Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemical Research Methods
Andreas Schweikert, Sarah Theiner, Debora Wernitznig, Anna Schoeberl, Martin Schaier, Sophie Neumayer, Bernhard K. Keppler, Gunda Koellensperger
Summary: A novel standardization strategy for quantitative elemental bioimaging was evaluated in this study, showing promising results with multi-element quantification using micro-droplet standards. The high-throughput analysis enabled the establishment of imaging measurement sequences with quality control and standardization samples, providing an important experimental method for future research.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhongxian Fan, Jiaen Xie, Rajesh Kushwaha, Shaoxia Liang, Wenqing Li, Arif Ali Mandal, Li Wei, Samya Banerjee, Huaiyi Huang
Summary: The rapid efflux of Pt-based chemotherapeutics by cancer cells is a major cause of drug resistance. To overcome this, high cellular uptake and adequate retention efficiency of an anticancer agent are important. However, quantifying metallic drug concentration in individual cancer cells remains challenging. In this study, using newly developed single cell inductively coupled plasma mass spectrometry (SC-ICP-MS), it was found that Ru(II)-based complex Ru3 had remarkable intracellular uptake and retention efficiency in every single cancer cell, and showed high photocatalytic therapeutic activity to overcome cisplatin resistance. Additionally, Ru3 exhibited excellent in-vitro and in-vivo biocompatibility with sensational photocatalytic anticancer properties under light exposure.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Analytical
Carine Arnaudguilhem, Marion Larroque, Olivia Sgarbura, Dominique Michau, Francois Quenet, Sebastien Carrere, Brice Bouyssiere, Sandra Mounicou
Summary: This study developed a quantitative LA-ICP MS bioimaging methodology based on polymer film strategy and internal standardization, which can simultaneously map eight elements in biological tissue sections. Different elements exhibit varied responses to analytical conditions and internal standards, primarily dependent on First Ionization Potential. The methodology was validated for clinical human samples and showed promising results.
Article
Chemistry, Analytical
Laurie Labeyrie, Germain Salvato Vallverdu, Dominique Michau, Stephanie Fontagne-Dicharry, Sandra Mounicou
Summary: The quantitative imaging of trace elements in biological samples can provide information on their assimilation pathways and help understand their toxicity or essentiality. This study developed two quantitative LA-ICP MS methods and applied them to the imaging of Se, Hg, Cu, Zn, and Mo in rainbow trout. The results showed that the polymer films method provided more accurate quantification compared to the MMS method.
MICROCHEMICAL JOURNAL
(2023)
Article
Geochemistry & Geophysics
Alexander Simpson, Sarah Gilbert, Renee Tamblyn, Martin Hand, Carl Spandler, Jack Gillespie, Angus Nixon, Stijn Glorie
Summary: Lu-Hf geochronology is a powerful method for constraining the temporal evolution of geological systems, with traditional methods requiring time-consuming chemical separations and potentially losing the textural context of analysed minerals. In contrast, the in-situ approach offers rapid analysis with high spatial resolution, but is hindered by isobaric interferences of Yb-176 and Lu-176 on Hf-176.
Article
Chemistry, Physical
Viet-Hung Do, P. Prabhu, Yinghao Li, Wenjie Xie, Pinit Kidkhunthod, Guangzhao Wang, Xin Wang, Jong-Min Lee
Summary: Transition metal nitrides with atomically thin Os nanoclusters confined on 2D 6-MoN exhibit enhanced catalytic performance, particularly in hydrogen evolution, due to optimized surface electron configurations and abundant active sites.
