: A series of targeted poly(ethylene glycol)-desferrioxamine/gallium (PEG-DG) conjugates were evaluated for their antimicrobial activity, showing enhanced sensitivity of P. aeruginosa to vancomycin. The synergistic effect was observed with specific PEG-DG conjugates characterized by polymer length and molecular weight, contributing to improved antimicrobial efficacy against P. aeruginosa strains.
MOLECULAR PHARMACEUTICS
(2021)
Article
Microbiology
Fengyu Guo, Qianping Chen, Qiong Liang, Ming Zhang, Wenxue Chen, Haiming Chen, Yonghuan Yun, Qiuping Zhong, Weijun Chen
Summary: Linalool exhibited strong antibacterial activity against Pseudomonas fluorescens by damaging the cell membrane, disrupting bacterial metabolism and oxidative respiration, inhibiting cellular respiration, and interfering with cellular functions to the extent of causing cell death.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Polymer Science
Hong-Fang Zhang, Qian Hao, Hong-Chi Tian, Peng-Jun Yao, Xue-Ying Liu, Bing Yu, Nan-Ying Ning, Ming Tian, Li-Qun Zhang
Summary: This study investigated the compatibility effect of different polyurethane-polysiloxane copolymers on SiR/TPU blends. The results showed that the copolymer with the highest polysiloxane segment content exhibited good compatibility and led to the successful preparation of SiR/TPU TPV with excellent mechanical performance.
CHINESE JOURNAL OF POLYMER SCIENCE
(2023)
Article
Engineering, Multidisciplinary
Haijun Ji, Hui Yang, Xinxin Zhou, Chaoying Sun, Liwei Li, Shuainan Zhao, Jie Yu, Sai Li, Runguo Wang, Liqun Zhang
Summary: In this study, a new type of bio-based elastomer PDMIBs was successfully synthesized, and its properties were regulated by adjusting comonomer ratios and compositions. The bio-based elastomer exhibited excellent mechanical properties, abrasion resistance, and oil resistance, making it suitable for various engineering applications.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Zhibo Huang, Xiaohui Wu, Yan Shi, Liqun Zhang
Summary: By improved solution blending method with polytetramethylene ether glycol as interface agent, organic montmorillonite/brominated butyl rubber nanocomposites were successfully prepared with good dispersion effect and intercalated/exfoliated structures. The mechanical performances and gas barrier properties of the nanocomposites were greatly improved, demonstrating the preparation of high-performance clay/rubber nanocomposites in nonpolar solvent.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Polymer Science
Xin Qi, Yingdong Zhang, Liqun Zhang, Dongmei Yue
Summary: This study presents a novel method for preparing stereocontrolled polymer using sustainable Eucommia ulmoides gum as a raw material. The isomerization mechanism of the gum was verified by density functional theoretical calculation. The isomerized gum exhibited potential applications in plastics, shape memory materials, and elastomer materials, with high tensile strength and elasticity comparable to natural rubber.
Article
Chemistry, Multidisciplinary
Binghui Jin, Yiling Yu, Chenghao Lou, Xiaodi Zhang, Bowen Gong, Jinghao Chen, Xiangxiang Chen, Zihan Zhou, Liqun Zhang, Jian Xiao, Jiajia Xue
Summary: A multi-functional nerve guidance conduit (NGC) is constructed to promote nerve regeneration by integrating ordered topological structure, density gradient of biomacromolecular nanoparticles, and controlled delivery of biological effectors. The NGC promotes the proliferation of Schwann cells and directional extension of neurites, achieving both anatomical and functional regeneration of the nerve. It provides a favorable microenvironment for peripheral nerve regeneration and holds great promise for nerve repair.
Review
Chemistry, Physical
Meng Yu Zhou, Jun Liu, Li Qun Zhang
Summary: This review summarizes the complex effects of two-dimensional (2D) nanomaterials as nanofillers on the mechanical, viscoelastic, thermal and electrical conductivity properties of high-performance polymer nanocomposites (PNCs) based on molecular dynamics (MD) simulation. Graphene and its derivatives, as well as MXenes, are considered as optimal choices for enhancing these properties. MMT and BN are widely used to improve the strength and thermal conductivity of polymers. The excellent performance of 2D nanosheet-based PNCs depends not only on the loading, aspect ratio and dispersion of nanofillers, but also on their compatibility with the polymer.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Xiaodi Zhang, Qi Li, Longfei Li, Jiang Ouyang, Tong Wang, Junjie Chen, Xiaoqing Hu, Yingfang Ao, Duotian Qin, Liqun Zhang, Jiajia Xue, Jin Cheng, Wei Tao
Summary: A bioinspired, staged photothermal effect-reinforced multifunctional scaffold was developed for bone repair. The scaffold possessed near-infrared responsive capability, selectively recruited MSCs, and released antibacterial drugs upon thermal stimulation. The scaffold promoted bone regeneration through the photothermal-mediated up-regulation of heat shock proteins and accelerated biodegradation.
