Article
Chemistry, Multidisciplinary
Meng Gao, Bolong Xu, Yang Huang, Jiayu Cao, Lili Yang, Xi Liu, Alisher Djumaev, Di Wu, Moxichexra Shoxiddinova, Xiaoming Cai, Behruz Tojiyev, Huizhen Zheng, Xuehua Li, Kunduz Normurodova, Huiyu Liu, Ruibin Li
Summary: Biofilm formation is a significant threat to industry, the environment, and human health. By mimicking the activity of lactonase, a promising antifouling approach can be achieved through catalytic interception of bacterial communications. The synthesis of a lactonase-like Zn-N-x-C nanomaterial successfully prevented biofilm formation by selectively catalyzing the hydrolysis of bacterial quorum sensing signals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Danqing Liu, Yuejing Xi, Shunzhi Yu, Kexin Yang, Fan Zhang, Yuying Yang, Tianlong Wang, Shisheng He, Yunqing Zhu, Zhen Fan, Jianzhong Du
Summary: Aging population has increased the demand for orthopedic implants. However, biofilm formation on implants due to antibiotic insensitivity and antimicrobial resistance has been a major challenge. In this study, an antibacterial polypeptide coating was developed to prevent biofilm formation and acquired antibiotic resistance. The coating demonstrated excellent in vivo adhesive capacity and strong antibacterial activity. It also inhibited the expression of genes associated with antimicrobial resistance. In vivo experiments confirmed the effectiveness of the coating in preventing biofilm formation and infections. Overall, this study provides a simple method for preparing antibacterial orthopedic implants without inducing antimicrobial resistance.
Article
Biochemistry & Molecular Biology
Chih-Chien Hu, Selvaraj Rajesh Kumar, Truong Thi Tuong Vi, Yu-Tzu Huang, Dave W. Chen, Shingjiang Jessie Lue
Summary: In this study, the antimicrobial peptide GL13K was coated onto a PEEK substrate, resulting in significant antibacterial and biofilm-inhibitory effects against Staphylococcus aureus bacteria. The coating technique used in this study holds promise for providing bactericidal activity and biofilm resistance to medical implantable devices.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jiong Zhang, Xiangxiang Zhao, John R. Cappiello, Yi Yang, Yunfei Cheng, Guang Liu, Wenjing Fang, Yinzhu Luo, Yu Zhang, Jiajia Dong, Lixin Zhang, K. Barry Sharpless
Summary: A series of arylfluorosulfates synthesized via SuFEx, including compounds 3, 81, and 101, showed potent antibacterial activity, the ability to overcome multidrug resistance, and a lack of susceptibility to resistance development. These compounds also demonstrated rapid bactericidal potency, selectivity against gram-positive bacteria, and the capability to disrupt bacterial biofilms and kill persisters. Additionally, compound 3 exhibited synergy with streptomycin and gentamicin, while their anti-MRSA activity was evaluated using the Caenorhabditis elegans model.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Krukiewicz, Alicja Kazek-Kesik, Monika Brzychczy-Wloch, Marek J. Los, Collins Njie Ateba, Parvaneh Mehrbod, Saeid Ghavami, Divine Yufetar Shyntum
Summary: Biofilms, formed by bacteria, fungi, or viruses, are complex structures that can be found in almost any part of the human body. The increase in biofilm-associated diseases is mainly attributed to the use of medical devices, which provide opportunities for clinically important bacteria and fungi to form biofilms. Due to their resistance to antibiotics and host immunity, biofilms are associated with the development and persistence of clinically important diseases, posing a significant burden on patients and healthcare systems. Therefore, it is crucial to develop innovative strategies to tackle biofilm growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Laia Fernandez-Barat, Nil Vazquez Burgos, Victoria Alcaraz, Leticia Bueno-Freire, Ruben Lopez-Aladid, Roberto Cabrera, Albert Gabarrus, Andrea Palomeque, Patricia Oscanoa, Adrian Ceccato, Ana Motos, Rosanel Amaro, Thierry Bernardi, Christian Provot, Alba Soler-Comas, Laura Munoz, Jordi Vila, Antoni Torres
Summary: The aim of this study was to validate and identify additional applications of the BioFilm Ring Test (BRT) for Pseudomonas aeruginosa (PA) isolates from patients with bronchiectasis (BE), and evaluate its relationship with antimicrobial stewardship. The results showed that a BPI value below 14.75 at 5 hours predicted the mucoid PA phenotype. In conclusion, the BRT has the potential to reveal biofilm features with clinical implications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Robin Kock, Franziska Schuler, Evgeny A. Idelevich, Frieder Schaumburg