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
C. Ashley Norris, Leonid Danyushevsky, Paul Olin, Nicholas R. West
Summary: Insufficient sampling of periodic signals can lead to aliasing, which causes erroneous variations in measured element concentrations. A fire control circuit has been developed to align laser firing with the measurement cycle of the mass spectrometer to lessen or eliminate aliasing. This technique can maintain measurement precision even when the extent of mixing between individual laser pulses is reduced by an order of magnitude.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2021)
Article
Biochemistry & Molecular Biology
Dylan Johnson, David Clases, Maria Luisa Fernandez-Sanchez, Noemi Eiro, Luis O. Gonzalez, Francisco J. Vizoso, Philip A. Doble, Raquel Gonzalez de Vega
Summary: A study on quantitative and multiplexed imaging of MMP-11 and CD45 in breast cancer tissues using LA-ICP-MS was successfully developed and optimized. By analyzing the concentrations and distributions of these biomarkers, improved cancer characterization and patient stratification could be achieved.
Article
Spectroscopy
Lukas Brunnbauer, Veronika Zeller, Zuzana Gajarska, Silvia Larisegger, Stefan Schwab, Hans Lohninger, Andreas Limbeck
Summary: Epoxy molding compounds, consisting of a polymer-based matrix, inorganic filler particles, and various additives, are widely used in the semiconductor industry for encapsulation. This study explores the use of a Tandem LA-ICP-MS/LIBS approach to comprehensively characterize epoxy molding compounds and construct a classification model capable of distinguishing different types. The analysis of 29 samples from 4 suppliers using exploratory data analysis and a Random Decision Forest-based classifier demonstrates the potential of this method.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Meng Wang, Lingna Zheng, Bing Wang, Pu Yang, Hao Fang, Shanshan Liang, Wei Chen, Weiyue Feng
Summary: This study demonstrates the use of laser ablation-single particle inductively coupled plasma mass spectrometry (LA-sp-ICP-MS) for high-resolution, sensitive, and accurate imaging of the in situ distribution of particulate Ag and released ionic Ag in the sub-organs of mice after intravenous injection of Ag nanoparticles. The imaging results provide visual evidence of the accumulation and distribution of particulate Ag in the spleen and liver parenchyma, as well as the release and distribution of ionic Ag in the organs. The developed LA-sp-ICP-MS method is a powerful tool for studying the in vivo degradation behavior of metallic nanoparticles.
CHINESE CHEMICAL LETTERS
(2022)
Article
Geosciences, Multidisciplinary
Shitou Wu, Yueheng Yang, Nick M. W. Roberts, Ming Yang, Hao Wang, Zhongwu Lan, Bohang Xie, Tianyi Li, Lei Xu, Chao Huang, Liewen Xie, Jinhui Yang, Fuyuan Wu
Summary: The study on U-Pb geochronology of calcite using LA-ICP-MS is an emerging method with improved sensitivity, resulting in precise measurements of U and Pb isotopes. The optimized instrument parameters allowed for accurate analysis of commonly-used calcite U-Pb reference materials, demonstrating the reliability of the technique in obtaining robust ages. The image-guided approach using LA-ICP-MS elemental mapping proved to be an efficient tool in age determination.
SCIENCE CHINA-EARTH SCIENCES
(2022)
Article
Environmental Sciences
Ryouta Torimoto, Chihiro Ishii, Hiroshi Sato, Keisuke Saito, Yukiko Watanabe, Kohei Ogasawara, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Atsushi Kobayashi, Takashi Kimura, Shouta M. M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka
Summary: Lead localization in organs of experimentally lead-exposed ducks and kites was investigated using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Lead accumulation was diffuse in the liver, renal cortex, and brain in both species, with differences observed in lead distribution patterns between the two avian species; copper distribution in the brain was also altered in lead-exposed ducks.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Valentin Fuchs, Klaudia Cseh, Michaela Hejl, Petra Vician, Benjamin Neuditschko, Samuel M. Meier-Menches, Lukas Janker, Andrea Bileck, Natalie Gajic, Julia Kronberger, Martin Schaier, Sophie Neumayer, Gunda Koellensperger, Christopher Gerner, Walter Berger, Michael A. Jakupec, Michael S. Malarek, Bernhard K. Keppler
Summary: A series of highly lipophilic Cp-substituted molybdenocenes with different bioactive chelating ligands were synthesized and characterized. They showed significantly increased cytotoxic potency compared to non-Cp-substituted counterparts. In vivo experiments demonstrated tumor growth inhibition for the most active complex containing the thioflavone ligand, along with significant regulation of tubulin-associated and mitochondrial inner membrane proteins.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Olga V. Kuznetsova, Bernhard K. Keppler, Andrei R. Timerbaev
Summary: This study developed a unified protocol for the preparation of seawater samples for ICP-MS analysis of nanoparticles, which involved acidification and ultrafiltration to stabilize the particles and facilitate metal analysis. High-resolution ICP-MS method was used to achieve very low limits of detection.