Article
Chemistry, Multidisciplinary
Jianxun Zhu, Shuang He, Huayang Tian, Yiming Hu, Chen Xin, Xiaoxin Xie, Lipeng Zhang, Jian Gao, Shu-Meng Hao, Weidong Zhou, Liqun Zhang
Summary: Trace N, N-dimethylformamide(DMF) containing composite polymer electrolytes (CPEs) have attracted attention due to increased Li+-conductivity. The influences of DMF in PEO and PVDF based CPEs on Li+-conductivity and interfacial stability were studied. In PEO-based CPEs, DMF cannot be confined due to a stronger interaction between LiTFSI and PEO. Only a small amount of DMF is absorbed, resulting in increased Li+-conductivity and stable interface with Li-metal. However, excessive DMF leads to serious interfacial reactions. In PVDF-based CPEs, approximately 8wt.% DMF is confined by LiTFSI, leading to short-term stable interface but aggravated reactions with Li-metal in the long term or at higher current densities. PVDF based CPEs show better cycling performance when used as catholytes.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yunfei Zhang, Zhishan Xu, Yue Yuan, Chaoyong Liu, Ming Zhang, Liqun Zhang, Pengbo Wan
Summary: In this study, a flexible multifunctional epidermal sensor based on conductive hydrogel is developed, which shows high sensitivity, wide sensing range, and reliable cycling stability for ultrasensitive human-machine interfacing. It also exhibits excellent antiswelling capability and can be triggered for on-demand drug release and photothermal therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuangjian Yu, Siwu Wu, Shifeng Fang, Zhenghai Tang, Liqun Zhang, Baochun Guo
Summary: By introducing dynamic interfacial sulfides, a skeletal network elastomer with continuous reprocessability was successfully constructed. These elastomers exhibit high gel contents, high resilience, low creep, and competitive reinforcement compared to traditional vulcanizates, surpassing commercial thermoplastic vulcanizates (TPVs) materials.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Weixiao Song, Zixuan Wang, Min Wang, Ganggang Zhang, Fanzhu Li, Xi Zhang, Yonglai Lu, Liqun Zhang
Summary: Vulcanization systems and epoxidation degree have significant effects on the microstructure and macro-properties of ENR. The influence of sulfur, dicumyl peroxide, and itaconic acid vulcanization systems on strain-induced crystallization, molecular chain orientation, and microstructure evolution of ENRs were studied. Results showed that ENR-10 with 10% epoxidation degree exhibited the best mechanical properties, and its tensile strength and elongation were significantly higher than ENR-10-DCP and ENR-10-IA.
Article
Polymer Science
Zilong Chen, Weichao Wang, Jian Li, Jun Lin, Fanzhu Li, Liqun Zhang, Shaojian He
Summary: An efficient and environmentally friendly strategy of enhancing the interfacial interaction between NBR and MMT nanocomposites was demonstrated by coating the MMT surface with PDA and then compounding it with solid NBR via gel compounding method. The hydrogen bond interactions between DMMT and NBR were found to be responsible for the nanodispersion of DMMT as well as for effective stress transfer, resulting in significant improvement in the mechanical properties of the NBR/DMMT nanocomposite at low DMMT loading. With only 6 phr DMMT, the tensile strength of the NBR/DMMT nanocomposite reached 15.9 MPa, which is 4.1 times that of pure NBR.
Article
Polymer Science
Hailan Kang, Shaowei Wu, Haoyu Wang, Yufeng Liang, Long Li, Qinan Zhang, Liqun Zhang
Summary: Bio-TPVs with tunable elasticity, high strength, and satisfactory cytocompatibility were fabricated via an in situ dynamic vulcanizing strategy using BPE and PCL. The bio-TPVs exhibited good tensile properties and demonstrated satisfactory processability and reprocessability. Moreover, they promoted cell adhesion and proliferation. The combination of improved sustainability, processability, cytocompatibility, and mechanical performance makes these bio-TPVs potential candidates for biomedical and engineering materials.
