期刊
METALLOMICS
卷 10, 期 6, 页码 794-801出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8mt00049b
关键词
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资金
- JSPS KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology Japan (MEXT) [25702050]
- Naito Foundation
- Kato Memorial Bioscience Foundation
- [15J11637]
- Grants-in-Aid for Scientific Research [25702050] Funding Source: KAKEN
Mitochondria are iron-rich organelles that are involved in the process of energy production through the electron-transporting system and heme synthesis. We developed a new mitochondria-targeted fluorescent probe, MtFluNox/Ac MtFluNox, for Fe(u) based on N-oxide chemistry, which we recently established as a Fe(u)-selective fluorogenic switch. The deacetyLated form MtFluNox showed a turn-on response towards Fe(ii) with high metal selectivity in cuvette experiments, and an imaging study using its cell-compatible analogue Ac MtFluNox demonstrated mitochondria-specific fluorescence enhancement in response to Fe(u) in Living cells. Furthermore, the probe was able to detect endogenously accumulated Fe(u) induced as a result of the inhibition of heme synthesis.
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