Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Liu, Bo Zhou, Wentao Tang, Donghao Xu, Zhiping Yan, Li Ren, Dexiang Zhu, Guodong He, Ye Wei, Wenju Chang, Jianmin Xu
Summary: The study aimed to evaluate the safety and efficacy of preoperative DEB-TACE in patients with colorectal liver metastases. The results showed that preoperative DEB-TACE can significantly prolong recurrence-free survival and has mild toxicities.
EUROPEAN RADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yonghua Bi, Fazhong Li, Jianzhuang Ren, Xinwei Han
Summary: This study retrospectively enrolled patients with unresectable or advanced lung cancer who underwent drug-eluting beads transarterial chemoembolization with oxaliplatin-loaded CalliSpheres beads. The results showed that this treatment was safe, effective, and resulted in longer survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Guangshao Cao, Yuyan Liu, Lupeng Li, Xiaoyang Zhao, Ruiqing Liu, Jian Liu, Jianwen Liu, Huicun Cao
Summary: This study compared the occurrence of adverse events (AEs) among radiofrequency ablation (RFA), conventional transarterial chemoembolization (cTACE), and drug-eluting bead TACE (DEB-TACE) in treating HCC patients. It found that cTACE resulted in the highest incidence of AEs, with male gender, bronchial asthma, and disease duration being independent predictive factors for total AEs risk.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biology
Su Min Cho, Hee Ho Chu, Jong Woo Kim, Jin Hyung Kim, Dong Il Gwon
Summary: DEB-TACE using HepaSpheres 20-40 μm can serve as a safe and effective initial treatment for patients with HCC > 5 cm. Subsequent Cis-TACE acts as a good adjuvant method to enhance tumor response following initial DEB-TACE.
Article
Medicine, General & Internal
Ningjie Li, Jiao Chen
Summary: DEB-TACE plus apatinib achieves prolonged progression-free survival (PFS) and overall survival (OS) in huge HCC patients, while exhibiting similar adverse events occurrence compared to DEB-TACE alone.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Daehee Kim, Mary Louise Keohan, Mrinal M. Gounder, Aimee M. Crago, Joseph P. Erinjeri
Summary: DEB-TACE may be a safe and effective alternative local treatment for patients with DT.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yonghua Bi, Bo Zhang, Jianzhuang Ren, Xinwei Han, Wenze Wu
Summary: DEB-TACE with gemcitabine-loaded CalliSpheres beads is a safe, feasible and effective treatment strategy for patients with advanced and inoperable lung cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Marco Fronda, Francesco Mistretta, Marco Calandri, Fernanda Ciferri, Floriana Nardelli, Laura Bergamasco, Paolo Fonio, Andrea Doriguzzi Breatta
Summary: This study evaluated the efficacy of unenhanced CBCT in predicting early radiologic response of HCC nodules to DEB-TACE. The results showed that the presence of an intense contrast media deposit with clear and complete margins in treated HCC lesions is associated with complete response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Liang Cai, Honglu Li, Jiang Guo, Wenpeng Zhao, Youjia Duan, Xiaopu Hou, Long Cheng, Hongliu Du, Xihong Shao, Zhenying Diao, Yiwei Hao, Xinmei Zheng, Changqing Li, Wei Li
Summary: This study compared the treatment efficacy and tolerance of drug-eluting beads transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (cTACE) in patients with hepatocellular carcinoma (HCC) and arterioportal fistula (APF). The DEB-TACE group showed better treatment response and longer progression-free survival (PFS) compared to the cTACE group. Safety profiles were similar between the two groups.
CANCER BIOLOGY & THERAPY
(2022)
Review
Oncology
Khalid I. Bzeizi, Mohammad Arabi, Negar Jamshidi, Ali Albenmousa, Faisal M. Sanai, Waleed Al-Hamoudi, Saad Alghamdi, Dieter Broering, Saleh A. Alqahtani
Summary: DEB-TACE treatment shows better objective response, disease control, and lower all-cause mortality with fewer severe complications compared to C-TACE, while not demonstrating clear superiority in complete or partial response, disease stability, or controlling disease progression.