Summary: This study assessed the frequency of changes in antimicrobial susceptibility patterns in consecutive isolates of the same species from one patient, finding that such changes occur occasionally and the timing varies depending on the species and type of specimen.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Wanchen Zou, Ruize Sun, Aifang Yao, Mei Zhou, Xiaoling Chen, Chengbang Ma, Tao Wang, Yangyang Jiang, Tianbao Chen, Chris Shaw, Lei Wang
Summary: This study reports a novel antimicrobial peptide B1LTe with remarkable antimicrobial effects. However, its narrow therapeutic index may lead to adverse drug reactions. Rational design and modification of the peptide enhanced its application potential. Among the derivatives, 5R showed the highest selectivity and effectiveness against antibiotic-resistant strains, indicating its potential as a promising antibiotic agent for further clinical development.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Immunology
Marion Elligsen, Ruxandra Pinto, Jerome A. Leis, Sandra A. N. Walker, Derek R. MacFadden, Nick Daneman
Summary: A hospital-wide intervention focusing on evaluating clinically significant discordance and providing alternative therapy recommendations improved prescribing practices, resulting in a higher proportion of patients receiving empiric therapy concordant with prior culture results and a shorter time to receiving concordant therapy. Unnecessary vancomycin therapy duration was also reduced.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biophysics
Xiao Meng, Hao Xiong, Fangling Ji, Xiaorong Gao, Lulu Han, Zhenlin Wu, Lingyun Jia, Jun Ren
Summary: This study presents a simple surface treatment strategy to form antimicrobial coatings on medical plastics. The method involves activating the surface and using lysozyme to inhibit bacterial colonization and biofilm formation. This lysozyme-based antimicrobial coating is effective and can be applied to various medical plastics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Medicinal
Dibyajit Lahiri, Moupriya Nag, Sayantani Garai, Rina Rani Ray
Summary: Plant compounds have long been used for their antimicrobial properties, particularly against biofilm-associated chronic infections. With the rise of antibiotic resistance, phytocompounds have become an alternative treatment option due to their effectiveness in combating infections. Research focuses on classifying plant compounds based on their chemical properties and investigating their mechanisms of action against pathogens.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Infectious Diseases
Rafael Canton, Thomas Gottlieb, Geoffrey W. Coombs, Patrick C. Y. Woo, Tony M. Korman, Maria Garcia-Castillo, Denise Daley, Karri A. Bauer, Michael Wong, Dominik J. Wolf, Fakhar Siddiqui, Mary Motyl
Summary: Antimicrobial resistance (AMR) is a major global public health threat, particularly affecting patients in resource-poor settings. Various surveillance programs exist worldwide, and one of the largest is the SMART program, which has been running for 20 years. The SMART database includes data from nearly 500,000 isolates from over 60 countries, and can help monitor and guide clinical treatment.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Jaime Robledo, Natalia Maldonado, Carlos Robledo, Laura Ceballos Naranjo, Valentin Hernandez Galeano, Juan Jose Pino
Summary: This study analyzed antimicrobial susceptibility trends of bloodstream infections in healthcare institutions from Medellin and nearby towns in Colombia from 2010 to 2019. The results showed an increasing trend in antimicrobial resistance for certain microorganisms, while others did not show significant changes. Antimicrobial surveillance plays a crucial role in antibiotic resistance control.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Pharmacology & Pharmacy
Huaxin Tan, Junyao Wang, Yuxin Song, Sisi Liu, Ziyan Lu, Haodang Luo, Xing Tang
Summary: Researchers have studied antimicrobial peptides in the venom of Lycosa sinensis and found that two peptides have inhibitory activity against multiple drug-resistant bacteria, and exhibit synergistic therapeutic effects with traditional antibiotics. These peptides disrupt the integrity of bacterial cell membranes and inhibit bacterial growth within a short period of time.
Article
Chemistry, Multidisciplinary
Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang, Xuliang Deng, Cyrille Boyer, Weiping Gao
Summary: Microbial resistance to antibiotics is a major challenge in global healthcare. A study found that a photoinduced cationic polymer conjugated with lysozyme can effectively overcome bacterial resistance and improve therapeutic efficacy in a rat periodontitis model. This discovery provides an efficient strategy to enhance antimicrobial activities and overcome antimicrobial resistance.