Article
Pharmacology & Pharmacy
Janos P. Meszaros, Wolfgang Kandioller, Gabriella Spengler, Alexander Prado-Roller, Bernhard K. Keppler, Eva A. Enyedy
Summary: This study introduces half-sandwich Rh complexes that can be activated in the acidic, extracellular pH of tumor tissue, reducing the side effects and improving the efficacy of chemotherapy.
Article
Multidisciplinary Sciences
Johannes J. Kovarik, Andrea Bileck, Gerhard Hagn, Samuel M. Meier-Menches, Tobias Frey, Anna Kaempf, Marlene Hollenstein, Tarik Shoumariyeh, Lukas Skos, Birgit Reiter, Marlene C. Gerner, Andreas Spannbauer, Ena Hasimbegovic, Doreen Schmidl, Gerhard Garhofer, Mariann Gyongyosi, Klaus G. Schmetterer, Christopher Gerner
Summary: In order to understand the pathophysiology of long COVID-19 syndrome (LCS), an exploratory study was conducted using blood plasma samples from three groups: healthy vaccinated individuals without SARS-CoV-2 exposure, asymptomatic recovered patients at least three months after SARS-CoV-2 infection, and symptomatic patients at least three months after SARS-CoV-2 infection with LCS. The study found that recovered individuals had slightly elevated pro-inflammatory cytokine levels compared to patients with LCS. Additionally, LCS patients showed low levels of acute phase proteins and macrophage-derived secreted proteins, but high levels of anti-inflammatory oxylipins and osmolytes. The study proposes that alternatively polarized macrophages may be a major contributor to these molecular alterations.
Review
Biochemistry & Molecular Biology
Yasmin Borutzki, Lukas Skos, Christopher Gerner, Samuel M. Meier-Menches
Summary: In recent years, metal-based candidate drugs have shown promise as modulators of cytoskeletal and cytoskeleton-associated proteins. Actin, vimentin, and plectin have been identified as targets of ruthenium(II) and platinum(II)-based modulators. However, there is limited structural information available on molecular interactions. This article compiles scattered reports on metal-based candidate molecules influencing the cytoskeleton and its associated proteins, exploring their potential in cancer-related processes.
Review
Biochemistry & Molecular Biology
Lukas Skos, Yasmin Borutzki, Christopher Gerner, Samuel M. Meier-Menches
Summary: Metal-based anticancer agents occupy a unique chemical space and can be tuned to target proteins as well as DNA. Tailored proteomics strategies are crucial for identifying and validating protein targets of metal-based drugs. Experimental approaches discussed in this article have shown that metals such as ruthenium, gold, rhenium, and platinum can selectively target proteins with downstream effects. Target identification strategies are expected to greatly support the clinical translation of metal-based drugs.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yvonne Lerchbammer-Kreith, Michaela Hejl, Petra Vician, Michael A. Jakupec, Walter Berger, Mathea S. Galanski, Bernhard K. Keppler
Summary: Based on their drug delivery properties and activity against tumors, PAMAM dendrimers were combined with platinum(IV) complexes to improve anticancer treatment. The conjugates showed faster reduction behavior compared to the platinum(IV) complexes and exhibited significantly increased cytotoxic activity in human cell lines. In vivo experiments demonstrated tumor growth inhibition and prolonged animal survival.