Article
Gastroenterology & Hepatology
Junjun Tang, Zongliang Huang, Jichong Xu, Qi Lv, Peijun Wang
Summary: DEB-TACE shows superiority over cTACE in HCC patients with cTACE treatment history.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Oncology
Weihua Zhang, Lei Chen, Yanyan Cao, Bo Sun, Yanqiao Ren, Tao Sun, Chuansheng Zheng
Summary: The study found that treating unresectable HCC patients with D-TACE-A did not result in improved survival compared to C-TACE-A. However, in specific subgroups, D-TACE-A showed lower risks in certain aspects. Different patients may benefit from different treatment strategies.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Medicine, General & Internal
Marcello Andrea Tipaldi, Edoardo Ronconi, Elena Lucertini, Miltiadis Krokidis, Marta Zerunian, Tiziano Polidori, Paola Begini, Massimo Marignani, Federica Mazzuca, Damiano Caruso, Michele Rossi, Andrea Laghi
Summary: The study investigated the prognostic value of CT-based radiomics features in patients with HCC undergoing DEB-TACE, showing significant correlations with treatment response and survival outcomes. Predictive models based on texture analysis and clinical data were able to identify patients with high or low probabilities of treatment response and survival, providing valuable insights for personalized treatment approaches.
Article
Gastroenterology & Hepatology
Li-Jun Wang, Liang Yin, Kai-Cai Liu, Wei-Fu Lv, Dong Lu
Summary: This study investigated the clinical features, incidence, pathogenesis, and management of liver abscess after drug-eluting bead transarterial chemoembolization (DEB-TACE) for primary and metastatic hepatic malignant tumors. The results showed that the incidence of liver abscess after DEB-TACE is relatively high and can have serious consequences, including death.
HEPATOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Zi-Yu Wang, Chun-Feng Xie, Kun-Liang Feng, Cheng-Ming Xiong, Jun-Hai Huang, Qing-Lian Chen, Chong Zhong, Zhai-Wen Zhou
Summary: DEB-TACE shows significantly improved objective tumor response rate compared to cTACE, but is similar to cTACE in terms of overall survival and adverse events rate, indicating that it is not superior to cTACE.
Article
Engineering, Environmental
Weicheng Xu, Xueding Jiang, Haihui Chen, Xin Chen, Limin Chen, Junliang Wu, Mingli Fu, Daiqi Ye
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Engineering, Civil
Tengfei Xu, Guoqing Chen, Kailai Deng, Limin Chen, Xiaolong Li, Song Lou
Article
Spectroscopy
Qiyun Xie, Lihuan Xu, Chengxiang Hu, Limin Chen, Jiajin Zheng, Wei Wang, Handi Yin, Guofeng Cheng, Xiaoqian Ai
Summary: Understanding the phonon-phonon anharmonic effect in HfTe5 is crucial for both scientific interest and potential thermoelectric applications. Raman spectroscopy was used to study the phonon anharmonicity by measuring the temperature dependence of phonon mode softening and broadening in HfTe5 single crystals. Results showed that four phonon anharmonic effects are significant, leading to low thermal conductivity in HfTe5 crystals due to reduced phonon lifetime from enhanced phonon scattering.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Douglas K. Pleskow, Lei Zhang, Vladimir Turzhitsky, Mark F. Coughlan, Umar Khan, Xuejun Zhang, Conor J. Sheil, Maria Glyavina, Liming Chen, Shweta Shinagare, Yuri N. Zakharov, Edward Vitkin, Irving Itzkan, Lev T. Perelman, Le Qiu
Summary: The novel coherent confocal light scattering and absorption spectroscopic microscopy enables high-resolution imaging of structures in live cells, down to 10 nm spatial scales, and can sense differences in cancer aggressiveness in live cells and identify cancer grades in tumor tissues without labels.
Article
Pharmacology & Pharmacy
Daniel Rizzolo, Bo Kong, Stephanie Piekos, Liming Chen, Xiaobo Zhong, Jie Lu, Jian Shi, Hao-jie Zhu, Qian Yang, Albert Li, Linhao Li, Hongbing Wang, Anna Siemiatkowska, Celine Park, Leonid Kagan, Grace L. Guo
Summary: Fibroblast growth factors 15 and 19 are important in maintaining bile acid homeostasis, and are currently being tested as potential treatments for certain liver diseases. This study found that long-term elevations of these growth factors can lead to increased expression of drug metabolizing enzymes, affecting drug metabolism and pharmacokinetics. The overexpression of Fgf15 was also found to cause a switch in the expression pattern of these enzymes in male mice, similar to the pattern observed in female mice. This change was associated with differences in growth hormone secretion and STAT5 signaling.