POLYMER INTERNATIONAL
(2023)
Article
Polymer Science
Zhenghai Tang, Yi Chen, Chengfeng Zhang, Siwu Wu, Baochun Guo, Liqun Zhang
Summary: Constructing dynamic covalent bonds (DCBs) in rubbers is a hopeful approach to balance between chemical crosslinking and recyclability. However, the reinforcement of dynamic covalent networks without affecting the dynamic properties remains challenging. In this work, a dual dynamic crosslinking strategy was developed to improve mechanical performance while maintaining malleability and reprocessability. The addition of reversible noncovalent bonds enhanced the strength, modulus, toughness, and shape memory effect of the networks.
POLYMER INTERNATIONAL
(2023)
Article
Chemistry, Physical
Mingyuan Chao, Pengju Di, Yue Yuan, Yajin Xu, Liqun Zhang, Pengbo Wan
Summary: This work successfully develops a flexible breathable electronic sensor with excellent sensing ability, good breathability, and reliable photothermal properties. By delicately assembling conductive MXene nanosheets and silver nanowires on electrospun elastomeric substrates, the sensor achieves ultrasensitive sensing of human physiological signals and wearable human-machine interaction, as well as integrated functionalities of disease diagnosis and photothermal therapy. This research provides a simple and effective method for the development of flexible breathable multifunctional electronic sensors, which can be used for long-term healthcare monitoring, ultrasensitive wearable human-machine interfacing, smart disease diagnosis, and treatment.
Article
Microbiology
Vera Analise Schommer, Mateus Torres Nazari, Flavia Melara, Julia Catiane Arenhart Braun, Alan Rempel, Lara Franco dos Santos, Valdecir Ferrari, Luciane Maria Colla, Aline Dettmer, Jeferson Steffanello Piccin
Summary: This review introduces the techniques and mechanisms of bacteria immobilization on biochar, as well as its applications in bioremediation and agriculture. The immobilization characteristics of biochar depend on pyrolysis methods, raw materials, and properties of biochar. Scanning electron microscope and colony forming unit analysis are commonly used to verify the immobilization efficiency. Applying biochar-immobilized bacteria can improve soil quality, plant growth, and crop yield.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Manoj Kumar Solanki, Naveen Chandra Joshi, Prashant Kumar Singh, Sandeep Kumar Singh, Gustavo Santoyo, Lucas Carvalho Basilio de Azevedo, Ajay Kumar
Summary: The rhizosphere microbiome plays a crucial role in plant growth and health. Rhizosphere engineering can be used to modify the microbiome and improve plant productivity and resilience.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Xin Cao, Xing-Wang Cheng, Yin-Ying Liu, Hong-Wei Dai, Ren-You Gan
Summary: Maintaining oral health is crucial for overall well-being. Imbalances in oral microorganisms can lead to various infectious diseases. Exploring alternatives for prevention and management of oral infections is important due to limitations of current treatments. Natural products offer potential as reliable, effective, and affordable therapeutic options for oral infectious diseases.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Jose David Flores-Felix, Ana Carolina Goncalves, Sara Meirinho, Ana Raquel Nunes, Gilberto Alves, Cristina Garcia-Viguera, Diego A. Moreno, Luis R. Silva
Summary: The application of bacterial biofortifiers is increasing and has been shown to improve the nutritional characteristics of blueberries in Portugal.
MICROBIOLOGICAL RESEARCH
(2024)
Review
Microbiology
Asma Sani, Wan-Qi Qin, Jia-Yi Li, Yi-Fan Liu, Lei Zhou, Shi-Zhong Yang, Bo-Zhong Mu
Summary: This article summarizes the structural diversity of microbial lipopeptide biosurfactants and their applications as biocontrol agents in plants. Lipopeptides have low toxicity and wide range of applications, making them important in the pesticide industry.
MICROBIOLOGICAL RESEARCH
(2024)
Article
Microbiology
Xiao-Yu Sun, Jie Deng, Chenhui Zhang, Sin-Yee Fung, Kam-Leung Siu, Ying-Ying Cheng, Liumei Ye, Jiaoxia Qin, Ke Wang, Jiu-Xin Qu, Wenying Gao, Fuxiang Wang, Dong-Yan Jin, Liang Yang
Summary: In this study, a novel c-di-GMP binding protein SodA that regulates oxidative stress tolerance in S. maltophilia was identified. The enzyme activity of SodA was shown to be directly modulated by c-di-GMP through various in vivo and in vitro experiments.
MICROBIOLOGICAL RESEARCH
(2024)