Article
Pharmacology & Pharmacy
Theresa Mendrina, Isabella Poetsch, Hemma Schueffl, Dina Baier, Christine Pirker, Alexander Ries, Bernhard K. K. Keppler, Christian R. R. Kowol, Dan Gibson, Michael Grusch, Walter Berger, Petra Heffeter
Summary: Platinum compounds are effective treatment options for various cancer types, but their use is limited by side effects and drug resistance. A new multi-targeted platinum(IV) prodrug, cisPt(PhB)(2), has shown promising anticancer activity and the ability to overcome drug resistance mechanisms. The drug's mode of action is influenced by cellular fatty acid metabolism and mitochondrial activity. Specifically, it is more effective against cisplatin-resistant cancer cells with Warburg-like properties. This orally applicable prodrug has the potential to improve cancer treatment outcomes.
Article
Chemistry, Multidisciplinary
Martin Schaier, Sarah Theiner, Dina Baier, Gabriel Braun, Walter Berger, Gunda Koellensperger
Summary: In this study, a workflow combining low-dispersion laser ablation with inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOFMS) was presented, enabling spatial single-cell metallomics in tissue to decode cellular heterogeneity. The toolbox of single-cell metallomics was expanded by integrating the concepts of imaging mass cytometry (IMC) to utilize metal-labeled antibodies for cellular tissue profiling.
Article
Chemistry, Analytical
Felina Hildebrand, Harald Schoeny, Evelyn Rampler, Gunda Koellensperger
Summary: Lipidomics studies focus on identifying and quantifying lipids comprehensively. Reversed phase liquid chromatography (RP-LC) coupled with high resolution mass spectrometry (MS) is commonly used for lipid identification, but accurate lipid quantification remains challenging. We established a dual flow injection and chromatography setup to address the issue of solvent composition affecting ionization response. Our results confirmed that changing solvent conditions significantly influence ionization response and quantification biases. This finding was further supported by quantifying human plasma lipids and a panel of lipid species standards under different ionization conditions.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Alexander Kastner, Hemma Schueffl, Patrick A. Yassemipour, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: Platinum(IV) prodrugs are promising alternatives to platinum(II) anticancer therapeutics. This study investigated the reactivity and synthetic usability of a platinum(IV) complex with hydrolyzable equatorial ligands, and successfully synthesized stable platinum(IV) complexes suitable for long-circulating tumor-targeting strategies. Additionally, platinum(IV) complexes with equatorial maleimides were synthesized, showing prolonged plasma half-life and improved anticancer activity compared to oxaliplatin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Martin Schaier, Enrico Falcone, Tomas Prstek, Bertrand Vileno, Sonja Hager, Bernhard K. Keppler, Petra Heffeter, Gunda Koellensperger, Peter Faller, Christian R. Kowol
Summary: Thiosemicarbazones (TSCs) are biologically active compounds that have potential anticancer activity by chelating iron and targeting ribonucleotide reductase. Recent findings suggest that the stability and reduction properties of copper complexes are essential for the action of specific TSC derivatives. This study investigated the interaction between TSCs and human serum albumin (HSA) as a potential source of copper, and found that TSCs specifically chelate copper from HSA and form ternary HSA conjugates.
Article
Chemistry, Inorganic & Nuclear
Alexander Kastner, Theresa Mendrina, Florian Bachmann, Walter Berger, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: In this study, oxaliplatin(iv)-based complexes were developed as platinum(iv) prodrugs to release aspirin, which has shown antitumor activity against colon cancer. The newly synthesized complex demonstrated increased reduction stability compared to a cisplatin analog and exhibited desired prodrug properties in cell culture. A derivative with albumin-binding properties showed improved pharmacokinetics and tumor accumulation, leading to enhanced antitumor activity and overall survival in tumor-bearing mice.
INORGANIC CHEMISTRY FRONTIERS
(2023)