DRUG METABOLISM AND DISPOSITION
(2022)
Review
Cell Biology
Mehrdad Izadirad, Zoufang Huang, Farideh Jafari, Amir Ali Hamidieh, Ahmad Gharehbaghian, Yi-Dong Li, Leila Jafari, Zhe-Sheng Chen
Summary: Despite their small size, extracellular vesicles (EVs) play a significant role in the pathogenesis of acute leukemia, especially as carriers of important molecules like miRNA. Research has shown a growing interest in the potential prognostic value and role of leukemia-derived EVs in clinical settings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunhong Mo, Zhao Wang, Jianying Yang, Yiqiang Ouyang, Qian Mo, Shuting Li, Ping He, Limin Chen, Xinchun Li
Summary: This study presents a facile design and construction of a nanodrug system integrating targeted drug delivery and synergistic chemo-photothermal antitumor activity. The prepared nanocarrier using MoS2 nanosheets modified by alpha(v)beta(3) integrin binding peptide (RGD) and thiolated doxorubicin (DOX) showed favorable stability, biocompatibility, and photothermal conversion efficiency. The nanodrug exhibited targeted delivery to Hela cells and significantly reduced cardiotoxicity compared to free DOX, demonstrating powerful photothermal induced tumor-killing efficacy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang, Shuo Fang
Summary: This study reveals CDK6-PI3K as a novel target signaling axis to reverse ABCB1-mediated multidrug resistance for the first time in cancers. Deficiency of CDK6 leads to downregulation of ABCB1 expression and reversal of multidrug resistance.
Article
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Yunfeng Lin, Yi-Dong Li, Jing-Quan Wang, Zhuo Chen, Feng-Feng Ping, Zhe-Sheng Chen
Summary: In this study, the researchers investigated the effect of the CDK4/6 inhibitor, ribociclib, on multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) in human epidermoid carcinoma cells. They found that ribociclib increased the efficacy of a P-gp substrate drug, colchicine, by down-regulating the expression of P-gp and increasing its ATPase activity. Docking studies suggested that ribociclib interacted with the drug-substrate binding site of P-gp. Additionally, ribociclib inhibited the drug efflux activity of P-gp, leading to increased intracellular accumulation of doxorubicin. These findings suggest that ribociclib may be a potential agent for combined therapy in cancers with P-gp-mediated MDR.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Douglas K. Pleskow, Mandeep S. Sawhney, Paul K. Upputuri, Tyler M. Berzin, Mark F. Coughlan, Umar Khan, Maria Glyavina, Xuejun Zhang, Liming Chen, Conor J. Sheil, Jonah M. Cohen, Edward Vitkin, Yuri N. Zakharov, Irving Itzkan, Lei Zhang, Le Qiu, Lev T. Perelman
Summary: Bile duct cancer is a common type of liver cancer, often diagnosed in late stages resulting in poor survival rates. A reliable technique for detecting pre-cancerous changes in the bile duct is urgently needed. This study presents an endoscopic light scattering technique that can accurately evaluate the malignant potential of the bile duct. The technique showed high accuracy in detecting malignant transformation in a pilot study, indicating its potential for non-invasive in vivo identification of biliary duct pre-cancer.
NATURE COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Juntao Li, Yue Wu, Xinxin Yu, Xinyu Zheng, Jiechen Xian, Senjie Li, Wanyin Shi, Yun Tang, Zhe-Sheng Chen, Guixia Liu, Shen Yao, Jian Xu, Xiangwei Zheng
Summary: This study revealed for the first time the pharmacodynamic mechanism of 8-isopentenyl flavonoids in Epimedium sagittatum Maxim. for treating erectile dysfunction (ED), and identified several compounds with significant inhibitory activities and the ability to activate cellular signaling pathways.
Review
Chemistry, Multidisciplinary
Yanyan Wang, Limin Chen, Siyang Li, Luhua Lai
Summary: Biomolecular condensates, formed as membraneless organelles, have diverse biological functions and are associated with diseases. Understanding the roles of intrinsically disordered proteins in their formation and regulation can guide the design of novel drugs.
PROGRESS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuhai Sun, Junliang Wu, Yaolin Wang, Jingjing Li, Ni Wang, Jonathan Harding, Shengpeng Mo, Limin Chen, Peirong Chen, Mingli Fu, Daiqi Ye, Jun Huang, Xin Tu
Summary: The reaction pathways of plasma-enhanced catalytic CO2 hydrogenation were investigated in this study. Placing Pd/ZnO in a DBD reactor under plasma environment significantly improved the conversion of CO2 and the yield of CO. In the Plasma + ZnO system, CO2 splitting played an important role in the conversion of CO2.
Meeting Abstract
Medicine, Research & Experimental
Giuseppe Pettinato, Mark F. Coughlan, Xuejun Zhang, Liming Chen, Maria Glyavina, Yuri N. Zakharov, Lei Zhang, Le Qiu, Robert A. Fisher, Lev T. Perelman
XENOTRANSPLANTATION
(2021)
Article
Medicine, Research & Experimental
Wei Chong, Liang Shang, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Zhe Wang, Yang Chen, Shengtao Jia, Liming Chen, Leping Li, Hao Chen
Summary: Recent studies have shown that m(6)A modification is significantly associated with TME diversity, and different m(6)A modification patterns in colon cancer are correlated with distinct clinical outcomes and biological pathways.