Article
Anthropology
Naida Babic, Serkan Dogan, Jasmina Cakar, Amela Pilav, Damir Marjanovic, Vesna Hadziavdic
ANNALS OF HUMAN BIOLOGY
(2017)
Article
Anthropology
Serkan Dogan, Adna Asic, Gulsen Dogan, Larisa Besic, Damir Marjanovic
Article
Food Science & Technology
Larisa Besic, Adna Asic, Imer Muhovic, Serkan Dogan, Yusuf Turan
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2017)
Article
Agronomy
Hacer Konakli, Zafer Konakli, Senol Dogan, Damir Marjanovic, Serkan Dogan
Article
Multidisciplinary Sciences
Serkan Dogan, Cemal Gurkan, Mustafa Dogan, Hasan Emin Balkaya, Ramazan Tunc, Damla Kanliada Demirdov, Nihad Ahmed Ameen, Damir Marjanovic
Article
Medicine, General & Internal
Adna Asic, Ramona Salazar, Niels Storm, Serkan Dogan, Wolfgang Hoeppner, Damir Marjanovic, Dragan Primorac
CROATIAN MEDICAL JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Andrew J. Pakstis, Cemal Gurkan, Mustafa Dogan, Hasan Emin Balkaya, Serkan Dogan, Pavlos I. Neophytou, Lotfi Cherni, Sami Boussetta, Houssein Khodjet-El-Khil, Amel Ben Ammar ElGaaied, Nina Mjolsnes Salvo, Kirstin Janssen, Gunn-Hege Olsen, Sibte Hadi, Eida Khalaf Almohammed, Vania Pereira, Ditte Mikkelsen Truelsen, Ozlem Bulbul, Usha Soundararajan, Haseena Rajeevan, Judith R. Kidd, Kenneth K. Kidd
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Merisa Cenanovic, Serkan Dogan, Adna Asic, Larisa Besic, Damir Marjanovic
Summary: The distribution of the ACE1 D allele in Bosnia and Herzegovina was found to be similar to other European populations, with no significant correlation observed between D allele frequency and COVID-19 incidence, mortality, and case severity across the examined populations.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Genetics & Heredity
Kenneth K. Kidd, Ozlem Bulbul, Cemal Gurkan, Mustafa Dogan, Serkan Dogan, Pavlos Neophytou, Lotfi Cherni, David Gurwitz, William C. Speed, Michael Murtha, Judith R. Kidd, Andrew J. Pakstis
Summary: This study assembled data on 151 autosomal genetic markers for 95 populations in the SWAMSE region and other parts of the world, identifying at least five biogeographic clusters, including a clear grouping of populations from SWAMSE and northern Europe. Further analysis revealed that northern European populations cluster separately from SWAMSE populations.
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2021)
Article
Genetics & Heredity
Naida Babic Jordamovic, Tamara Kojovic, Serkan Dogan, Larisa Besic, Lana Salihefendic, Rijad Konjhodzic, Vedrana Skaro, Petar Projic, Vesna Hadziavdic, Adna Asic, Damir Marjanovic
Summary: This study analyzed Y-chromosomal haplogroups of adult males from Bosnia and Herzegovina, identifying 14 different haplogroups with I2a, R1a, and E1b1b being the most prevalent. Compared to previous studies, this research had a significantly larger sample size, providing more accurate results and a higher likelihood of detecting rare haplogroups.
FRONTIERS IN GENETICS
(2021)
Article
Anthropology
Negra Hadzic Metjahic, Maruska Vidovic, Jasmina Cakar, Mirela Dzehverovic, Amela Pilav, Serkan Dogan, Damir Marjanovic
HOMO-JOURNAL OF COMPARATIVE HUMAN BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Emir Mahmutbegovic, Damir Marjanovic, Edin Medjedovic, Nevena Mahmutbegovic, Serkan Dogan, Amina Valjevac, Ewa Czerska, Anna Pawinska-Matecka, Agnieszka Madlani, Grazyna Adler
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2017)
Proceedings Paper
Engineering, Biomedical
Hacer Konakli, Hasan Emin Balkaya, Indira Ozcoban, Serkan Dogan
PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MEDICAL AND BIOLOGICAL ENGINEERING 2017 (CMBEBIH 2017)
(2017)
Proceedings Paper
Engineering, Biomedical
Mahmutbegovic Emir, Adler Grazyna, Edin Medjedovic, Mahmutbegovic Nevena, Serkan Dogan, Pawinska-Matecka Anna, Czerska Ewa, Damir Marjanovic
PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MEDICAL AND BIOLOGICAL ENGINEERING 2017 (CMBEBIH 2017)
(2017)